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Gene: Fermt2 MGI:2385001

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Gene Summary

Name:
fermitin family member 2
Synonyms:
Plekhc1,  Mig2,  Kindlin-2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Fermt2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Fermt2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fermt2.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland. Cell death & disease (October 2023) Fermt2tm1c(EUCOMM)Wtsi Fermt2tm1a(EUCOMM)Wtsi PMC10576046
Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice. Cell death & disease (June 2021) Fermt2tm1c(EUCOMM)Wtsi PMC8196014
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis. Molecular metabolism (January 2021) Fermt2tm1a(EUCOMM)Wtsi PMC7808956
Kindlin-2 deficiency induces fatal intestinal obstruction in mice. Theranostics (May 2020) Fermt2tm1a(EUCOMM)Wtsi PMC7255029
Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1. Cell reports (December 2019) Fermt2tm1a(EUCOMM)Wtsi 31825843
Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9. Cancer letters (February 2015) Fermt2tm1a(EUCOMM)Wtsi 25724625

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Fermt2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Fermt2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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