Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

influenza virus NS1A binding protein
1700126I16Rik,  1190004M08Rik,  NS-1,  NS1-BP,  ND1,  Nd1-S,  Nd1-L,  HSPC068

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ivns1abp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ivns1abp by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Immunodeficiency 70
Achalasia, Recurrent sinusitis OMIM:618969

The table below shows human diseases predicted to be associated to Ivns1abp by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Congenital Pulmonary Lymphangiectasia
Respiratory distress, Hepatomegaly, Tricuspid regurgitation, Congestive heart failure, Splenomega... ORPHA:2414
Pleural Mesothelioma
Respiratory distress, Hepatomegaly, Abnormal pleura morphology, Dyspnea, Abnormal lung morphology... ORPHA:50251
Fetal Parvovirus Syndrome
Increased nuchal translucency, Hypertrophic cardiomyopathy, Ascites, Hydrops fetalis ORPHA:295
Congenital Heart Block
First degree atrioventricular block, Gallop rhythm, Crackles, Congestive heart failure, Patent du... ORPHA:60041
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pericardial effusion, Stillbirth, Pleural effusion, Ge... OMIM:618773
Cardiomyopathy, Familial Restrictive, 6
Hepatomegaly, Tricuspid regurgitation, Hydrops fetalis, Ascites, Pulmonic stenosis, Restrictive c... OMIM:619433
Focal Segmental Glomerulosclerosis 1
Hypertension, Pleural effusion, Ascites, Edema OMIM:603278
Primary Effusion Lymphoma
Pericardial effusion, Dyspnea, Pleural effusion ORPHA:48686
Hydrops Fetalis
Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, Pericardial effusion, Capillary leak, Pleu... ORPHA:1041
Sarcoidosis, Susceptibility To, 2
Hepatomegaly, Dyspnea, Splenomegaly, Pneumothorax, Bronchiectasis, Abnormal pulmonary interstitia... OMIM:612387
Lymphatic Malformation 7
Respiratory distress, Nonimmune hydrops fetalis, Edema, Lymphedema, Facial edema, Pericardial eff... OMIM:617300
Malignant Atrophic Papulosis
Gastrointestinal hemorrhage, Constrictive pericarditis, Pleural effusion OMIM:602248
Acute Interstitial Pneumonia
Peribronchovascular interstitial thickening, Nodular pattern on pulmonary HRCT, Crackles, Pericar... ORPHA:79126
Combined Oxidative Phosphorylation Deficiency 10
Pericardial effusion, Pleural effusion, Bradycardia, Hypertrophic cardiomyopathy, Ascites, Oligoh... OMIM:614702
Lymphangiectasia, Pulmonary, Congenital
Recurrent respiratory infections, Palpebral edema, Nonimmune hydrops fetalis, Polyhydramnios, Ede... OMIM:265300
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Plantar telangiectasia, Predominantly lower limb lymphedema, Palpebral edema, Hydrops fetalis, Pa... ORPHA:69735
Pulmonary Non-Tuberculous Mycobacterial Infection
Respiratory distress, Crackles, Pericardial effusion, Dyspnea, Chronic pulmonary obstruction, Pne... ORPHA:411703
Pericardial effusion, Ascites OMIM:256150
Ovarian Hyperstimulation Syndrome
Ascites OMIM:608115
Staphylococcal Necrotizing Pneumonia
Shock, Respiratory distress, Pneumonia, Nonproductive cough, Dyspnea, Tachypnea, Pneumothorax, Ac... ORPHA:36238
Wild Type Attr Amyloidosis
Abnormal EKG, Hepatomegaly, Myocardial infarction, Congestive heart failure, Abnormal pulmonary i... ORPHA:330001
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Ascites ORPHA:2198
Diffuse Neonatal Hemangiomatosis
Hepatomegaly, Polyhydramnios, Patent ductus arteriosus, Hydrops fetalis, Ascites ORPHA:2123
Lethal Hemolytic Anemia-Genital Anomalies Syndrome
Polyhydramnios, Splenomegaly, Respiratory insufficiency, Aplasia/Hypoplasia of the lungs, Ascites... ORPHA:1046
Pulmonary Capillary Hemangiomatosis
Pulmonary edema, Diffuse alveolar hemorrhage, Right ventricular failure, Pericardial effusion, Pu... ORPHA:199241
Hemochromatosis, Type 1
Hepatomegaly, Congestive heart failure, Splenomegaly, Telangiectasia, Cardiomyopathy, Pleural eff... OMIM:235200
Tempi Syndrome
Transudative pleural effusion, Telangiectasia, Intracranial hemorrhage, Hypoxemia, Abnormality of... ORPHA:284227
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Dyspnea, Ascites OMIM:174050
Follicular Lymphoma
Splenomegaly, Pleural effusion, Lymphedema ORPHA:545
Hepatic Veno-Occlusive Disease
Hepatomegaly, Respiratory failure, Ascites ORPHA:890
Chylous Ascites
Ascites, Lymphedema ORPHA:1160
Pseudo-Torch Syndrome 2
Hepatomegaly, Acute respiratory distress syndrome, Cerebral hemorrhage, Patent ductus arteriosus,... OMIM:617397
Systemic Capillary Leak Syndrome
Pericarditis, Rhinorrhea, Myocarditis, Pedal edema, Cardiorespiratory arrest, Pleural effusion, H... ORPHA:188
Klippel-Trénaunay Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Edema, Pulmonary embolism, Congestive heart failure, P... ORPHA:90308
Cardiomyopathy, Familial Hypertrophic, 4
Respiratory distress, Hepatomegaly, Transient ischemic attack, Cardiac arrest, Sudden cardiac dea... OMIM:115197
Multiple pulmonary cysts, Respiratory failure requiring assisted ventilation, Nonproductive cough... ORPHA:723
Hypocomplementemic Urticarial Vasculitis
Hepatomegaly, Pericardial effusion, Dyspnea, Angioedema, Emphysema, Splenomegaly, Restrictive ven... ORPHA:36412
Glycogen Storage Disease Iv
Polyhydramnios, Portal hypertension, Edema, Hydrops fetalis, Hepatosplenomegaly, Cardiomyopathy, ... OMIM:232500
Glycogen Storage Disease Of Heart, Lethal Congenital
Respiratory distress, Prolonged QRS complex, Apnea, Left axis deviation, Pericardial effusion, Co... OMIM:261740
Familial Atrial Myxoma
Tricuspid regurgitation, Congestive heart failure, Heart murmur, Pedal edema, Ascites, Exertional... ORPHA:615
Sialidosis Type 2
Hepatomegaly, Dyspnea, Splenomegaly, Hydrops fetalis, Pedal edema, Ascites ORPHA:87876
Noonan Syndrome 8
Polyhydramnios, Patent ductus arteriosus, Pleural effusion, Mitral regurgitation, Pulmonic stenos... OMIM:615355
Sinusitis, Pneumonia, Dyspnea, Asthma, Chronic pulmonary obstruction, Hypersensitivity pneumoniti... ORPHA:1163
Ovarian Fibroma
Pleural effusion, Ascites ORPHA:314473
Idiopathic Chronic Eosinophilic Pneumonia
Crackles, Dyspnea, Nonproductive cough, Atelectasis, Wheezing, Asthma, Hypersensitivity pneumonit... ORPHA:2902
Systemic-Onset Juvenile Idiopathic Arthritis
Hepatomegaly, Pericarditis, Splenomegaly, Joint swelling, Pleural effusion ORPHA:85414
Ovarian Hyperstimulation Syndrome
Generalized edema, Hypovolemia, Capillary leak, Peripheral edema, Pleural effusion, Ascites, Pulm... ORPHA:64739
Infantile Sialic Acid Storage Disease
Hepatomegaly, Splenomegaly, Congestive heart failure, Hydrops fetalis, Ascites OMIM:269920
Car T Cell Therapy-Associated Cytokine Release Syndrome
Tachycardia, Heart block, Tachypnea, Capillary leak, Hypoxemia, Pleural effusion, Respiratory fai... ORPHA:542323
Immunodeficiency 91 And Hyperinflammation
Hepatomegaly, Edema, Recurrent pneumonia, Abnormal pulmonary interstitial morphology, Hepatosplen... OMIM:619644
Alpha-Heavy Chain Disease
Splenomegaly, Hepatomegaly, Ascites ORPHA:100025
Meige Disease
Predominantly lower limb lymphedema, Edema of the dorsum of hands, Facial edema, Periorbital edem... ORPHA:90186
Hemolytic Disease Of Fetus And Newborn, Rh-Induced
Hepatomegaly, Fetal ascites, Polyhydramnios, Splenomegaly, Hydrops fetalis OMIM:619462
Splenoportal Vascular Anomalies
Splenomegaly, Ascites OMIM:271500
Lymphatic Malformation 6
Genital edema, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Periorbital edema,... OMIM:616843
Pericarditis, Sinusitis, Bronchial breath sound, Pneumonia, Bronchitis, Abnormal respiratory syst... ORPHA:449280
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Palpebral edema, Edema, Pulmonary embolism, Facial edema, Respiratory tract infection, Dyspnea, P... ORPHA:567546
Congenital Enterovirus Infection
Respiratory distress, Polyhydramnios, Fetal ascites, Pericardial effusion, Myocarditis, Hydrops f... ORPHA:292
Respiratory distress, Tachycardia, Pneumonia, Cough, Pleural effusion ORPHA:3392
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Polyhydramnios, Hydrops fetalis, Pleural effusion, Pulmonary hypoplasia, Hypertrophic cardiomyopa... OMIM:616897
Congenital Disorder Of Glycosylation, Type Iir
Hepatomegaly, Ascites OMIM:301045
Avian Influenza
Respiratory distress, Pneumonia, Productive cough, Congestive heart failure, Nonproductive cough,... ORPHA:454836
Cirrhotic Cardiomyopathy
Prolonged QT interval, Hepatomegaly, Elevated jugular venous pressure, Left ventricular diastolic... ORPHA:57777
Neuraminidase Deficiency
Hepatomegaly, Facial edema, Splenomegaly, Hydrops fetalis, Cardiomyopathy, Ascites OMIM:256550
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Nonimmune hydrops fetalis, Patent ductus arteriosus, Respiratory insufficiency, Hypertension, Sec... OMIM:617021
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Hepatomegaly, Tricuspid regurgitation, Crackles, Atelectasis, Dyspnea, Asthma, Wheezing, Bronchie... OMIM:620233
Portal Hypertension, Noncirrhotic, 2
Hepatomegaly, Epistaxis, Portal hypertension, Splenomegaly, Ascites OMIM:619463
Pulmonary Arteriovenous Malformation
Transient ischemic attack, Epistaxis, Myocardial infarction, Dyspnea, Heart murmur, Telangiectasi... ORPHA:2038
Mulibrey Nanism
Hepatomegaly, Congestive heart failure, Hydrops fetalis, Recurrent lower respiratory tract infect... OMIM:253250
Pontocerebellar Hypoplasia, Type 13
Pleural effusion, Asthma, Recurrent respiratory infections, Edema OMIM:618606
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Respiratory distress, Hepatomegaly, Nonimmune hydrops fetalis, Portal hypertension, Polyhydramnio... ORPHA:367
Congenital Disorder Of Glycosylation, Type Ih
Hepatomegaly, Edema, Patent ductus arteriosus, Neonatal death, Ascites, Oligohydramnios OMIM:608104
Ovarian Fibrothecoma
Pleural effusion, Ascites ORPHA:314478
Cholestasis, Progressive Familial Intrahepatic, 5
Pleural effusion, Ascites, Nonimmune hydrops fetalis OMIM:617049
Combined Oxidative Phosphorylation Deficiency 5
Hypertrophic cardiomyopathy, Ascites, Edema OMIM:611719
Free Sialic Acid Storage Disease
Recurrent respiratory infections, Hepatomegaly, Splenomegaly, Hydrops fetalis, Ascites ORPHA:834
Congenital Toxoplasmosis
Hepatomegaly, Ascites ORPHA:858
Familial Idiopathic Dilatation Of The Right Atrium
Hepatomegaly, Abnormal cardiac ventricular function, Tricuspid regurgitation, Paroxysmal atrial f... ORPHA:1677
Pseudomyxoma Peritonei
Ascites, Respiratory insufficiency ORPHA:26790
Malignant Peritoneal Mesothelioma
Dyspnea, Ascites, Pedal edema ORPHA:168811
Amoebiasis Due To Entamoeba Histolytica
Lung abscess, Dyspnea, Congestive heart failure, Pleural empyema, Cough, Constrictive pericarditi... ORPHA:67
Congenital Disorder Of Glycosylation, Type Il
Hepatomegaly, Edema, Pericardial effusion, Hepatosplenomegaly, Ascites OMIM:608776
Dengue Fever
Gastrointestinal hemorrhage, Hepatomegaly, Epistaxis, Cerebral hemorrhage, Cardiorespiratory arre... ORPHA:99828
Pediatric Systemic Lupus Erythematosus
Edema, Raynaud phenomenon, Dyspnea, Pericardial effusion, Pleural effusion, Ascites ORPHA:93552
Glycogen Storage Disease Ii
Wolff-Parkinson-White syndrome, Recurrent respiratory infections, Right axis deviation, Hepatomeg... OMIM:232300
Gorham-Stout Disease
Pleural effusion, Edema, Rhinorrhea ORPHA:73
Poems Syndrome
Edema, Pericardial effusion, Respiratory insufficiency due to muscle weakness, Restrictive ventil... ORPHA:2905
Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Ascites, Pericarditis, Pleuritis, Mitral regurgitation ORPHA:2848
Waldenström Macroglobulinemia
Gastrointestinal hemorrhage, Hepatomegaly, Epistaxis, Periorbital edema, Congestive heart failure... ORPHA:33226
Primary Intestinal Lymphangiectasia
Edema, Pericardial effusion, Pleural effusion, Ascites, Generalized edema ORPHA:90362
Ring Chromosome 22 Syndrome
Pleural effusion, Edema, Lymphedema ORPHA:1446
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Hepatomegaly, Edema, Pulmonary embolism, Budd-Chiari syndrome, Recurrent lower respiratory tract ... OMIM:226300
Ascites, Chylous
Chylous ascites OMIM:208300
Eosinophilic Gastroenteritis
Allergic rhinitis, Edema, Asthma, Hematochezia, Ascites ORPHA:2070
Diarrhea 10, Protein-Losing Enteropathy Type
Polyhydramnios, Pericardial effusion, Recurrent upper respiratory tract infections, Hematochezia,... OMIM:618183
Lymphoproliferative Syndrome 1
Pericardial effusion, Hepatomegaly, Pleural effusion, Splenomegaly OMIM:613011
Lymphoproliferative Syndrome 2
Hepatomegaly, Splenomegaly, Recurrent pneumonia, Hepatosplenomegaly, Ascites OMIM:615122
Lymphatic Malformation 12
Neonatal respiratory distress, Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, Fetal ascit... OMIM:620014
Reynolds Syndrome
Hepatomegaly, Telangiectasia of the skin, Xerostomia, Respiratory insufficiency, Ascites, Mucosal... ORPHA:779
Gastrointestinal hemorrhage, Recurrent respiratory infections, Lymphedema, Atelectasis, Dyspnea, ... ORPHA:538
Kaposiform Lymphangiomatosis
Epidural hemorrhage, Epistaxis, Pericardial effusion, Dyspnea, Abnormal lung morphology, Splenome... ORPHA:464329
Tropical Endomyocardial Fibrosis
Prolonged QRS complex, Restrictive cardiomyopathy, Atrioventricular block, Left bundle branch blo... ORPHA:75565
Malignant Atrophic Papulosis
Gastrointestinal hemorrhage, Telangiectasia of the skin, Myocardial infarction, Respiratory failu... ORPHA:679
Q Fever
Respiratory distress, Hepatomegaly, Pericarditis, Pneumonia, Pericardial effusion, Myocarditis, S... ORPHA:781
Wolman Disease
Splenomegaly, Hepatomegaly, Ascites ORPHA:75233
Lymphatic Malformation 13
Nonimmune hydrops fetalis, Lymphedema, Patent ductus arteriosus, Mitral regurgitation, Neonatal d... OMIM:620244
Congenital Sialidosis Type 2
Abnormal EKG, Hepatomegaly, Edema, Respiratory tract infection, Telangiectasia, Hepatosplenomegal... ORPHA:93400
Necrotizing Enterocolitis
Shock, Apnea, Edema, Bradycardia, Hypotension, Ascites ORPHA:391673
Niemann-Pick Disease, Type A
Splenomegaly, Recurrent respiratory infections, Ascites, Hepatomegaly OMIM:257200
Noonan Syndrome 10
Mitral stenosis, Patent ductus arteriosus, Increased nuchal translucency, Pleural effusion, Mitra... OMIM:616564
Alkuraya-Kucinskas Syndrome
Pericardial effusion, Pleural effusion, Edema OMIM:617822
Mucopolysaccharidosis Type 7
Recurrent respiratory infections, Abnormal pleura morphology, Lymphedema, Splenomegaly, Hydrops f... ORPHA:584
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Nonimmune hydrops fetalis, Lymphedema, Patent ductus arterio... OMIM:153400
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Splenomegaly, Recurrent pneumonia, Hepatosplenomegaly, Pulmonary fibrosis, Pleural effusion OMIM:618935
Ascites, Hydrops fetalis, Edema, Oligohydramnios ORPHA:79325
Classic Galactosemia
Hepatomegaly, Ascites ORPHA:79239
Secondary Intestinal Lymphangiectasia
Intestinal lymphedema, Edema, Lymphedema, Right ventricular failure, Chylous ascites, Intestinal ... ORPHA:90363
Griscelli Syndrome
Splenomegaly, Hepatomegaly, Ascites, Pedal edema ORPHA:381
Hellp Syndrome
Pulmonary edema, Cerebral hemorrhage, Hypotension, Pleural effusion, Internal hemorrhage, General... ORPHA:244242
Radio-Renal Syndrome
Respiratory distress, Dyspnea, Respiratory failure, Chylothorax, Pleural effusion ORPHA:3015
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Hepatomegaly, Portal hypertension, Splenomegaly, Ascites ORPHA:131
Congenital Myopathy 22B, Severe Fetal
Respiratory distress, Hepatomegaly, Nonimmune hydrops fetalis, Polyhydramnios, Pulmonary hypoplas... OMIM:620369
Primary Hepatic Neuroendocrine Carcinoma
Hepatomegaly, Right ventricular failure, Dyspnea, Heart murmur, Neoplasm of the lung, Bronchospas... ORPHA:100085
Aggressive Systemic Mastocytosis
Gastrointestinal hemorrhage, Portal hypertension, Hepatosplenomegaly, Hypotension, Ascites ORPHA:98850
Hemorrhagic Fever-Renal Syndrome
Shock, Respiratory distress, Tachycardia, Epistaxis, Pneumonia, Hematemesis, Dyspnea, Capillary l... ORPHA:340
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Nonimmune hydrops fetalis, Lymphedema, Periorbital edema, Pericardial effusion, Pulmonary lymphan... OMIM:235510
Gaucher Disease Type 1
Hepatomegaly, Pericardial effusion, Splenomegaly, Abnormal pulmonary interstitial morphology, Ped... ORPHA:77259
Desmoplastic Small Round Cell Tumor
Neoplasm of the lung, Hepatomegaly, Ascites ORPHA:83469
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Gastrointestinal hemorrhage, Cerebral hemorrhage, Diffuse alveolar hemorrhage, Hematemesis, Abnor... ORPHA:464321
Capillary Malformation-Arteriovenous Malformation
Epistaxis, Nonimmune hydrops fetalis, Lymphedema, High-output congestive heart failure, Congestiv... ORPHA:137667
Gaucher Disease, Perinatal Lethal
Respiratory distress, Hepatomegaly, Apnea, Nonimmune hydrops fetalis, Polyhydramnios, Splenomegal... OMIM:608013
Cirrhosis, Familial
Hypertension, Ascites, Pulmonary arterial hypertension OMIM:215600
Cholestasis, Progressive Familial Intrahepatic, 3
Splenomegaly, Hepatomegaly, Ascites OMIM:602347
Eisenmenger Syndrome
Respiratory distress, Ventricular tachycardia, Pedal edema, Aortopulmonary window, Supraventricul... ORPHA:97214
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Recurrent respiratory infections, Hepatomegaly, Portal hypertension, Hepatosplenomegaly, Pulmonar... ORPHA:79124
Aicardi-Goutieres Syndrome 9
Hepatomegaly, Pericarditis, Portal hypertension, Edema, Pericardial effusion, Hepatosplenomegaly,... OMIM:619487
Idiopathic Hypereosinophilic Syndrome
Respiratory distress, Transient ischemic attack, Supraventricular arrhythmia, Pulmonary embolism,... ORPHA:3260
Sarcoidosis, Susceptibility To, 1
Hepatomegaly, Pericardial effusion, Dyspnea, Splenomegaly, Bronchiectasis, Abnormal pulmonary int... OMIM:181000
Immunodeficiency 22
Pericarditis, Recurrent upper respiratory tract infections, Capillary leak, Recurrent lower respi... OMIM:615758
Hepatoportal Sclerosis
Gastrointestinal hemorrhage, Splenomegaly, Ascites, Portal hypertension ORPHA:64743
Erdheim-Chester Disease
Dyspnea, Congestive heart failure, Abnormal pulmonary interstitial morphology, Joint swelling, Pu... ORPHA:35687
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hepatomegaly, Portal hypertension, Splenomegaly, Hepatocellular necrosis, Ascites OMIM:251880
Granulomatous Disease, Chronic, X-Linked
Hepatomegaly, Atelectasis, Splenomegaly, Recurrent pneumonia, Cough, Pleural effusion, Ascites OMIM:306400
Farber Disease
Respiratory distress, Nodular pattern on pulmonary HRCT, Atelectasis, Recurrent upper respiratory... ORPHA:333
Autoimmune Hepatitis
Gastrointestinal hemorrhage, Splenomegaly, Ascites, Spider hemangioma ORPHA:2137
Short-Rib Thoracic Dysplasia 12
Hepatomegaly, Polyhydramnios, Edema, Atelectasis, Patent ductus arteriosus, Splenomegaly, Respira... OMIM:269860
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Hepatomegaly, Polyhydramnios, Lymphedema, Splenomegaly, Pulmonary lymphangiectasia, Ascites OMIM:235255
Fraser Syndrome 3
Nonimmune hydrops fetalis, Abnormal lung lobation, Stillbirth, Ascites, Oligohydramnios OMIM:617667
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Neonatal respiratory distress, Nonimmune hydrops fetalis, Polyhydramnios, Patent ductus arteriosu... OMIM:265380
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Portal hypertension, Pulmonary artery atresia, Pulmonary arterial hy... ORPHA:974
Sclerosing Cholangitis, Neonatal
Splenomegaly, Hepatomegaly, Ascites, Portal hypertension OMIM:617394
Congenital Myopathy 2C, Severe Infantile, Autosomal Dominant
Respiratory distress, Cerebral hemorrhage, Subdural hemorrhage, Respiratory failure, Chylothorax OMIM:620278
Familial Mediterranean Fever
Hepatomegaly, Pericarditis, Splenomegaly, Pleural effusion, Pleuritis OMIM:249100
Immunodeficiency 87 And Autoimmunity
Hepatomegaly, Dilated cardiomyopathy, Hypertension, Anasarca, Third degree atrioventricular block... OMIM:619573
Sinusitis, Lung abscess, Pneumonia, Productive cough, Hypersensitivity pneumonitis, Bronchiectasi... ORPHA:228119
Chondrodysplasia, Blomstrand Type
Stillbirth, Fetal ascites, Hydrops fetalis, Polyhydramnios OMIM:215045
Respiratory distress, Pericarditis, Pneumonia, Productive cough, Nonproductive cough, Dyspnea, Pn... ORPHA:31204
Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure
Pleural effusion, Anasarca, Edema OMIM:254900
Gastrointestinal hemorrhage, Pericarditis, Sinusitis, Epistaxis, Hematemesis, Myocarditis, Perior... ORPHA:73263
Respiratory distress, Pneumonia, Nodular pattern on pulmonary HRCT, Dyspnea, Cough, Pleural effus... ORPHA:1546
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Neonatal respiratory distress, Chylothorax, Polyhydramnios OMIM:619036
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Ascites, Pulmonary hypoplasia, Hydrops fetalis OMIM:614091
Primary Sclerosing Cholangitis
Hepatomegaly, Portal hypertension, Spider hemangioma, Congestive heart failure, Splenomegaly, Hep... ORPHA:171
Hennekam Syndrome
Recurrent respiratory infections, Lymphedema, Pericardial effusion, Splenomegaly, Pulmonary lymph... ORPHA:2136
Chédiak-Higashi Syndrome
Recurrent respiratory infections, Epistaxis, Edema, Pericardial effusion, Splenomegaly, Hepatospl... ORPHA:167
Carney Triad
Gastrointestinal hemorrhage, Tachycardia, Hypertension, Arrhythmia, Ascites ORPHA:139411
Wolcott-Rallison Syndrome
Hepatomegaly, Ascites, Dehydration ORPHA:1667
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hepatomegaly, Polyhydramnios, Splenomegaly, Pulmonary lymphangiectasia, Hepatosplenomegaly, Ascites ORPHA:1655
Behçet Disease
Aortic regurgitation, Gastrointestinal hemorrhage, Pericarditis, Myocardial infarction, Pulmonary... ORPHA:117
Hepatomegaly, Abnormal cardiac ventricular function, Portal hypertension, Abnormal pleura morphol... ORPHA:797
Familial Mediterranean Fever
Pericarditis, Myocardial infarction, Splenomegaly, Vasculitis, Pedal edema, Pleuritis, Arrhythmia... ORPHA:342
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Increased nuchal translucency, Pleural effusion ORPHA:453499
Infection-Related Hemolytic Uremic Syndrome
Pneumonia, Edema, Respiratory tract infection, Myocarditis, Dyspnea, Hypertension, Pleural empyem... ORPHA:544482
Osteopetrosis, Autosomal Recessive 5
Hepatomegaly, Splenomegaly, Hepatosplenomegaly, Respiratory failure, Stillbirth, Ascites OMIM:259720
Gracile Bone Dysplasia
Ascites OMIM:602361
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Polyhydramnios, Lymphedema, Splenomegaly, Hepatosplenomegaly, Mitral regurgitation, Chylothorax, ... OMIM:613563
Pancreatitis, Hereditary
Pleural effusion OMIM:167800
Intrahepatic Cholestasis Of Pregnancy
Neonatal respiratory distress, Ascites ORPHA:69665
Xfe Progeroid Syndrome
Hypertension, Ascites OMIM:610965
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Respiratory distress, Congestive heart failure, Ascites, Polyhydramnios OMIM:617156
Respiratory distress, Hepatomegaly, Pericarditis, First degree atrioventricular block, Retinal he... ORPHA:509
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Abnormal left ventricular function, Internal hemorrhage, Hepatomegaly, Peric... ORPHA:99827
Peripheral Primitive Neuroectodermal Tumor
Ascites, Pelvic mass ORPHA:370348
Functioning Gonadotropic Adenoma
Ascites ORPHA:91348
Acrocephalopolydactylous Dysplasia
Hepatomegaly, Ascites, Pulmonary hypoplasia, Extrapulmonary sequestrum OMIM:200995
Hepatomegaly, Pericarditis, Lung abscess, Transient ischemic attack, Pneumonia, Bronchitis, Myoca... ORPHA:1304
Respiratory distress, Pericarditis, Pneumonia, Vasculitis, Vasospasm, Cerebral ischemia, Pleural ... ORPHA:228123
Atresia Of Urethra
Ascites, Pulmonary insufficiency, Oligohydramnios ORPHA:105
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Pleural effusion, Chylothorax, Edema, Lymphedema ORPHA:2526
Cutis Laxa, Autosomal Recessive, Type Ic
Periorbital edema, Atelectasis, Recurrent pneumonia, Pulmonary hypoplasia, Tracheomalacia, Emphys... OMIM:613177
Cutis Marmorata Telangiectatica Congenita
Patent ductus arteriosus, Ascites, Telangiectasia of the skin ORPHA:1556
Caroli Disease
Splenomegaly, Hepatomegaly, Ascites, Portal hypertension ORPHA:53035
Chronic Graft Versus Host Disease
Dyspnea, Wheezing, Pneumothorax, Xerostomia, Bronchiectasis, Bronchiolitis obliterans, Cough, Ple... ORPHA:99921
Kikuchi-Fujimoto Disease
Hepatomegaly, Palpebral edema, Myocarditis, Splenomegaly, Vasculitis, Abnormal pulmonary intersti... ORPHA:50918
Mosaic Variegated Aneuploidy Syndrome
Aortic regurgitation, Apnea, Polyhydramnios, Increased nuchal translucency, Abnormal lung lobatio... ORPHA:1052
Tyrosinemia, Type I
Gastrointestinal hemorrhage, Hepatomegaly, Splenomegaly, Melena, Hypertrophic cardiomyopathy, Asc... OMIM:276700
Primary Biliary Cholangitis
Orthostatic hypotension, Ascites, Portal hypertension ORPHA:186
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Respiratory distress, Hepatomegaly, Ascites, Hepatocellular necrosis OMIM:256810
Rajab Interstitial Lung Disease With Brain Calcifications 1
Portal hypertension, Tachypnea, Abnormal pulmonary interstitial morphology, Respiratory insuffici... OMIM:613658
Perlman Syndrome
Ascites, Polyhydramnios, Visceromegaly, Edema OMIM:267000
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Hypoventilation, Spontaneous pneumothorax, Portal hypertension, Sple... ORPHA:731
Multiple Myeloma
Splenomegaly, Pleural effusion ORPHA:29073
Senior-Boichis Syndrome
Hypertension, Ascites, Portal hypertension, Hepatosplenomegaly ORPHA:84081
Mitchell-Riley Syndrome
Ascites OMIM:615710
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Splenomegaly, Hepatomegaly, Ascites, Aspiration pneumonia OMIM:301072
Lysosomal Acid Lipase Deficiency
Hypovolemia, Dehydration, Hepatosplenomegaly, Hypotension, Pulmonary arterial hypertension, Ascites ORPHA:275761
Fumarase Deficiency
Ascites, Polyhydramnios OMIM:606812
Hepatomegaly, Respiratory insufficiency due to muscle weakness, Abnormal abdomen morphology, Dehy... ORPHA:97282
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Abnormal abdomen morphology ORPHA:97278
Wilson Disease
Hepatomegaly, Edema, Splenomegaly, Pedal edema, Ascites OMIM:277900
Lipodystrophy, Familial Partial, Type 7
Orthostatic hypotension, Spontaneous pneumothorax, Pulmonary arteriovenous malformation, Hyperten... OMIM:606721
Gastrointestinal hemorrhage, Hepatomegaly, Abnormal abdomen morphology, Neoplasm of the lung, Asc... ORPHA:97261
Gallbladder Neuroendocrine Tumor
Ascites ORPHA:100086
Fryns Syndrome
Chylothorax, Stillbirth, Pulmonary hypoplasia, Polyhydramnios OMIM:229850
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Abnormal abdomen morphology ORPHA:97283
Niemann-Pick Disease Type C
Hepatomegaly, Fetal ascites, Splenomegaly, Abnormal lung morphology, Hydrops fetalis, Respiratory... ORPHA:646
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Hypoventilation, Hepatomegaly, Anasarca, Tracheomalacia, Ascites OMIM:203700
Gastrointestinal hemorrhage, Hepatomegaly, Ascites, Abnormal abdomen morphology ORPHA:97280
Noonan Syndrome 1
Lymphedema, Patent ductus arteriosus, Chylothorax, Pulmonic stenosis, Hypertrophic cardiomyopathy OMIM:163950
Biliary, Renal, Neurologic, And Skeletal Syndrome
Aortic regurgitation, Recurrent respiratory infections, Pulmonary artery dilatation, Tricuspid re... OMIM:619534
Liver Disease, Severe Congenital
Hepatomegaly, Pneumonia, Splenomegaly, Patent ductus arteriosus, Abnormal left ventricular functi... OMIM:619991
Generalized Arterial Calcification Of Infancy
Respiratory distress, Transient ischemic attack, Edema, Polyhydramnios, Pericardial effusion, Ret... ORPHA:51608
Congenital Tracheal Stenosis
Respiratory distress, Fetal ascites, Polyhydramnios, Neonatal asphyxia, Patent ductus arteriosus,... ORPHA:141127
Niemann-Pick Disease, Type C2
Hepatomegaly, Neonatal respiratory distress, Fetal ascites, Polyhydramnios, Splenomegaly, Respira... OMIM:607625
Singleton-Merten Syndrome 1
Congestive heart failure, Aortic valve stenosis, Recurrent respiratory infections, Pleural effusion OMIM:182250
Johanson-Blizzard Syndrome
Hepatomegaly, Portal hypertension, Splenomegaly, Dilated cardiomyopathy, Anasarca, Ascites, Gener... OMIM:243800
Niemann-Pick Disease, Type C1
Splenomegaly, Hepatomegaly, Fetal ascites OMIM:257220
D-Bifunctional Protein Deficiency
Splenomegaly, Hepatomegaly, Fetal ascites, Polyhydramnios OMIM:261515
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Neonatal respiratory distress, Apnea, Portal hypertension, Fetal ascites, Asthma, Hepatosplenomeg... OMIM:619503
Faundes-Banka Syndrome
Fetal ascites OMIM:619376
Immunodeficiency 70
Achalasia, Recurrent sinusitis OMIM:618969


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ivns1abp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ivns1abp.

No publications found that use IMPC mice or data for Ivns1abp.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ivns1abptm107929(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ivns1abptm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter