Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

influenza virus NS1A binding protein
1700126I16Rik,  1190004M08Rik,  NS-1,  NS1-BP,  ND1,  Nd1-S,  Nd1-L,  HSPC068

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ivns1abp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ivns1abp by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Immunodeficiency 70
Recurrent sinusitis, Achalasia OMIM:618969

The table below shows human diseases predicted to be associated to Ivns1abp by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Congenital Pulmonary Lymphangiectasia
Congestive heart failure, Hydrops fetalis, Splenomegaly, Pleural effusion, Pulmonic stenosis, Cou... ORPHA:2414
Pleural Mesothelioma
Abnormal respiratory system physiology, Abnormal cardiovascular system physiology, Pleural effusi... ORPHA:50251
Fetal Parvovirus Syndrome
Hydrops fetalis, Hypertrophic cardiomyopathy, Increased nuchal translucency, Ascites ORPHA:295
Cardiomyopathy, Familial Restrictive, 6
Pulmonary insufficiency, Hydrops fetalis, Hepatomegaly, Pulmonic stenosis, Restrictive cardiomyop... OMIM:619433
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Pleural effusion, Polyhydramnios, Generalized edema, Stillbirth, Peric... OMIM:618773
Sarcoidosis, Susceptibility To, 2
Emphysema, Restrictive ventilatory defect, Hypoxemia, Elevated bronchoalveolar lavage fluid lymph... OMIM:612387
Primary Effusion Lymphoma
Pleural effusion, Pericardial effusion, Dyspnea ORPHA:48686
Acute Interstitial Pneumonia
Nonproductive cough, Reticulonodular pattern on pulmonary HRCT, Hypoxemia, Peripheral edema, Crac... ORPHA:79126
Malignant Atrophic Papulosis
Constrictive pericarditis, Pleural effusion, Gastrointestinal hemorrhage OMIM:602248
Hydrops Fetalis
Arrhythmia, Nonimmune hydrops fetalis, Pleural effusion, Capillary leak, Lymphedema, Polyhydramni... ORPHA:1041
Lymphangiectasia, Pulmonary, Congenital
Chylothorax, Nonimmune hydrops fetalis, Pleural effusion, Pulmonary lymphangiectasia, Palpebral e... OMIM:265300
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular fibrillation, Cardiac arrest, Hypertrophic cardiomyopathy, Right bundle branch block,... OMIM:115197
Staphylococcal Necrotizing Pneumonia
Nonproductive cough, Pulmonary pneumatocele, Pneumonia, Hypoxemia, Tachypnea, Hypotension, Cough,... ORPHA:36238
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Hydrops fetalis, Plantar telangiectasia, Pleural effusion, Predominantly lower limb lymphedema, P... ORPHA:69735
Diffuse Neonatal Hemangiomatosis
Patent ductus arteriosus, Hydrops fetalis, Hepatomegaly, Polyhydramnios, Ascites ORPHA:2123
Ovarian Hyperstimulation Syndrome
Ascites OMIM:608115
Wild Type Attr Amyloidosis
Arrhythmia, Congestive heart failure, Abnormal EKG, Hypertrophic cardiomyopathy, Myocardial infar... ORPHA:330001
Pulmonary Capillary Hemangiomatosis
Pulmonary capillary hemangiomatosis, Diffuse alveolar hemorrhage, Hypoxemia, Abnormal pulmonary v... ORPHA:199241
Pulmonary Non-Tuberculous Mycobacterial Infection
Crackles, Cough, Pleural effusion, Bronchiectasis, Dyspnea, Chronic pulmonary obstruction, Pneumo... ORPHA:411703
Pericardial effusion, Ascites OMIM:256150
Tempi Syndrome
Transudative pleural effusion, Hypoxemia, Ascites, Telangiectasia, Abnormality of the pulmonary v... ORPHA:284227
Hemochromatosis, Type 1
Arrhythmia, Congestive heart failure, Splenomegaly, Pleural effusion, Hepatomegaly, Cardiomyopath... OMIM:235200
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Hepatomegaly, Gastrointestinal hemorrhage, Ascites ORPHA:2198
Chylous Ascites
Lymphedema, Ascites ORPHA:1160
Follicular Lymphoma
Lymphedema, Splenomegaly, Pleural effusion ORPHA:545
Klippel-Trénaunay Syndrome
Gastrointestinal hemorrhage, Patent ductus arteriosus, Congestive heart failure, Hydrops fetalis,... ORPHA:90308
Lethal Hemolytic Anemia-Genital Anomalies Syndrome
Aplasia/Hypoplasia of the lungs, Splenomegaly, Polyhydramnios, Ascites, Respiratory insufficiency... ORPHA:1046
Combined Oxidative Phosphorylation Deficiency 5
Edema, Hypertrophic cardiomyopathy, Ascites OMIM:611719
Hepatic Veno-Occlusive Disease
Respiratory failure, Hepatomegaly, Ascites ORPHA:890
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Ascites, Dyspnea OMIM:174050
Systemic Capillary Leak Syndrome
Arrhythmia, Myocarditis, Hypotension, Cough, Rhinorrhea, Pleural effusion, Pedal edema, Cardiores... ORPHA:188
Hemolytic Anemia, Lethal Congenital Nonspherocytic, With Genital And Other Abnormalities
Hepatosplenomegaly, Ascites OMIM:600461
Hypocomplementemic Urticarial Vasculitis
Emphysema, Restrictive ventilatory defect, Airway obstruction, Angioedema, Splenomegaly, Cough, S... ORPHA:36412
Glycogen Storage Disease Iv
Portal hypertension, Hepatosplenomegaly, Hydrops fetalis, Polyhydramnios, Cardiomyopathy, Ascites... OMIM:232500
Nonproductive cough, Respiratory failure requiring assisted ventilation, Hypoxemia, Interstitial ... ORPHA:723
Ovarian Fibroma
Pleural effusion, Ascites ORPHA:314473
Ovarian Hyperstimulation Syndrome
Hypovolemia, Peripheral edema, Pleural effusion, Capillary leak, Ascites, Generalized edema, Pulm... ORPHA:64739
Sinusitis, Hypersensitivity pneumonitis, Pneumonia, Abnormality on pulmonary function testing, As... ORPHA:1163
Noonan Syndrome 8
Patent ductus arteriosus, Hypertrophic cardiomyopathy, Pleural effusion, Pulmonic stenosis, Polyh... OMIM:615355
Familial Atrial Myxoma
Congestive heart failure, Exertional dyspnea, Pedal edema, Heart murmur, Ascites, Tricuspid regur... ORPHA:615
Sialidosis Type 2
Hydrops fetalis, Splenomegaly, Hepatomegaly, Dyspnea, Pedal edema, Ascites ORPHA:87876
Systemic-Onset Juvenile Idiopathic Arthritis
Splenomegaly, Hepatomegaly, Pleural effusion, Pericarditis, Joint swelling ORPHA:85414
Idiopathic Chronic Eosinophilic Pneumonia
Nonproductive cough, Hypersensitivity pneumonitis, Restrictive ventilatory defect, Hypoxemia, Ast... ORPHA:2902
Pseudo-Torch Syndrome 2
Patent ductus arteriosus, Bradycardia, Pleural effusion, Hepatomegaly, Acute respiratory distress... OMIM:617397
Meige Disease
Peripheral edema, Pleural effusion, Predominantly lower limb lymphedema, Lymphedema, Pedal edema,... ORPHA:90186
Immunodeficiency 91 And Hyperinflammation
Recurrent pneumonia, Hepatosplenomegaly, Pulmonary hemorrhage, Pleural effusion, Hepatomegaly, Re... OMIM:619644
Infantile Sialic Acid Storage Disease
Congestive heart failure, Hydrops fetalis, Splenomegaly, Hepatomegaly, Ascites OMIM:269920
Car T Cell Therapy-Associated Cytokine Release Syndrome
Reduced ejection fraction, Arrhythmia, Hypoxemia, Tachypnea, Hypotension, Heart block, Capillary ... ORPHA:542323
Lymphatic Malformation 6
Chylothorax, Nonimmune hydrops fetalis, Splenomegaly, Pleural effusion, Genital edema, Lymphedema... OMIM:616843
Abnormal respiratory system physiology, Sinusitis, Pneumonia, Bronchial breath sound, Respiratory... ORPHA:449280
Congenital Enterovirus Infection
Hydrops fetalis, Hypotension, Myocarditis, Pleural effusion, Polyhydramnios, Cardiomyopathy, Resp... ORPHA:292
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Anasarca, Pulmonary embolism, Respiratory tract infection, Pleural effusion, Palpebral edema, Dys... ORPHA:567546
Alpha-Heavy Chain Disease
Splenomegaly, Hepatomegaly, Ascites ORPHA:100025
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Hydrops fetalis, Hypertrophic cardiomyopathy, Pleural effusion, Polyhydramnios, Ascites, Pulmonar... OMIM:616897
Splenoportal Vascular Anomalies
Splenomegaly, Ascites OMIM:271500
Pneumonia, Pleural effusion, Cough, Respiratory distress, Tachycardia ORPHA:3392
Congenital Disorder Of Glycosylation, Type Iir
Hepatomegaly, Ascites OMIM:301045
Hypervitaminosis A, Susceptibility To
Ascites OMIM:240150
Neuraminidase Deficiency
Hydrops fetalis, Splenomegaly, Hepatomegaly, Cardiomyopathy, Ascites, Facial edema OMIM:256550
Pontocerebellar Hypoplasia, Type 13
Asthma, Sleep apnea, Pleural effusion, Recurrent respiratory infections, Edema OMIM:618606
Congenital Disorder Of Glycosylation, Type Ih
Oligohydramnios, Hepatomegaly, Patent ductus arteriosus, Ascites OMIM:608104
Pulmonary Arteriovenous Malformation
Epistaxis, Hypoxemia, Pulmonary hemorrhage, Myocardial infarction, Cough, Dyspnea, Pulmonary arte... ORPHA:2038
Ovarian Fibrothecoma
Pleural effusion, Ascites ORPHA:314478
Portal Hypertension, Noncirrhotic, 2
Portal hypertension, Splenomegaly, Hepatomegaly, Ascites, Epistaxis OMIM:619463
Mulibrey Nanism
Congestive heart failure, Hydrops fetalis, Hepatomegaly, Ascites, Recurrent lower respiratory tra... OMIM:253250
Cirrhotic Cardiomyopathy
Left ventricular diastolic dysfunction, Elevated jugular venous pressure, Reduced ejection fracti... ORPHA:57777
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Ascites OMIM:617156
Glycogen Storage Disease Of Heart, Lethal Congenital
Shortened PR interval, Congestive heart failure, Hypotension, Cardiomyopathy, Ascites, Bradycardi... OMIM:261740
Familial Idiopathic Dilatation Of The Right Atrium
Midsystolic murmur, Paroxysmal atrial fibrillation, Holosystolic murmur, Reduced ejection fractio... ORPHA:1677
Amoebiasis Due To Entamoeba Histolytica
Constrictive pericarditis, Lung abscess, Congestive heart failure, Pleural effusion, Cough, Dyspn... ORPHA:67
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Dilated cardiomyopathy, Portal hypertension, Hepatosplenomegaly, Congestive heart failure, Nonimm... ORPHA:367
Malignant Peritoneal Mesothelioma
Ascites, Pedal edema, Dyspnea ORPHA:168811
Cholestasis, Progressive Familial Intrahepatic, 5
Nonimmune hydrops fetalis, Pleural effusion, Ascites OMIM:617049
Pseudomyxoma Peritonei
Respiratory insufficiency, Ascites ORPHA:26790
Congenital Toxoplasmosis
Hepatomegaly, Ascites ORPHA:858
Dengue Fever
Gastrointestinal hemorrhage, Hypotension, Hepatomegaly, Cardiorespiratory arrest, Ascites, Cerebr... ORPHA:99828
Avian Influenza
Nonproductive cough, Pneumonia, Hypoxemia, Congestive heart failure, Tachypnea, Respiratory failu... ORPHA:454836
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Pneumonia, Pulmonary embolism, Hepatomegaly, Budd-Chiari syndrome, Ascites, Edema, Generalized edema OMIM:226300
Congenital Disorder Of Glycosylation, Type Il
Hepatosplenomegaly, Hepatomegaly, Ascites, Edema, Pericardial effusion OMIM:608776
Pediatric Systemic Lupus Erythematosus
Pleural effusion, Dyspnea, Ascites, Raynaud phenomenon, Edema, Pericardial effusion ORPHA:93552
Gorham-Stout Disease
Edema, Pleural effusion, Rhinorrhea ORPHA:73
Poems Syndrome
Restrictive ventilatory defect, Visceromegaly, Pleural effusion, Pulmonary arterial hypertension,... ORPHA:2905
Diarrhea 10, Protein-Losing Enteropathy Type
Anasarca, Hematochezia, Pleural effusion, Polyhydramnios, Ascites, Pericardial effusion OMIM:618183
Waldenström Macroglobulinemia
Gastrointestinal hemorrhage, Retinal hemorrhage, Congestive heart failure, Splenomegaly, Pleural ... ORPHA:33226
Eosinophilic Gastroenteritis
Hematochezia, Asthma, Allergic rhinitis, Ascites, Edema ORPHA:2070
Ring Chromosome 22 Syndrome
Lymphedema, Edema, Pleural effusion ORPHA:1446
Lymphoproliferative Syndrome 2
Recurrent pneumonia, Hepatosplenomegaly, Splenomegaly, Hepatomegaly, Ascites OMIM:615122
Primary Intestinal Lymphangiectasia
Pleural effusion, Ascites, Edema, Generalized edema, Pericardial effusion ORPHA:90362
Reynolds Syndrome
Mucosal telangiectasiae, Hepatomegaly, Telangiectasia of the skin, Ascites, Respiratory insuffici... ORPHA:779
Free Sialic Acid Storage Disease
Hydrops fetalis, Splenomegaly, Hepatomegaly, Recurrent respiratory infections, Ascites ORPHA:834
Emphysema, Chylothorax, Restrictive ventilatory defect, Gastrointestinal hemorrhage, Pulmonary ly... ORPHA:538
Ascites, Chylous
Chylous ascites OMIM:208300
Tropical Endomyocardial Fibrosis
Abnormal ST segment, Right bundle branch block, Left bundle branch block, Atrial fibrillation, Pu... ORPHA:75565
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Portal hypertension, Splenomegaly, Hepatomegaly, Hepatocellular necrosis, Ascites OMIM:251880
Malignant Atrophic Papulosis
Gastrointestinal hemorrhage, Respiratory failure, Myocardial infarction, Pleural effusion, Arteri... ORPHA:679
Kaposiform Lymphangiomatosis
Subconjunctival hemorrhage, Hepatosplenomegaly, Splenomegaly, Cough, Pleural effusion, Dyspnea, E... ORPHA:464329
Q Fever
Pneumonia, Hepatosplenomegaly, Abnormal left ventricular function, Myocarditis, Cough, Pleural ef... ORPHA:781
Necrotizing Enterocolitis
Hypotension, Ascites, Bradycardia, Apnea, Edema, Shock ORPHA:391673
Mucopolysaccharidosis Type 7
Hydrops fetalis, Abnormal pleura morphology, Splenomegaly, Recurrent respiratory infections, Lymp... ORPHA:584
Lymphoproliferative Syndrome 1
Hepatomegaly, Splenomegaly, Pleural effusion, Pericardial effusion OMIM:613011
Congenital Sialidosis Type 2
Hepatosplenomegaly, Abnormal EKG, Respiratory tract infection, Hepatomegaly, Ascites, Telangiecta... ORPHA:93400
Wolman Disease
Splenomegaly, Hepatomegaly, Ascites ORPHA:75233
Noonan Syndrome 10
Patent ductus arteriosus, Hypertrophic cardiomyopathy, Pleural effusion, Pulmonic stenosis, Mitra... OMIM:616564
Primary Hepatic Neuroendocrine Carcinoma
Hepatomegaly, Dyspnea, Neoplasm of the lung, Heart murmur, Bronchospasm, Ascites, Palpitations, R... ORPHA:100085
Secondary Intestinal Lymphangiectasia
Anasarca, Constrictive pericarditis, Pleural effusion, Chylous ascites, Lymphedema, Intestinal bl... ORPHA:90363
Hepatomegaly, Ascites ORPHA:352
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent pneumonia, Hepatosplenomegaly, Splenomegaly, Pleural effusion, Pulmonary fibrosis OMIM:618935
Griscelli Syndrome
Pedal edema, Splenomegaly, Hepatomegaly, Ascites ORPHA:381
Budd-Chiari Syndrome
Portal hypertension, Gastrointestinal hemorrhage, Splenomegaly, Hepatomegaly, Ascites ORPHA:131
Classic Galactosemia
Hepatomegaly, Ascites ORPHA:79239
Hydrops fetalis, Edema, Oligohydramnios, Ascites ORPHA:79325
Arteritis, Familial Granulomatous, With Juvenile Polyarthritis
Granulomatous coronary arteritis, Hypertension, Pleural effusion, Pericardial effusion OMIM:108050
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Hematochezia, Diffuse alveolar hemorrhage, Gastrointestinal hemorrhage, Retinal hemorrhage, Hyper... ORPHA:464321
Gaucher Disease, Perinatal Lethal
Hepatosplenomegaly, Nonimmune hydrops fetalis, Splenomegaly, Hepatomegaly, Polyhydramnios, Respir... OMIM:608013
Hemorrhagic Fever-Renal Syndrome
Subconjunctival hemorrhage, Pneumonia, Shock, Respiratory failure, Hypotension, Cough, Capillary ... ORPHA:340
Hellp Syndrome
Hypotension, Pleural effusion, Internal hemorrhage, Cerebral hemorrhage, Generalized edema, Pulmo... ORPHA:244242
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Portal hypertension, Gastrointestinal hemorrhage, Hypotension, Ascites ORPHA:98850
Radio-Renal Syndrome
Chylothorax, Respiratory failure, Pleural effusion, Dyspnea, Respiratory distress ORPHA:3015
Eisenmenger Syndrome
Hypoxemia, Left-to-right shunt, Increased pulmonary vascular resistance, Right bundle branch bloc... ORPHA:97214
Capillary Malformation-Arteriovenous Malformation
Chylothorax, High-output congestive heart failure, Congestive heart failure, Nonimmune hydrops fe... ORPHA:137667
Desmoplastic Small Round Cell Tumor
Neoplasm of the lung, Hepatomegaly, Ascites ORPHA:83469
Aicardi-Goutieres Syndrome 9
Portal hypertension, Hepatosplenomegaly, Hepatomegaly, Increased blood pressure, Hypertension, As... OMIM:619487
Gaucher Disease Type 1
Abnormal pulmonary interstitial morphology, Splenomegaly, Hepatomegaly, Pulmonary arterial hypert... ORPHA:77259
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Portal hypertension, Hepatosplenomegaly, Pulmonary hemorrhage, Cough, Hepatomegaly, Recurrent res... ORPHA:79124
Idiopathic Hypereosinophilic Syndrome
Vasculitis in the skin, Dilated cardiomyopathy, Hepatosplenomegaly, Angioedema, Congestive heart ... ORPHA:3260
Sarcoidosis, Susceptibility To, 1
Emphysema, Restrictive ventilatory defect, Hypoxemia, Elevated bronchoalveolar lavage fluid lymph... OMIM:181000
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Pleural effusion, Periorbital edema, Lymphedema, Pericardial effusion, Pleural lymphangiectasia OMIM:235510
Granulomatous Disease, Chronic, X-Linked
Recurrent pneumonia, Splenomegaly, Pleural effusion, Cough, Hepatomegaly, Atelectasis, Ascites OMIM:306400
Erdheim-Chester Disease
Congestive heart failure, Cough, Pleural effusion, Dyspnea, Pulmonary fibrosis, Joint swelling, A... ORPHA:35687
Hepatoportal Sclerosis
Splenomegaly, Portal hypertension, Gastrointestinal hemorrhage, Ascites ORPHA:64743
Niemann-Pick Disease, Type A
Recurrent respiratory infections, Splenomegaly, Hepatomegaly, Ascites OMIM:257200
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Splenomegaly, Hepatomegaly, Pulmonary lymphangiectasia, Polyhydramnios, Lymphedema, Ascites OMIM:235255
Adams-Oliver Syndrome
Portal hypertension, Gastrointestinal hemorrhage, Pulmonary arterial hypertension, Pulmonary arte... ORPHA:974
Autoimmune Hepatitis
Spider hemangioma, Splenomegaly, Gastrointestinal hemorrhage, Ascites ORPHA:2137
Short-Rib Thoracic Dysplasia 12
Patent ductus arteriosus, Splenomegaly, Hepatomegaly, Atelectasis, Polyhydramnios, Ascites, Neona... OMIM:269860
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Pulmonary insufficiency, Patent ductus arteriosus, Nonimmune hydrops fetalis, Neonatal respirator... OMIM:265380
Farber Disease
Recurrent upper respiratory tract infections, Hepatosplenomegaly, Hydrops fetalis, Atelectasis, R... ORPHA:333
Emphysema, Nonproductive cough, Pneumonia, Respiratory failure, Pleural effusion, Dyspnea, Produc... ORPHA:31204
Familial Mediterranean Fever
Splenomegaly, Hepatomegaly, Pleural effusion, Pericarditis, Pleuritis OMIM:249100
Sinusitis, Hypersensitivity pneumonitis, Pneumonia, Lung abscess, Pleural effusion, Bronchiectasi... ORPHA:228119
Immunodeficiency 87 And Autoimmunity
Anasarca, Dilated cardiomyopathy, Third degree atrioventricular block, Pleural effusion, Hepatome... OMIM:619573
Primary Sclerosing Cholangitis
Spider hemangioma, Portal hypertension, Hepatosplenomegaly, Congestive heart failure, Splenomegal... ORPHA:171
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Hydrops fetalis, Pulmonary hypoplasia, Ascites OMIM:614091
Hematochezia, Sinusitis, Gastrointestinal hemorrhage, Myocarditis, Cough, Rhinorrhea, Pleural eff... ORPHA:73263
Cerebral edema, Pneumonia, Pleural effusion, Cough, Dyspnea, Respiratory distress, Nodular patter... ORPHA:1546
Chédiak-Higashi Syndrome
Epistaxis, Hepatosplenomegaly, Splenomegaly, Pleural effusion, Recurrent respiratory infections, ... ORPHA:167
Carney Triad
Gastrointestinal hemorrhage, Arrhythmia, Hypertension, Ascites, Tachycardia ORPHA:139411
Behçet Disease
Gastrointestinal hemorrhage, Aortic regurgitation, Pulmonary embolism, Myocardial infarction, Ple... ORPHA:117
Osteopetrosis, Autosomal Recessive 5
Respiratory failure, Splenomegaly, Hepatomegaly, Ascites, Stillbirth OMIM:259720
Familial Mediterranean Fever
Arrhythmia, Ascites, Myocardial infarction, Splenomegaly, Pedal edema, Vasculitis, Pericarditis, ... ORPHA:342
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Neonatal respiratory distress, Chylothorax, Polyhydramnios OMIM:619036
Hennekam Syndrome
Chylothorax, Hydrops fetalis, Splenomegaly, Pulmonary lymphangiectasia, Recurrent respiratory inf... ORPHA:2136
Wolcott-Rallison Syndrome
Dehydration, Hepatomegaly, Ascites ORPHA:1667
Infection-Related Hemolytic Uremic Syndrome
Pneumonia, Myocarditis, Respiratory tract infection, Dyspnea, Hypertensive crisis, Hypertension, ... ORPHA:544482
Emphysema, Chylothorax, Portal hypertension, Ventricular tachycardia, Arrhythmia, Abnormal pleura... ORPHA:797
Hepatocellular Carcinoma
Anasarca, Portal hypertension, Hypotension, Hepatomegaly, Dyspnea, Hepatic necrosis, Pedal edema,... ORPHA:88673
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Hepatosplenomegaly, Splenomegaly, Hepatomegaly, Pulmonary lymphangiectasia, Polyhydramnios, Ascites ORPHA:1655
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Chylothorax, Lymphedema, Polyhydramnios, Mitral regurgitation, Aortic valve stenosis OMIM:613563
Intrahepatic Cholestasis Of Pregnancy
Neonatal respiratory distress, Ascites ORPHA:69665
Crimean-Congo Hemorrhagic Fever
Subconjunctival hemorrhage, Bundle branch block, Subdural hemorrhage, Hypertension, Hematemesis, ... ORPHA:99827
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Pleural effusion, Increased nuchal translucency ORPHA:453499
Pancreatitis, Hereditary
Pleural effusion OMIM:167800
Subconjunctival hemorrhage, Arrhythmia, Retinal hemorrhage, First degree atrioventricular block, ... ORPHA:509
Pulmonary granulomatosis, Pneumonia, Lung abscess, Myocarditis, Pleural effusion, Splenomegaly, A... ORPHA:1304
Acrocephalopolydactylous Dysplasia
Extrapulmonary sequestrum, Hepatomegaly, Pulmonary hypoplasia, Ascites OMIM:200995
Caroli Disease
Splenomegaly, Portal hypertension, Hepatomegaly, Ascites ORPHA:53035
Xfe Progeroid Syndrome
Hypertension, Ascites OMIM:610965
Gracile Bone Dysplasia
Ascites OMIM:602361
Functioning Gonadotropic Adenoma
Ascites ORPHA:91348
Vasospasm, Pneumonia, Cough, Pleural empyema, Vasculitis, Respiratory distress, Pericarditis, Cer... ORPHA:228123
Perlman Syndrome
Polyhydramnios, Edema, Visceromegaly, Ascites OMIM:267000
Chronic Graft Versus Host Disease
Airway obstruction, Cough, Pleural effusion, Bronchiectasis, Dyspnea, Bronchiolitis obliterans, P... ORPHA:99921
Tyrosinemia, Type I
Gastrointestinal hemorrhage, Hypertrophic cardiomyopathy, Splenomegaly, Hepatomegaly, Ascites OMIM:276700
Autosomal Recessive Polycystic Kidney Disease
Hypoventilation, Recurrent pneumonia, Portal hypertension, Gastrointestinal hemorrhage, Hepatospl... ORPHA:731
Primary Biliary Cholangitis
Orthostatic hypotension, Portal hypertension, Ascites ORPHA:186
Cutis Marmorata Telangiectatica Congenita
Telangiectasia of the skin, Patent ductus arteriosus, Ascites ORPHA:1556
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Chylothorax, Lymphedema, Edema, Pleural effusion ORPHA:2526
Peripheral Primitive Neuroectodermal Tumor
Pelvic mass, Ascites ORPHA:370348
Mosaic Variegated Aneuploidy Syndrome
Aortic regurgitation, Polyhydramnios, Increased nuchal translucency, Ascites, Abnormal lung lobat... ORPHA:1052
Kikuchi-Fujimoto Disease
Vasculitis in the skin, Myocarditis, Pleural effusion, Palpebral edema, Splenomegaly, Hepatomegal... ORPHA:50918
Atresia Of Urethra
Oligohydramnios, Pulmonary insufficiency, Ascites ORPHA:105
Rajab Interstitial Lung Disease With Brain Calcifications 1
Emphysema, Anasarca, Portal hypertension, Tachypnea, Respiratory failure, Cough, Ascites, Respira... OMIM:613658
Senior-Boichis Syndrome
Hepatosplenomegaly, Portal hypertension, Hypertension, Ascites ORPHA:84081
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97278
Multiple Myeloma
Splenomegaly, Pleural effusion ORPHA:29073
Gastrointestinal hemorrhage, Hepatomegaly, Neoplasm of the lung, Abnormal abdomen morphology, Asc... ORPHA:97261
Lysosomal Acid Lipase Deficiency
Hypovolemia, Hepatosplenomegaly, Hypotension, Pulmonary arterial hypertension, Ascites, Dehydration ORPHA:275761
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97283
Lipodystrophy, Familial Partial, Type 7
Orthostatic hypotension, Pleural effusion, Pulmonary arterial hypertension, Pulmonary arterioveno... OMIM:606721
Gallbladder Neuroendocrine Tumor
Ascites ORPHA:100086
Hepatomegaly, Respiratory insufficiency due to muscle weakness, Abnormal abdomen morphology, Asci... ORPHA:97282
Niemann-Pick Disease Type C
Hepatosplenomegaly, Abnormal lung morphology, Hydrops fetalis, Respiratory failure, Splenomegaly,... ORPHA:646
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97280
Biliary, Renal, Neurologic, And Skeletal Syndrome
Portal hypertension, Cardiac arrest, Patent ductus arteriosus, Aortic regurgitation, Asthma, Left... OMIM:619534
Fryns Syndrome
Chylothorax, Polyhydramnios, Stillbirth, Pulmonary hypoplasia OMIM:229850
Noonan Syndrome 1
Chylothorax, Patent ductus arteriosus, Hypertrophic cardiomyopathy, Pulmonic stenosis, Lymphedema OMIM:163950
Generalized Arterial Calcification Of Infancy
Left ventricular systolic dysfunction, Retinal hemorrhage, Ascites, Hydrops fetalis, Pulmonary ar... ORPHA:51608
Congenital Tracheal Stenosis
Patent ductus arteriosus, Dyspnea, Polyhydramnios, Upper airway obstruction, Neonatal asphyxia, P... ORPHA:141127
Niemann-Pick Disease, Type C2
Respiratory failure, Splenomegaly, Hepatomegaly, Respiratory insufficiency, Fetal ascites OMIM:607625
Niemann-Pick Disease, Type C1
Hepatomegaly, Splenomegaly, Fetal ascites OMIM:257220
D-Bifunctional Protein Deficiency
Hepatomegaly, Polyhydramnios, Splenomegaly, Fetal ascites OMIM:261515
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Portal hypertension, Hepatosplenomegaly, Aspiration, Asthma, Neonatal respiratory distress, Apnea... OMIM:619503
Faundes-Banka Syndrome
Fetal ascites OMIM:619376
Immunodeficiency 70
Recurrent sinusitis, Achalasia OMIM:618969


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ivns1abp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ivns1abp.

No publications found that use IMPC mice or data for Ivns1abp.

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MGI Allele Allele Type Produced
Ivns1abptm107929(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ivns1abptm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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