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Gene: Ivns1abp MGI:2152389

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
influenza virus NS1A binding protein
Synonyms:
1700126I16Rik,  1190004M08Rik,  NS1-BP,  NS-1,  ND1,  Nd1-S,  Nd1-L,  HSPC068

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ivns1abp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ivns1abp by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Immunodeficiency 70
Achalasia, Recurrent sinusitis OMIM:618969

The table below shows human diseases predicted to be associated to Ivns1abp by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Pulmonary Lymphangiectasia
Congestive heart failure, Tricuspid regurgitation, Ascites, Pleural effusion, Splenomegaly, Pulmo... ORPHA:2414
Fetal Parvovirus Syndrome
Hypertrophic cardiomyopathy, Increased nuchal translucency, Hydrops fetalis, Ascites ORPHA:295
Lymphatic Malformation 8
Generalized edema, Pleural effusion, Nonimmune hydrops fetalis, Stillbirth, Polyhydramnios, Peric... OMIM:618773
Congenital Heart Block
Atrioventricular block, Second degree atrioventricular block, Third degree atrioventricular block... ORPHA:60041
Pleural Mesothelioma
Abnormal pleura morphology, Abnormal cardiovascular system physiology, Pleural effusion, Hepatome... ORPHA:50251
Focal Segmental Glomerulosclerosis 1
Ascites, Hypertension, Edema, Pleural effusion OMIM:603278
Cardiomyopathy, Familial Restrictive, 6
Restrictive cardiomyopathy, Tricuspid regurgitation, Ascites, Hepatomegaly, Pulmonary insufficien... OMIM:619433
Hydrops Fetalis
Generalized edema, Lymphedema, Ascites, Pleural effusion, Nonimmune hydrops fetalis, Arrhythmia, ... ORPHA:1041
Primary Effusion Lymphoma
Pericardial effusion, Pleural effusion ORPHA:48686
Malignant Atrophic Papulosis
Constrictive pericarditis, Gastrointestinal hemorrhage, Pleural effusion OMIM:602248
Combined Oxidative Phosphorylation Deficiency 10
Hypertrophic cardiomyopathy, Ascites, Oligohydramnios, Pleural effusion, Bradycardia, Pericardial... OMIM:614702
Lymphatic Malformation 7
Facial edema, Chylothorax, Lymphedema, Ascites, Increased nuchal translucency, Pleural effusion, ... OMIM:617300
Lymphangiectasia, Pulmonary, Congenital
Facial edema, Chylothorax, Edema, Lymphedema, Ascites, Pleural effusion, Nonimmune hydrops fetali... OMIM:265300
Sarcoidosis, Susceptibility To, 2
Emphysema, Pleural effusion, Splenomegaly, Pulmonary arterial hypertension, Pneumothorax, Hepatom... OMIM:612387
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome
Predominantly lower limb lymphedema, Palmar telangiectasia, Ascites, Pleural effusion, Plantar te... ORPHA:69735
Nephrosialidosis
Ascites, Pericardial effusion OMIM:256150
Ovarian Hyperstimulation Syndrome
Ascites OMIM:608115
Diffuse Neonatal Hemangiomatosis
Ascites, Polyhydramnios, Hepatomegaly, Hydrops fetalis, Patent ductus arteriosus ORPHA:2123
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome
Ascites, Hepatomegaly, Gastrointestinal hemorrhage ORPHA:2198
Wild Type Attr Amyloidosis
Aortic valve stenosis, Congestive heart failure, Hypertrophic cardiomyopathy, Abnormal EKG, Pleur... ORPHA:330001
Hemochromatosis, Type 1
Cardiomyopathy, Congestive heart failure, Ascites, Pleural effusion, Splenomegaly, Telangiectasia... OMIM:235200
Follicular Lymphoma
Pleural effusion, Splenomegaly, Lymphedema ORPHA:545
Chylous Ascites
Ascites, Lymphedema ORPHA:1160
Acute Interstitial Pneumonia
Reticulonodular pattern on pulmonary HRCT, Atelectasis, Interlobular septal thickening, Periphera... ORPHA:79126
Lethal Hemolytic Anemia-Genital Anomalies Syndrome
Ascites, Oligohydramnios, Splenomegaly, Aplasia/Hypoplasia of the lungs, Polyhydramnios ORPHA:1046
Tempi Syndrome
Ascites, Transudative pleural effusion, Telangiectasia, Abnormality of the pulmonary vasculature,... ORPHA:284227
Pulmonary Capillary Hemangiomatosis
Diffuse alveolar hemorrhage, Right ventricular failure, Interlobular septal thickening, Hemothora... ORPHA:199241
Hepatic Veno-Occlusive Disease
Ascites, Hepatomegaly ORPHA:890
Klippel-Trénaunay Syndrome
Gastrointestinal hemorrhage, Pulmonary embolism, Congestive heart failure, Ascites, Abnormality o... ORPHA:90308
Cardiomyopathy, Familial Hypertrophic, 4
Atrioventricular block, Congestive heart failure, Hypertrophic cardiomyopathy, Reduced left ventr... OMIM:115197
Noonan Syndrome 8
Hypertrophic cardiomyopathy, Pleural effusion, Mitral regurgitation, Polyhydramnios, Patent ductu... OMIM:615355
Pseudo-Torch Syndrome 2
Ascites, Pleural effusion, Bradycardia, Cerebral hemorrhage, Hepatomegaly, Patent ductus arteriosus OMIM:617397
Ovarian Fibroma
Ascites, Pleural effusion ORPHA:314473
Polycystic Liver Disease 1 With Or Without Kidney Cysts
Ascites OMIM:174050
Infantile Sialic Acid Storage Disease
Congestive heart failure, Ascites, Splenomegaly, Hepatomegaly, Hydrops fetalis OMIM:269920
Staphylococcal Necrotizing Pneumonia
Pneumonia, Hypotension, Shock, Pleural effusion, Pneumothorax, Acute infectious pneumonia, Pulmon... ORPHA:36238
Ovarian Hyperstimulation Syndrome
Generalized edema, Ascites, Peripheral edema, Pleural effusion, Pulmonary edema, Capillary leak, ... ORPHA:64739
Glycogen Storage Disease Of Heart, Lethal Congenital
Hypotension, Anasarca, Cardiomyopathy, Congestive heart failure, Hypertrophic cardiomyopathy, Asc... OMIM:261740
Glycogen Storage Disease Iv
Cardiomyopathy, Ascites, Hepatosplenomegaly, Portal hypertension, Bradycardia, Polyhydramnios, Hy... OMIM:232500
Pulmonary Non-Tuberculous Mycobacterial Infection
Pericardial effusion, Pneumothorax, Pleural effusion, Bronchiectasis ORPHA:411703
Immunodeficiency 91 And Hyperinflammation
Recurrent pneumonia, Abnormal pulmonary interstitial morphology, Pulmonary hemorrhage, Hepatosple... OMIM:619644
Sialidosis Type 2
Ascites, Splenomegaly, Hepatomegaly, Hydrops fetalis, Pedal edema ORPHA:87876
Alpha-Heavy Chain Disease
Ascites, Hepatomegaly, Splenomegaly ORPHA:100025
Systemic Capillary Leak Syndrome
Hypotension, Pleural effusion, Pulmonary edema, Arrhythmia, Myocarditis, Pedal edema, Pericarditis ORPHA:188
Familial Atrial Myxoma
Congestive heart failure, Tricuspid regurgitation, Ascites, Heart murmur, Pedal edema ORPHA:615
Hemolytic Disease Of Fetus And Newborn, Rh-Induced
Fetal ascites, Polyhydramnios, Splenomegaly, Hepatomegaly, Hydrops fetalis OMIM:619462
Splenoportal Vascular Anomalies
Ascites, Splenomegaly OMIM:271500
Systemic-Onset Juvenile Idiopathic Arthritis
Pleural effusion, Splenomegaly, Joint swelling, Hepatomegaly, Pericarditis ORPHA:85414
Meige Disease
Facial edema, Predominantly lower limb lymphedema, Lymphedema, Peripheral edema, Pleural effusion... ORPHA:90186
Hypocomplementemic Urticarial Vasculitis
Angioedema, Ascites, Emphysema, Pleural effusion, Splenomegaly, Hepatomegaly, Pericardial effusio... ORPHA:36412
Cirrhotic Cardiomyopathy
Congestive heart failure, Ascites, Elevated pulmonary artery pressure, Ventricular arrhythmia, Re... ORPHA:57777
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Hypertrophic cardiomyopathy, Ascites, Pleural effusion, Polyhydramnios, Hydrops fetalis, Pulmonar... OMIM:616897
Lymphatic Malformation 6
Facial edema, Generalized edema, Chylothorax, Lymphedema, Ascites, Genital edema, Pleural effusio... OMIM:616843
Congenital Disorder Of Glycosylation, Type Iir
Ascites, Hepatomegaly OMIM:301045
Idiopathic Steroid-Sensitive Nephrotic Syndrome With Secondary Steroid Resistance
Facial edema, Pulmonary embolism, Edema, Anasarca, Ascites, Pleural effusion, Respiratory tract i... ORPHA:567546
Congenital Enterovirus Infection
Hypotension, Fetal ascites, Cardiomyopathy, Pleural effusion, Polyhydramnios, Myocarditis, Hydrop... ORPHA:292
Portal Hypertension, Noncirrhotic, 2
Epistaxis, Ascites, Portal hypertension, Splenomegaly, Hepatomegaly OMIM:619463
Neuraminidase Deficiency
Facial edema, Cardiomyopathy, Ascites, Splenomegaly, Hepatomegaly, Hydrops fetalis OMIM:256550
Congenital Disorder Of Glycosylation, Type Ih
Ascites, Oligohydramnios, Neonatal death, Hepatomegaly, Patent ductus arteriosus, Edema OMIM:608104
Aspergillosis
Pneumonia, Pleural effusion, Hypersensitivity pneumonitis, Intracranial hemorrhage, Pulmonary fib... ORPHA:1163
Car T Cell Therapy-Associated Cytokine Release Syndrome
Hypotension, Reduced left ventricular ejection fraction, Pleural effusion, Pulmonary edema, Arrhy... ORPHA:542323
Tularemia
Pneumonia, Tachycardia, Pleural effusion ORPHA:3392
Mulibrey Nanism
Congestive heart failure, Ascites, Hepatomegaly, Recurrent lower respiratory tract infections, Hy... OMIM:253250
Hydrops, Lactic Acidosis, And Sideroblastic Anemia
Second degree atrioventricular block, Ascites, Oligohydramnios, Nonimmune hydrops fetalis, Pulmon... OMIM:617021
Combined Oxidative Phosphorylation Deficiency 5
Hypertrophic cardiomyopathy, Edema, Ascites OMIM:611719
Ovarian Fibrothecoma
Ascites, Pleural effusion ORPHA:314478
Free Sialic Acid Storage Disease
Ascites, Splenomegaly, Hepatomegaly, Recurrent respiratory infections, Hydrops fetalis ORPHA:834
Congenital Toxoplasmosis
Hepatomegaly, Ascites ORPHA:858
Pontocerebellar Hypoplasia, Type 13
Recurrent respiratory infections, Pleural effusion, Edema OMIM:618606
Alpha-Thalassemia
Generalized edema, Congestive heart failure, Hepatosplenomegaly, Pleural effusion, Splenomegaly, ... ORPHA:846
Cholestasis, Progressive Familial Intrahepatic, 5
Ascites, Pleural effusion, Nonimmune hydrops fetalis OMIM:617049
Scedosporiosis
Pneumonia, Bronchitis, Pulmonary fibrosis, Pleuritis, Pleural empyema, Pericarditis ORPHA:449280
Tafro Syndrome
Anasarca, Ascites, Hepatosplenomegaly, Pleural effusion, Splenomegaly, Hepatomegaly ORPHA:457077
Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency
Dilated cardiomyopathy, Congestive heart failure, Ascites, Hepatosplenomegaly, Portal hypertensio... ORPHA:367
Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Ascites, Pleuritis, Mitral regurgitation, Pericarditis ORPHA:2848
Familial Idiopathic Dilatation Of The Right Atrium
Atrioventricular block, Complete heart block with narrow QRS complexes, Holosystolic murmur, Paro... ORPHA:1677
Pulmonary Arteriovenous Malformation
Epistaxis, Transient ischemic attack, Pulmonary hemorrhage, Palpitations, Hemothorax, Ischemic st... ORPHA:2038
Dengue Fever
Epistaxis, Hypotension, Gastrointestinal hemorrhage, Ascites, Cerebral hemorrhage, Hepatomegaly ORPHA:99828
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Generalized edema, Pulmonary embolism, Budd-Chiari syndrome, Ascites, Hepatomegaly, Recurrent low... OMIM:226300
Pseudomyxoma Peritonei
Ascites ORPHA:26790
Pediatric Systemic Lupus Erythematosus
Ascites, Pleural effusion, Raynaud phenomenon, Pericardial effusion, Edema ORPHA:93552
Idiopathic Chronic Eosinophilic Pneumonia
Hypersensitivity pneumonitis, Pleural effusion, Atelectasis ORPHA:2902
Amoebiasis Due To Entamoeba Histolytica
Congestive heart failure, Pleural effusion, Constrictive pericarditis, Lung abscess, Pleural empyema ORPHA:67
Diarrhea 10, Protein-Losing Enteropathy Type
Hematochezia, Recurrent upper respiratory tract infections, Anasarca, Ascites, Pleural effusion, ... OMIM:618183
Primary Intestinal Lymphangiectasia
Generalized edema, Ascites, Pleural effusion, Pericardial effusion, Edema ORPHA:90362
Malignant Peritoneal Mesothelioma
Ascites, Pedal edema ORPHA:168811
Pneumocystosis
Interstitial pneumonitis, Multiple pulmonary cysts, Pleural effusion, Acute infectious pneumonia ORPHA:723
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Abnormal pulmonary interstitial morphology, Atelectasis, Tricuspid regurgitation, Pleural effusio... OMIM:620233
Poems Syndrome
Visceromegaly, Ascites, Pleural effusion, Splenomegaly, Pulmonary arterial hypertension, Hepatome... ORPHA:2905
Ring Chromosome 22 Syndrome
Pleural effusion, Edema, Lymphedema ORPHA:1446
Lymphoproliferative Syndrome 2
Recurrent pneumonia, Ascites, Hepatosplenomegaly, Splenomegaly, Hepatomegaly OMIM:615122
Gorham-Stout Disease
Pleural effusion, Edema ORPHA:73
Ascites, Chylous
Chylous ascites OMIM:208300
Waldenström Macroglobulinemia
Vasculitis, Gastrointestinal hemorrhage, Epistaxis, Periorbital edema, Congestive heart failure, ... ORPHA:33226
Avian Influenza
Pneumonia, Pneumothorax, Pleural effusion, Congestive heart failure ORPHA:454836
Lymphoproliferative Syndrome 1
Hepatomegaly, Pericardial effusion, Pleural effusion, Splenomegaly OMIM:613011
Congenital Disorder Of Glycosylation, Type Il
Ascites, Splenomegaly, Hepatomegaly, Hydrops fetalis, Pericardial effusion OMIM:608776
Lymphatic Malformation 12
Fetal ascites, Lymphedema, Neonatal death, Nonimmune hydrops fetalis, Polyhydramnios, Pleural thi... OMIM:620014
Wolman Disease
Ascites, Hepatomegaly, Splenomegaly ORPHA:75233
Mucopolysaccharidosis Type 7
Lymphedema, Ascites, Abnormal pleura morphology, Splenomegaly, Recurrent respiratory infections, ... ORPHA:584
Reynolds Syndrome
Xerostomia, Ascites, Telangiectasia of the skin, Hepatomegaly, Mucosal telangiectasiae ORPHA:779
Congenital Sialidosis Type 2
Abnormal EKG, Ascites, Hepatosplenomegaly, Respiratory tract infection, Telangiectasia, Hepatomeg... ORPHA:93400
Eosinophilic Gastroenteritis
Ascites, Hematochezia, Edema ORPHA:2070
Niemann-Pick Disease, Type A
Hepatomegaly, Recurrent respiratory infections, Splenomegaly, Ascites OMIM:257200
Glycogen Storage Disease Ii
Sinus tachycardia, Pleural effusion, Splenomegaly, Shortened PR interval, Subarachnoid hemorrhage... OMIM:232300
Noonan Syndrome 10
Hypertrophic cardiomyopathy, Increased nuchal translucency, Pleural effusion, Mitral regurgitatio... OMIM:616564
Lymphangioleiomyomatosis
Gastrointestinal hemorrhage, Chylothorax, Atelectasis, Lymphedema, Ascites, Emphysema, Pulmonary ... ORPHA:538
Kaposiform Lymphangiomatosis
Epistaxis, Hepatosplenomegaly, Pleural effusion, Splenomegaly, Pericardial effusion, Subconjuncti... ORPHA:464329
Q Fever
Pneumonia, Vasculitis, Hepatosplenomegaly, Pleural effusion, Splenomegaly, Hepatomegaly, Myocardi... ORPHA:781
Alkuraya-Kucinskas Syndrome
Pericardial effusion, Pleural effusion, Edema OMIM:617822
Tropical Endomyocardial Fibrosis
Abnormal atrioventricular valve physiology, Restrictive cardiomyopathy, P pulmonale, Mitral regur... ORPHA:75565
Lymphatic Malformation 13
Lymphedema, Ascites, Mitral regurgitation, Nonimmune hydrops fetalis, Neonatal death, Pulmonary a... OMIM:620244
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent pneumonia, Hepatosplenomegaly, Pleural effusion, Splenomegaly, Pulmonary fibrosis OMIM:618935
Lymphedema-Distichiasis Syndrome
Predominantly lower limb lymphedema, Chylothorax, Lymphedema, Nonimmune hydrops fetalis, Arrhythm... OMIM:153400
Classic Galactosemia
Hepatomegaly, Ascites ORPHA:79239
Secondary Intestinal Lymphangiectasia
Intestinal bleeding, Right ventricular failure, Anasarca, Lymphedema, Pleural effusion, Constrict... ORPHA:90363
Budd-Chiari Syndrome
Gastrointestinal hemorrhage, Ascites, Portal hypertension, Splenomegaly, Hepatomegaly ORPHA:131
Malignant Atrophic Papulosis
Gastrointestinal hemorrhage, Arteritis, Ischemic stroke, Pleural effusion, Telangiectasia of the ... ORPHA:679
Alg8-Cdg
Ascites, Oligohydramnios, Hydrops fetalis, Edema ORPHA:79325
Griscelli Syndrome
Hepatomegaly, Ascites, Splenomegaly, Pedal edema ORPHA:381
Hellp Syndrome
Generalized edema, Hypotension, Pleural effusion, Pulmonary edema, Internal hemorrhage, Cerebral ... ORPHA:244242
Desmoplastic Small Round Cell Tumor
Ascites, Hepatomegaly, Neoplasm of the lung ORPHA:83469
Aggressive Systemic Mastocytosis
Hypotension, Gastrointestinal hemorrhage, Ascites, Hepatosplenomegaly, Portal hypertension ORPHA:98850
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Lymphedema, Pleural effusion, Nonimmune hydrops fetalis, Pulmonary lymphangiectasia, Periorbital ... OMIM:235510
Congenital Myopathy 22B, Severe Fetal
Ascites, Pleural effusion, Polyhydramnios, Nonimmune hydrops fetalis, Hepatomegaly, Pulmonary hyp... OMIM:620369
Capillary Malformation-Arteriovenous Malformation
Epistaxis, Chylothorax, Congestive heart failure, Lymphedema, Cerebral ischemia, High-output cong... ORPHA:137667
Cholestasis, Progressive Familial Intrahepatic, 3
Ascites, Hepatomegaly, Splenomegaly OMIM:602347
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome
Hematochezia, Gastrointestinal hemorrhage, Diffuse alveolar hemorrhage, Melena, Hypertrophic card... ORPHA:464321
Cirrhosis, Familial
Ascites, Pulmonary arterial hypertension, Hypertension OMIM:215600
Immunodeficiency 22
Recurrent upper respiratory tract infections, Ascites, Recurrent lower respiratory tract infectio... OMIM:615758
Primary Hepatic Neuroendocrine Carcinoma
Right ventricular failure, Ascites, Palpitations, Facial telangiectasia, Hepatomegaly, Heart murm... ORPHA:100085
Necrotizing Enterocolitis
Hypotension, Shock, Ascites, Bradycardia, Edema ORPHA:391673
Aicardi-Goutieres Syndrome 9
Ascites, Hepatosplenomegaly, Pericardial effusion, Portal hypertension, Hepatomegaly, Hypertensio... OMIM:619487
Hepatoportal Sclerosis
Ascites, Gastrointestinal hemorrhage, Portal hypertension, Splenomegaly ORPHA:64743
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Recurrent respiratory infections, Ascites, Pulmonary hemorrhage, Hepatosplenomegaly, Portal hyper... ORPHA:79124
Gaucher Disease, Perinatal Lethal
Ascites, Hepatosplenomegaly, Polyhydramnios, Splenomegaly, Nonimmune hydrops fetalis, Neonatal de... OMIM:608013
Hemorrhagic Fever-Renal Syndrome
Pneumonia, Epistaxis, Hypotension, Subconjunctival hemorrhage, Shock, Palpitations, Pleural effus... ORPHA:340
Autoimmune Hepatitis
Ascites, Gastrointestinal hemorrhage, Spider hemangioma, Splenomegaly ORPHA:2137
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Lymphedema, Ascites, Polyhydramnios, Splenomegaly, Pulmonary lymphangiectasia, Hepatomegaly OMIM:235255
Erdheim-Chester Disease
Congestive heart failure, Pleural effusion, Joint swelling, Abnormal pulmonary interstitial morph... ORPHA:35687
Immunodeficiency 87 And Autoimmunity
Dilated cardiomyopathy, Third degree atrioventricular block, Anasarca, Ascites, Oligohydramnios, ... OMIM:619573
Granulomatous Disease, Chronic, X-Linked
Recurrent pneumonia, Atelectasis, Ascites, Pleural effusion, Splenomegaly, Hepatomegaly OMIM:306400
Fraser Syndrome 3
Abnormal lung lobation, Ascites, Oligohydramnios, Nonimmune hydrops fetalis, Stillbirth OMIM:617667
Adams-Oliver Syndrome
Gastrointestinal hemorrhage, Ascites, Portal hypertension, Pulmonary arterial hypertension, Pulmo... ORPHA:974
Idiopathic Hypereosinophilic Syndrome
Dilated cardiomyopathy, Pulmonary embolism, Angioedema, Congestive heart failure, Transient ische... ORPHA:3260
Eisenmenger Syndrome
Elevated jugular venous pressure, Hepatomegaly, Patent ductus arteriosus, Pedal edema, Right vent... ORPHA:97214
Sclerosing Cholangitis, Neonatal
Hepatomegaly, Portal hypertension, Splenomegaly, Ascites OMIM:617394
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Pulmonary artery dilatation, Right-to-left shunt, Abnormal lung lobation, Alveolar capillary dysp... OMIM:265380
Short-Rib Thoracic Dysplasia 12
Atelectasis, Ascites, Polyhydramnios, Splenomegaly, Neonatal death, Hepatomegaly, Patent ductus a... OMIM:269860
Epilepsy, Progressive Myoclonic, 4, With Or Without Renal Failure
Pleural effusion, Anasarca, Edema OMIM:254900
Familial Mediterranean Fever
Pleural effusion, Splenomegaly, Hepatomegaly, Pleuritis, Pericarditis OMIM:249100
Radio-Renal Syndrome
Chylothorax, Pleural effusion ORPHA:3015
Farber Disease
Recurrent upper respiratory tract infections, Atelectasis, Ascites, Hepatosplenomegaly, Nodular p... ORPHA:333
Sarcoidosis, Susceptibility To, 1
Abnormal pulmonary interstitial morphology, Emphysema, Pleural effusion, Splenomegaly, Pulmonary ... OMIM:181000
Primary Sclerosing Cholangitis
Spider hemangioma, Palmar telangiectasia, Congestive heart failure, Ascites, Hepatosplenomegaly, ... ORPHA:171
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly
Ascites, Hydrops fetalis, Pulmonary hypoplasia OMIM:614091
Chondrodysplasia, Blomstrand Type
Polyhydramnios, Fetal ascites, Hydrops fetalis, Stillbirth OMIM:215045
Fusariosis
Pneumonia, Pleural effusion, Lung abscess, Hypersensitivity pneumonitis, Bronchiectasis ORPHA:228119
Zygomycosis
Hematochezia, Gastrointestinal hemorrhage, Epistaxis, Periorbital edema, Atelectasis, Pleural eff... ORPHA:73263
Gaucher Disease Type 1
Ascites, Hepatosplenomegaly, Portal hypertension, Splenomegaly, Pulmonary arterial hypertension, ... ORPHA:77259
Hennekam Syndrome
Chylothorax, Lymphedema, Ascites, Splenomegaly, Pulmonary lymphangiectasia, Pericardial effusion,... ORPHA:2136
Carney Triad
Gastrointestinal hemorrhage, Ascites, Arrhythmia, Tachycardia, Hypertension ORPHA:139411
Wolcott-Rallison Syndrome
Hepatomegaly, Dehydration, Ascites ORPHA:1667
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Ascites, Hepatosplenomegaly, Polyhydramnios, Splenomegaly, Pulmonary lymphangiectasia, Hepatomegaly ORPHA:1655
Chédiak-Higashi Syndrome
Epistaxis, Hepatosplenomegaly, Pleural effusion, Splenomegaly, Pericardial effusion, Recurrent re... ORPHA:167
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hepatomegaly, Portal hypertension, Splenomegaly, Ascites OMIM:251880
Behçet Disease
Aortic regurgitation, Vasculitis, Gastrointestinal hemorrhage, Pulmonary embolism, Cerebral ische... ORPHA:117
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Polyhydramnios, Chylothorax OMIM:619036
Congenital Myopathy 2C, Severe Infantile, Autosomal Dominant
Chylothorax, Subdural hemorrhage, Cerebral hemorrhage OMIM:620278
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Increased nuchal translucency, Pleural effusion ORPHA:453499
Noonan Syndrome-Like Disorder With Or Without Juvenile Myelomonocytic Leukemia
Aortic valve stenosis, Chylothorax, Lymphedema, Hepatosplenomegaly, Mitral regurgitation, Splenom... OMIM:613563
Gracile Bone Dysplasia
Ascites OMIM:602361
Infection-Related Hemolytic Uremic Syndrome
Pneumonia, Hypertensive crisis, Generalized edema, Pleuritis, Respiratory tract infection, Myocar... ORPHA:544482
Xfe Progeroid Syndrome
Ascites, Hypertension OMIM:610965
Pancreatitis, Hereditary
Pleural effusion OMIM:167800
Sarcoidosis
Chylothorax, Emphysema, Abnormal pleura morphology, Portal hypertension, Pleural effusion, Joint ... ORPHA:797
Cryptococcosis
Pneumonia, Cerebral edema, Nodular pattern on pulmonary HRCT, Pleural effusion ORPHA:1546
Atresia Of Urethra
Ascites, Pulmonary insufficiency, Oligohydramnios ORPHA:105
Osteopetrosis, Autosomal Recessive 5
Ascites, Hepatosplenomegaly, Splenomegaly, Stillbirth, Hepatomegaly OMIM:259720
Familial Mediterranean Fever
Vasculitis, Ascites, Splenomegaly, Arrhythmia, Pleuritis, Myocardial infarction, Pedal edema, Per... ORPHA:342
Nocardiosis
Pneumonia, Emphysema, Pleural effusion, Pneumothorax, Pleuritis, Pericarditis ORPHA:31204
Crimean-Congo Hemorrhagic Fever
Hepatomegaly, Tachycardia, Diffuse alveolar hemorrhage, Bundle branch block, Ascites, Hemothorax,... ORPHA:99827
Acrocephalopolydactylous Dysplasia
Hepatomegaly, Extrapulmonary lobar sequestration, Ascites, Pulmonary hypoplasia OMIM:200995
Functioning Gonadotropic Adenoma
Ascites ORPHA:91348
Brucellosis
Pneumonia, Arteritis, Pulmonary granulomatosis, Bronchitis, Transient ischemic attack, Pleural ef... ORPHA:1304
Intrahepatic Cholestasis Of Pregnancy
Ascites ORPHA:69665
Caroli Disease
Hepatomegaly, Portal hypertension, Splenomegaly, Ascites ORPHA:53035
Peripheral Primitive Neuroectodermal Tumor
Ascites, Pelvic mass ORPHA:370348
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Chylothorax, Pleural effusion, Edema, Lymphedema ORPHA:2526
Cutis Marmorata Telangiectatica Congenita
Ascites, Telangiectasia of the skin, Patent ductus arteriosus ORPHA:1556
Coccidioidomycosis
Pneumonia, Vasculitis, Vasospasm, Exudative pleural effusion, Cerebral ischemia, Pleural empyema,... ORPHA:228123
Cutis Laxa, Autosomal Recessive, Type Ic
Peripheral pulmonary artery stenosis, Recurrent pneumonia, Atelectasis, Ascites, Emphysema, Perio... OMIM:613177
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Ascites, Polyhydramnios, Congestive heart failure OMIM:617156
Kikuchi-Fujimoto Disease
Vasculitis, Abnormal pulmonary interstitial morphology, Pleural effusion, Splenomegaly, Hepatomeg... ORPHA:50918
Leptospirosis
Hypotension, Pulmonary hemorrhage, Pleural effusion, Hepatomegaly, Arrhythmia, First degree atrio... ORPHA:509
Mosaic Variegated Aneuploidy Syndrome
Aortic regurgitation, Abnormal lung lobation, Ascites, Increased nuchal translucency, Polyhydramnios ORPHA:1052
Perlman Syndrome
Ascites, Visceromegaly, Polyhydramnios, Edema OMIM:267000
Tyrosinemia, Type I
Gastrointestinal hemorrhage, Hypertrophic cardiomyopathy, Ascites, Splenomegaly, Melena, Hepatome... OMIM:276700
Senior-Boichis Syndrome
Hypertension, Hepatosplenomegaly, Portal hypertension, Ascites ORPHA:84081
Multiple Myeloma
Pleural effusion, Splenomegaly ORPHA:29073
Fumarase Deficiency
Ascites, Polyhydramnios OMIM:606812
Mitchell-Riley Syndrome
Ascites OMIM:615710
Lysosomal Acid Lipase Deficiency
Hypotension, Ascites, Hepatosplenomegaly, Pulmonary arterial hypertension, Dehydration, Hypovolemia ORPHA:275761
Primary Biliary Cholangitis
Ascites, Portal hypertension, Splenomegaly, Orthostatic hypotension, Hepatomegaly ORPHA:186
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Hepatomegaly, Splenomegaly, Ascites, Aspiration pneumonia OMIM:301072
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Spontaneous pneumothorax, Recurrent pneumonia, Ascites, Hepatospleno... ORPHA:731
Chronic Graft Versus Host Disease
Xerostomia, Ascites, Pleural effusion, Pneumothorax, Bronchiolitis obliterans, Bronchiectasis ORPHA:99921
Lipodystrophy, Familial Partial, Type 7
Spontaneous pneumothorax, Pleural effusion, Pulmonary arteriovenous malformation, Pulmonary arter... OMIM:606721
Ppoma
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97278
Grfoma
Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites, Hepatomegaly, Neoplasm of the ... ORPHA:97261
Rajab Interstitial Lung Disease With Brain Calcifications 1
Anasarca, Ascites, Emphysema, Oligohydramnios, Portal hypertension, Abnormal pulmonary interstiti... OMIM:613658
Fryns Syndrome
Polyhydramnios, Pulmonary hypoplasia, Chylothorax, Stillbirth OMIM:229850
Gallbladder Neuroendocrine Tumor
Ascites ORPHA:100086
Somatostatinoma
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97283
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Hepatomegaly, Ascites OMIM:256810
Vipoma
Hepatomegaly, Abnormal abdomen morphology, Dehydration, Ascites ORPHA:97282
Glucagonoma
Hepatomegaly, Gastrointestinal hemorrhage, Abnormal abdomen morphology, Ascites ORPHA:97280
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Hepatomegaly, Anasarca, Ascites OMIM:203700
Niemann-Pick Disease Type C
Fetal ascites, Aspiration pneumonia, Ascites, Hepatosplenomegaly, Splenomegaly, Hepatomegaly, Abn... ORPHA:646
Noonan Syndrome 1
Chylothorax, Lymphedema, Hypertrophic cardiomyopathy, Patent ductus arteriosus, Pulmonic stenosis OMIM:163950
Wilson Disease
Ascites, Splenomegaly, Hepatomegaly, Edema, Pedal edema OMIM:277900
Biliary, Renal, Neurologic, And Skeletal Syndrome
Aortic regurgitation, Bidirectional shunt, Generalized edema, Pulmonary artery dilatation, Edema,... OMIM:619534
Liver Disease, Severe Congenital
Pneumonia, Ascites, Splenomegaly, Pulmonary edema, Hepatomegaly, Abnormal left ventricular functi... OMIM:619991
Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections
Pulmonary cyst, Recurrent pneumonia, Recurrent upper respiratory tract infections, Recurrent sino... OMIM:147060
Generalized Arterial Calcification Of Infancy
Ascites, Transient ischemic attack, Left ventricular systolic dysfunction, Polyhydramnios, Perica... ORPHA:51608
Singleton-Merten Syndrome 1
Aortic valve stenosis, Recurrent respiratory infections, Pleural effusion, Congestive heart failure OMIM:182250
Niemann-Pick Disease, Type C2
Fetal ascites, Polyhydramnios, Splenomegaly, Hepatomegaly, Pulmonary fibrosis OMIM:607625
Congenital Tracheal Stenosis
Fetal ascites, Abnormal lung morphology, Abnormal lung lobation, Anomalous origin of left pulmona... ORPHA:141127
Johanson-Blizzard Syndrome
Generalized edema, Dilated cardiomyopathy, Anasarca, Ascites, Portal hypertension, Splenomegaly, ... OMIM:243800
Niemann-Pick Disease, Type C1
Hepatomegaly, Fetal ascites, Splenomegaly OMIM:257220
D-Bifunctional Protein Deficiency
Hepatomegaly, Fetal ascites, Polyhydramnios, Splenomegaly OMIM:261515
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Fetal ascites, Hepatosplenomegaly, Ischemic stroke, Portal hypertension, Oligohydramnios, Joint s... OMIM:619503
Faundes-Banka Syndrome
Fetal ascites OMIM:619376
Immunodeficiency 70
Achalasia, Recurrent sinusitis OMIM:618969

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ivns1abp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ivns1abp.

No publications found that use IMPC mice or data for Ivns1abp.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ivns1abptm107929(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ivns1abptm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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