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Gene: Card10 MGI:2146012

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
caspase recruitment domain family, member 10
Synonyms:
CARMA3,  Bimp1

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Card10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Card10 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Immunodeficiency 89 And Autoimmunity
OMIM:619632

The table below shows human diseases predicted to be associated to Card10 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Congenital Herpes Simplex Virus Infection
Microcephaly, Hydranencephaly ORPHA:293
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Cerebellar agenesis, Cerebellar hypoplasia, Hydrocephalus, Holoprosencephaly, Da... OMIM:617967
Neural Tube Defects, Susceptibility To
Myelomeningocele, Spina bifida occulta, Anencephaly, Hydrocephalus OMIM:182940
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Anencephaly 2
Anencephaly OMIM:619452
Hydrolethalus Syndrome 2
Anencephaly, Hydrocephalus, Agenesis of corpus callosum OMIM:614120
Diprosopus
Anencephaly ORPHA:1681
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Schisis Association
Microcephaly, Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Meckel Syndrome, Type 4
Agenesis of cerebellar vermis, Encephalocele, Hypoplasia of the corpus callosum, Microcephaly, Hy... OMIM:611134
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Microcephaly, Hydranencephaly OMIM:601355
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Cerebral cortical atrophy, Hydranencephaly, Aplasia/Hypoplasia of the corpus callosum, Microcepha... ORPHA:2570
Microhydranencephaly
Hydranencephaly, Hypoplasia of the brainstem, Agenesis of corpus callosum, Cerebellar hypoplasia,... OMIM:605013
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Aplasia/Hypoplasia of the corpus callosum, Encephalocele, Microcephaly, Aplasi... ORPHA:1908
Distal Deletion 13Q
Aplasia/Hypoplasia of the corpus callosum, Encephalocele, Microcephaly, Holoprosencephaly, Anence... ORPHA:1590
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hydranencephaly, Hypoplasia of the brainstem, Neonatal death, Cerebellar hypoplasia, Stillbirth OMIM:236500
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hydranencephaly, Polymicrogyria, Hypoplasia of the brainstem, Agenesis of corpus callosum, Cerebe... OMIM:225790
Pyknoachondrogenesis
Stillbirth OMIM:265880
Meckel Syndrome, Type 5
Occipital encephalocele, Anencephaly OMIM:611561
Meckel Syndrome, Type 2
Meningocele, Anencephaly, Encephalocele, Dandy-Walker malformation OMIM:603194
Meckel Syndrome, Type 10
Cerebellar hypoplasia, Occipital encephalocele, Dandy-Walker malformation, Anencephaly OMIM:614175
Hydrolethalus
Hydrocephalus, Anencephaly, Absent septum pellucidum, Agenesis of corpus callosum ORPHA:2189
Cerebrocostomandibular Syndrome
Hydranencephaly, Myelomeningocele, Cerebral calcification, Death in infancy, Microcephaly, Spina ... ORPHA:1393
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Occipital encephalocele, Hypoplasia of the brainstem, Type II lissencephaly, Agenesis of cerebell... OMIM:615287
Iniencephaly
Lissencephaly, Spinal dysraphism, Myelomeningocele, Encephalocele, Hydrocephalus, Spina bifida, H... ORPHA:63259
Chromosome 13Q33-Q34 Deletion Syndrome
Encephalocele, Agenesis of corpus callosum, Microcephaly, Anencephaly, Dandy-Walker malformation OMIM:619148
Meckel Syndrome, Type 6
Occipital encephalocele, Hydrocephalus, Anencephaly OMIM:612284
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Cerebellar vermis hypoplasia, Hypoplasia of the brainstem, Polymicrogyria, Occipital meningocele,... OMIM:616546
Pelvis-Shoulder Dysplasia
Hydranencephaly, Hydrocephalus, Spina bifida ORPHA:2839
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity
Hydranencephaly, Reduced cerebral white matter volume, Polymicrogyria, Periventricular cysts, Bas... OMIM:620371
Pentalogy Of Cantrell
Hydrocephalus, Anencephaly, Encephalocele ORPHA:1335
Vacterl/Vater Association
Occipital encephalocele, Anencephaly ORPHA:887
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Anencephaly, Hydrocephalus, Neonatal death OMIM:269860
Trisomy 18
Aplasia/Hypoplasia of the corpus callosum, Microcephaly, Spina bifida, Holoprosencephaly, Anencep... ORPHA:3380
Thoracoabdominal Syndrome
Anencephaly, Hydrocephalus OMIM:313850
Meckel Syndrome
Aplasia/Hypoplasia of the corpus callosum, Encephalocele, Microcephaly, Hydrocephalus, Anencephal... ORPHA:564
Limb Body Wall Complex
Myelomeningocele, Encephalocele, Short umbilical cord, Hydrocephalus, Spina bifida, Spina bifida ... ORPHA:2369
Meckel Syndrome, Type 1
Cerebral hypoplasia, Occipital encephalocele, Large placenta, Agenesis of corpus callosum, Cerebe... OMIM:249000
Neu-Laxova Syndrome 1
Hydranencephaly, Stillbirth, Small placenta, Short umbilical cord, Agenesis of corpus callosum, C... OMIM:256520
Cousin Syndrome
Hydranencephaly, Hydrocephalus OMIM:260660
Hydrolethalus Syndrome 1
Abnormal cortical gyration, Absent septum pellucidum, Agenesis of corpus callosum, Stillbirth, An... OMIM:236680
Ring Chromosome 13 Syndrome
Microcephaly, Anencephaly, Agenesis of corpus callosum ORPHA:96176
Immunodeficiency 89 And Autoimmunity
OMIM:619632

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Card10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Card10.

No publications found that use IMPC mice or data for Card10.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Card10tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Card10tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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