Genes Phenotypes

Gene: Nsd3

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Name
nuclear receptor binding SET domain protein 3
MGI ID
MGI:2142581
Synonyms
Whsc1l1 WHISTLE
Viability
Homozygous - Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (258) All data table (811)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal snout morphology Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 2.65×10-05
small spleen Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 5.49×10-10
tremors Nsd3tm1b(EUCOMM)Hmgu HET Early adult 6.49×10-06
increased total body fat amount Nsd3tm1b(EUCOMM)Hmgu HET Early adult 6.12×10-05
abnormal behavior Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 8.11×10-06
trunk curl Nsd3tm1b(EUCOMM)Hmgu HET Early adult 9.52×10-09
preweaning lethality, incomplete penetrance Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
increased prepulse inhibition Nsd3tm1b(EUCOMM)Hmgu HET Early adult 9.55×10-05
decreased fasting circulating glucose level Nsd3tm1b(EUCOMM)Hmgu HET Early adult 3.73×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (1/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (3)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
digestive system (5)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (4)
Lymph Node expression
MA:0000139
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000168
postnatal mouse (25)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
trunk (15)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (4/4) N/A
Ear 2  (1/504)  (4/4) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (2/4) N/A
Foot 2  (1/504)  (4/4) N/A
Forebrain 2  (1/504)  (4/4) N/A
Forelimb 2  (1/504)  (4/4) N/A
Hand 2  (1/503)  (4/4) N/A
Head 2  (5/504)  (4/4) N/A
Heart 2  (1/504)  (2/4) N/A
Hindbrain 2  (6/504)  (4/4) N/A
Hindlimb 2  (1/503)  (4/4) N/A
Liver 2  (1/504)  (2/4) N/A
Lung 2  (1/500)  (2/4) N/A
Mandibular process 2  (1/504)  (2/4) N/A
Maxillary process 2  (1/504)  (2/4) N/A
Midbrain 2  (1/504)  (4/4) N/A
Oral cavity 2  (1/504)  (2/4) N/A
Skin 2  (1/504)  (2/4) N/A
Tail 2  (1/504)  (4/4) N/A
Tail somite 2  (1/504)  (4/4) N/A

 Associated Images

Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
8 Images
Adult LacZ: LacZ Images Wholemount
25 Images
X-ray: XRay Images Whole Body Dorso Ventral
18 Images
X-ray: XRay Images Whole Body Lateral Orientation
17 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
Echo: M-Mode Images
52 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nsd3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Nsd3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nsd3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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