Gene: Nsd3

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 1.40×10-10
tremors Nsd3tm1b(EUCOMM)Hmgu HET postnatal 5.33×10-06
abnormal behavior Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 1.03×10-05
abnormal snout morphology Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 3.45×10-05
impaired glucose tolerance Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 6.66×10-05
increased total body fat amount Nsd3tm1b(EUCOMM)Hmgu HET postnatal 6.42×10-05
preweaning lethality, incomplete penetrance Nsd3tm1b(EUCOMM)Hmgu HOM n/a 0.00
decreased fasted circulating glucose level Nsd3tm1b(EUCOMM)Hmgu HET postnatal 4.00×10-05
small spleen Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 0.00
increased prepulse inhibition Nsd3tm1b(EUCOMM)Hmgu HET postnatal 6.70×10-05
short tibia Nsd3tm1b(EUCOMM)Hmgu HET postnatal 8.81×10-05
trunk curl Nsd3tm1b(EUCOMM)Hmgu HET postnatal 1.36×10-08

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (1/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (4/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (2/4) N/A
Foot 2  (1/485)  (4/4) N/A
Forebrain 2  (1/485)  (4/4) N/A
Forelimb 2  (1/485)  (4/4) N/A
Hand 2  (1/485)  (4/4) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485)  (2/4) N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485)  (4/4) N/A
Liver 2  (1/485)  (2/4) N/A
Lung 2  (1/485)  (2/4) N/A
Mandibular process 2  (1/485)  (2/4) N/A
Maxillary process 2  (1/485)  (2/4) N/A
Midbrain 2  (1/485)  (4/4) N/A
Oral cavity 2  (1/485)  (2/4) N/A
Skin 2  (1/485)  (2/4) N/A
Tail 2  (1/485)  (4/4) N/A
Tail somite 2  (1/485)  (4/4) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
17 Images
Adult LacZ: LacZ Images Wholemount
25 Images
Echo: M-Mode Images
52 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Dorso Ventral
18 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nsd3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nsd3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Nsd3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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