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Gene: Nsd3

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Name
nuclear receptor binding SET domain protein 3
MGI ID
MGI:2142581
Synonyms
WHISTLE Whsc1l1
Viability
Data available
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (16) Measurements chart (234) All data table (821)
Expression & images (67) Disease models (0) Histopathology (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased monocyte cell number Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 3.01×10-07
small spleen Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal behavior Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 3.19×10-11
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 6.69×10-07
trunk curl Nsd3tm1b(EUCOMM)Hmgu HET Early adult 7.73×10-09
increased circulating alkaline phosphatase level Nsd3tm1b(EUCOMM)Hmgu HOM   Early adult 7.62×10-05
preweaning lethality, incomplete penetrance Nsd3tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
increased thigmotaxis Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 3.19×10-11
tremors Nsd3tm1b(EUCOMM)Hmgu HET Early adult 5.23×10-06
increased total body fat amount Nsd3tm1b(EUCOMM)Hmgu HET   Early adult 6.15×10-05
abnormal snout morphology Nsd3tm1b(EUCOMM)Hmgu HOM   Early adult 2.95×10-05
hypoactivity Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 4.01×10-06
hyperactivity Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 2.07×10-08
increased anxiety-related response Nsd3tm1b(EUCOMM)Hmgu HOM Early adult 1.68×10-10
increased prepulse inhibition Nsd3tm1b(EUCOMM)Hmgu HET Early adult 1.39×10-05
decreased fasting circulating glucose level Nsd3tm1b(EUCOMM)Hmgu HET Early adult 9.90×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590)  (2/2)  Wholemount images
Aorta 2 No  (1/590)  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/590)  (2/2)  Wholemount images
Brainstem 2 No  (2/590)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/590)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/590)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/590)  (2/2) N/A
Hippocampus 2 No  (3/590)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/590)  (2/2)  Wholemount images
Kidney 2 No  (20/590)  (2/2)  Wholemount images
Large intestine 2 No  (10/590)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (1/590)  (2/2)  Wholemount images
Lung 2 No  (1/590)  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/590)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/590)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/590)  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/590)  (2/2)  Wholemount images
Prostate gland 2 No  (12/590)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/590)  (2/2)  Wholemount images
Spinal cord 2 No  (2/590)  (2/2)  Wholemount images
Spleen 2 No  (2/590)  (1/2)  Wholemount images
Stomach 2 No  (13/590)  (2/2)  Wholemount images
Striatum 2 No  (3/590)  (2/2)  Wholemount images
Testis 2 No  (5/590)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/590)  (2/2)  Wholemount images
Trachea 2 No  (2/590)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (3)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
digestive system (5)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (4)
Lymph Node expression
MA:0000139
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
nervous system (5)
Brain expression
Brainstem expression
Cerebral Cortex expression
Cerebellum expression
Hippocampus expression
Hypothalamus expression
Olfactory Lobe expression
Striatum expression
MA:0000191
MA:0000169
MA:0000198
MA:0000891
MA:0000168
MA:0002413
MA:0000185
MA:0000173
postnatal mouse (25)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
trunk (15)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (4/4) N/A
Ear 2  (1/506)  (4/4) N/A
Embryo 2  (1/507)  (4/4) N/A
Eye 2  (1/506)  (2/4) N/A
Foot 2  (1/506)  (4/4) N/A
Forebrain 2  (1/506)  (4/4) N/A
Forelimb 2  (1/506)  (4/4) N/A
Hand 2  (1/506)  (4/4) N/A
Head 2  (5/506)  (4/4) N/A
Heart 2  (1/506)  (2/4) N/A
Hindbrain 2  (6/506)  (4/4) N/A
Hindlimb 2  (1/506)  (4/4) N/A
Liver 2  (1/504)  (2/4) N/A
Lung 2  (1/504)  (2/4) N/A
Mandibular process 2  (1/506)  (2/4) N/A
Maxillary process 2  (1/506)  (2/4) N/A
Midbrain 2  (1/506)  (4/4) N/A
Oral cavity 2  (1/504)  (2/4) N/A
Skin 2  (1/506)  (2/4) N/A
Tail 2  (1/506)  (4/4) N/A
Tail somite 2  (1/506)  (4/4) N/A

 Associated Images

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X-ray: XRay Images Whole Body Dorso Ventral
18 Images
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Echo: M-Mode Images
52 Images
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X-ray: XRay Images Whole Body Lateral Orientation
17 Images
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Embryo LacZ: LacZ images wholemount
8 Images
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Adult LacZ: LacZ Images Wholemount
25 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nsd3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Nsd3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nsd3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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