Genes Phenotypes

Gene: Nsd3

Log in to follow

Name
nuclear receptor binding SET domain protein 3
MGI ID
MGI:2142581
Synonyms
Whsc1l1 WHISTLE
Viability
Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (12) Measurements chart (250) All data table (599)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased startle reflex Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 1.40×10-10
tremors Nsd3tm1b(EUCOMM)Hmgu HET postnatal 5.33×10-06
abnormal behavior Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 1.03×10-05
abnormal snout morphology Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 3.45×10-05
impaired glucose tolerance Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 6.66×10-05
increased total body fat amount Nsd3tm1b(EUCOMM)Hmgu HET postnatal 6.42×10-05
preweaning lethality, incomplete penetrance Nsd3tm1b(EUCOMM)Hmgu HOM n/a 0.00
decreased fasted circulating glucose level Nsd3tm1b(EUCOMM)Hmgu HET postnatal 4.00×10-05
small spleen Nsd3tm1b(EUCOMM)Hmgu HOM postnatal 0.00
increased prepulse inhibition Nsd3tm1b(EUCOMM)Hmgu HET postnatal 6.70×10-05
short tibia Nsd3tm1b(EUCOMM)Hmgu HET postnatal 8.81×10-05
trunk curl Nsd3tm1b(EUCOMM)Hmgu HET postnatal 1.36×10-08

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584)  (1/2)  Wholemount images
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (3)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
digestive system (5)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (4)
Lymph Node expression
MA:0000139
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000168
postnatal mouse (25)
Adrenal gland expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Cartilage tissue expression
Bone expression
Vascular System expression
MA:0000104
MA:0001459
MA:0002718
trunk (15)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (4/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (2/4) N/A
Foot 2  (1/485)  (4/4) N/A
Forebrain 2  (1/485)  (4/4) N/A
Forelimb 2  (1/485)  (4/4) N/A
Hand 2  (1/485)  (4/4) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485)  (2/4) N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485)  (4/4) N/A
Liver 2  (1/485)  (2/4) N/A
Lung 2  (1/485)  (2/4) N/A
Mandibular process 2  (1/485)  (2/4) N/A
Maxillary process 2  (1/485)  (2/4) N/A
Midbrain 2  (1/485)  (4/4) N/A
Oral cavity 2  (1/485)  (2/4) N/A
Skin 2  (1/485)  (2/4) N/A
Tail 2  (1/485)  (4/4) N/A
Tail somite 2  (1/485)  (4/4) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
17 Images
Adult LacZ: LacZ Images Wholemount
25 Images
Echo: M-Mode Images
52 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
16 Images
X-ray: XRay Images Dorso Ventral
18 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nsd3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Nsd3tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Nsd3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter