Mbd5 | methyl-CpG binding domain protein 5
Physiological systems
19 / 24 physiological systems tested
9 Significantly impacted by the knock-out
Immune system Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Mortality/aging
10 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
decreased total retina thickness | 2 supporting datasets | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 8.68x10-8 | ||
decreased locomotor activity | 2 supporting datasets | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2x10-5 | ||
decreased leukocyte cell number | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 4.96x10-5 | ||
decreased exploration in new environment | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 6x10-7 | ||
abnormal lip morphology | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.08x10-5 | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
short tibia | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.55x10-5 | ||
decreased lymphocyte cell number | 1 supporting dataset | Mbd5tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.8x10-5 |
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External links
No external links available for Mbd5.
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Mbd5tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Mbd5tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Mbd5tm3a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Mbd5tm3e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |