Mbd5 | methyl-CpG binding domain protein 5

GeneMGI:2138934Synonyms: OTTMUSG00000012483, 9430004D19Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Immune system Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased total retina thickness2 supporting datasetsMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult8.68x10-8 
decreased locomotor activity2 supporting datasetsMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult2x10-5 
decreased leukocyte cell number1 supporting datasetMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult4.96x10-5 
decreased exploration in new environment1 supporting datasetMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult6x10-7 
abnormal lip morphology1 supporting datasetMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult1.08x10-5 
preweaning lethality, complete penetrance1 supporting datasetMbd5tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
short tibia1 supporting datasetMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult1.55x10-5 
decreased lymphocyte cell number1 supporting datasetMbd5tm1b(EUCOMM)WtsiheterozygoteEarly adult2.8x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Mbd5tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Mbd5tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Mbd5tm3a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Mbd5tm3e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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