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Gene: Myocd MGI:2137495

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
myocardin
Synonyms:
Srfcp

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Myocd mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Myocd by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Megabladder, Congenital
Fetal megacystis, Stage 5 chronic kidney disease, Multiple glomerular cysts, Hyperechogenic kidneys OMIM:618719

The table below shows human diseases predicted to be associated to Myocd by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Urofacial Syndrome 2
Megacystis, Recurrent urinary tract infections, Renal insufficiency, Vesicoureteral reflux, Hydro... OMIM:615112
Atresia Of Urethra
Hydroureter, Megacystis, Recurrent urinary tract infections, Bladder fistula, Renal insufficiency... ORPHA:105
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 4
Recurrent urinary tract infections, Fetal pyelectasis, Megacystis, Nephrolithiasis OMIM:619365
Adrenomyodystrophy
Abnormality of the urinary system, Myopathy, Megacystis ORPHA:977
Nephrosialidosis
Ascites, Bone-marrow foam cells, Pericardial effusion OMIM:256150
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Hydronephrosis, Hydroureter, Megacystis OMIM:619431
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polyuria, Megacystis OMIM:125800
Lymphatic Malformation 8
Generalized edema, Pleural effusion, Nonimmune hydrops fetalis, Stillbirth, Polyhydramnios, Peric... OMIM:618773
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polyuria, Megacystis OMIM:304800
Congenital Heart Block
Intrauterine growth retardation, Endocardial fibroelastosis, Pleural effusion, Oligohydramnios, P... ORPHA:60041
Familial Visceral Myopathy
Hydroureter, Megacystis, Camptodactyly of finger, Vesicoureteral reflux, Aplasia/Hypoplasia of th... ORPHA:2604
Combined Oxidative Phosphorylation Deficiency 10
Ascites, Hypertrophic cardiomyopathy, Intrauterine growth retardation, Oligohydramnios, Pleural e... OMIM:614702
Primary Effusion Lymphoma
Pericardial effusion, Pleural effusion ORPHA:48686
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Megabladder, Congenital
Fetal megacystis, Stage 5 chronic kidney disease, Multiple glomerular cysts, Hyperechogenic kidneys OMIM:618719
Visceral Myopathy 2
Megacystis OMIM:619350
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Multicystic kidney dysplasia, Hydroureter, Megacystis ORPHA:2241
Congenital Pulmonary Lymphangiectasia
Ascites, Pleural effusion, Hydrops fetalis, Growth delay, Chylopericardium, Pulmonic stenosis ORPHA:2414
Cantu Syndrome
Congenital hypertrophy of left ventricle, Lymphedema, Umbilical hernia, Cardiomegaly, Bicuspid ao... OMIM:239850
Visceral Myopathy 1
Hydronephrosis, Vesicoureteral reflux, Urinary retention, Megacystis OMIM:155310
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 2
Renal cortical hyperechogenicity, Anuria, Megacystis, Pyelonephritis, Fetal megacystis OMIM:619351
Hydrops Fetalis
Generalized edema, Lymphedema, Ascites, Abnormal heart morphology, Pleural effusion, Nonimmune hy... ORPHA:1041
Lymphatic Malformation 7
Facial edema, Chylothorax, Lymphedema, Ascites, Increased nuchal translucency, Pleural effusion, ... OMIM:617300
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1
Hydroureter, Fetal megacystis OMIM:249210
Neurodevelopmental Disorder With Short Stature, Prominent Forehead, And Feeding Difficulties
Multiple muscular ventricular septal defects, Polyhydramnios, Aortic aneurysm, Limb hypertonia, A... OMIM:620070
Meckel Syndrome, Type 8
Pericardial effusion, Occipital encephalocele, Encephalocele OMIM:613885
Brain-Lung-Thyroid Syndrome
Vesicoureteral reflux, Hypospadias, Megacystis ORPHA:209905
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular hypertrophy, Ascites, Hypertrophic cardiomyopathy, Muscular ventricular septal defect... OMIM:115197
Craniofaciofrontodigital Syndrome
Aortic valve stenosis, Lower eyelid edema, Abnormal heart valve morphology, Polyhydramnios, Ventr... ORPHA:363705
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3
Duplicated collecting system, Hydroureter, Ureterocele, Megacystis, Renal agenesis, Vesicouretera... OMIM:604292
Hypertelorism And Other Facial Dysmorphism, Brachydactyly, Genital Abnormalities, Impaired Intellectual Development, And Recurrent Inflammatory Episodes
Pericardial effusion OMIM:614684
Congenital Tricuspid Valve Dysplasia
Intrauterine growth retardation, Abnormal tricuspid valve annulus morphology, Patent foramen oval... ORPHA:555874
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Hydronephrosis, Fetal megacystis, Hydroureter, Neonatal death OMIM:619362
Congenital Disorder Of Glycosylation, Type Il
Ascites, Hydrops fetalis, Pericardial effusion, Atrial septal defect OMIM:608776
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Joint contracture of the hand, Umbilical hernia, Lymphedema, Mild postnatal growth retardation, P... OMIM:235510
Pulmonary Non-Tuberculous Mycobacterial Infection
Pericardial effusion, Pleural effusion ORPHA:411703
Hypocomplementemic Urticarial Vasculitis
Angioedema, Ascites, Abnormal heart valve morphology, Pleural effusion, Pericardial effusion ORPHA:36412
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Restrictive cardiomyopathy, Endocardial fibroelastosis, Nonimmune hydrops fetalis, Pericardial ef... OMIM:619313
Congenital Enterovirus Infection
Fetal ascites, Cardiomyopathy, Pleural effusion, Polyhydramnios, Myocarditis, Hydrops fetalis, Pe... ORPHA:292
Glycogen Storage Disease Of Heart, Lethal Congenital
Macroglossia, Anasarca, Cardiomyopathy, Biventricular hypertrophy, Ascites, Hypertrophic cardiomy... OMIM:261740
Primary Intestinal Lymphangiectasia
Generalized edema, Ascites, Pleural effusion, Pericardial effusion, Growth delay, Edema ORPHA:90362
Patent Urachus
Recurrent urinary tract infections, Cystocele, Patent urachus, Congenital posterior urethral valv... ORPHA:431341
Neurodegeneration, Childhood-Onset, With Multisystem Involvement Due To Mitochondrial Dysfunction
Pericardial effusion, Skeletal muscle atrophy, Cardiomyopathy OMIM:620089
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypertrophic cardiomyopathy, Intrauterine growth retardation, Pericardial effusion, Ventricular s... OMIM:618775
Aicardi-Goutieres Syndrome 9
Lower limb hypertonia, Ascites, Intrauterine growth retardation, Left ventricular hypertrophy, Pe... OMIM:619487
Cardiac-Urogenital Syndrome
Hypoplastic left heart, Coronary sinus enlargement, Interrupted aortic arch, Biventricular hypert... OMIM:618280
Alkuraya-Kucinskas Syndrome
Pleural effusion, Camptodactyly, Pericardial effusion, Arthrogryposis multiplex congenita, Edema OMIM:617822
Drug-Induced Lupus Erythematosus
Pericardial effusion, Pericarditis ORPHA:231111
Pediatric Systemic Lupus Erythematosus
Ascites, Pleural effusion, Myositis, Pericardial effusion, Edema ORPHA:93552
Arrhythmogenic Cardiomyopathy With Variable Ectodermal Abnormalities
Dilated cardiomyopathy, Myofiber disarray, Patent foramen ovale, Ventricular septal defect, Bicus... OMIM:620519
Cardiomyopathy, Dilated, 1A
Pericardial effusion, Dilated cardiomyopathy OMIM:115200
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Pericardial effusion, Muscular dystrophy, Dilated cardiomyopathy, Abnormal myocardium morphology ORPHA:300751
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Dilated cardiomyopathy, Exercise-induced rhabdomyolysis, Patent foramen ovale, Ventricular septal... ORPHA:26793
Acute Interstitial Pneumonia
Pericardial effusion, Peripheral edema, Pleural effusion ORPHA:79126
Alpha-Thalassemia
Pericardial effusion, Generalized edema, Hydrops fetalis, Pleural effusion ORPHA:846
Congenital Disorder Of Glycosylation, Type Ia
Cardiomyopathy, Nonimmune hydrops fetalis, Pericardial effusion, Flexion contracture, Edema, Peri... OMIM:212065
Lymphoproliferative Syndrome 1
Pericardial effusion, Pleural effusion OMIM:613011
Myhre Syndrome
Aortic valve stenosis, Skeletal muscle hypertrophy, Intrauterine growth retardation, Ventricular ... OMIM:139210
Classical-Like Ehlers-Danlos Syndrome Type 2
Aortic root aneurysm, Umbilical hernia, Mitral valve prolapse, Carotid artery stenosis, Pericardi... ORPHA:536532
Aymé-Gripp Syndrome
Postnatal growth retardation, Congenital diaphragmatic hernia, Camptodactyly, Short stature, Peri... ORPHA:1272
Poems Syndrome
Ascites, Pericardial effusion, Pleural effusion, Edema ORPHA:2905
Diarrhea 10, Protein-Losing Enteropathy Type
Anasarca, Ascites, Pleural effusion, Polyhydramnios, Pericardial effusion OMIM:618183
Pulmonary Capillary Hemangiomatosis
Pulmonary edema, Pericardial effusion, Pleural effusion, Pedal edema ORPHA:199241
Alg9-Cdg
Rhizomelia, Hypoplasia of the musculature, Abnormal heart morphology, Oligohydramnios, Ventricula... ORPHA:79328
Gaucher Disease Type 3
Aortic valve calcification, Abnormal heart valve morphology, Mitral valve calcification, Abnormal... ORPHA:77261
Ehlers-Danlos Syndrome, Arthrochalasia Type, 2
Bladder diverticulum OMIM:617821
Q Fever
Abnormal heart valve morphology, Pleural effusion, Myocarditis, Pericardial effusion, Endocarditi... ORPHA:781
Hennekam Syndrome
Chylothorax, Lymphedema, Ascites, Camptodactyly of finger, Mild postnatal growth retardation, Per... ORPHA:2136
Bladder Exstrophy And Epispadias Complex
Unilateral renal agenesis, Hydroureter, Horseshoe kidney, Bladder exstrophy, Epispadias OMIM:600057
Duplication Of Urethra
Anuria, Recurrent urinary tract infections, Dysuria, Rectourethral fistula, Distal urethral dupli... ORPHA:237
Aicardi-Goutieres Syndrome 7
Hypertrophic cardiomyopathy, Intrauterine growth retardation, Oligohydramnios, Limb hypertonia, P... OMIM:615846
Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Proteinuria, Multiple bladder diverticula ORPHA:2728
Kaposiform Lymphangiomatosis
Pericardial effusion, Pleural effusion ORPHA:464329
Cutis Laxa, Autosomal Recessive, Type Ia
Bladder diverticulum, Congenital diaphragmatic hernia OMIM:219100
Visceral Neuropathy-Brain Anomalies-Facial Dysmorphism-Developmental Delay Syndrome
Multicystic kidney dysplasia, Fetal megacystis ORPHA:73246
Pseudoleprechaunism Syndrome, Patterson Type
Bladder diverticulum ORPHA:2976
Generalized Arterial Calcification Of Infancy
Ventricular hypertrophy, Aortic dissection, Medial calcification of large arteries, Ascites, Arte... ORPHA:51608
Chédiak-Higashi Syndrome
Pericardial effusion, Pleural effusion, Edema ORPHA:167
Acro-Renal-Ocular Syndrome
Horseshoe kidney, Crossed fused renal ectopia, Vesicoureteral reflux, Renal hypoplasia/aplasia, B... ORPHA:959
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2
Bladder diverticulum, Type 1 muscle fiber predominance, Skeletal muscle atrophy, Myopathy OMIM:614557
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Pulmonary edema, Dilated cardiomyopathy, Pericardial effusion ORPHA:73224
Lymphangioleiomyomatosis
Ascites, Chylothorax, Chylopericardium, Lymphedema ORPHA:538
Autosomal Recessive Cutis Laxa Type 1
Multiple bladder diverticula, Urethral diverticulum, Recurrent urinary tract infections, Pyelonep... ORPHA:90349
Gitelman Syndrome
Pericardial effusion, Delayed puberty, Rhabdomyolysis ORPHA:358
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Delayed puberty ORPHA:91347
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Duplicated collecting system, Hydroureter, Ureterocele, Renal agenesis, Vesicoureteral reflux, Hy... OMIM:129900
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio, Bladder diverticulum, Incre... OMIM:225400
Cutis Laxa, Autosomal Recessive, Type Ic
Morgagni diaphragmatic hernia, Multiple bladder diverticula, Posterolateral diaphragmatic hernia,... OMIM:613177
Occipital Horn Syndrome
Hydronephrosis, Ureteral obstruction, Bladder diverticulum OMIM:304150
Menkes Disease
Bladder diverticulum, Aplasia/Hypoplasia of the abdominal wall musculature ORPHA:565
Crimean-Congo Hemorrhagic Fever
Ascites, Pericardial effusion, Myocarditis ORPHA:99827
Kyphoscoliotic Ehlers-Danlos Syndrome
Bladder diverticulum, Skeletal muscle atrophy, Myopathy ORPHA:536545
Sarcoidosis, Susceptibility To, 1
Pericardial effusion, Pleural effusion OMIM:181000
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Hydroureter, Dilatation of the renal pelvis, Diastasis recti, Dilatation of the bladder, Neonatal... OMIM:265380
Williams Syndrome
Renal hypoplasia, Nephrocalcinosis, Recurrent urinary tract infections, Renal insufficiency, Vesi... ORPHA:904
Occipital Horn Syndrome
Bladder diverticulum, Recurrent urinary tract infections ORPHA:198
Autosomal Dominant Cutis Laxa
Unilateral renal agenesis, Pyelonephritis, Bladder diverticulum ORPHA:90348
Williams-Beuren Syndrome
Renal hypoplasia, Nephrocalcinosis, Recurrent urinary tract infections, Flexion contracture, Rena... OMIM:194050
Mitochondrial Complex I Deficiency, Nuclear Type 32
Patent urachus, Skeletal muscle atrophy OMIM:618252
Classical Ehlers-Danlos Syndrome
Bladder diverticulum ORPHA:287
Pmm2-Cdg
Anasarca, Lymphedema, Hypertrophic cardiomyopathy, Multiple joint contractures, Pericardial effus... ORPHA:79318
Vascular Ehlers-Danlos Syndrome
Cystocele, Bladder diverticulum, Aplasia/Hypoplasia of the abdominal wall musculature, Renovascul... ORPHA:286

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myocd

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myocd.

No publications found that use IMPC mice or data for Myocd.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Myocdtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Myocdtm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Myocdtm309(L1L2_gt1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Myocdtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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