Tmem108 | transmembrane protein 108

GeneMGI:1932411Synonyms: B130017P16Rik

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Vision/eye Behavior/neurological Skeleton

12 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased bone mineral content1 supporting datasetTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult8.85x10-5 
increased total body fat amount2 supporting datasetsTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult1.06x10-5 
decreased lean body mass1 supporting datasetTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult5.69x10-6 
abnormal cornea morphology1 supporting datasetTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult6.29x10-5 
abnormal auditory brainstem response2 supporting datasetsTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult1.7x10-5 
limb grasping1 supporting datasetTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult6.95x10-5 
increased circulating aspartate transaminase level1 supporting datasetTmem108tm1b(EUCOMM)WtsihomozygoteEarly adult1.96x10-9 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmem108tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tmem108tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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