Gene Summary

G protein-coupled receptor 155
PGR22,  1110017O10Rik,  F730029F15Rik,  DEPDC3

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged lymph nodes Gpr155em1(IMPC)Mbp HOM Early adult 0.00
small seminal vesicle Gpr155em1(IMPC)Mbp HOM Early adult 0.00
enlarged kidney Gpr155em1(IMPC)Mbp HOM Early adult 0.00
abnormal kidney morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00
abnormal seminal vesicle morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

30 Images


XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Gpr155 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr155 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Congenital Megacalycosis
Hydronephrosis, Tubulointerstitial nephritis, Dilatation of renal calices, Abnormal renal physiol... ORPHA:93109
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Immunodeficiency, Common Variable, 6
Macroscopic hematuria, Hepatomegaly, Hydronephrosis, Mesangial Immune complex deposition, Stage 5... OMIM:613496
Reticuloendotheliosis, X-Linked
Lymphadenopathy, Hepatosplenomegaly OMIM:312500
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Elevated circulating growth hormone concentration, Polycystic ovaries, Enlarged polycystic ovarie... ORPHA:90301
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Goiter, Renal oncocytoma, Nodular goiter, Renal cortical adenoma, Abnormality of the lymph nodes,... ORPHA:97290
Nephronophthisis 16
Nephronophthisis, Polycystic kidney dysplasia, Renal insufficiency, Enlarged kidney OMIM:615382
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Hepatomegaly, Pancreatic cysts, Tubulointerstitial fibrosis, Renal cyst, Splenomegaly, Polycystic... OMIM:263200
Kimura Disease
Lymphadenopathy, Abnormal salivary gland morphology, Follicular hyperplasia ORPHA:482
Renal Dysplasia
Abnormal renal calyx morphology, Chronic kidney disease, Abnormal nephron morphology, Vesicovagin... ORPHA:93108
Immunodeficiency 75
Lymphadenopathy, Hepatosplenomegaly, Follicular hyperplasia OMIM:619126
Granulomatous Slack Skin
Acute kidney injury, Abnormality of the lymph nodes, Nephrocalcinosis ORPHA:33111
Kerion Celsi
Lymphadenopathy ORPHA:499
Aa Amyloidosis
Hepatomegaly, Nephrotic syndrome, Acute kidney injury, Nephropathy, Chronic kidney disease, Prote... ORPHA:85445
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:608971
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Hepatomegaly, Recurrent urinary tract infections, Splenomegaly OMIM:618495
Nephronophthisis 2
Chronic tubulointerstitial nephritis, Nephronophthisis, Stage 5 chronic kidney disease, Absence o... OMIM:602088
Renal-Hepatic-Pancreatic Dysplasia 2
Cystic renal dysplasia, Hepatomegaly, Asplenia, Enlarged kidney OMIM:615415
Familial Papillary Or Follicular Thyroid Carcinoma
Goiter, Nodular goiter, Abnormality of the lymph nodes, Chronic noninfectious lymphadenopathy, Pa... ORPHA:319487
Immunodeficiency With Hyper-Igm, Type 5
Lymphadenopathy, Epididymitis OMIM:608106
Autosomal Dominant Polycystic Kidney Disease
Pancreatic cysts, Pituitary growth hormone cell adenoma, Decreased glomerular filtration rate, He... ORPHA:730
Renal-Hepatic-Pancreatic Dysplasia 1
Hepatomegaly, Pancreatic cysts, Asplenia, Polysplenia, Renal dysplasia, Bile duct proliferation, ... OMIM:208540
Autoinflammation With Episodic Fever And Lymphadenopathy
Lymphadenopathy, Hepatomegaly, Recurrent tonsillitis, Splenomegaly OMIM:618852
Hemihyperplasia-Multiple Lipomatosis Syndrome
Ovarian serous cystadenoma, Abnormality of the lymphatic system, Nephroblastoma, Hydrocele testis... ORPHA:276280
Mast Cell Sarcoma
Lymphadenopathy, Hepatomegaly, Mediastinal lymphadenopathy, Splenomegaly ORPHA:66661
Mu-Heavy Chain Disease
Hepatomegaly, Lymphadenopathy, Bence Jones Proteinuria, Splenomegaly, Nephropathy ORPHA:100024
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Urethral atresia, Hydronephrosis, Enlarged kidney OMIM:314390
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Genital ulcers, Aplasia of the thymus, Lymph node hypoplasia OMIM:602450
Alpha-Heavy Chain Disease
Lymphadenopathy, Hepatomegaly, Premature ovarian insufficiency, Splenomegaly ORPHA:100025
Kaposiform Lymphangiomatosis
Pancreatic cysts, Abnormal lymphatic vessel morphology, Lymphangioma, Abnormality of the lymphati... ORPHA:464329
Immunodeficiency 7
Lymphadenopathy OMIM:615387
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:86893
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the ovary, Abnormality of the lymph nodes ORPHA:543
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormal testis morphology, Abnormality of the lymphatic system, Abnormality of the kidney, Abnor... ORPHA:54251
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy, Hepatomegaly OMIM:615895
Hypospadias, Sex reversal, Micropenis, Ambiguous genitalia, Hyperechogenic kidneys, Cryptorchidis... OMIM:612651
H Syndrome
Azoospermia, Lymphadenopathy, Hypogonadism, Micropenis, Hepatosplenomegaly, Decreased testicular ... ORPHA:168569
Hereditary Amyloidosis With Primary Renal Involvement
Renal tubular atrophy, Hepatomegaly, Oligospermia, Tubulointerstitial nephritis, Nephrotic syndro... ORPHA:85450
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Mucopolysaccharidosis-Plus Syndrome
Renal tubular atrophy, Hepatomegaly, Focal segmental glomerulosclerosis, Nephrotic syndrome, Neph... OMIM:617303
Igg4-Related Kidney Disease
Tubulointerstitial nephritis, Lymphadenopathy, Chronic kidney disease, Lymphadenitis, Renal inter... ORPHA:449395
Congenital Anomalies Of Kidney And Urinary Tract 2
Cystic renal dysplasia, Renal hypoplasia, Hydronephrosis, Renal sarcoma, Nephrotic syndrome, Cong... OMIM:143400
Autoimmune Lymphoproliferative Syndrome, Type Iii
Hepatomegaly, Mediastinal lymphadenopathy, Nephrotic syndrome, Lymphadenopathy, Membranous nephro... OMIM:615559
Follicular Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Acrocephalopolydactylous Dysplasia
Cystic renal dysplasia, Hepatomegaly, Pancreatic fibrosis, Polysplenia, Enlarged kidney OMIM:200995
Hodgkin Lymphoma
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:98293
Lymphoproliferative Syndrome 3
Lymphadenopathy, Hepatosplenomegaly OMIM:618261
Beckwith-Wiedemann Syndrome
Renal cortical cysts, Hepatomegaly, Pancreatic hyperplasia, Nephrocalcinosis, Gonadoblastoma, Car... OMIM:130650
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy, Adrenocorticotropic hormone excess ORPHA:100083
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Hepatomegaly, Ureteral duplication, Hydronephrosis, Cardiomegaly, Polycystic kidney dysplasia, Lo... OMIM:608836
Lymphoid Interstitial Pneumonia
Hepatomegaly, Mediastinal lymphadenopathy, Enlarged kidney ORPHA:79128
Tyrosinemia, Type I
Renal Fanconi syndrome, Hepatomegaly, Nephrocalcinosis, Glomerular sclerosis, Splenomegaly, Renal... OMIM:276700
Desmoplastic Small Round Cell Tumor
Hepatomegaly, Ovarian neoplasm, Mediastinal lymphadenopathy, Lymphadenopathy, Neoplasm of the pan... ORPHA:83469
Cystic renal dysplasia, Nephrogenic rest, Nephroblastomatosis, Enlarged kidney OMIM:608022
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Pfapa Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:42642
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
Lymphatic Filariasis
Lymphangiectasis, Vaginal hydrocele, Nephrotic syndrome, Lymphadenopathy, Lymphadenitis, Hematuri... ORPHA:2035
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:603552
Fish-Eye Disease
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:79292
Immunodeficiency 72 With Autoinflammation
Lymphadenopathy, Hepatosplenomegaly OMIM:618982
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Hepatomegaly, Glomerulonephritis, Splenomegaly OMIM:619375
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Cold Agglutinin Disease
Lymphadenopathy, Hepatomegaly, Abnormal urinary color, Splenomegaly ORPHA:56425
Paternal Uniparental Disomy Of Chromosome 1
Macroscopic hematuria, Proteinuria, Membranoproliferative glomerulonephritis, Enlarged kidney ORPHA:251004
Immunodeficiency, Common Variable, 2
Lymphadenopathy, Hepatomegaly, Follicular hyperplasia, Splenomegaly OMIM:240500
Candidiasis, Familial, 2
Lymphadenopathy OMIM:212050
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly
Renal dysplasia, Micropenis, Ambiguous genitalia, Polycystic kidney dysplasia, Enlarged kidney OMIM:613091
Meacham Syndrome
Horseshoe kidney, Accessory spleen, Bicornuate uterus, Septate vagina, Blind vagina, Male pseudoh... OMIM:608978
Heme Oxygenase 1 Deficiency
Hepatomegaly, Asplenia, Lymphadenopathy, Hematuria, Nephritis, Cervical lymphadenopathy, Proteinuria OMIM:614034
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Leukocyte Adhesion Deficiency, Type Iii
Hepatomegaly, Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Glycogen Storage Disease Ia
Hepatomegaly, Focal segmental glomerulosclerosis, Decreased glomerular filtration rate, Nephrolit... OMIM:232200
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly OMIM:613101
Immunodeficiency 64
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Cervical lymphade... OMIM:618534
Thymic Neuroendocrine Tumor
Pancreatic islet cell adenoma, Mediastinal lymphadenopathy, Neoplasm of the thymus, Pituitary ade... ORPHA:97289
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Lymphadenopathy, Hematuria, Nephroblastoma ORPHA:654
Glycogen Storage Disease Ib
Hepatomegaly, Focal segmental glomerulosclerosis, Decreased glomerular filtration rate, Nephrolit... OMIM:232220
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:300853
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Autosomal Recessive Polycystic Kidney Disease
Pancreatic cysts, Stage 5 chronic kidney disease, Splenomegaly, Recurrent urinary tract infection... ORPHA:731
Immunodeficiency 54
Lymphadenopathy, Hepatomegaly, Adrenocorticotropic hormone excess, Splenomegaly OMIM:609981
Classic Mycosis Fungoides
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:2584
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Heavy proteinuria, Nephrotic syndrome, Bone marrow hypocellularity, Hepatosplenomegaly, Urinary g... ORPHA:505248
Schnitzler Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:37748
Pleural Mesothelioma
Lymphadenopathy, Hepatomegaly ORPHA:50251
Immunodeficiency 27A
Lymphadenopathy, Hepatosplenomegaly, Enlarged mesenteric lymph node, Splenomegaly OMIM:209950
Beckwith-Wiedemann Syndrome
Hepatomegaly, Ureteral duplication, Gonadoblastoma, Congenital megaureter, Cardiomegaly, Nephroli... ORPHA:116
Congenital Toxoplasmosis
Lymphadenopathy, Hepatomegaly, Cardiomegaly ORPHA:858
Rhabdoid Tumor
Lymphadenopathy, Renal neoplasm, Hematuria ORPHA:69077
Indolent Systemic Mastocytosis
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:98848
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:607594
Classic Hodgkin Lymphoma
Lymphadenopathy, Hepatomegaly, Bone marrow hypocellularity, Splenomegaly ORPHA:391
Hepatomegaly, Hydronephrosis, Hypoplastic nipples, Abnormal renal artery morphology, Hypoplasia o... ORPHA:79328
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Immunodeficiency 91 And Hyperinflammation
Hepatomegaly, Nephrotic syndrome, Lymphadenopathy, Hemolytic-uremic syndrome, Hepatosplenomegaly,... OMIM:619644
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy, Ovarian neoplasm ORPHA:2221
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Agammaglobulinemia, X-Linked
Recurrent urinary tract infections, Epididymitis, Prostatitis, Lymph node hypoplasia OMIM:300755
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Omenn Syndrome
Lymphadenopathy, Hepatomegaly, Hypoplasia of the thymus, Splenomegaly OMIM:603554
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Hepatomegaly, Nephrocalcinosis, Tubulointerstitial fibrosis, Polycystic ovaries, Stage 5 chronic ... ORPHA:79259
Hepatomegaly, Long penis, Nephrocalcinosis, Enlarged ovaries, Labial hypertrophy, Clitoral hypert... ORPHA:508
Ras-Associated Autoimmune Leukoproliferative Disorder
Hepatomegaly, Follicular hyperplasia, Splenomegaly OMIM:614470
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:85414
Medullary Thyroid Carcinoma
Lymphadenopathy, Primary hyperparathyroidism, Nodular goiter, Pheochromocytoma ORPHA:1332
Roifman Syndrome
Lymphadenopathy, Hepatosplenomegaly, Hypogonadotropic hypogonadism ORPHA:353298
Lig4 Syndrome
Lymphadenopathy, Hepatomegaly, Cryptorchidism, Hypoplasia of penis ORPHA:99812
Lymphoproliferative Syndrome 2
Lymphadenopathy, Hepatomegaly, Hepatosplenomegaly, Splenomegaly OMIM:615122
Thyroid Lymphoma
Lymphadenopathy, Goiter ORPHA:97285
Autoimmune Lymphoproliferative Syndrome, Type Iia
Hepatomegaly, Nephrotic syndrome, Lymphadenopathy, Nephritis, Splenomegaly, Chronic noninfectious... OMIM:603909
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy, Proteinuria ORPHA:69126
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Combined Immunodeficiency Due To Zap70 Deficiency
Nephrotic syndrome, Lymphadenopathy, Lymphadenitis, Abnormality of the lymph nodes, Hepatosplenom... ORPHA:911
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Boutonneuse Fever
Lymphadenopathy, Renal insufficiency, Cervical lymphadenopathy ORPHA:83313
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Nephrotic syndrome, Lymphadenopathy, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Recurrent t... OMIM:618935
Lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy, Cervica... ORPHA:3392
Griscelli Syndrome Type 2
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:79477
Roifman Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:616651
Castleman Disease
Ureteral obstruction, Mediastinal lymphadenopathy, Lymphadenopathy, Hematuria, Generalized lympha... ORPHA:160
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:308240
Cinca Syndrome
Lymphadenopathy, Hepatosplenomegaly OMIM:607115
Hypocomplementemic Urticarial Vasculitis
Hepatomegaly, Lymphadenopathy, Hematuria, Splenomegaly, Glomerulopathy, Proteinuria, Renal insuff... ORPHA:36412
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:507
Autoimmune Lymphoproliferative Syndrome
Hepatomegaly, Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:601859
Klatskin Tumor
Lymphadenopathy, Hepatomegaly ORPHA:99978
Deafness-Lymphedema-Leukemia Syndrome
Lymphadenopathy, Hepatomegaly, Bone marrow hypocellularity, Splenomegaly ORPHA:3226
Melkersson-Rosenthal Syndrome
Oligosacchariduria, Lymphadenopathy ORPHA:2483
Scrub Typhus
Lymphadenopathy, Renal insufficiency, Splenomegaly ORPHA:83317
Anaplastic Thyroid Carcinoma
Lymphadenopathy, Nodular goiter, Goiter ORPHA:142
Prostate neoplasm, Urinary bladder inflammation, Urinary urgency, Urinary hesitancy, Hematuria, D... ORPHA:556
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:619183
Tall Stature-Intellectual Disability-Renal Anomalies Syndrome
Renal malrotation, Bifid ureter, Multicystic kidney dysplasia, Nephroblastoma, Enlarged kidney ORPHA:500095
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Hepatomegaly, Lymph node hypoplasia ORPHA:276
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Sézary Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:3162
Omenn Syndrome
Lymphadenopathy, Hepatomegaly, Nephrotic syndrome, Splenomegaly ORPHA:39041
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Simpson-Golabi-Behmel Syndrome, Type 1
Hypospadias, Hepatomegaly, Hydronephrosis, Right ventricular hypertrophy, Renal cyst, Splenomegal... OMIM:312870
Igg4-Related Submandibular Gland Disease
Abnormal salivary gland morphology, Prostatitis, Lymphadenopathy, Abnormal pancreas morphology, A... ORPHA:449432
Griscelli Syndrome
Lymphadenopathy, Hepatomegaly, Bone marrow hypocellularity, Splenomegaly ORPHA:381
Pancreatic calcification, Abnormality of the lymph nodes ORPHA:677
American Trypanosomiasis
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:3386
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:616100
Legionnaires Disease
Lymphadenopathy, Hematuria, Bone marrow hypocellularity, Splenomegaly, Proteinuria, Renal insuffi... ORPHA:549
Pediatric Systemic Lupus Erythematosus
Nephrotic syndrome, Lymphadenopathy, Abnormality of the urinary system, Hematuria, Nephritis, Dar... ORPHA:93552
Primary Myelofibrosis
Lymphadenopathy, Hepatomegaly, Hepatosplenomegaly, Splenomegaly ORPHA:824
Purine Nucleoside Phosphorylase Deficiency
Recurrent urinary tract infections, Lymph node hypoplasia, Splenomegaly OMIM:613179
Abnormal morphology of female internal genitalia, Lymphadenopathy, Hematuria, Abnormality of the ... ORPHA:538
Felty Syndrome
Hepatomegaly, Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Recurrent urinary tract... ORPHA:47612
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Diffuse Cutaneous Mastocytosis
Lymphadenopathy, Abnormality of the spleen, Hepatomegaly ORPHA:79456
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:169090
Cinca Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:1451
Histiocytosis-Lymphadenopathy Plus Syndrome
Hepatomegaly, Pancreatic hypoplasia, Azoospermia, Lymphadenopathy, Cardiomegaly, Splenomegaly, Mi... OMIM:602782
Familial Mediterranean Fever
Nephrotic syndrome, Nephrocalcinosis, Lymphadenopathy, Splenomegaly, Nephropathy, Orchitis, Prote... ORPHA:342
Mixed Connective Tissue Disease
Hepatomegaly, Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly, Nephropathy ORPHA:809
Lymphoproliferative Syndrome 1
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:613011
Drug Reaction With Eosinophilia And Systemic Symptoms
Renal insufficiency, Tubulointerstitial nephritis, Lymphadenopathy, Nephrotic syndrome ORPHA:139402
Niemann-Pick Disease, Type A
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:257200
Cyclic Neutropenia
Lymphadenopathy, Cervical lymphadenopathy, Recurrent tonsillitis ORPHA:2686
Gamma-Heavy Chain Disease
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:100026
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Adult-Onset Still Disease
Hepatomegaly, Generalized lymphadenopathy, Bone marrow hypocellularity, Splenomegaly ORPHA:829
Immunodeficiency With Hyper-Igm, Type 1
Hepatomegaly, Enlarged tonsils, Absence of lymph node germinal center, Splenomegaly OMIM:308230
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy, Glomerulonephritis OMIM:304790
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Abnormal renal physiology, Hepatomegaly, Splenomegaly ORPHA:540
Macrophage Activation Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:158061
Aggressive Systemic Mastocytosis
Lymphadenopathy, Hepatosplenomegaly, Hypersplenism ORPHA:98850
Hyper-Igd Syndrome
Lymphadenopathy, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Renal angiomyolipoma, Elevated ... OMIM:260920
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy, Hepatomegaly ORPHA:343
Familial Pancreatic Carcinoma
Lymphadenopathy, Hepatosplenomegaly, Ovarian carcinoma, Pancreatic adenocarcinoma ORPHA:1333
Acute Monoblastic/Monocytic Leukemia
Cervical lymphadenopathy, Oliguria ORPHA:514
Multiple Myeloma
Nephrotic syndrome, Lymphadenopathy, Splenomegaly, Acute kidney injury, Nephropathy, Abnormality ... ORPHA:29073
Mevalonic Aciduria
Fluctuating splenomegaly, Lymphadenopathy, Fluctuating hepatomegaly, Hepatosplenomegaly, Elevated... OMIM:610377
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphadenopathy, Hepatosplenomegaly ORPHA:169154
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Hepatosplenomegaly, Enlarged tonsils OMIM:606367
Poems Syndrome
Lymphadenopathy, Increased circulating prolactin concentration, Hypogonadism, Visceromegaly ORPHA:2905
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenopathy, Hepatomegaly, Lymphadenitis, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenopathy, Hepatomegaly, Lymphadenitis, Splenomegaly OMIM:233710
Immunodeficiency, Common Variable, 8, With Autoimmunity
Lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:614700
Kikuchi-Fujimoto Disease
Hepatomegaly, Lymphadenopathy, Abnormality of the lymph nodes, Splenomegaly, Generalized lymphade... ORPHA:50918
Proteasome-Associated Autoinflammatory Syndrome 3
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:617591
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatomegaly, Hepatosplenomegaly, Absence of lymph node germinal center, Urinary retention ORPHA:79124
Acute Promyelocytic Leukemia
Lymphadenopathy, Hematuria ORPHA:520
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenopathy, Hepatomegaly, Lymphadenitis, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenopathy, Hepatomegaly, Lymphadenitis, Splenomegaly OMIM:306400
Waldenström Macroglobulinemia
Lymphadenopathy, Hepatomegaly, Renal insufficiency, Splenomegaly ORPHA:33226
Carney Triad
Lymphadenopathy, Pheochromocytoma, Mediastinal lymphadenopathy ORPHA:139411
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:267700
Hemophagocytic Lymphohistiocytosis, Familial, 2
Lymphadenopathy, Hepatomegaly, Hepatosplenomegaly, Splenomegaly OMIM:603553
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Lymphadenitis, Generalized lymphadenopathy, Hepatosplenomegaly OMIM:618986
Multiple Endocrine Neoplasia Type 2
Pheochromocytoma, Elevated urinary epinephrine, Cervical neoplasm, Elevated urinary vanillylmande... ORPHA:653
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Abnormal sperm morphology, Abnormality of the spleen, Mediastinal lymphadenopathy, Abnormality of... ORPHA:228123
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Autoimmune Lymphoproliferative Syndrome
Hepatomegaly, Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hypersplenism, Chronic ... ORPHA:3261
Aregenerative Anemia
Lymphadenopathy, Bone marrow hypocellularity ORPHA:101096
Pulmonary Capillary Hemangiomatosis
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:199241
Q Fever
Hepatomegaly, Lymphadenopathy, Hematuria, Splenomegaly, Hepatosplenomegaly ORPHA:781
Chediak-Higashi Syndrome
Lymphadenopathy, Hepatomegaly, Splenomegaly OMIM:214500
Hennekam Syndrome
Pulmonary lymphangiectasia, Horseshoe kidney, Lymphadenopathy, Lymphangioma, Splenomegaly, Ectopi... ORPHA:2136
Thymic Aplasia
Lymphadenopathy, Recurrent urinary tract infections, Aplasia of the thymus ORPHA:83471
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy, Tubulointerstitial fibrosis OMIM:607944
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:98849
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Orchitis, Splenomegaly ORPHA:32960
Duodenal Neuroendocrine Tumor
Lymphadenopathy, Elevated circulating growth hormone concentration, Hydronephrosis, Insulinoma ORPHA:100076
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Igg4-Related Ophthalmic Disease
Abnormality of the anterior pituitary, Prostatitis, Lymphadenopathy, Sialadenitis, Orchitis, Abno... ORPHA:449563
Graft Versus Host Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:39812
Malt Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:52417
Igg4-Related Dacryoadenitis And Sialadenitis
Abnormal salivary gland morphology, Tubulointerstitial nephritis, Lymphadenopathy, Nodular goiter... ORPHA:79078
Ileal Neuroendocrine Tumor
Lymphadenopathy, Hydronephrosis ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy, Hydronephrosis ORPHA:100077
Hepatomegaly, Tubulointerstitial nephritis, Nephrocalcinosis, Lymphadenopathy, Abnormal reproduct... ORPHA:797
Farber Disease
Lymphadenopathy, Hepatosplenomegaly ORPHA:333
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Tubulointerstitial nephritis, Nephrotic syndrome, Lymphadenopathy, Membranous nephropathy, Spleno... ORPHA:37042
Hepatomegaly, Lymphadenopathy, Epididymitis, Splenomegaly, Intrarenal abscess, Hypersplenism, Orc... ORPHA:1304
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Hepatomegaly, Lymphadenopathy, Bone marrow hypocellularity, Splenomegaly, Hepatosplenomegaly, Ren... OMIM:615688
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Hepatomegaly, Lymphadenopathy, Splenomegaly, Accessory spleen, Polysplenia OMIM:619418
Tangier Disease
Left ventricular hypertrophy, Hepatosplenomegaly, Chronic noninfectious lymphadenopathy, Orange d... ORPHA:31150
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Behçet Disease
Lymphadenopathy, Splenomegaly, Glomerulopathy, Orchitis, Renal insufficiency ORPHA:117
Selective Igm Deficiency
Lymphadenopathy, Recurrent urinary tract infections, Lymphadenitis ORPHA:331235
Sarcoidosis, Susceptibility To, 1
Abnormal salivary gland morphology, Hepatomegaly, Mediastinal lymphadenopathy, Splenomegaly, Gene... OMIM:181000
X-Linked Lymphoproliferative Disease
Lymphadenopathy, Nephritis, Bone marrow hypocellularity, Splenomegaly, Hepatosplenomegaly, Cervic... ORPHA:2442
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Primary Sjögren Syndrome
Tubulointerstitial nephritis, Lymphadenopathy, Parotitis, Vaginal dryness, Glomerulonephritis, Re... ORPHA:289390
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Lymphadenopathy, Hepatosplenomegaly ORPHA:85408
Neuroendocrine Neoplasm Of Appendix
Hepatomegaly, Chronic noninfectious lymphadenopathy, Adrenocorticotropic hormone excess, Ovarian ... ORPHA:100079
Blau Syndrome
Abnormal salivary gland morphology, Lymphadenopathy, Clear cell renal cell carcinoma, Stage 5 chr... ORPHA:90340
Chédiak-Higashi Syndrome
Lymphadenopathy, Hepatosplenomegaly, Splenomegaly ORPHA:167
Crimean-Congo Hemorrhagic Fever
Hepatomegaly, Lymphadenopathy, Hematuria, Epididymitis, Splenomegaly, Parotitis, Orchitis, Protei... ORPHA:99827
Proteasome-Associated Autoinflammatory Syndrome 1
Hepatomegaly, Lymphadenopathy, Epididymitis, Cardiomegaly, Splenomegaly, Parotitis, Elevated circ... OMIM:256040
Marburg Hemorrhagic Fever
Lymphadenopathy, Orchitis, Renal insufficiency ORPHA:99826
Cushing Syndrome Due To Ectopic Acth Secretion
Adrenal hyperplasia, Increased urinary cortisol level, Neoplasm of the thymus, Pancreatic adenoca... ORPHA:99889
Autosomal Recessive Malignant Osteopetrosis
Lymphadenopathy, Hepatomegaly, Splenomegaly ORPHA:667
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
African Trypanosomiasis
Abnormal prolactin level, Hepatomegaly, Lymphadenopathy, Splenomegaly, Urinary incontinence, Hepa... ORPHA:3385
Lymphadenopathy, Hepatomegaly, Acute kidney injury, Cellular urinary casts ORPHA:509
Immunodeficiency 82 With Systemic Inflammation
Lymphadenopathy, Anoperineal fistula, Follicular hyperplasia, Splenomegaly OMIM:619381


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr155

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr155.

No publications found that use IMPC mice or data for Gpr155.

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MGI Allele Allele Type Produced
Gpr155em1(IMPC)Mbp Exon Deletion Mice, Tissue
Gpr155tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gpr155tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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