Gene Summary

G protein-coupled receptor 155
PGR22,  1110017O10Rik,  F730029F15Rik,  DEPDC3

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal kidney morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00
small seminal vesicle Gpr155em1(IMPC)Mbp HOM Early adult 0.00
abnormal seminal vesicle morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00
abnormal lymph node morphology Gpr155em1(IMPC)Mbp HOM Early adult 0.00
enlarged kidney Gpr155em1(IMPC)Mbp HOM Early adult 0.00
enlarged lymph nodes Gpr155em1(IMPC)Mbp HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

30 Images


XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Gpr155 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr155 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Polycystic Kidney Disease 5
Hyperechogenic kidneys, Hepatosplenomegaly, Stage 5 chronic kidney disease, Reduced renal cortico... OMIM:617610
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Immunodeficiency 38 With Basal Ganglia Calcification
Axillary lymphadenopathy, Inguinal lymphadenopathy, Lymphadenopathy OMIM:616126
Hepatorenocardiac Degenerative Fibrosis
Hyperechogenic kidneys, Hepatosplenomegaly, Reduced renal corticomedullary differentiation, Hyper... OMIM:619902
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Congenital Megacalycosis
Abnormal renal physiology, Recurrent urinary tract infections, Nephrolithiasis, Hydronephrosis, R... ORPHA:93109
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Neutropenia, Severe Congenital, 5, Autosomal Recessive
Hepatomegaly, Splenomegaly, Enlarged kidney OMIM:615285
Immunodeficiency, Common Variable, 6
Mesangial Immune complex deposition, Stage 5 chronic kidney disease, Hydronephrosis, Hepatomegaly... OMIM:613496
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Mantle Cell Lymphoma
Splenomegaly, Lymphadenopathy ORPHA:52416
Nephronophthisis 16
Nephronophthisis, Stage 5 chronic kidney disease, Renal insufficiency, Polycystic kidney dysplasi... OMIM:615382
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Goiter, Abnormal lymph node morphology, Papillary renal cell carcinoma, Chronic noninfectious lym... ORPHA:97290
Immunodeficiency 75 With Lymphoproliferation
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Enlarged polycystic ovaries, Enlarged kidney, Elevated circulating growth hormone concentration, ... ORPHA:90301
Kimura Disease
Abnormal salivary gland morphology, Follicular hyperplasia, Lymphadenopathy ORPHA:482
Nephronophthisis 3
Nephronophthisis, Stage 5 chronic kidney disease, Renal insufficiency, Proteinuria, Renal cortico... OMIM:604387
Renal Dysplasia
Chronic kidney disease, Thickened glomerular basement membrane, Multicystic kidney dysplasia, Ure... ORPHA:93108
Granulomatous Slack Skin
Acute kidney injury, Nephrocalcinosis, Abnormal lymph node morphology ORPHA:33111
Kerion Celsi
Lymphadenopathy ORPHA:499
Meckel Syndrome, Type 8
Ambiguous genitalia, Polycystic kidney dysplasia, Enlarged kidney, Hyperechogenic kidneys OMIM:613885
Denys-Drash Syndrome
Nephropathy, Focal segmental glomerulosclerosis, Ovarian gonadoblastoma, Uterus didelphys, Gonada... OMIM:194080
Aa Amyloidosis
Nephropathy, Chronic kidney disease, Acute kidney injury, Renal amyloidosis, Proteinuria, Abnorma... ORPHA:85445
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Multiple small medullary renal cysts, Hyperechogenic kidneys, Renal insufficiency, Splenomegaly, ... OMIM:263200
Nephronophthisis 2
Nephronophthisis, Hyperechogenic kidneys, Stage 5 chronic kidney disease, Absence of renal cortic... OMIM:602088
Familial Papillary Or Follicular Thyroid Carcinoma
Abnormal lymph node morphology, Goiter, Papillary renal cell carcinoma, Chronic noninfectious lym... ORPHA:319487
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Immunodeficiency With Hyper-Igm, Type 5
Epididymitis, Lymphadenopathy OMIM:608106
Immunodeficiency 104
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:608971
Autosomal Dominant Polycystic Kidney Disease
Chronic kidney disease, Abnormal urinary electrolyte concentration, Recurrent urinary tract infec... ORPHA:730
Multicystic Dysplastic Kidney
Unilateral renal agenesis, Multicystic kidney dysplasia, Ureterocele, Horseshoe kidney, Vesicoure... ORPHA:1851
Autoinflammation With Episodic Fever And Lymphadenopathy
Hepatomegaly, Recurrent tonsillitis, Splenomegaly, Lymphadenopathy OMIM:618852
Mu-Heavy Chain Disease
Nephropathy, Bence Jones Proteinuria, Splenomegaly, Lymphadenopathy, Hepatomegaly ORPHA:100024
Mast Cell Sarcoma
Hepatomegaly, Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy ORPHA:66661
Hemihyperplasia-Multiple Lipomatosis Syndrome
Nephroblastoma, Abnormality of the lymphatic system, Ovarian serous cystadenoma, Hydrocele testis... ORPHA:276280
Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor
Enlarged kidney, Nephroblastoma OMIM:618272
Renal-Hepatic-Pancreatic Dysplasia 1
Renal dysplasia, Polysplenia, Stage 5 chronic kidney disease, Renal insufficiency, Splenomegaly, ... OMIM:208540
Kaposiform Lymphangiomatosis
Hepatosplenomegaly, Splenomegaly, Lymphangioma, Abnormality of the lymphatic system, Abnormal lym... ORPHA:464329
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:86893
Burkitt Lymphoma
Abnormality of the ovary, Abnormality of the spleen, Abnormal lymph node morphology ORPHA:543
Hereditary Amyloidosis With Primary Renal Involvement
Nephropathy, Abnormal urinary electrolyte concentration, Abnormal lymph node morphology, Hypogona... ORPHA:85450
Renal-Hepatic-Pancreatic Dysplasia 2
Hepatomegaly, Asplenia, Enlarged kidney, Cystic renal dysplasia OMIM:615415
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormal lymph node morphology, Abnormality of the lymphatic system, Abnormality of the kidney, A... ORPHA:54251
H Syndrome
Hypogonadism, Decreased testicular size, Azoospermia, Hepatosplenomegaly, Lymphadenopathy, Abnorm... ORPHA:168569
Congenital Anomalies Of Kidney And Urinary Tract 3
Renal hypoplasia, Multicystic kidney dysplasia, Vesicoureteral reflux, Hydronephrosis, Ectopic ki... OMIM:618270
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Splenomegaly, Lymphadenopathy ORPHA:444463
Follicular Lymphoma
Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy ORPHA:545
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Autoimmune Lymphoproliferative Syndrome, Type Iii
Recurrent urinary tract infections, Hepatosplenomegaly, Stage 5 chronic kidney disease, Splenomeg... OMIM:615559
Igg4-Related Kidney Disease
Chronic kidney disease, Lymphadenitis, Urethritis, Hematuria, Prostatitis, Abnormality of the ant... ORPHA:449395
Mucopolysaccharidosis-Plus Syndrome
Focal segmental glomerulosclerosis, Nephritis, Bone marrow hypocellularity, Splenomegaly, Protein... OMIM:617303
Immunodeficiency 32A
Lymphadenitis, Lymphadenopathy OMIM:614893
Alpha-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:100025
Glycogen Storage Disease Ib
Focal segmental glomerulosclerosis, Decreased glomerular filtration rate, Splenomegaly, Nephrolit... OMIM:232220
Acrocephalopolydactylous Dysplasia
Polysplenia, Pancreatic fibrosis, Hepatomegaly, Enlarged kidney, Cystic renal dysplasia OMIM:200995
Laryngeal Neuroendocrine Tumor
Adrenocorticotropic hormone excess, Chronic noninfectious lymphadenopathy ORPHA:100083
Lymphatic Filariasis
Urethral obstruction, Lymphadenitis, Abnormal scrotum morphology, Orchitis, Hematuria, Proteinuri... ORPHA:2035
Beckwith-Wiedemann Syndrome
Nephrocalcinosis, Pancreatic hyperplasia, Overgrowth of external genitalia, Renal cortical cysts,... OMIM:130650
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Genital ulcers, Lymph node hypoplasia, Splenomegaly, Aplasia of the thymus, Generalized lymphaden... OMIM:602450
Desmoplastic Small Round Cell Tumor
Lymphadenopathy, Testicular neoplasm, Hepatomegaly, Ovarian neoplasm, Mediastinal lymphadenopathy... ORPHA:83469
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant
Splenomegaly, Lymphadenopathy OMIM:615513
Hyperparathyroidism, Transient Neonatal
Hyperparathyroidism, Unilateral renal agenesis, Splenic cyst, Ovarian cyst, Enlarged kidney OMIM:618188
Nephroblastomatosis, Horseshoe kidney, Nephrogenic rest, Enlarged kidney, Cystic renal dysplasia OMIM:608022
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Lymphoid Interstitial Pneumonia
Hepatomegaly, Mediastinal lymphadenopathy, Enlarged kidney ORPHA:79128
Pfapa Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:42642
Immunodeficiency 76
Splenomegaly, Lymphadenopathy OMIM:619164
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Renal dysplasia, Renal insufficiency, Hydronephrosis, Cardiomegaly, Long-chain dicarboxylic acidu... OMIM:608836
Small scrotum, Microphallus, Hyperechogenic kidneys, Cryptorchidism, Ambiguous genitalia, Hypospa... OMIM:612651
Fish-Eye Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:79292
Hemophagocytic Lymphohistiocytosis, Familial, 4
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:603552
Meacham Syndrome
Accessory spleen, Horseshoe kidney, Septate vagina, Male pseudohermaphroditism, Blind vagina, Bic... OMIM:608978
Vacterl Association, X-Linked, With Or Without Hydrocephalus
Hydronephrosis, Urethral atresia, Enlarged kidney OMIM:314390
Cold Agglutinin Disease
Hepatomegaly, Lymphadenopathy, Splenomegaly, Abnormal urinary color ORPHA:56425
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Immunodeficiency, Common Variable, 2
Hepatomegaly, Splenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:240500
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy OMIM:300853
Thymic Neuroendocrine Tumor
Calcium nephrolithiasis, Pituitary adenoma, Pituitary prolactin cell adenoma, Increased circulati... ORPHA:97289
Paternal Uniparental Disomy Of Chromosome 1
Proteinuria, Membranoproliferative glomerulonephritis, Enlarged kidney, Macroscopic hematuria ORPHA:251004
Immunodeficiency 54
Adrenocorticotropic hormone excess, Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:609981
Heme Oxygenase 1 Deficiency
Nephritis, Cervical lymphadenopathy, Hematuria, Proteinuria, Lymphadenopathy, Hepatomegaly, Asplenia OMIM:614034
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly
Renal dysplasia, Ambiguous genitalia, Micropenis, Polycystic kidney dysplasia, Enlarged kidney OMIM:613091
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Hepatomegaly, Splenomegaly, Glomerulonephritis, Lymphadenopathy OMIM:619375
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Pleural Mesothelioma
Hepatomegaly, Lymphadenopathy ORPHA:50251
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Immunodeficiency 64 With Lymphoproliferation
Cervical lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Mediastinal lymphade... OMIM:618534
Hematuria, Lymphadenopathy, Nephroblastoma ORPHA:654
Tyrosinemia, Type I
Nephrocalcinosis, Elevated urinary succinylacetone level, Renal insufficiency, Splenomegaly, Rena... OMIM:276700
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:613101
Leukocyte Adhesion Deficiency, Type Iii
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Abnormal lymph node morphology OMIM:612840
Cardiac-Urogenital Syndrome
Accessory spleen, Bifid scrotum, Cryptorchidism, Aplasia of the uterus, Penoscrotal hypospadias, ... OMIM:618280
Glycogen Storage Disease Ia
Focal segmental glomerulosclerosis, Decreased glomerular filtration rate, Nephrolithiasis, Protei... OMIM:232200
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Hepatomegaly, Lymphadenopathy, Splenomegaly, Recurrent urinary tract infections OMIM:618495
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Follicular hyperplasia, Lymphadenopathy OMIM:619846
Classic Mycosis Fungoides
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:2584
Immunodeficiency 27A
Enlarged mesenteric lymph node, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:209950
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Congenital Toxoplasmosis
Hepatomegaly, Cardiomegaly, Lymphadenopathy ORPHA:858
Caspase 8 Deficiency
Splenomegaly, Lymphadenopathy OMIM:607271
Classic Hodgkin Lymphoma
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:391
Schnitzler Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:37748
Autosomal Recessive Polycystic Kidney Disease
Acute kidney injury, Oliguria, Recurrent urinary tract infections, Hepatosplenomegaly, Reduced re... ORPHA:731
Activated Pi3K-Delta Syndrome
Hepatomegaly, Recurrent tonsillitis, Splenomegaly, Lymphadenopathy ORPHA:397596
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Bone marrow hypocellularity, Heparan sulfate excretion in urine, Hepatosplenomegaly, Urinary glyc... ORPHA:505248
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Immunodeficiency 109 With Lymphoproliferation
Generalized lymphadenopathy, Splenomegaly OMIM:620282
Indolent Systemic Mastocytosis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:98848
Beckwith-Wiedemann Syndrome
Nephropathy, Visceromegaly, Abnormal pancreas morphology, Vesicoureteral reflux, Cryptorchidism, ... ORPHA:116
Familial Cold Autoinflammatory Syndrome 2
Splenomegaly, Lymphadenopathy OMIM:611762
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Immunodeficiency 52
Splenomegaly, Lymphadenopathy OMIM:617514
Rhabdoid Tumor
Hematuria, Renal neoplasm, Lymphadenopathy ORPHA:69077
Immunodeficiency 91 And Hyperinflammation
Hepatosplenomegaly, Renal insufficiency, Lymphadenopathy, Membranoproliferative glomerulonephriti... OMIM:619644
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Lymphadenopathy ORPHA:2221
Immunodeficiency 103, Susceptibility To Fungal Infections
Lymphadenopathy OMIM:212050
Hypoplasia of the bladder, Abnormal renal artery morphology, Hydronephrosis, Hypoplastic nipples,... ORPHA:79328
Immunodeficiency 105
Hepatosplenomegaly, Absence of lymph node germinal center OMIM:619924
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Immunodeficiency, Common Variable, 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:607594
Immunodeficiency 7
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:615387
Ras-Associated Autoimmune Leukoproliferative Disorder
Hepatomegaly, Splenomegaly, Follicular hyperplasia OMIM:614470
Autoimmune Lymphoproliferative Syndrome, Type Iia
Nephritis, Chronic noninfectious lymphadenopathy, Splenomegaly, Follicular hyperplasia, Lymphaden... OMIM:603909
Thyroid Lymphoma
Lymphadenopathy, Goiter ORPHA:97285
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Nephrocalcinosis, Stage 5 chronic kidney disease, Nephrolithiasis, Proteinuria, Polycystic ovarie... ORPHA:79259
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Immune Dysregulation, Autoimmunity, And Autoinflammation
Cervical lymphadenopathy, Inguinal lymphadenopathy OMIM:620514
Mucolipidosis Ii Alpha/Beta
Splenomegaly, Cardiomegaly, Mucopolysacchariduria, Hepatomegaly, Enlarged kidney OMIM:252500
Lig4 Syndrome
Hepatomegaly, Hypoplasia of penis, Cryptorchidism, Lymphadenopathy ORPHA:99812
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Splenomegaly, Lymphadenopathy OMIM:150550
Roifman Syndrome
Hypogonadotropic hypogonadism, Hepatosplenomegaly, Lymphadenopathy ORPHA:353298
Boutonneuse Fever
Cervical lymphadenopathy, Renal insufficiency, Lymphadenopathy ORPHA:83313
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Cervical lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy... ORPHA:3392
Lymphoproliferative Syndrome 2
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:615122
Papa Syndrome
Proteinuria, Lymphadenopathy ORPHA:69126
Medullary Thyroid Carcinoma
Nodular goiter, Pheochromocytoma, Lymphadenopathy, Primary hyperparathyroidism ORPHA:1332
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Abnormal lymph node morphology, Hepatosplenomegaly, Lymphadenopathy, Nephrotic syn... ORPHA:911
Nephrocalcinosis, Long penis, Clitoral hypertrophy, Overgrowth of external genitalia, Labial hype... ORPHA:508
Griscelli Syndrome Type 2
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:79477
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Lymphadenitis, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Nephroti... OMIM:618935
Castleman Disease
Ureteral obstruction, Renal insufficiency, Follicular hyperplasia, Hematuria, Generalized lymphad... ORPHA:160
Systemic-Onset Juvenile Idiopathic Arthritis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:85414
Heterotaxy, Visceral, 1, X-Linked
Renal agenesis, Polysplenia, Horseshoe kidney, Cardiomegaly, Hepatomegaly, Asplenia, Enlarged kidney OMIM:306955
Anaplastic Thyroid Carcinoma
Nodular goiter, Lymphadenopathy, Goiter ORPHA:142
Scrub Typhus
Renal insufficiency, Splenomegaly, Lymphadenopathy ORPHA:83317
Roifman Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:616651
Hypocomplementemic Urticarial Vasculitis
Renal insufficiency, Splenomegaly, Hematuria, Proteinuria, Glomerulopathy, Lymphadenopathy, Hepat... ORPHA:36412
Purine Nucleoside Phosphorylase Deficiency
Decreased urinary urate, Recurrent urinary tract infections, Elevated urinary inosine level, Lymp... OMIM:613179
Helsmoortel-Van Der Aa Syndrome
Enuresis nocturna, Recurrent urinary tract infections, Decreased response to growth hormone stimu... OMIM:615873
Ogden Syndrome
Decreased testicular size, Cryptorchidism, Cardiomegaly, Global glomerulosclerosis, Hydrocele tes... OMIM:300855
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:507
Deafness-Lymphedema-Leukemia Syndrome
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:3226
Urinary bladder inflammation, Urinary hesitancy, Prostate neoplasm, Follicular hyperplasia, Orchi... ORPHA:556
Pancreatic calcification, Abnormal lymph node morphology ORPHA:677
Proteasome-Associated Autoinflammatory Syndrome 4
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:619183
Immunodeficiency 10
Recurrent urinary tract infections, Splenomegaly, Lymphadenopathy, Hepatomegaly, Nephrotic syndrome OMIM:612783
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Autoimmune Lymphoproliferative Syndrome
Hepatomegaly, Chronic noninfectious lymphadenopathy, Splenomegaly, Follicular hyperplasia OMIM:601859
Tafro Syndrome
Hepatosplenomegaly, Renal insufficiency, Splenomegaly, Lymphadenopathy, Hepatomegaly ORPHA:457077
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Sézary Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:3162
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Hepatomegaly, Absent tonsils, Lymph node hypoplasia ORPHA:276
Omenn Syndrome
Hepatomegaly, Nephrotic syndrome, Splenomegaly, Lymphadenopathy ORPHA:39041
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Melkersson-Rosenthal Syndrome
Oligosacchariduria, Lymphadenopathy ORPHA:2483
Klatskin Tumor
Hepatomegaly, Lymphadenopathy ORPHA:99978
Tall Stature-Intellectual Disability-Renal Anomalies Syndrome
Multicystic kidney dysplasia, Bifid ureter, Nephroblastoma, Renal malrotation, Enlarged kidney ORPHA:500095
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Hepatosplenomegaly, Lymphadenopathy OMIM:619750
Igg4-Related Submandibular Gland Disease
Enlarged lacrimal glands, Abnormal pancreas morphology, Abnormality of the submandibular glands, ... ORPHA:449432
Niemann-Pick Disease, Type A
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:257200
Griscelli Syndrome
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:381
Proteus Syndrome
Long penis, Thymus hyperplasia, Neoplasm of the thymus, Splenomegaly, Lymphangioma, Enlarged poly... ORPHA:744
Glycogen Storage Disease Of Heart, Lethal Congenital
Cardiomegaly, Enlarged kidney OMIM:261740
Omenn Syndrome
Hepatomegaly, Hypoplasia of the thymus, Splenomegaly, Lymphadenopathy OMIM:603554
Primary Myelofibrosis
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy ORPHA:824
Lymphoproliferative Syndrome, X-Linked, 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:308240
American Trypanosomiasis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:3386
Abnormal morphology of female internal genitalia, Abnormal urinary color, Pulmonary lymphangiomyo... ORPHA:538
Legionnaires Disease
Bone marrow hypocellularity, Renal insufficiency, Splenomegaly, Hematuria, Proteinuria, Lymphaden... ORPHA:549
Simpson-Golabi-Behmel Syndrome, Type 1
Duplication of renal pelvis, Polysplenia, Supernumerary nipple, Cryptorchidism, Nephroblastoma, R... OMIM:312870
Pediatric Systemic Lupus Erythematosus
Nephritis, Abnormality of the urinary system, Dark urine, Renal insufficiency, Hematuria, Protein... ORPHA:93552
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:616100
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Diffuse Cutaneous Mastocytosis
Hepatomegaly, Abnormality of the spleen, Lymphadenopathy ORPHA:79456
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Hypopituitarism, Absent peripheral lymph nodes in presence of infection ORPHA:98813
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Drug Reaction With Eosinophilia And Systemic Symptoms
Tubulointerstitial nephritis, Nephrotic syndrome, Renal insufficiency, Lymphadenopathy ORPHA:139402
Immunodeficiency 98 With Autoinflammation, X-Linked
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy OMIM:301078
Immunodeficiency 97 With Autoinflammation
Recurrent urinary tract infections, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Mediastina... OMIM:619802
Gamma-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:100026
Felty Syndrome
Bone marrow hypocellularity, Recurrent urinary tract infections, Splenomegaly, Lymphadenopathy, H... ORPHA:47612
Adult-Onset Still Disease
Bone marrow hypocellularity, Splenomegaly, Proteinuria, Generalized lymphadenopathy, Lymphadenopa... ORPHA:829
Lymphoproliferative Syndrome 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:613011
Agammaglobulinemia, X-Linked
Prostatitis, Lymph node hypoplasia, Epididymitis, Recurrent urinary tract infections OMIM:300755
Histiocytosis-Lymphadenopathy Plus Syndrome
Pancreatic hypoplasia, Decreased response to growth hormone stimulation test, Cervical lymphadeno... OMIM:602782
Combined Immunodeficiency Due To Crac Channel Dysfunction
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:169090
Cinca Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:1451
Mixed Connective Tissue Disease
Nephropathy, Splenomegaly, Lymphadenopathy, Hepatomegaly, Mediastinal lymphadenopathy ORPHA:809
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Cyclic Neutropenia
Cervical lymphadenopathy, Recurrent tonsillitis, Lymphadenopathy ORPHA:2686
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Glomerulonephritis, Lymphadenopathy OMIM:304790
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Lymphadenopathy, Hypersplenism ORPHA:98850
Familial Hemophagocytic Lymphohistiocytosis
Hepatomegaly, Lymphadenopathy, Splenomegaly, Abnormal renal physiology ORPHA:540
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenitis, Vesicoureteral reflux, Splenomegaly, Lymphadenopathy, Hepatomegaly OMIM:615895
Hyperimmunoglobulinemia D With Periodic Fever
Hepatomegaly, Lymphadenopathy ORPHA:343
Acute Monoblastic/Monocytic Leukemia
Cervical lymphadenopathy, Oliguria ORPHA:514
Hyper-Igd Syndrome
Lymphadenitis, Hepatosplenomegaly, Splenomegaly, Elevated urine mevalonic acid level, Renal angio... OMIM:260920
Multiple Myeloma
Nephropathy, Acute kidney injury, Splenomegaly, Lymphadenopathy, Nephrotic syndrome, Abnormality ... ORPHA:29073
Mevalonic Aciduria
Fluctuating splenomegaly, Hepatosplenomegaly, Elevated urine mevalonic acid level, Fluctuating he... OMIM:610377
Poems Syndrome
Visceromegaly, Increased circulating prolactin concentration, Hypogonadism, Splenomegaly, Lymphad... ORPHA:2905
Macrophage Activation Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:158061
Familial Mediterranean Fever
Nephropathy, Nephrocalcinosis, Splenomegaly, Orchitis, Proteinuria, Lymphadenopathy, Nephrotic sy... ORPHA:342
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:436159
Familial Pancreatic Carcinoma
Pancreatic adenocarcinoma, Hepatosplenomegaly, Lymphadenopathy, Ovarian carcinoma ORPHA:1333
Immunodeficiency With Hyper-Igm, Type 1
Hepatomegaly, Enlarged tonsils, Absence of lymph node germinal center, Splenomegaly OMIM:308230
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Enlarged tonsils, Hepatosplenomegaly, Lymphadenopathy OMIM:606367
Acute Promyelocytic Leukemia
Hematuria, Lymphadenopathy ORPHA:520
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Hepatomegaly, Lymphadenitis, Splenomegaly, Lymphadenopathy OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Hepatomegaly, Lymphadenitis, Splenomegaly, Lymphadenopathy OMIM:233710
Immunodeficiency, Common Variable, 8, With Autoimmunity
Generalized lymphadenopathy, Splenomegaly, Lymphadenopathy OMIM:614700
Kikuchi-Fujimoto Disease
Abnormal lymph node morphology, Cervical lymphadenopathy, Enlargement of parotid gland, Splenomeg... ORPHA:50918
Hemophagocytic Lymphohistiocytosis, Familial, 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:267700
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:603553
Waldenström Macroglobulinemia
Hepatomegaly, Renal insufficiency, Splenomegaly, Lymphadenopathy ORPHA:33226
Proteasome-Associated Autoinflammatory Syndrome 3
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:617591
Acute Generalized Exanthematous Pustulosis
Renal insufficiency, Lymphadenopathy ORPHA:293173
Elevated urinary homovanillic acid, Lymphadenopathy, Elevated urinary vanillylmandelic acid, Elev... ORPHA:635
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Hepatomegaly, Lymphadenitis, Splenomegaly, Lymphadenopathy OMIM:233690
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatomegaly, Hepatosplenomegaly, Absence of lymph node germinal center, Urinary retention ORPHA:79124
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Hepatosplenomegaly, Generalized lymphadenopathy, Lymphadenitis OMIM:618986
Carney Triad
Pheochromocytoma, Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Bronchial Neuroendocrine Tumor
Hepatomegaly, Chronic noninfectious lymphadenopathy, Elevated circulating growth hormone concentr... ORPHA:97287
Abnormality of the male genitalia, Abnormality of the spleen, Renal insufficiency, Abnormality of... ORPHA:228123
Neuroendocrine Tumor Of The Colon
Hepatomegaly, Chronic noninfectious lymphadenopathy ORPHA:100080
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Hennekam Syndrome
Horseshoe kidney, Splenomegaly, Lymphadenopathy, Pulmonary lymphangiectasia, Lymphangioma, Ectopi... ORPHA:2136
Multiple Endocrine Neoplasia Type 2
Thyroid C cell hyperplasia, Elevated urinary norepinephrine level, Cervical lymphadenopathy, Pheo... ORPHA:653
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Joint Contractures, Osteochondromas, And B-Cell Lymphoma
Generalized lymphadenopathy OMIM:620232
T-Cell Immunodeficiency With Thymic Aplasia
Aplasia of the thymus, Lymphadenopathy, Recurrent urinary tract infections ORPHA:83471
Aregenerative Anemia
Bone marrow hypocellularity, Lymphadenopathy ORPHA:101096
Q Fever
Hepatosplenomegaly, Splenomegaly, Hematuria, Lymphadenopathy, Hepatomegaly ORPHA:781
Graft Versus Host Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:39812
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Splenomegaly, Membranous nephropathy, Lymphadenopathy, Tubulointerstitial nephritis, Nephrotic sy... ORPHA:37042
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Chediak-Higashi Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:214500
Nephrocalcinosis, Parotitis, Abnormal lymph node morphology, Renal insufficiency, Enlargement of ... ORPHA:797
Farber Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:333
Congenital Syphilis
Nephrotic syndrome, Hepatosplenomegaly, Lymphadenopathy ORPHA:499009
Igg4-Related Dacryoadenitis And Sialadenitis
Abnormal salivary gland morphology, Abnormality of the submandibular glands, Enlargement of parot... ORPHA:79078
Spondyloenchondrodysplasia With Immune Dysregulation
Tubulointerstitial fibrosis, Lymphadenopathy OMIM:607944
Systemic Mastocytosis With Associated Hematologic Neoplasm
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:98849
Granulomatous Disease, Chronic, X-Linked
Hepatomegaly, Lymphadenitis, Splenomegaly, Lymphadenopathy OMIM:306400
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Lymphadenopathy, Splenomegaly, Orchitis ORPHA:32960
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Accessory spleen, Polysplenia, Splenomegaly, Lymphadenopathy, Hepatomegaly OMIM:619418
Igg4-Related Ophthalmic Disease
Sialadenitis, Orchitis, Prostatitis, Abnormality of the anterior pituitary, Lymphadenopathy, Abno... ORPHA:449563
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Bone marrow hypocellularity, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Hepatomegaly, Ren... OMIM:615688
Autoimmune Lymphoproliferative Syndrome
Bone marrow hypocellularity, Hypersplenism, Renal insufficiency, Splenomegaly, Chronic noninfecti... ORPHA:3261
Intrarenal abscess, Hypersplenism, Splenomegaly, Orchitis, Glomerulonephritis, Lymphadenopathy, H... ORPHA:1304
Ileal Neuroendocrine Tumor
Hydronephrosis, Lymphadenopathy ORPHA:100078
Common Variable Immunodeficiency
Splenomegaly, Lymphadenopathy ORPHA:1572
Tangier Disease
Hepatosplenomegaly, Orange discolored tonsils, Chronic noninfectious lymphadenopathy, Left ventri... ORPHA:31150
Sarcoidosis, Susceptibility To, 1
Abnormal salivary gland morphology, Splenomegaly, Hypercalciuria, Generalized lymphadenopathy, He... OMIM:181000
Immunodeficiency 31C
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:614162
Behçet Disease
Renal insufficiency, Splenomegaly, Orchitis, Glomerulopathy, Lymphadenopathy ORPHA:117
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy, Recurrent urinary tract infections ORPHA:331235
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Cervical lymphadenopathy, Lymphadenopathy OMIM:617718
Neuroendocrine Neoplasm Of Appendix
Adrenocorticotropic hormone excess, Hepatomegaly, Ovarian neoplasm, Chronic noninfectious lymphad... ORPHA:100079
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Primary Sjögren Syndrome
Parotitis, Renal insufficiency, Glomerulonephritis, Abnormality of the kidney, Lymphadenopathy, T... ORPHA:289390
Blau Syndrome
Nephropathy, Stage 5 chronic kidney disease, Clear cell renal cell carcinoma, Splenomegaly, Lymph... ORPHA:90340
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Hepatosplenomegaly, Lymphadenopathy ORPHA:85408
Systemic Lupus Erythematosus
Hematuria, Proteinuria, Lupus nephritis, Lymphadenopathy, Pyuria ORPHA:536
Chédiak-Higashi Syndrome
Hepatosplenomegaly, Splenomegaly, Lymphadenopathy ORPHA:167
Crimean-Congo Hemorrhagic Fever
Parotitis, Splenomegaly, Orchitis, Hematuria, Proteinuria, Lymphadenopathy, Hepatomegaly, Epididy... ORPHA:99827
Proteasome-Associated Autoinflammatory Syndrome 1
Parotitis, Splenomegaly, Cardiomegaly, Lymphadenopathy, Hepatomegaly, Epididymitis OMIM:256040
Cushing Syndrome Due To Ectopic Acth Secretion
Abnormal lymph node morphology, Increased urinary cortisol level, Pancreatic adenocarcinoma, Pheo... ORPHA:99889
Autosomal Recessive Malignant Osteopetrosis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:667
Marburg Hemorrhagic Fever
Renal insufficiency, Lymphadenopathy, Orchitis ORPHA:99826
Immunodeficiency 82 With Systemic Inflammation
Anoperineal fistula, Splenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619381
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Cervical lymphadenopathy, Lymphadenopathy ORPHA:324625
Hepatomegaly, Acute kidney injury, Cellular urinary casts, Lymphadenopathy ORPHA:509
African Trypanosomiasis
Hepatosplenomegaly, Renal insufficiency, Splenomegaly, Hepatomegaly, Lymphadenopathy, Abnormal pr... ORPHA:3385


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr155

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr155.

No publications found that use IMPC mice or data for Gpr155.

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MGI Allele Allele Type Produced
Gpr155em1(IMPC)Mbp Exon Deletion Mice, Tissue
Gpr155tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gpr155tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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