Genes Phenotypes

Gene: Cdh23

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Name
cadherin 23 (otocadherin)
MGI ID
MGI:1890219
Synonyms
sals bob 4930542A03Rik nmf252 nmf181 nmf112 ahl USH1D mdfw
Viability
Homozygous - Subviable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (37) Measurements chart (527) All data table (648)
Expression & images (0) Disease models (0) Order (7)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
trunk curl Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.37×10-19
increased CD8-positive, alpha-beta T cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
increased circulating sodium level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.97×10-08
decreased B cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
increased bone mineral content Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.31×10-08
absent pinna reflex Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.97×10-18
preweaning lethality, incomplete penetrance Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
decreased circulating LDL cholesterol level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 3.67×10-05
increased NK cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
decreased leukocyte cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 8.11×10-09
increased circulating LDL cholesterol level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 3.67×10-05
decreased bone mineral content Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 5.72×10-05
decreased circulating triglyceride level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 6.05×10-05
decreased total body fat amount Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.21×10-10
increased lean body mass Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.95×10-08
increased alpha-beta T cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 7.00×10-07
impaired righting response Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 4.20×10-14
decreased eosinophil cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
decreased fasting circulating glucose level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 3.82×10-16
decreased mature B cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 0.00
decreased Ly6C low monocyte number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 5.00×10-07
increased circulating chloride level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 2.53×10-18
decreased monocyte cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.53×10-05
decreased Ly6C high monocyte number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.53×10-05
decreased circulating glucose level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.20×10-07
decreased circulating potassium level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 6.83×10-05
increased mean corpuscular hemoglobin Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 7.71×10-06
decreased lean body mass Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 4.45×10-06
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.35×10-05
stereotypic behavior Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.64×10-20
increased T cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 6.00×10-07
decreased circulating insulin level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 2.94×10-06
abnormal gait Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.77×10-14
decreased body length Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 2.10×10-05
abnormal bone structure Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 3.99×10-09
increased CD4-positive, alpha beta T cell number Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 1.53×10-05
decreased circulating calcium level Cdh23tm2b(EUCOMM)Wtsi HOM Early adult 4.96×10-05

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 Expression

Expression data not available

 Associated Images

DSS Histology
8 Images
Legacy Phenotype Associated Images
Cdh23v
body, HET, Female, WTSI
Cdh23v
HET, Female, WTSI
Cdh23v
HET, Female, WTSI
Cdh23v
body, HOM, Female, WTSI
Cdh23v
body, HET, Female, WTSI

View all 181 images

Cdh23v
eye, cataracts, HOM, Male, WTSI
Cdh23v
eye, cataracts, HET, Female, WTSI
Cdh23v
eye, cataracts, HET, Female, WTSI

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Cdh23em3(IMPC)H Point Mutation Mice
Cdh23tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdh23tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdh23em1H Point Mutation Mice
Cdh23em2H Point Mutation Mice
Cdh23tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cdh23tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells