Synrg | synergin, gamma

GeneMGI:1354742Synonyms: L71-5, Ap1gbp1

Physiological systems

18 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Mortality/aging Cardiovascular system

16 No significant impact

6 Not tested

Gene metrics:2Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsSynrgtm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased heart rate1 supporting datasetSynrgtm1b(EUCOMM)WtsiheterozygoteEarly adult5.79x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteWholemount images
100% (2/2)0.7% (4/570)
aortaheterozygoteWholemount images
100% (2/2)0.19% (1/533)
boneheterozygoteWholemount images
100% (2/2)0% (0/394)
brainheterozygoteWholemount images
100% (2/2)0.86% (5/579)
brainstemheterozygoteWholemount images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteWholemount images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteWholemount images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteWholemount images
100% (2/2)0.41% (2/491)
esophagusheterozygoteWholemount images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Synrgtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Synrgtm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Synrgtm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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