Casr | calcium-sensing receptor

GeneMGI:1351351Synonyms: cation sensing receptor, Gprc2a, +1 more

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Nervous system Mortality/aging

16 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
8Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating calcium level1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteEarly adult4.42x10-5 
preweaning lethality, complete penetrance1 supporting datasetCasrtm1b(KOMP)MbphomozygoteEarly adultN/A * 
small superior vagus ganglion1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteEarly adultN/A * 
increased circulating phosphate level1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteEarly adult3.26x10-5 
edema1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteE15.5N/A * 
enlarged uterus1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteEarly adultN/A * 
abnormal pancreas morphology1 supporting datasetCasrtm1b(KOMP)MbpheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Casrtm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Casrtm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Casrtm1b(KOMP)MbpReporter-tagged deletion allele (with selection cassette)mouse

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