Mapkbp1 | mitogen-activated protein kinase binding protein 1

GeneMGI:1347004Synonyms: Jnkbp1, 2810483F24Rik

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Cardiovascular system Renal/urinary system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

3Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Phy. System:



increased circulating phosphate level	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.34x10^-5
increased blood urea nitrogen level	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.24x10^-7
increased spleen weight	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.77x10^-10
increased kidney weight	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.64x10^-5
impaired glucose tolerance	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.08x10^-5
increased heart weight	1 supporting dataset	Mapkbp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.7x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mapkbp1.

Associated images

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Histopathology

There is no histopathology data found for Mapkbp1.

IMPC related publications

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External links

No external links available for Mapkbp1.

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*Mapkbp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Mapkbp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mapkbp1^{tm1c(EUCOMM)Hmgu}*	Wild type floxed exon (post-Flp)	‌	mouse
*Mapkbp1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell
*Mapkbp1^{tm28155(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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