Gene Summary

Name:
poly (ADP-ribose) polymerase family, member 1
Synonyms:
PARP,  Adprp,  5830444G22Rik,  parp-1,  sPARP-1,  Adprt1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased NK cell number Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 1.63×10-07
preweaning lethality, incomplete penetrance Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
decreased total retina thickness Parp1tm1b(EUCOMM)Hmgu HOM Early adult 1.39×10-07
increased prepulse inhibition Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 7.75×10-06
abnormal retinal inner nuclear layer morphology Parp1tm1b(EUCOMM)Hmgu HOM Early adult 1.16×10-05
immune system phenotype Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 3.45×10-05
decreased grip strength Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 2.30×10-05
increased effector memory CD8-positive, alpha-beta T cell number Parp1tm1b(EUCOMM)Hmgu HOM   Early adult 2.08×10-06

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

12 Images

X-ray

XRay Images Whole Body Dorso Ventral

12 Images

Immunophenotyping

Panel B FCS file(s)

6 Images

Immunophenotyping

Panel A FCS file(s)

6 Images

Human diseases caused by Parp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Parp1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Renal Failure, Progressive, With Hypertension
Elevated circulating creatinine concentration, Nephritis, Stage 5 chronic kidney disease, Microsc... OMIM:161900
Idiopathic Non-Lupus Full-House Nephropathy
Abnormal glomerular mesangium morphology, Synovitis, Nephrotic syndrome, Elevated circulating cre... ORPHA:567544
Interstitial Nephritis, Karyomegalic
Tubulointerstitial nephritis, Nephronophthisis, Hematuria, Elevated circulating creatinine concen... OMIM:614817
Ichthyosis, Mental Retardation, Dwarfism, And Renal Impairment
Elevated circulating creatinine concentration, Decreased glomerular filtration rate, Nephropathy OMIM:242530
Nephronophthisis-Like Nephropathy 2
Bronchiectasis, Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, Po... OMIM:619468
Tubulointerstitial Nephritis With Uveitis
Elevated circulating creatinine concentration, Reversible renal failure, Anterior uveitis, Panuve... OMIM:607665
C3 Glomerulopathy
Nephrotic syndrome, Hematuria, Elevated circulating creatinine concentration, Stage 5 chronic kid... ORPHA:329918
Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency
Macroscopic hematuria, Elevated circulating creatinine concentration, Dysuria, Gout, Hyperuricemi... ORPHA:79233
Lymphoproliferative Syndrome 3
Reduced natural killer cell count, Hepatosplenomegaly OMIM:618261
Immunodeficiency 20
Reduced natural killer cell count OMIM:615707
Thrombotic Thrombocytopenic Purpura
Hematuria, Decreased serum creatinine, Acute kidney injury, Proteinuria, Renal insufficiency ORPHA:54057
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Acute lymphoblastic leukemia, Neutropenia, Anemia, Splenomegaly, Acute myeloid leukemia, Hepatosp... ORPHA:158057
Immunodeficiency 57 With Autoinflammation
B lymphocytopenia, Reduced natural killer cell count, T lymphocytopenia, Perianal abscess OMIM:618108
Hereditary Renal Hypouricemia
Hypouricemia, Uric acid urolithiasis independent of gout, Abnormal renal physiology, Hematuria, D... ORPHA:94088
Immunodeficiency 85 And Autoimmunity
Reduced natural killer cell count, Decreased proportion of CD4-positive helper T cells, Lymphopen... OMIM:619510
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Renal tubular atrophy, Renal hypoplasia, Tubulointerstitial nephritis, Renal cortical atrophy, De... OMIM:174000
Bloom Syndrome
Chromosome breakage, Decreased fertility in females, Abnormality of chromosome stability, Small f... OMIM:210900
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Anuria, Hematuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Acut... OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Anuria, Hematuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Acut... OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Anuria, Hematuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Acut... OMIM:612925
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Anuria, Hematuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Acut... OMIM:612924
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Anuria, Hematuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Acut... OMIM:612926
Autoinflammation With Infantile Enterocolitis
Anemia, Splenomegaly, Reduced natural killer cell count, Pancytopenia, Thrombocytopenia OMIM:616050
Cryoglobulinemia, Familial Mixed
Abnormal renal physiology, Hematuria, Elevated circulating creatinine concentration, Chronic kidn... OMIM:123550
Xeroderma Pigmentosum, Complementation Group F
Defective DNA repair after ultraviolet radiation damage, Decreased body weight, Hearing impairment OMIM:278760
Lcat Deficiency
Decreased HDL cholesterol concentration, Decreased glomerular filtration rate, Stage 5 chronic ki... ORPHA:650
Preeclampsia
Elevated circulating creatinine concentration, Acute kidney injury, Chronic kidney disease, Prote... ORPHA:275555
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
B lymphocytopenia, Impaired lymphocyte transformation with phytohemagglutinin, Hypoplasia of the ... OMIM:619313
Xeroderma Pigmentosum, Autosomal Dominant, Mild
Defective DNA repair after ultraviolet radiation damage OMIM:194400
Nephronophthisis 2
Hyperkalemia, Chronic tubulointerstitial nephritis, Nephronophthisis, Elevated circulating creati... OMIM:602088
Polycystic Kidney Disease 6 With Or Without Polycystic Liver Disease
Renal insufficiency, Decreased glomerular filtration rate, Gout, Stage 5 chronic kidney disease OMIM:618061
Xeroderma Pigmentosum, Complementation Group G
Defective DNA repair after ultraviolet radiation damage OMIM:278780
Immunodeficiency 54
Reduced natural killer cell count, Splenomegaly OMIM:609981
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Decreased proportion of naive T cells, Decreased proportion of CD3-positive T cells, Reduced natu... ORPHA:276
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Failure to thrive, Chromosomal breakage induced by crosslinking agents, Decreased body weight OMIM:619060
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Hyponatremia, Hypernatriuria, Decreased serum creatinine, Decreased circulating renin level OMIM:300539
Fanconi Anemia, Complementation Group D1
Failure to thrive, Chromosomal breakage induced by crosslinking agents, Bone marrow hypocellularity OMIM:605724
Autosomal Dominant Polycystic Kidney Disease
Decreased glomerular filtration rate, Hematuria, Pyelonephritis, Renal cyst, Nephrolithiasis, Sta... ORPHA:730
Fanconi Anemia, Complementation Group A
Small for gestational age, Deficient excision of UV-induced pyrimidine dimers in DNA, Hearing imp... OMIM:227650
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, Recurrent urinary ... OMIM:613095
Fragile X Syndrome
Sinusitis, Folate-dependent fragile site at Xq28, Chronic otitis media, Otitis media, Protruding ear ORPHA:908
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Fragile X Syndrome
Macrotia, Folate-dependent fragile site at Xq28, Periventricular heterotopia OMIM:300624
Hypocalcemia, Autosomal Dominant 1
Hypokalemia, Nephrocalcinosis, Decreased glomerular filtration rate, Nephrolithiasis, Hypomagnese... OMIM:601198
Pgm3-Cdg
Abnormal CD4:CD8 ratio, Neutropenia, Abnormal proportion of CD8-positive T cells, Leukopenia, Neu... ORPHA:443811
Fanconi Anemia, Complementation Group E
Small for gestational age, Deficient excision of UV-induced pyrimidine dimers in DNA, Hearing imp... OMIM:600901
Nijmegen Breakage Syndrome-Like Disorder
Chromosomal breakage induced by ionizing radiation OMIM:613078
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Reduced natural killer cell count, T lymphocytopenia OMIM:242860
Fanconi Anemia, Complementation Group C
Small for gestational age, Deficient excision of UV-induced pyrimidine dimers in DNA, Bone marrow... OMIM:227645
Fanconi Anemia, Complementation Group J
Chromosomal breakage induced by crosslinking agents, Bone marrow hypocellularity OMIM:609054
Oligomeganephronia
Bilateral renal hypoplasia, Renal tubular atrophy, Abnormal nephron morphology, Abnormality of me... ORPHA:2260
Hermansky-Pudlak Syndrome 2
Neutropenia, Ocular albinism, Enlarged platelet dense granules, Absent platelet dense granules, S... OMIM:608233
Pauci-Immune Glomerulonephritis
Macroscopic hematuria, Tubulointerstitial nephritis, Decreased glomerular filtration rate, Elevat... ORPHA:93126
Igg4-Related Kidney Disease
Tubulointerstitial nephritis, Chronic kidney disease, Elevated circulating C-reactive protein con... ORPHA:449395
Coenzyme Q10 Deficiency, Primary, 8
Renal dysplasia, Elevated circulating creatinine concentration, Abnormal renal corticomedullary d... OMIM:616733
Fanconi Anemia, Complementation Group S
Chromosome breakage, Failure to thrive OMIM:617883
Transcobalamin Deficiency
Abnormality of chromosome stability, Decreased circulating IgA level, Decreased circulating IgG l... ORPHA:859
Fanconi Anemia, Complementation Group Q
Chromosome breakage, Bone marrow hypocellularity OMIM:615272
Primary Hyperoxaluria Type 1
Calcinosis, Hyperoxaluria, Nephrocalcinosis, Hematuria, Decreased glomerular filtration rate, Dys... ORPHA:93598
Igg4-Related Retroperitoneal Fibrosis
Psoriasiform dermatitis, Hydronephrosis, Deep dermal perivascular inflammatory infiltrate, Nephro... ORPHA:49041
Hereditary Amyloidosis With Primary Renal Involvement
Renal tubular atrophy, Decreased HDL cholesterol concentration, Tubulointerstitial nephritis, Nep... ORPHA:85450
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly
Renal hypoplasia, Chronic tubulointerstitial nephritis, Elevated circulating creatinine concentra... OMIM:614376
Fanconi Anemia, Complementation Group D2
Small for gestational age, Deficient excision of UV-induced pyrimidine dimers in DNA, Bone marrow... OMIM:227646
Immunodeficiency 68
B lymphocytopenia, Abscess, T lymphocytopenia, Abnormal natural killer cell count OMIM:612260
Combined Immunodeficiency With Faciooculoskeletal Anomalies
B lymphocytopenia, Optic nerve hypoplasia, Reduced natural killer cell count, Decreased proportio... ORPHA:221139
Juvenile Nephropathic Cystinosis
Renal Fanconi syndrome, Hyponatremia, Hypocalcemic tetany, Hypouricemia, Hypokalemia, Proximal tu... ORPHA:411634
X-Linked Lymphoproliferative Disease
Increased B cell count, B lymphocytopenia, Increased T cell count, Splenomegaly, Absent natural k... ORPHA:2442
Immunodeficiency 21
Abnormal natural killer cell morphology, Neutropenia, Lymphopenia, Myeloid leukemia, Monocytopeni... OMIM:614172
Fanconi Anemia, Complementation Group L
Chromosome breakage, Bone marrow hypocellularity, Abnormality of chromosome stability, Microtia OMIM:614083
Orthostatic Hypotension 2
Decreased glomerular filtration rate OMIM:618182
Bacterial Toxic-Shock Syndrome
Sinusitis, Myocarditis, Infectious encephalitis, Pneumonia, Peritonitis, Myositis, Elevated circu... ORPHA:36234
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
Aapoaiv Amyloidosis
Hyperlipidemia, Elevated circulating creatinine concentration, Abnormal renal medulla morphology,... ORPHA:439232
Fanconi Anemia, Complementation Group I
Chromosomal breakage induced by crosslinking agents, Decreased body weight, Bone marrow hypocellu... OMIM:609053
N Syndrome
Abnormality of chromosome stability, Hearing impairment OMIM:310465
Thrombotic Thrombocytopenic Purpura, Hereditary
Abnormal renal physiology, Elevated circulating creatinine concentration, Hemolytic-uremic syndro... OMIM:274150
Coach Syndrome 2
Hyperechogenic kidneys, Elevated circulating creatinine concentration OMIM:619111
Car T Cell Therapy-Associated Cytokine Release Syndrome
Decreased urine output, Elevated circulating creatinine concentration, Hyperbilirubinemia, Increa... ORPHA:542323
Fanconi Anemia, Complementation Group F
Conductive hearing impairment, Pneumonia, Failure to thrive, Bone marrow hypocellularity, Patent ... OMIM:603467
Radial-Renal Syndrome
Chromosome breakage OMIM:179280
Bartter Syndrome, Type 4B, Neonatal, With Sensorineural Deafness
Hyponatremia, Hypokalemia, Increased urinary potassium, Decreased glomerular filtration rate, Hyp... OMIM:613090
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyponatremia, Hypokalemia, Increased urinary potassium, Decreased glomerular filtration rate, Tub... OMIM:602522
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Hyperlipidemia, Anuria, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome,... OMIM:235400
Multiple Myeloma
Hyperproteinemia, Hypercalcemia, Nephrotic syndrome, Increased circulating IgA level, Elevated ci... ORPHA:29073
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent natural killer cells, Impaired lymphocyte transformation with phytohemagglutinin, T lympho... OMIM:600802
Relapsing Fever
Abnormality of the urinary system, Hematuria, Elevated circulating creatinine concentration, Incr... ORPHA:91547
Riddle Syndrome
Pneumonia, Decreased circulating IgA level, Weight loss, Decreased circulating IgG level, Chronic... ORPHA:420741
Renal Cysts And Diabetes Syndrome
Hypospadias, Renal hypoplasia, Elevated circulating creatinine concentration, Gout, Renal cyst, N... OMIM:137920
Chromosomal Instability With Tissue-Specific Radiosensitivity
Abnormality of chromosome stability OMIM:215510
Glycogen Storage Disease Ia
Focal segmental glomerulosclerosis, Hyperlipidemia, Decreased glomerular filtration rate, Gout, P... OMIM:232200
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Abnormal B cell count, Decreased proportion of CD3-positive T cells, Hepatosplenomegaly, Abnormal... ORPHA:331206
Ataxia-Telangiectasia
Failure to thrive, Decreased circulating antibody level, Abnormality of chromosome stability ORPHA:100
Ataxia-Telangiectasia With Generalized Skin Pigmentation And Early Death
Chromosome breakage, Decreased circulating IgA level, Abnormality of chromosome stability OMIM:208910
Glycogen Storage Disease Ib
Focal segmental glomerulosclerosis, Hyperlipidemia, Decreased glomerular filtration rate, Gout, P... OMIM:232220
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Abnormality of chromosome stability OMIM:600546
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
B lymphocytopenia, Impaired lymphocyte transformation with phytohemagglutinin, Absent natural kil... ORPHA:35078
Tubulointerstitial Nephritis And Uveitis Syndrome
Tubulointerstitial nephritis, Decreased glomerular filtration rate, Microscopic hematuria, Mild p... ORPHA:91500
Lysinuric Protein Intolerance
Tubulointerstitial nephritis, Oroticaciduria, Decreased glomerular filtration rate, Decreased cir... ORPHA:470
Xeroderma Pigmentosum, Complementation Group A
Sensorineural hearing impairment, Defective DNA repair after ultraviolet radiation damage, Conjun... OMIM:278700
Glycogen Storage Disease Ic
Focal segmental glomerulosclerosis, Hyperlipidemia, Hematuria, Decreased glomerular filtration ra... OMIM:232240
Diffuse Alveolar Hemorrhage
Hematuria, Proteinuria, Elevated circulating creatinine concentration ORPHA:90060
Fanconi Anemia, Complementation Group G
Abnormality of chromosome stability OMIM:614082
De Sanctis-Cacchione Syndrome
Sensorineural hearing impairment, Defective DNA repair after ultraviolet radiation damage, Kerati... OMIM:278800
Xeroderma Pigmentosum, Complementation Group D
Keratoconjunctivitis sicca, Keratitis, Sensorineural hearing impairment, Defective DNA repair aft... OMIM:278730
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Hyponatremia, Hemoglobinuria, Unconjugated hyperbilirubinemia, Hypokalemia, Peritonitis, Anuria, ... ORPHA:90038
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Pneumonia, Elevated circulating creatinine concentration, Glomerular sclerosis, Skin rash, Nephro... ORPHA:247691
Distal Renal Tubular Acidosis
Hyperphosphaturia, Aminoaciduria, Hypokalemia, Nephrocalcinosis, Proximal tubulopathy, Decreased ... ORPHA:18
Severe Growth Deficiency-Strabismus-Extensive Dermal Melanocytosis-Intellectual Disability Syndrome
Tubulointerstitial nephritis, Nephrotic syndrome, Decreased glomerular filtration rate, Chronic k... ORPHA:488627
Macrophage Activation Syndrome
Neutropenia, Anemia, Splenomegaly, Thrombocytopenia, Hemophagocytosis, Abnormal natural killer ce... ORPHA:158061
Xeroderma Pigmentosum, Complementation Group E
Conjunctivitis, Defective DNA repair after ultraviolet radiation damage, Keratitis OMIM:278740
Hereditary Arterial And Articular Multiple Calcification Syndrome
Decreased serum creatinine ORPHA:289601
Hemorrhagic Fever-Renal Syndrome
Hyperkalemia, Hyperphosphatemia, Decreased urine output, Tubulointerstitial nephritis, Pneumonia,... ORPHA:340
Trichothiodystrophy
Keratoconjunctivitis sicca, Eczema, Defective DNA repair after ultraviolet radiation damage, Panh... ORPHA:33364
Xeroderma Pigmentosum, Complementation Group C
Conjunctivitis, Defective DNA repair after ultraviolet radiation damage, Keratitis OMIM:278720
Dopamine Beta-Hydroxylase Deficiency
Rhinitis, Elevated circulating creatinine concentration, Increased blood urea nitrogen, Elevated ... ORPHA:230
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Anemia, Hepatosplenomegaly, Decreased proportion of memory B cells, Pancytopenia, Thrombocytopeni... ORPHA:79124
Congenital Disorder Of Glycosylation, Type Iit
Decreased HDL cholesterol concentration, Urinary incontinence, Hypotriglyceridemia, Decreased ser... OMIM:618885
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Abnormal renal physiology, Elevated circulating creatinine concentration, Glomerular sclerosis, I... OMIM:223900
Sickle Cell Anemia
Elevated circulating creatinine concentration, Unconjugated hyperbilirubinemia, Osteomyelitis ORPHA:232
Porokeratosis 1, Multiple Types
Abnormality of chromosome stability OMIM:175800
Fanconi Anemia, Complementation Group N
Chromosomal breakage induced by crosslinking agents OMIM:610832
Hemophagocytic Syndrome Associated With An Infection
Neutropenia, Anemia, Splenomegaly, Abnormal T cell subset distribution, Pancytopenia, Thrombocyto... ORPHA:158048
Acute Interstitial Pneumonia
Elevated circulating creatinine concentration, Elevated circulating C-reactive protein concentrat... ORPHA:79126
Meningioma
Amenorrhea, Tinnitus, Hypogonadotropic hypogonadism, Impotence, Obesity, Chromosomal breakage ind... ORPHA:2495
Fanconi Anemia, Complementation Group B
Abnormality of chromosome stability, Overfolded helix, Patent ductus arteriosus, Hypogonadism, Hy... OMIM:300514
Marburg Hemorrhagic Fever
Hyperamylasemia, Pericarditis, Hypokalemia, Elevated circulating creatine kinase concentration, E... ORPHA:99826
Alkaptonuria
Elevated urinary homogentisic acid, Decreased glomerular filtration rate, Arthritis, Nephrolithiasis OMIM:203500
Immunodeficiency 82 With Systemic Inflammation
B lymphocytopenia, Decreased proportion of naive T cells, Anemia, Splenomegaly, Reduced natural k... OMIM:619381
Yellow Fever
Anuria, Elevated circulating creatine kinase concentration, Elevated circulating creatinine conce... ORPHA:99829
Structural Heart Defects And Renal Anomalies Syndrome
Renal insufficiency, Elevated circulating creatinine concentration, Renal cyst OMIM:617478
Cardiogenic Shock
Oliguria, Elevated circulating creatinine concentration ORPHA:97292
Icf Syndrome
Decreased circulating antibody level, Abnormality of chromosome stability ORPHA:2268
Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Renal tubular atrophy, Focal segmental glomerulosclerosis, Nephrotic syndrome, Decreased glomerul... OMIM:614748
Lig4 Syndrome
Abnormality of chromosome stability ORPHA:99812
Nijmegen Breakage Syndrome
Abnormality of neuronal migration, Cachexia, Abnormality of chromosome stability, Macrotia, Recur... ORPHA:647
Cartilage-Hair Hypoplasia
Abnormality of chromosome stability, Failure to thrive, Decreased circulating antibody level, Mac... ORPHA:175
Chédiak-Higashi Syndrome
Abnormal natural killer cell morphology, Abnormality of retinal pigmentation, Neutropenia, Thromb... ORPHA:167
Fanconi Anemia
Abnormality of chromosome stability, Azoospermia, Weight loss, Patent ductus arteriosus, Hearing ... ORPHA:84
Biliary, Renal, Neurologic, And Skeletal Syndrome
Hydronephrosis, Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, Pa... OMIM:619534

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Parp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Parp1.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proceedings of the National Academy of Sciences of the United States of America (October 2021) Parp1tm1c(EUCOMM)Hmgu 34580230
Differential regulation of breast cancer bone metastasis by PARP1 and PARP2. Nature communications (March 2020) Parp1tm1c(EUCOMM)Hmgu PMC7101362
ARTD1 in Myeloid Cells Controls the IL-12/18-IFN-γ Axis in a Model of Sterile Sepsis, Chronic Bacterial Infection, and Cancer. Journal of immunology (Baltimore, Md. : 1950) (January 2019) Parp1tm1c(EUCOMM)Hmgu 30674576
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PloS one (July 2017) Parp16tm1.1(KOMP)Mbp PMC5503261
PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity. Molecular cell (January 2017) Parp1tm1c(EUCOMM)Hmgu Parp1tm1a(EUCOMM)Hmgu PMC5258183
Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. Biology of reproduction (February 2015) Parp11tm1(KOMP)Vlcg PMC4376083

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MGI Allele Allele Type Produced
Parp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Parp1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Parp1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Parp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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