Genes Phenotypes

Gene: Parp1

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Name
poly (ADP-ribose) polymerase family, member 1
MGI ID
MGI:1340806
Synonyms
PARP sPARP-1 Adprp parp-1 5830444G22Rik Adprt1
Viability
Homozygous - Subviable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (262) All data table (437)
Expression & images (0) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased memory-marker CD4-negative NK T cell number Parp1tm1b(EUCOMM)Hmgu HOM Early adult 1.69×10-05
decreased leukocyte cell number Parp1tm1b(EUCOMM)Hmgu HOM Early adult 5.30×10-05
decreased total retina thickness Parp1tm1b(EUCOMM)Hmgu HOM Early adult 4.65×10-07
preweaning lethality, incomplete penetrance Parp1tm1b(EUCOMM)Hmgu HOM Early adult 0.00
immune system phenotype Parp1tm1b(EUCOMM)Hmgu HOM Early adult 2.47×10-07
abnormal retinal inner nuclear layer morphology Parp1tm1b(EUCOMM)Hmgu HOM Early adult 8.57×10-07
decreased lymphocyte cell number Parp1tm1b(EUCOMM)Hmgu HOM Early adult 6.08×10-05
decreased grip strength Parp1tm1b(EUCOMM)Hmgu HOM Early adult 1.92×10-05
abnormal total retina thickness Parp1tm1b(EUCOMM)Hmgu HOM Early adult 2.58×10-08
abnormal grip strength Parp1tm1b(EUCOMM)Hmgu HOM Early adult 3.46×10-05

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 Expression

Expression data not available

 Associated Images

Immunophenotyping: Panel B FCS file(s)
17 Images
Immunophenotyping: Panel A FCS file(s)
17 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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MGI Allele Allele Type Produced
Parp1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Parp1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Parp1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors

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