Tmc6 | transmembrane channel-like gene family 6

GeneMGI:1098686Synonyms: EVER1, D11Ertd204e

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Skeleton Cardiovascular system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

vertebral fusion1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult5.02x10-5 
decreased circulating cholesterol level1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult4.8x10-5 
decreased circulating serum albumin level1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult1.81x10-5 
increased lean body mass1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult3.97x10-5 
decreased circulating HDL cholesterol level1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult1.72x10-6 
increased heart weight1 supporting datasetTmc6tm1a(EUCOMM)WtsihomozygoteEarly adult2.53x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmc6tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse

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