Atf2 | activating transcription factor 2

GeneMGI:109349Synonyms: ATF-2, Creb2, +3 more

Physiological systems

23 / 24 physiological systems tested

10 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Respiratory system Hematopoietic system Cardiovascular system Renal/urinary system

13 No significant impact

1 Not tested

Gene metrics:13Significant phenotypes
0Associated diseases
Expression examined in:78Adult tissues
35Embryo tissues

Phenotypes

enlarged heart1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
abnormal urinary bladder morphology1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
abnormal kidney morphology1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
increased fasting circulating glucose level1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adult1.04x10-5 
decreased circulating chloride level1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adult3.8x10-6 
abnormal skin morphology1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
increased lung elastance2 supporting datasetsAtf2tm1b(EUCOMM)HmguheterozygoteEarly adult8.42x10-5 
decreased mean platelet volume1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adult5.39x10-8 
abnormal spleen morphology2 supporting datasetsAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
abnormal testis morphology1 supporting datasetAtf2tm1b(EUCOMM)HmguheterozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
50% (1/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
bloodheterozygoten/an/a0% (0/17)
boneheterozygoteSection images
50% (1/2)0% (0/394)
bone marrowheterozygoten/an/a0% (0/22)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
50% (1/2)0.41% (2/490)
brown adipose tissueheterozygoteSection images
50% (1/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cecumheterozygoteSection images
0% (0/1)7.75% (22/284)
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Histopathology

IMPC related publications

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Atf2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Atf2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Atf2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Atf2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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