Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Bid by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Diabetes Insipidus, Neurohypophyseal | Gliosis | OMIM:125700 | |
Developmental And Epileptic Encephalopathy 71 | Gliosis | OMIM:618328 | |
Immunodeficiency 83, Susceptibility To Viral Infections | Gliosis | OMIM:613002 | |
Emphysema, Hereditary Pulmonary | Emphysema, Chronic bronchitis | OMIM:130700 | |
Developmental And Epileptic Encephalopathy 14 | Gliosis | OMIM:614959 | |
Huntington Disease | Gliosis | OMIM:143100 | |
Pontocerebellar Hypoplasia, Type 4 | Gliosis | OMIM:225753 | |
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 3 | Pneumonia, Gliosis | OMIM:608033 | |
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia | Gliosis | OMIM:300857 | |
Pyruvate Dehydrogenase E1-Alpha Deficiency | Recurrent aspiration pneumonia, Lateral ventricle dilatation, Agenesis of corpus callosum, Gliosi... | ORPHA:79243 | |
Congenital Neuronal Ceroid Lipofuscinosis | Abnormal astrocyte morphology, Gliosis, Agenesis of corpus callosum | ORPHA:168486 | |
Mitochondrial Complex Iv Deficiency, Nuclear Type 6 | Gliosis | OMIM:615119 | |
Microcephaly 10, Primary, Autosomal Recessive | Gliosis, Agenesis of corpus callosum | OMIM:615095 | |
Pick Disease Of Brain | Gliosis | OMIM:172700 | |
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies | Gliosis | OMIM:604218 | |
Mosaic Variegated Aneuploidy Syndrome 4 | Abnormality of chromosome stability | OMIM:620153 | |
Sporadic Creutzfeldt-Jakob Disease | Recurrent aspiration pneumonia, Astrocytosis, Gliosis | ORPHA:204 | |
Hemimegalencephaly | Gliosis | ORPHA:99802 | |
Adducted Thumbs Syndrome | Myelin-dependent gliosis | OMIM:201550 | |
Spinocerebellar Ataxia, Autosomal Recessive 2 | Gliosis | OMIM:213200 | |
Primary Non-Essential Cutis Verticis Gyrata | Gliosis | ORPHA:357225 | |
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1 | Gliosis | OMIM:221820 | |
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 | Lateral ventricle dilatation, Gliosis | OMIM:221770 | |
Lissencephaly, X-Linked, 2 | Gliosis, Agenesis of corpus callosum | OMIM:300215 | |
Neuropathy, Hereditary Motor And Sensory, Okinawa Type | Gliosis | OMIM:604484 | |
Spinocerebellar Ataxia, Autosomal Recessive 27 | Gliosis | OMIM:618369 | |
Leukoencephalopathy With Vanishing White Matter 1 | Gliosis | OMIM:603896 | |
Cerebrooculofacioskeletal Syndrome 1 | Recurrent pneumonia, Gliosis, Agenesis of corpus callosum | OMIM:214150 | |
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 | Gliosis | OMIM:105550 | |
Duodenal Atresia | Abnormality of the pulmonary artery, Annular pancreas, Abnormality of the pancreas | ORPHA:1203 | |
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome | Pulmonary fibrosis, Gliosis | ORPHA:457240 | |
Spinocerebellar Ataxia 17 | Gliosis | OMIM:607136 | |
Leigh Syndrome, Nuclear | Gliosis | OMIM:256000 | |
Frontotemporal Dementia With Motor Neuron Disease | Gliosis | ORPHA:275872 | |
Spastic Paraplegia 50, Autosomal Recessive | Gliosis | OMIM:612936 | |
Spongiform Encephalopathy With Neuropsychiatric Features | Gliosis | OMIM:606688 | |
Combined Oxidative Phosphorylation Deficiency 24 | Gliosis, Agenesis of corpus callosum | OMIM:616239 | |
Intellectual Developmental Disorder, X-Linked 12 | Gliosis | OMIM:300957 | |
Huntington Disease-Like 1 | Gliosis | ORPHA:157941 | |
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal | Gliosis | OMIM:614498 | |
L-2-Hydroxyglutaric Aciduria | Gliosis | OMIM:236792 | |
Mitochondrial Complex Iv Deficiency, Nuclear Type 2 | Gliosis, Basal ganglia gliosis | OMIM:604377 | |
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly | Lateral ventricle dilatation, Gliosis | OMIM:619847 | |
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related | Lateral ventricle dilatation, Gliosis | OMIM:607485 | |
Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant | Gliosis | OMIM:169500 | |
Pancreatitis, Hereditary | Exocrine pancreatic insufficiency, Pleural effusion, Pancreatic calcification, Pancreatitis, Panc... | OMIM:167800 | |
Neurodegeneration With Brain Iron Accumulation 2A | Gliosis | OMIM:256600 | |
Pontocerebellar Hypoplasia, Type 2A | Gliosis | OMIM:277470 | |
Familial Acute Necrotizing Encephalopathy | Gliosis | ORPHA:88619 | |
Combined Oxidative Phosphorylation Deficiency 14 | Gliosis, Basal ganglia gliosis | OMIM:614946 | |
Multiple Acyl-Coa Dehydrogenase Deficiency | Gliosis, Pulmonary hypoplasia | OMIM:231680 | |
Machado-Joseph Disease | Gliosis | OMIM:109150 | |
Early-Onset Progressive Leukoencephalopathy-Central Nervous System Calcification-Deafness-Visual Impairment Syndrome | Gliosis | ORPHA:3240 | |
Kleefstra Syndrome Due To A Point Mutation | Gliosis | ORPHA:261652 | |
Pelizaeus-Merzbacher Disease, Connatal Form | Gliosis | ORPHA:280210 | |
Multiple Acyl-Coa Dehydrogenase Deficiency | Gliosis | ORPHA:26791 | |
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity | Lateral ventricle dilatation, Atelectasis, Colpocephaly, Gliosis, Pulmonary artery atresia, Pulmo... | OMIM:620371 | |
Progressive Supranuclear Palsy | Gliosis | ORPHA:683 | |
Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Thin Corpus Callosum | Gliosis | OMIM:617193 | |
Leigh Syndrome | Gliosis, Agenesis of corpus callosum | ORPHA:506 | |
Scleroderma, Familial Progressive | Chromosome breakage, Abnormality of chromosome stability | OMIM:181750 | |
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2 | Gliosis | OMIM:618321 | |
Mannosidosis, Alpha B, Lysosomal | Gliosis | OMIM:248500 | |
Tay-Sachs Disease | Gliosis, Aspiration pneumonia | ORPHA:845 | |
Parkinson Disease 1, Autosomal Dominant | Gliosis | OMIM:168601 | |
Combined Oxidative Phosphorylation Deficiency 58 | Gliosis | OMIM:620451 | |
Papillorenal Syndrome | Gliosis | OMIM:120330 | |
Mitochondrial Complex I Deficiency, Nuclear Type 2 | Gliosis | OMIM:618222 | |
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis | Gliosis, Aspiration pneumonia | OMIM:301072 | |
Molybdenum Cofactor Deficiency, Type B | Gliosis | OMIM:252160 | |
Molybdenum Cofactor Deficiency, Type A | Gliosis | OMIM:252150 | |
Hereditary Late-Onset Parkinson Disease | Gliosis | ORPHA:411602 | |
D-Bifunctional Protein Deficiency | Gliosis | OMIM:261515 | |
Helsmoortel-Van Der Aa Syndrome | Lateral ventricle dilatation, Gliosis, Recurrent respiratory infections | OMIM:615873 | |
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome | Recurrent respiratory infections, Gliosis | ORPHA:404454 | |
Congenital Disorder Of Deglycosylation 1 | Recurrent respiratory infections, Gliosis | OMIM:615273 | |
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2 | Lateral ventricle dilatation, Gliosis | OMIM:300868 | |
Cerebrotendinous Xanthomatosis | Abnormal lung morphology, Gliosis | ORPHA:909 | |
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type) | Astrocytosis, Gliosis | OMIM:203700 | |
Cutis Laxa, Autosomal Recessive, Type Iid | Pneumothorax, Gliosis | OMIM:617403 | |
Supranuclear Palsy, Progressive, 1 | Astrocytosis, Gliosis | OMIM:601104 | |
Cockayne Syndrome | Gliosis | ORPHA:191 | |
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion | Gliosis | ORPHA:268261 | |
Gabriele-De Vries Syndrome | Gliosis, Agenesis of corpus callosum | ORPHA:506358 | |
Mitochondrial Complex Iv Deficiency, Nuclear Type 5 | Pulmonary edema, Partial agenesis of the corpus callosum, Gliosis | OMIM:220111 | |
Supranuclear Palsy, Progressive, 2 | Gliosis | OMIM:609454 | |
Diets-Jongmans Syndrome | Gliosis | OMIM:618846 | |
Mitochondrial Complex Iii Deficiency, Nuclear Type 1 | Gliosis | OMIM:124000 | |
Neurodevelopmental Disorder With Hypotonia And Speech Delay, With Or Without Seizures | Gliosis | OMIM:620455 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Bidtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Bidtm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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