Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

BH3 interacting domain death agonist

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bid mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bid by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Spongiform Encephalopathy With Neuropsychiatric Features
Gliosis OMIM:606688
Mitochondrial Complex Iv Deficiency, Nuclear Type 6
Gliosis OMIM:615119
Diabetes Insipidus, Neurohypophyseal
Gliosis OMIM:125700
Spinocerebellar Ataxia, Autosomal Recessive 27
Gliosis OMIM:618369
Immunodeficiency 83, Susceptibility To Viral Infections
Gliosis OMIM:613002
Developmental And Epileptic Encephalopathy 14
Gliosis OMIM:614959
Huntington Disease
Gliosis OMIM:143100
Pontocerebellar Hypoplasia, Type 4
Gliosis OMIM:225753
Congenital Neuronal Ceroid Lipofuscinosis
Abnormal astrocyte morphology, Gliosis, Agenesis of corpus callosum ORPHA:168486
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia
Gliosis OMIM:300857
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 3
Gliosis, Pneumonia OMIM:608033
Pick Disease Of Brain
Gliosis OMIM:172700
Spastic Paraplegia 50, Autosomal Recessive
Gliosis OMIM:612936
Spinocerebellar Ataxia, Autosomal Recessive 2
Gliosis OMIM:213200
Primary Non-Essential Cutis Verticis Gyrata
Gliosis ORPHA:357225
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Gliosis OMIM:604218
Adducted Thumbs Syndrome
Myelin-dependent gliosis OMIM:201550
Sporadic Creutzfeldt-Jakob Disease
Recurrent aspiration pneumonia, Gliosis, Astrocytosis ORPHA:204
Gliosis ORPHA:99802
Combined Oxidative Phosphorylation Deficiency 14
Gliosis OMIM:614946
Pyruvate Dehydrogenase E1-Alpha Deficiency
Gliosis, Cerebellar gliosis, Basal ganglia gliosis, Partial agenesis of the corpus callosum, Recu... ORPHA:79243
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Gliosis OMIM:604484
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1
Gliosis OMIM:221820
Lissencephaly, X-Linked, 2
Gliosis, Agenesis of corpus callosum OMIM:300215
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Gliosis OMIM:614498
Microcephaly 10, Primary, Autosomal Recessive
Gliosis OMIM:615095
Leukoencephalopathy With Vanishing White Matter
Gliosis OMIM:603896
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1
Gliosis OMIM:105550
Cerebrooculofacioskeletal Syndrome 1
Gliosis, Agenesis of corpus callosum, Recurrent pneumonia OMIM:214150
Spinocerebellar Ataxia 17
Gliosis OMIM:607136
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Gliosis, Pulmonary fibrosis ORPHA:457240
Duodenal Atresia
Annular pancreas, Abnormality of the pulmonary artery, Abnormality of the pancreas ORPHA:1203
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1
Gliosis OMIM:221770
Combined Oxidative Phosphorylation Deficiency 24
Gliosis, Agenesis of corpus callosum OMIM:616239
Frontotemporal Dementia With Motor Neuron Disease
Gliosis ORPHA:275872
L-2-Hydroxyglutaric Aciduria
Gliosis OMIM:236792
Leigh Syndrome
Gliosis OMIM:256000
Huntington Disease-Like 1
Gliosis ORPHA:157941
Spinocerebellar Ataxia, X-Linked 3
Gliosis, Recurrent respiratory infections OMIM:301790
Intellectual Developmental Disorder, X-Linked 12
Gliosis OMIM:300957
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Gliosis OMIM:220111
Charcot-Marie-Tooth Disease With Ptosis And Parkinsonism
Gliosis OMIM:118301
Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant
Gliosis OMIM:169500
Neurodegeneration With Brain Iron Accumulation 2A
Gliosis OMIM:256600
Pontocerebellar Hypoplasia, Type 2A
Gliosis OMIM:277470
Pancreatitis, Hereditary
Exocrine pancreatic insufficiency, Pancreatitis, Pancreatic pseudocyst, Pleural effusion, Pancrea... OMIM:167800
Multiple Acyl-Coa Dehydrogenase Deficiency
Gliosis, Pulmonary hypoplasia OMIM:231680
Machado-Joseph Disease
Gliosis OMIM:109150
Familial Acute Necrotizing Encephalopathy
Gliosis ORPHA:88619
Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal
Gliosis OMIM:602613
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Gliosis ORPHA:3240
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly
Gliosis OMIM:619847
Kleefstra Syndrome Due To A Point Mutation
Gliosis ORPHA:261652
Progressive Supranuclear Palsy
Gliosis ORPHA:683
Pelizaeus-Merzbacher Disease, Connatal Form
Gliosis ORPHA:280210
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Gliosis OMIM:607485
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Gliosis, Astrocytosis OMIM:203700
Multiple Acyl-Coa Dehydrogenase Deficiency
Gliosis ORPHA:26791
Leigh Syndrome
Gliosis, Agenesis of corpus callosum ORPHA:506
Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Thin Corpus Callosum
Gliosis OMIM:617193
Mannosidosis, Alpha B, Lysosomal
Gliosis OMIM:248500
Parkinson Disease 1, Autosomal Dominant
Gliosis OMIM:168601
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Gliosis OMIM:618321
Molybdenum Cofactor Deficiency, Complementation Group B
Gliosis OMIM:252160
Tay-Sachs Disease
Aspiration pneumonia, Gliosis ORPHA:845
Mitochondrial Complex I Deficiency, Nuclear Type 2
Gliosis OMIM:618222
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Aspiration pneumonia, Gliosis OMIM:301072
Papillorenal Syndrome
Gliosis OMIM:120330
Cutis Laxa, Autosomal Recessive, Type Iid
Gliosis OMIM:617403
Molybdenum Cofactor Deficiency, Complementation Group A
Gliosis OMIM:252150
Hereditary Late-Onset Parkinson Disease
Gliosis ORPHA:411602
D-Bifunctional Protein Deficiency
Gliosis OMIM:261515
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Gliosis, Recurrent respiratory infections ORPHA:404454
Oxoglutaric Aciduria
Abnormality of Krebs cycle metabolism ORPHA:31
Congenital Disorder Of Deglycosylation 1
Gliosis, Recurrent respiratory infections OMIM:615273
Cerebrotendinous Xanthomatosis
Abnormal lung morphology, Gliosis ORPHA:909
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Gliosis OMIM:300868
Supranuclear Palsy, Progressive, 1
Gliosis, Astrocytosis OMIM:601104
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Gliosis ORPHA:268261
Cockayne Syndrome
Gliosis ORPHA:191
Gabriele-De Vries Syndrome
Gliosis, Agenesis of corpus callosum ORPHA:506358
Supranuclear Palsy, Progressive, 2
Gliosis OMIM:609454
Diets-Jongmans Syndrome
Gliosis OMIM:618846
Mitochondrial Dna-Associated Leigh Syndrome
Abnormality of Krebs cycle metabolism ORPHA:255210


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bid

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bid.

No publications found that use IMPC mice or data for Bid.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Bidtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bidtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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