Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

BH3 interacting domain death agonist

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bid mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Bid by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Diabetes Insipidus, Neurohypophyseal
Gliosis OMIM:125700
Developmental And Epileptic Encephalopathy 71
Gliosis OMIM:618328
Immunodeficiency 83, Susceptibility To Viral Infections
Gliosis OMIM:613002
Emphysema, Hereditary Pulmonary
Emphysema, Chronic bronchitis OMIM:130700
Developmental And Epileptic Encephalopathy 14
Gliosis OMIM:614959
Huntington Disease
Gliosis OMIM:143100
Pontocerebellar Hypoplasia, Type 4
Gliosis OMIM:225753
Encephalopathy, Acute, Infection-Induced, Susceptibility To, 3
Pneumonia, Gliosis OMIM:608033
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia
Gliosis OMIM:300857
Pyruvate Dehydrogenase E1-Alpha Deficiency
Gliosis, Basal ganglia gliosis, Recurrent aspiration pneumonia, Lateral ventricle dilatation, Age... ORPHA:79243
Congenital Neuronal Ceroid Lipofuscinosis
Agenesis of corpus callosum, Abnormal astrocyte morphology, Gliosis ORPHA:168486
Mitochondrial Complex Iv Deficiency, Nuclear Type 6
Gliosis OMIM:615119
Microcephaly 10, Primary, Autosomal Recessive
Gliosis, Agenesis of corpus callosum OMIM:615095
Pick Disease Of Brain
Gliosis OMIM:172700
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Gliosis OMIM:604218
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Sporadic Creutzfeldt-Jakob Disease
Astrocytosis, Recurrent aspiration pneumonia, Gliosis ORPHA:204
Gliosis ORPHA:99802
Adducted Thumbs Syndrome
Myelin-dependent gliosis OMIM:201550
Primary Non-Essential Cutis Verticis Gyrata
Gliosis ORPHA:357225
Spinocerebellar Ataxia, Autosomal Recessive 2
Gliosis OMIM:213200
Leukoencephalopathy, Hereditary Diffuse, With Spheroids 1
Gliosis OMIM:221820
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1
Gliosis, Lateral ventricle dilatation OMIM:221770
Lissencephaly, X-Linked, 2
Gliosis, Agenesis of corpus callosum OMIM:300215
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Gliosis OMIM:604484
Spinocerebellar Ataxia, Autosomal Recessive 27
Gliosis OMIM:618369
Leukoencephalopathy With Vanishing White Matter 1
Gliosis OMIM:603896
Cerebrooculofacioskeletal Syndrome 1
Gliosis, Recurrent pneumonia, Agenesis of corpus callosum OMIM:214150
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1
Gliosis OMIM:105550
Duodenal Atresia
Abnormality of the pulmonary artery, Annular pancreas, Abnormality of the pancreas ORPHA:1203
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Gliosis, Pulmonary fibrosis ORPHA:457240
Spinocerebellar Ataxia 17
Gliosis OMIM:607136
Frontotemporal Dementia With Motor Neuron Disease
Gliosis ORPHA:275872
Spastic Paraplegia 50, Autosomal Recessive
Gliosis OMIM:612936
Spongiform Encephalopathy With Neuropsychiatric Features
Gliosis OMIM:606688
Combined Oxidative Phosphorylation Deficiency 24
Gliosis, Agenesis of corpus callosum OMIM:616239
Leigh Syndrome
Gliosis OMIM:256000
Intellectual Developmental Disorder, X-Linked 12
Gliosis OMIM:300957
Huntington Disease-Like 1
Gliosis ORPHA:157941
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Gliosis OMIM:614498
L-2-Hydroxyglutaric Aciduria
Gliosis OMIM:236792
Mitochondrial Complex Iv Deficiency, Nuclear Type 2
Basal ganglia gliosis, Gliosis OMIM:604377
Neurodegeneration, Childhood-Onset, With Progressive Microcephaly
Gliosis, Lateral ventricle dilatation OMIM:619847
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Gliosis, Lateral ventricle dilatation OMIM:607485
Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant
Gliosis OMIM:169500
Pancreatitis, Hereditary
Pancreatic pseudocyst, Pancreatitis, Pleural effusion, Exocrine pancreatic insufficiency, Pancrea... OMIM:167800
Neurodegeneration With Brain Iron Accumulation 2A
Gliosis OMIM:256600
Pontocerebellar Hypoplasia, Type 2A
Gliosis OMIM:277470
Familial Acute Necrotizing Encephalopathy
Gliosis ORPHA:88619
Combined Oxidative Phosphorylation Deficiency 14
Basal ganglia gliosis, Gliosis OMIM:614946
Multiple Acyl-Coa Dehydrogenase Deficiency
Gliosis, Pulmonary hypoplasia OMIM:231680
Machado-Joseph Disease
Gliosis OMIM:109150
Early-Onset Progressive Leukoencephalopathy-Central Nervous System Calcification-Deafness-Visual Impairment Syndrome
Gliosis ORPHA:3240
Kleefstra Syndrome Due To A Point Mutation
Gliosis ORPHA:261652
Pelizaeus-Merzbacher Disease, Connatal Form
Gliosis ORPHA:280210
Multiple Acyl-Coa Dehydrogenase Deficiency
Gliosis ORPHA:26791
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity
Atelectasis, Gliosis, Pulmonary artery atresia, Pulmonary hypoplasia, Colpocephaly, Lateral ventr... OMIM:620371
Progressive Supranuclear Palsy
Gliosis ORPHA:683
Encephalopathy, Progressive, Early-Onset, With Brain Atrophy And Thin Corpus Callosum
Gliosis OMIM:617193
Leigh Syndrome
Gliosis, Agenesis of corpus callosum ORPHA:506
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Gliosis OMIM:618321
Mannosidosis, Alpha B, Lysosomal
Gliosis OMIM:248500
Tay-Sachs Disease
Gliosis, Aspiration pneumonia ORPHA:845
Parkinson Disease 1, Autosomal Dominant
Gliosis OMIM:168601
Combined Oxidative Phosphorylation Deficiency 58
Gliosis OMIM:620451
Papillorenal Syndrome
Gliosis OMIM:120330
Mitochondrial Complex I Deficiency, Nuclear Type 2
Gliosis OMIM:618222
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Gliosis, Aspiration pneumonia OMIM:301072
Molybdenum Cofactor Deficiency, Complementation Group B
Gliosis OMIM:252160
Molybdenum Cofactor Deficiency, Complementation Group A
Gliosis OMIM:252150
Hereditary Late-Onset Parkinson Disease
Gliosis ORPHA:411602
D-Bifunctional Protein Deficiency
Gliosis OMIM:261515
Helsmoortel-Van Der Aa Syndrome
Gliosis, Recurrent respiratory infections, Lateral ventricle dilatation OMIM:615873
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Gliosis, Recurrent respiratory infections ORPHA:404454
Congenital Disorder Of Deglycosylation 1
Gliosis, Recurrent respiratory infections OMIM:615273
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Gliosis, Lateral ventricle dilatation OMIM:300868
Cerebrotendinous Xanthomatosis
Abnormal lung morphology, Gliosis ORPHA:909
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Astrocytosis, Gliosis OMIM:203700
Cutis Laxa, Autosomal Recessive, Type Iid
Pneumothorax, Gliosis OMIM:617403
Supranuclear Palsy, Progressive, 1
Astrocytosis, Gliosis OMIM:601104
Cockayne Syndrome
Gliosis ORPHA:191
Dyrk1A-Related Intellectual Disability Syndrome Due To 21Q22.13Q22.2 Microdeletion
Gliosis ORPHA:268261
Gabriele-De Vries Syndrome
Gliosis, Agenesis of corpus callosum ORPHA:506358
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Pulmonary edema, Gliosis, Partial agenesis of the corpus callosum OMIM:220111
Supranuclear Palsy, Progressive, 2
Gliosis OMIM:609454
Diets-Jongmans Syndrome
Gliosis OMIM:618846
Mitochondrial Complex Iii Deficiency, Nuclear Type 1
Gliosis OMIM:124000
Neurodevelopmental Disorder With Hypotonia And Speech Delay, With Or Without Seizures
Gliosis OMIM:620455


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bid

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bid.

No publications found that use IMPC mice or data for Bid.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bidtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bidtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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