Hdac1 | histone deacetylase 1
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging Cardiovascular system
17 No significant impact
2 Not tested
Data collections
Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| cardiovascular system phenotype | 1 supporting dataset | Hdac1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.03x10-5 | ||
| decreased mean corpuscular hemoglobin | 1 supporting dataset | Hdac1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.63x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Hdac1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.73x10-7 | ||
| increased circulating cholesterol level | 1 supporting dataset | Hdac1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 6.52x10-9 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Hdac1tm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Hdac1tm1a(EUCOMM)Wtsi | heterozygote | Early adult | 8.74x10-5 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Hdac1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| decreased heart rate variability | 1 supporting dataset | Hdac1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.86x10-5 |
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| adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
External links
No external links available for Hdac1.
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| Hdac1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Hdac1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Hdac1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |