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Gene: Klc1 MGI:107978

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Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
kinesin light chain 1
Synonyms:
Kns2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Klc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Klc1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Charcot-Marie-Tooth Disease, Dominant Intermediate B
Axonal degeneration, Decreased number of peripheral myelinated nerve fibers, Peripheral axonal de... OMIM:606482
Amyotrophic Lateral Sclerosis 4, Juvenile
Amyotrophic lateral sclerosis, Axonal degeneration, Abnormal lower motor neuron morphology, Perip... OMIM:602433
Charcot-Marie-Tooth Disease, Type 4A
Hypertrophic nerve changes, Basal lamina onion bulb formation, Axonal degeneration, Decreased num... OMIM:214400
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Axonal degeneration, Degeneration of anterior horn cells, Decreased number of peripheral myelinat... OMIM:604484
Charcot-Marie-Tooth Disease, Axonal, Type 2P
Peripheral axonal degeneration, Axonal degeneration/regeneration, Axonal degeneration OMIM:614436
Charcot-Marie-Tooth Disease, Type 4C
Basal lamina onion bulb formation, Abnormal cranial nerve morphology, Axonal degeneration, Periph... OMIM:601596
Charcot-Marie-Tooth Disease Type 2B1
Sensory axonal neuropathy, Decreased number of large peripheral myelinated nerve fibers, Motor ax... ORPHA:98856
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Global brain atrophy, Neurofibrillary tangles, Amyotrophic lateral sclerosis OMIM:619132
Charcot-Marie-Tooth Disease, Axonal, Type 2S
Axonal degeneration OMIM:616155
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1
Cerebellar atrophy, Axonal degeneration, Decreased number of peripheral myelinated nerve fibers, ... OMIM:302800
Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Cerebral atrophy, Peripheral demyelination, Axonal degeneration, Peripheral hypomyelination, Peri... OMIM:604168
Amyotrophy, Hereditary Neuralgic
Peripheral axonal degeneration, Axonal degeneration OMIM:162100
Charcot-Marie-Tooth Disease, Axonal, Type 2R
Peripheral axonal neuropathy, Axonal degeneration, Decreased number of peripheral myelinated nerv... OMIM:615490
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 6
Peripheral axonal neuropathy, Axonal degeneration OMIM:620011
Early-onset Alzheimer disease with cerebral amyloid angiopathy
Senile plaques, Neurofibrillary tangles DECIPHER:48
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 1
Peripheral axonal degeneration, Degeneration of anterior horn cells, Axonal degeneration OMIM:604320
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23
Axonal degeneration OMIM:618138
Mitochondrial Dna Depletion Syndrome 18
Axonal degeneration OMIM:618811
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Decreased number of large peripheral myelinated nerve fibers, Peripheral axonal degeneration, Cer... OMIM:208920
Alzheimer Disease 9, Susceptibility To
Cerebral cortical atrophy, Senile plaques, Neurofibrillary tangles, Hippocampal atrophy OMIM:608907
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion Pathology
Senile plaques, Neurofibrillary tangles OMIM:605055
Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia
Lewy bodies, Amyotrophic lateral sclerosis OMIM:619133
Combined Oxidative Phosphorylation Deficiency 29
Optic atrophy, Global brain atrophy, Cerebellar atrophy, Axonal degeneration, Optic neuropathy OMIM:616811
Combined Oxidative Phosphorylation Defect Type 29
Diffuse cerebellar atrophy, Global brain atrophy, Neurodegeneration, Axonal degeneration, Optic n... ORPHA:478029
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Abnormal peripheral nerve morphology by anatomical site, Abnormal spinal cord morphology, Axonal ... ORPHA:88628
Adrenomyeloneuropathy
Axonal degeneration, Peripheral axonal degeneration, Dorsal column degeneration, Atrophy of the s... ORPHA:139399
Angioedema, Hereditary, 1
Peripheral axonal neuropathy, Axonal degeneration OMIM:106100
Alzheimer Disease 4
Senile plaques, Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:606889
De Sanctis-Cacchione Syndrome
Optic atrophy, Global brain atrophy, Cerebral atrophy, Axonal degeneration OMIM:278800
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Cerebral cortical atrophy, Lewy bodies, Neurofibrillary tangles, Neuronal loss in central nervous... OMIM:607485
Parkinson Disease 23, Autosomal Recessive Early-Onset
Cerebral cortical atrophy, Lewy bodies, Neurofibrillary tangles OMIM:616840
Cerebrotendinous Xanthomatosis
Optic atrophy, Global brain atrophy, Cerebellar atrophy, Myelopathy, Axonal degeneration, Optic d... ORPHA:909
Neurodegeneration With Brain Iron Accumulation 2B
Optic atrophy, Cerebellar atrophy, Neurofibrillary tangles, Cerebral atrophy, Neurodegeneration, ... OMIM:610217
Alzheimer Disease 2
Neurofibrillary tangles OMIM:104310
Kanzaki Disease
Peripheral axonal neuropathy, Cerebral atrophy, Axonal degeneration OMIM:609242
Neurodegeneration With Brain Iron Accumulation 4
Optic atrophy, Cerebellar atrophy, Neurodegeneration, Lewy bodies, Motor axonal neuropathy, Abnor... OMIM:614298
Alzheimer Disease, Familial, 1
Neurofibrillary tangles OMIM:104300
Alzheimer Disease 3
Cerebral cortical atrophy, Neurofibrillary tangles OMIM:607822
Idiopathic Camptocormia
Myelitis, Cerebral atrophy, Amyotrophic lateral sclerosis, Lewy bodies, Syringomyelia ORPHA:1320
Early-Onset Autosomal Dominant Alzheimer Disease
Cerebral cortical atrophy, Neurofibrillary tangles ORPHA:1020
Niemann-Pick Disease, Type C1
Neurofibrillary tangles, Neuronal loss in central nervous system OMIM:257220
Gerstmann-Straussler Disease
Cerebellar atrophy, Neurofibrillary tangles OMIM:137440
Spongiform Encephalopathy With Neuropsychiatric Features
Neurofibrillary tangles OMIM:606688
Dementia, Lewy Body
Lewy bodies OMIM:127750
Supranuclear Palsy, Progressive, 1
Neurofibrillary tangles, Cerebral atrophy, Neuronal loss in central nervous system, Senile plaque... OMIM:601104
Parkinson Disease, Late-Onset
Lewy bodies, Neuronal loss in central nervous system OMIM:168600
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:117300
Supranuclear Palsy, Progressive, 2
Neurofibrillary tangles, Neuronal loss in central nervous system, Granulovacuolar degeneration OMIM:609454
Primary Progressive Freezing Gait
Cerebral cortical atrophy, Lewy bodies ORPHA:75567
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
Lewy bodies OMIM:614251
Parkinson Disease 21
Lewy bodies OMIM:616361
Adult-Onset Dystonia-Parkinsonism
Generalized cerebral atrophy/hypoplasia, Frontotemporal cerebral atrophy, Neurofibrillary tangles ORPHA:199351
Parkinson Disease 1, Autosomal Dominant
Global brain atrophy, Lewy bodies OMIM:168601
Parkinson Disease 4, Autosomal Dominant
Lewy bodies OMIM:605543
Parkinson Disease 2, Autosomal Recessive Juvenile
Lewy bodies, Cerebral atrophy OMIM:600116
Parkinson Disease 8, Autosomal Dominant
Lewy bodies OMIM:607060
Niemann-Pick Disease, Type C2
Neurofibrillary tangles OMIM:607625
Waisman Syndrome
Lewy bodies OMIM:311510
Hereditary Late-Onset Parkinson Disease
Cerebral cortical atrophy, Lewy bodies ORPHA:411602
Early-Onset Lafora Body Disease
Lafora bodies ORPHA:324290
Parkinsonian-Pyramidal Syndrome
Lewy bodies ORPHA:171695
Lafora Disease
Lafora bodies, Brain atrophy ORPHA:501
Epilepsy, Progressive Myoclonic, 10
Lafora bodies OMIM:616640
Myoclonic Epilepsy Of Lafora 1
Lafora bodies OMIM:254780

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Klc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Klc1.

No publications found that use IMPC mice or data for Klc1.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Klc1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Klc1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Klc1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Klc1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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