Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
kinesin light chain 1
Synonyms:
Kns2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Klc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Klc1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Amyotrophic Lateral Sclerosis 4, Juvenile
Peripheral axonal degeneration, Abnormal lower motor neuron morphology, Atrophy of the spinal cor... OMIM:602433
Charcot-Marie-Tooth Disease, Dominant Intermediate B
Peripheral axonal degeneration, Segmental peripheral demyelination/remyelination, Onion bulb form... OMIM:606482
Charcot-Marie-Tooth Disease, Type 4A
Peripheral axonal degeneration, Hypertrophic nerve changes, Axonal degeneration, Decreased number... OMIM:214400
Charcot-Marie-Tooth Disease, Axonal, Type 2P
Peripheral axonal degeneration, Decreased motor nerve conduction velocity, Axonal degeneration, A... OMIM:614436
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Degeneration of anterior horn cells, Axonal degeneration, Decreased number of peripheral myelinat... OMIM:604484
Charcot-Marie-Tooth Disease, Type 4C
Peripheral axonal degeneration, Abnormal cranial nerve morphology, Decreased number of large peri... OMIM:601596
Charcot-Marie-Tooth Disease Type 2B1
Axonal loss, Sensory axonal neuropathy, Decreased number of large peripheral myelinated nerve fib... ORPHA:98856
Charcot-Marie-Tooth Disease, Axonal, Type 2S
Axonal degeneration OMIM:616155
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Global brain atrophy, Neurofibrillary tangles, Amyotrophic lateral sclerosis OMIM:619132
Neuropathy, Hereditary Sensory And Autonomic, Adult-Onset, With Anosmia
Peripheral axonal degeneration, Axonal degeneration, Decreased number of peripheral myelinated ne... OMIM:608720
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1
Peripheral axonal degeneration, Cerebellar atrophy, Onion bulb formation, Axonal degeneration, De... OMIM:302800
Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Peripheral axonal degeneration, Cerebral atrophy, Peripheral demyelination, Axonal degeneration, ... OMIM:604168
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23
Axonal degeneration, Decreased nerve conduction velocity OMIM:618138
Charcot-Marie-Tooth Disease, Axonal, Type 2R
Peripheral axonal neuropathy, Axonal degeneration, Decreased number of peripheral myelinated nerv... OMIM:615490
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Cerebral atrophy, Cerebellar atrophy, Axonal degeneration, Neurodegeneration OMIM:615157
Amyotrophy, Hereditary Neuralgic
Peripheral axonal degeneration, Axonal degeneration OMIM:162100
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1
Peripheral axonal degeneration, Degeneration of anterior horn cells, Axonal degeneration, Decreas... OMIM:604320
Early-onset Alzheimer disease with cerebral amyloid angiopathy
Neurofibrillary tangles, Senile plaques DECIPHER:48
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Peripheral axonal degeneration, Decreased number of large peripheral myelinated nerve fibers, Cer... OMIM:208920
Mitochondrial Dna Depletion Syndrome 18
Axonal degeneration OMIM:618811
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion Pathology
Neurofibrillary tangles, Senile plaques OMIM:605055
Alzheimer Disease 9, Susceptibility To
Hippocampal atrophy, Neurofibrillary tangles, Cerebral cortical atrophy, Senile plaques OMIM:608907
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Axonal degeneration, Abnormal sensory nerve conduction velocity, Abnormality of the spinal cord, ... ORPHA:88628
Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia
Lewy bodies, Amyotrophic lateral sclerosis OMIM:619133
Combined Oxidative Phosphorylation Deficiency 29
Cerebellar atrophy, Global brain atrophy, Optic neuropathy, Axonal degeneration, Optic atrophy OMIM:616811
Alzheimer Disease 2
Long-tract signs, Neurofibrillary tangles OMIM:104310
Combined Oxidative Phosphorylation Defect Type 29
Global brain atrophy, Optic neuropathy, Axonal degeneration, Neurodegeneration, Diffuse cerebella... ORPHA:478029
Alzheimer Disease, Familial, 1
Long-tract signs, Neurofibrillary tangles OMIM:104300
Adrenomyeloneuropathy
Peripheral axonal degeneration, Atrophy of the spinal cord, Dorsal column degeneration, Axonal de... ORPHA:139399
Angioedema, Hereditary, 1
Peripheral axonal neuropathy, Axonal degeneration OMIM:106100
Alzheimer Disease 4
Neurofibrillary tangles, Cerebral amyloid angiopathy, Senile plaques OMIM:606889
De Sanctis-Cacchione Syndrome
Global brain atrophy, Cerebral atrophy, Axonal degeneration, Optic atrophy OMIM:278800
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Neuronal loss in central nervous system, Lewy bodies, Cerebral cortical atrophy, Neurofibrillary ... OMIM:607485
Cerebrotendinous Xanthomatosis
Cerebellar atrophy, Global brain atrophy, Optic neuropathy, Axonal degeneration, Decreased nerve ... ORPHA:909
Parkinson Disease 23, Autosomal Recessive Early-Onset
Neurofibrillary tangles, Lewy bodies, Cerebral cortical atrophy OMIM:616840
Kanzaki Disease
Cerebral atrophy, Peripheral axonal neuropathy, Axonal degeneration OMIM:609242
Neurodegeneration With Brain Iron Accumulation 2B
Cerebral atrophy, Cerebellar atrophy, Neurofibrillary tangles, Lewy bodies, Neurodegeneration, Op... OMIM:610217
Neurodegeneration With Brain Iron Accumulation 4
Abnormal lower motor neuron morphology, Cerebellar atrophy, Lewy bodies, Neurodegeneration, Optic... OMIM:614298
Alzheimer Disease 3
Neurofibrillary tangles, Cerebral cortical atrophy OMIM:607822
Idiopathic Camptocormia
Cerebral atrophy, Syringomyelia, Lewy bodies, Myelitis, Amyotrophic lateral sclerosis ORPHA:1320
Early-Onset Autosomal Dominant Alzheimer Disease
Neurofibrillary tangles, Cerebral cortical atrophy ORPHA:1020
Niemann-Pick Disease, Type C1
Neuronal loss in central nervous system, Neurofibrillary tangles OMIM:257220
Gerstmann-Straussler Disease
Neurofibrillary tangles, Cerebellar atrophy OMIM:137440
Dementia, Lewy Body
Lewy bodies OMIM:127750
Parkinson Disease, Late-Onset
Neuronal loss in central nervous system, Lewy bodies OMIM:168600
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:117300
Primary Progressive Freezing Gait
Lewy bodies, Cerebral cortical atrophy ORPHA:75567
Supranuclear Palsy, Progressive, 2
Neuronal loss in central nervous system, Neurofibrillary tangles, Granulovacuolar degeneration OMIM:609454
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
Lewy bodies OMIM:614251
Parkinson Disease 21
Lewy bodies OMIM:616361
Supranuclear Palsy, Progressive, 1
Neuronal loss in central nervous system, Neurofibrillary tangles, Granulovacuolar degeneration OMIM:601104
Adult-Onset Dystonia-Parkinsonism
Neurofibrillary tangles, Frontotemporal cerebral atrophy, Generalized cerebral atrophy/hypoplasia ORPHA:199351
Parkinson Disease 4, Autosomal Dominant
Lewy bodies OMIM:605543
Niemann-Pick Disease, Type C2
Neurofibrillary tangles OMIM:607625
Parkinson Disease 8, Autosomal Dominant
Lewy bodies OMIM:607060
Waisman Syndrome
Lewy bodies OMIM:311510
Hereditary Late-Onset Parkinson Disease
Lewy bodies, Cerebral cortical atrophy ORPHA:411602
Early-Onset Lafora Body Disease
Lafora bodies ORPHA:324290
Parkinson Disease 1, Autosomal Dominant
Lewy bodies OMIM:168601
Parkinsonian-Pyramidal Syndrome
Lewy bodies ORPHA:171695
Lafora Disease
Brain atrophy, Lafora bodies ORPHA:501
Epilepsy, Progressive Myoclonic, 10
Lafora bodies OMIM:616640
Myoclonic Epilepsy Of Lafora
Lafora bodies OMIM:254780

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Klc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Klc1.

No publications found that use IMPC mice or data for Klc1.

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MGI Allele Allele Type Produced
Klc1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Klc1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Klc1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Klc1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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