Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
kinesin light chain 1
Synonyms:
Kns2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Klc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Klc1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Charcot-Marie-Tooth Disease, Dominant Intermediate B
Axonal degeneration, Decreased number of peripheral myelinated nerve fibers, Peripheral axonal de... OMIM:606482
Amyotrophic Lateral Sclerosis 4, Juvenile
Axonal degeneration, Pallor of dorsal columns of the spinal cord, Atrophy of the spinal cord, Dif... OMIM:602433
Charcot-Marie-Tooth Disease, Type 4A
Axonal degeneration, Hypertrophic nerve changes, Basal lamina onion bulb formation, Decreased num... OMIM:214400
Neuropathy, Hereditary Motor And Sensory, Okinawa Type
Degeneration of anterior horn cells, Decreased number of peripheral myelinated nerve fibers, Axon... OMIM:604484
Charcot-Marie-Tooth Disease, Axonal, Type 2P
Peripheral axonal degeneration, Axonal degeneration/regeneration, Axonal degeneration OMIM:614436
Charcot-Marie-Tooth Disease, Type 4C
Axonal degeneration, Abnormal cranial nerve morphology, Facial palsy, Basal lamina onion bulb for... OMIM:601596
Charcot-Marie-Tooth Disease Type 2B1
Axonal degeneration, Sensory axonal neuropathy, Decreased number of peripheral myelinated nerve f... ORPHA:98856
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Global brain atrophy, Amyotrophic lateral sclerosis, Neurofibrillary tangles OMIM:619132
Charcot-Marie-Tooth Disease, Axonal, Type 2S
Axonal degeneration OMIM:616155
Charcot-Marie-Tooth Disease, X-Linked Dominant, 1
Axonal degeneration, Cerebellar atrophy, Decreased number of peripheral myelinated nerve fibers, ... OMIM:302800
Congenital Cataracts, Facial Dysmorphism, And Neuropathy
Cerebral atrophy, Peripheral hypomyelination, Axonal degeneration, Peripheral axonal degeneration... OMIM:604168
Amyotrophy, Hereditary Neuralgic
Peripheral axonal degeneration, Axonal degeneration OMIM:162100
Charcot-Marie-Tooth Disease, Axonal, Type 2R
Peripheral axonal neuropathy, Decreased number of peripheral myelinated nerve fibers, Axonal dege... OMIM:615490
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 6
Peripheral axonal neuropathy, Axonal degeneration OMIM:620011
Early-onset Alzheimer disease with cerebral amyloid angiopathy
Senile plaques, Neurofibrillary tangles DECIPHER:48
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 1
Degeneration of anterior horn cells, Peripheral axonal degeneration, Axonal degeneration OMIM:604320
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 23
Axonal degeneration OMIM:618138
Mitochondrial Dna Depletion Syndrome 18
Axonal degeneration OMIM:618811
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Peripheral axonal degeneration, Cerebellar atrophy, Decreased number of large peripheral myelinat... OMIM:208920
Alzheimer Disease 9, Susceptibility To
Cerebral cortical atrophy, Hippocampal atrophy, Senile plaques, Neurofibrillary tangles OMIM:608907
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion Pathology
Senile plaques, Neurofibrillary tangles OMIM:605055
Amyotrophic Lateral Sclerosis 26 With Or Without Frontotemporal Dementia
Lewy bodies, Amyotrophic lateral sclerosis OMIM:619133
Combined Oxidative Phosphorylation Deficiency 29
Optic atrophy, Global brain atrophy, Axonal degeneration, Cerebellar atrophy, Optic neuropathy OMIM:616811
Combined Oxidative Phosphorylation Defect Type 29
Global brain atrophy, Axonal degeneration, Optic neuropathy, Diffuse cerebellar atrophy, Neurodeg... ORPHA:478029
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Abnormal spinal cord morphology, Abnormal peripheral nerve morphology by anatomical site, Axonal ... ORPHA:88628
Adrenomyeloneuropathy
Axonal degeneration, Dorsal column degeneration, Atrophy of the spinal cord, Atrophy/Degeneration... ORPHA:139399
Angioedema, Hereditary, 1
Peripheral axonal neuropathy, Axonal degeneration OMIM:106100
Alzheimer Disease 4
Senile plaques, Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:606889
De Sanctis-Cacchione Syndrome
Optic atrophy, Global brain atrophy, Cerebral atrophy, Axonal degeneration OMIM:278800
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Cerebral cortical atrophy, Neuronal loss in central nervous system, Neurofibrillary tangles, Lewy... OMIM:607485
Parkinson Disease 23, Autosomal Recessive Early-Onset
Cerebral cortical atrophy, Neurofibrillary tangles, Lewy bodies OMIM:616840
Cerebrotendinous Xanthomatosis
Optic atrophy, Global brain atrophy, Axonal degeneration, Cerebellar atrophy, Optic neuropathy, M... ORPHA:909
Neurodegeneration With Brain Iron Accumulation 2B
Optic atrophy, Cerebral atrophy, Cerebellar atrophy, Lewy bodies, Neurofibrillary tangles, Neurod... OMIM:610217
Alzheimer Disease 2
Neurofibrillary tangles OMIM:104310
Kanzaki Disease
Cerebral atrophy, Peripheral axonal neuropathy, Axonal degeneration OMIM:609242
Neurodegeneration With Brain Iron Accumulation 4
Optic atrophy, Cerebellar atrophy, Lewy bodies, Motor axonal neuropathy, Abnormal lower motor neu... OMIM:614298
Alzheimer Disease, Familial, 1
Neurofibrillary tangles OMIM:104300
Alzheimer Disease 3
Cerebral cortical atrophy, Neurofibrillary tangles OMIM:607822
Idiopathic Camptocormia
Cerebral atrophy, Syringomyelia, Myelitis, Lewy bodies, Amyotrophic lateral sclerosis ORPHA:1320
Early-Onset Autosomal Dominant Alzheimer Disease
Cerebral cortical atrophy, Neurofibrillary tangles ORPHA:1020
Niemann-Pick Disease, Type C1
Neuronal loss in central nervous system, Neurofibrillary tangles OMIM:257220
Gerstmann-Straussler Disease
Cerebellar atrophy, Neurofibrillary tangles OMIM:137440
Spongiform Encephalopathy With Neuropsychiatric Features
Neurofibrillary tangles OMIM:606688
Dementia, Lewy Body
Lewy bodies OMIM:127750
Supranuclear Palsy, Progressive, 1
Cerebral atrophy, Senile plaques, Neuronal loss in central nervous system, Granulovacuolar degene... OMIM:601104
Parkinson Disease, Late-Onset
Lewy bodies, Neuronal loss in central nervous system OMIM:168600
Cerebral Amyloid Angiopathy, Itm2B-Related, 2
Neurofibrillary tangles, Cerebral amyloid angiopathy OMIM:117300
Supranuclear Palsy, Progressive, 2
Neuronal loss in central nervous system, Granulovacuolar degeneration, Neurofibrillary tangles OMIM:609454
Primary Progressive Freezing Gait
Cerebral cortical atrophy, Lewy bodies ORPHA:75567
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
Lewy bodies OMIM:614251
Parkinson Disease 21
Lewy bodies OMIM:616361
Adult-Onset Dystonia-Parkinsonism
Frontotemporal cerebral atrophy, Generalized cerebral atrophy/hypoplasia, Neurofibrillary tangles ORPHA:199351
Parkinson Disease 1, Autosomal Dominant
Lewy bodies, Global brain atrophy OMIM:168601
Parkinson Disease 4, Autosomal Dominant
Lewy bodies OMIM:605543
Parkinson Disease 2, Autosomal Recessive Juvenile
Cerebral atrophy, Lewy bodies OMIM:600116
Parkinson Disease 8, Autosomal Dominant
Lewy bodies OMIM:607060
Niemann-Pick Disease, Type C2
Neurofibrillary tangles OMIM:607625
Waisman Syndrome
Lewy bodies OMIM:311510
Hereditary Late-Onset Parkinson Disease
Cerebral cortical atrophy, Lewy bodies ORPHA:411602
Early-Onset Lafora Body Disease
Lafora bodies ORPHA:324290
Parkinsonian-Pyramidal Syndrome
Lewy bodies ORPHA:171695
Lafora Disease
Lafora bodies, Brain atrophy ORPHA:501
Epilepsy, Progressive Myoclonic, 10
Lafora bodies OMIM:616640
Myoclonic Epilepsy Of Lafora 1
Lafora bodies OMIM:254780

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Klc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Klc1.

No publications found that use IMPC mice or data for Klc1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Klc1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Klc1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Klc1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Klc1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice

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