Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased circulating cholesterol level | Dync1i2tm1a(EUCOMM)Wtsi | HET | Early adult | 8.40×10-05 | ||
decreased circulating HDL cholesterol level | Dync1i2tm1a(EUCOMM)Wtsi | HET | Early adult | 2.81×10-06 | ||
increased leukocyte cell number | Dync1i2tm1a(EUCOMM)Wtsi | HET | Early adult | 8.00×10-06 | ||
decreased total body fat amount | Dync1i2tm1a(EUCOMM)Wtsi | HET | Early adult | 3.42×10-09 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Dync1i2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Neurodevelopmental Disorder With Microcephaly And Structural Brain Anomalies | Inability to walk | OMIM:618492 |
The table below shows human diseases predicted to be associated to Dync1i2 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dync1i2.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Dync1i2tm1a(EUCOMM)Wtsi | PMC7263671 |
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. | Nature communications (August 2019) | Dync1i2tm1a(EUCOMM)Wtsi | PMC6671969 |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. | PLoS biology (April 2019) | Dync1i2tm1a(EUCOMM)Wtsi | PMC6459510 |
WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. | Proceedings of the National Academy of Sciences of the United States of America (October 2017) | Dync1i2tm1a(EUCOMM)Wtsi | PMC5676932 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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MGI Allele | Allele Type | Produced |
---|---|---|
Dync1i2tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Dync1i2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
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