Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased circulating sodium level | Myo7btm1b(EUCOMM)Hmgu | HOM | Early adult | 3.65×10-14 | ||
decreased circulating glucose level | Myo7btm1b(EUCOMM)Hmgu | HOM | Early adult | 7.26×10-05 | ||
increased circulating chloride level | Myo7btm1b(EUCOMM)Hmgu | HOM | Early adult | 1.17×10-07 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | N/A | heterozygote | 0.0% (0 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 2) |
Bone | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brainstem | N/A | heterozygote | 0.0% (0 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
Epididymis | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Hippocampus | N/A | heterozygote | 0.0% (0 of 2) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 2) |
Kidney | N/A | heterozygote | 100% (2 of 2) |
Large intestine | N/A | heterozygote | 100% (2 of 2) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Main olfactory bulb | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 50% (1 of 2) |
Oviduct | N/A | heterozygote | 0.0% (0 of 2) |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | Not available |
Quadriceps | N/A | heterozygote | 0.0% (0 of 2) |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Small intestine | N/A | heterozygote | 100% (2 of 2) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Spleen | N/A | heterozygote | 0.0% (0 of 2) |
Stomach | N/A | heterozygote | 0.0% (0 of 2) |
Striatum | N/A | heterozygote | 0.0% (0 of 2) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 2) |
Testis | N/A | heterozygote | 50% (1 of 2) |
Thalamus | N/A | heterozygote | 0.0% (0 of 2) |
Thymus | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Trachea | N/A | heterozygote | 0.0% (0 of 2) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 2) |
Uterus | N/A | heterozygote | 50% (1 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | homozygote | 0.0% (0 of 1) |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 2) |
Dorsal root ganglion | N/A | homozygote | 0.0% (0 of 1) |
Ear | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | homozygote | 0.0% (0 of 1) |
Embryo | N/A | heterozygote | 0.0% (0 of 2) |
Embryo | N/A | homozygote | 0.0% (0 of 1) |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | homozygote | 0.0% (0 of 1) |
Footplate | N/A | heterozygote | 0.0% (0 of 2) |
Footplate | N/A | homozygote | 0.0% (0 of 1) |
Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
Forebrain | N/A | homozygote | 0.0% (0 of 1) |
Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
Forelimb | N/A | homozygote | 0.0% (0 of 1) |
Fronto-nasal process | N/A | heterozygote | 0.0% (0 of 2) |
Fronto-nasal process | N/A | homozygote | 0.0% (0 of 1) |
Handplate | N/A | heterozygote | 0.0% (0 of 2) |
Handplate | N/A | homozygote | 0.0% (0 of 1) |
Head | N/A | heterozygote | 0.0% (0 of 2) |
Head | N/A | homozygote | 0.0% (0 of 1) |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | homozygote | 0.0% (0 of 1) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
Hindbrain | N/A | homozygote | 0.0% (0 of 1) |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Hindlimb | N/A | homozygote | 0.0% (0 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | homozygote | 0.0% (0 of 1) |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | homozygote | 0.0% (0 of 1) |
Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
Mandibular process | N/A | homozygote | 0.0% (0 of 1) |
Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
Maxillary process | N/A | homozygote | 0.0% (0 of 1) |
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | homozygote | 0.0% (0 of 1) |
Nose | N/A | heterozygote | 0.0% (0 of 2) |
Nose | N/A | homozygote | 0.0% (0 of 1) |
Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | homozygote | 0.0% (0 of 1) |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | homozygote | 0.0% (0 of 1) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
Spinal cord | N/A | homozygote | 0.0% (0 of 1) |
Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | homozygote | 0.0% (0 of 1) |
Tail | N/A | heterozygote | 0.0% (0 of 2) |
Tail | N/A | homozygote | 0.0% (0 of 1) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
bone | 0.0% |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
main olfactory bulb | 0.0% |
mammary gland | 0.0% |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thalamus | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
urinary bladder | |
uterus | 0.0% |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 0.0% |
dorsal root ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
fronto-nasal process | Ambiguous |
handplate | 0.0% |
head | 0.0% |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
midbrain | 0.0% |
nose | Ambiguous |
oral cavity | 0.0% |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Myo7b by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Myo7b
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myo7b.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
The small EF-hand protein CALML4 functions as a critical myosin light chain within the intermicrovillar adhesion complex. | The Journal of biological chemistry (March 2020) | Myo7btm1b(EUCOMM)Hmgu | PMC7363140 |
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. | PloS one (July 2017) | Myo7btm1b(EUCOMM)Hmgu | PMC5503261 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Myo7btm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Myo7btm1b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | Mice |
Myo7btm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter