Rgl1 | ral guanine nucleotide dissociation stimulator,-like 1

GeneMGI:107484Synonyms: Rgl

Physiological systems

22 / 24 physiological systems tested

16 Significantly impacted by the knock-out

 Reproductive system Immune system Growth/size/body region Digestive/alimentary Hematopoietic system Craniofacial Cardiovascular system Renal/urinary system Homeostasis/metabolism Embryo Limbs/digits/tail Nervous system Vision/eye Liver/biliary system Behavior/neurological Mortality/aging

6 No significant impact

2 Not tested

Gene metrics:32Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

enlarged spleen2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adultN/A * 
cleft palate1 supporting datasetRgl1em1(IMPC)MbphomozygoteE15.5N/A * 
small liver2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adultN/A * 
decreased prepulse inhibition2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adult5.09x10-7 
enlarged lymph nodes2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal lymph node morphology2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adultN/A * 
abnormal midbrain development1 supporting datasetRgl1em1(IMPC)MbphomozygoteE9.5N/A * 
embryonic growth retardation1 supporting datasetRgl1em1(IMPC)MbphomozygoteE15.5N/A * 
increased neutrophil cell number2 supporting datasetsRgl1em1(IMPC)MbpheterozygoteEarly adult3.04x10-6 
edema1 supporting datasetRgl1em1(IMPC)MbphomozygoteE15.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rgl1em1(IMPC)MbpExon Deletionmouse
Rgl1tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Rgl1tm1e(KOMP)MbpTargeted, non-conditional allelees cell
Rgl1tm2a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Rgl1tm2e(KOMP)MbpTargeted, non-conditional allelees cell
Rgl1tm41618(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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