Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

myeloid zinc finger 1
Zfp98,  Znf42,  Mzf2,  Zfp121

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mzf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Mzf1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neutropenia, Severe Congenital, 5, Autosomal Recessive
Hepatomegaly, Neutropenia, Leukopenia, Anemia, Splenomegaly, Extramedullary hematopoiesis, Thromb... OMIM:615285
Acute Erythroid Leukemia
Leukopenia, Anemia, Bone marrow hypocellularity, Erythroid hypoplasia, Pancytopenia, Refractory a... ORPHA:318
Monosomy 7 Myelodysplasia And Leukemia Syndrome 2
Myelodysplasia, Increased mean corpuscular volume, Neutropenia, Anemia, Bone marrow hypocellulari... OMIM:619041
Myeloproliferative/Lymphoproliferative Neoplasms, Familial (Multiple Types), Susceptibility To
Myelodysplasia, Leukopenia, Monocytosis, Refractory anemia, Bone marrow hypocellularity, Lymphoma... OMIM:616871
Primary Myelofibrosis
Hepatomegaly, Leukocytosis, Thrombocytosis, Hemangioma, Lymphadenopathy, Anemia, Splenomegaly, He... ORPHA:824
Leukocyte Adhesion Deficiency, Type Iii
Hepatomegaly, Leukocytosis, Anemia, Abnormality of the lymph nodes, Splenomegaly, Hepatosplenomeg... OMIM:612840
Bone Marrow Failure Syndrome 1
Pancytopenia, Aplastic anemia, Myelodysplasia, Bone marrow hypocellularity OMIM:614675
Refractory Anemia
Macrocytic anemia, Normocytic anemia, Myelodysplasia, Neutropenia, Normochromic anemia, Bone marr... ORPHA:98826
Unclassified Myelodysplastic Syndrome
Leukocytosis, Myelodysplasia, Bone marrow hypocellularity, Multiple lineage myelodysplasia, Acute... ORPHA:98827
Myelodysplastic Syndrome Associated With Isolated Del(5Q) Chromosome Abnormality
Thrombocytosis, Macrocytic anemia, Myelodysplasia, Leukopenia, Bone marrow hypocellularity, Multi... ORPHA:86841
Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 2
Pancytopenia, Leukemia, Bone marrow hypocellularity, Cirrhosis, Myeloid leukemia, Aplastic anemia OMIM:614743
Acquired Idiopathic Sideroblastic Anemia
Hepatomegaly, Anemia of inadequate production, Leukocytosis, Neutropenia, Myelodysplasia, Normocy... ORPHA:75564
Dyskeratosis Congenita, Autosomal Recessive 3
Pancytopenia, Squamous cell carcinoma, Bone marrow hypocellularity OMIM:613988
Bone Marrow Failure Syndrome 2
Bone marrow hypocellularity, Anemia, Thrombocytopenia, Leukopenia OMIM:615715
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Beta-Thalassemia Intermedia
Hepatomegaly, Leukocytosis, Elevated hepatic iron concentration, Hepatocellular carcinoma, Erythr... ORPHA:231222
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Hereditary Spherocytosis
Hepatomegaly, Anemia, Cholelithiasis, Splenomegaly, Extramedullary hematopoiesis, Increased mean ... ORPHA:822
Osteopetrosis, Autosomal Recessive 2
Anemia, Hepatosplenomegaly, Extramedullary hematopoiesis, Pancytopenia, Thrombocytopenia OMIM:259710
Fanconi Anemia, Complementation Group T
Pancytopenia, Thrombocytopenia, Anemia, Bone marrow hypocellularity OMIM:616435
Osteopetrosis, Autosomal Recessive 5
Hepatomegaly, Anemia, Decreased osteoclast count, Splenomegaly, Extramedullary hematopoiesis, Hep... OMIM:259720
Aplastic Anemia
Aplastic anemia, Bone marrow hypocellularity OMIM:609135
Dominant Beta-Thalassemia
Hepatic fibrosis, Hepatocellular carcinoma, Hypochromic microcytic anemia, Splenomegaly, Cirrhosi... ORPHA:231226
Congenital Bile Acid Synthesis Defect Type 2
Abnormality of the intrahepatic bile duct, Hepatomegaly, Giant cell hepatitis, Elevated hepatic t... ORPHA:79303
Beta-Thalassemia Major
Hepatomegaly, Anisopoikilocytosis, Hepatic fibrosis, Hepatocellular carcinoma, Hypochromic microc... ORPHA:231214
Bone Marrow Failure Syndrome 6
Neutropenia, Increased mean corpuscular volume, Anemia, Bone marrow hypocellularity, Squamous cel... OMIM:618849
Amed Syndrome, Digenic
Myelodysplasia, Leukopenia, Anemia, Bone marrow hypocellularity, Acute myeloid leukemia, Thromboc... OMIM:619151
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cell carcinom... ORPHA:443167
Fanconi Anemia, Complementation Group D1
T-cell acute lymphoblastic leukemias, Acute myeloid leukemia, Bone marrow hypocellularity OMIM:605724
Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 1
Myelodysplasia, Pancytopenia, Mediastinal lymphadenopathy, Bone marrow hypocellularity, Anemia, C... OMIM:614742
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Dyskeratosis Congenita, Autosomal Recessive 2
Cirrhosis, Thrombocytopenia, Bone marrow hypocellularity, Pancytopenia OMIM:613987
Fgfr2-Related Bent Bone Dysplasia
Hepatosplenomegaly, Extramedullary hematopoiesis ORPHA:313855
Fanconi Anemia, Complementation Group V
Anemia, Thrombocytopenia, Neutropenia, Bone marrow hypocellularity OMIM:617243
Osteopetrosis, Autosomal Recessive 3
Hepatosplenomegaly, Anemia, Extramedullary hematopoiesis OMIM:259730
Deafness-Lymphedema-Leukemia Syndrome
Leukocytosis, Hepatomegaly, Acute leukemia, Lymphadenopathy, Bone marrow hypocellularity, Splenom... ORPHA:3226
Acute Panmyelosis With Myelofibrosis
Acute myelomonocytic leukemia, Bone marrow hypocellularity, Splenomegaly, Acute myeloid leukemia,... ORPHA:86843
Bone Marrow Failure Syndrome 4
Thrombocytopenia, Anemia, Bone marrow hypocellularity, Leukopenia OMIM:618116
Refractory Anemia With Excess Blasts
Leukocytosis, Abnormal mean corpuscular volume, Bone marrow hypocellularity, Multiple lineage mye... ORPHA:86839
Muir-Torre Syndrome
Sebaceous gland carcinoma, Malignant genitourinary tract tumor, Benign gastrointestinal tract tum... OMIM:158320
Classic Hodgkin Lymphoma
Hepatomegaly, Lymphadenopathy, Bone marrow hypocellularity, Neoplasm, Lymphoma, Splenomegaly ORPHA:391
Ghosal Hematodiaphyseal Dysplasia
Refractory anemia, Bone marrow hypocellularity, Thrombocytopenia, Leukopenia OMIM:231095
Pulmonary Fibrosis-Hepatic Hyperplasia-Bone Marrow Hypoplasia Syndrome
Bone marrow hypocellularity, Nodular regenerative hyperplasia of liver, Hepatosplenomegaly, Abnor... ORPHA:210136
Pulmonary Fibrosis And/Or Bone Marrow Failure, Telomere-Related, 5
Bone marrow hypocellularity OMIM:618674
Idiopathic Aplastic Anemia
Neutropenia, Anemia, Bone marrow hypocellularity, Reticulocytopenia, Pancytopenia, Thrombocytopenia ORPHA:88
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Isovaleric Acidemia
Pancytopenia, Thrombocytopenia, Bone marrow hypocellularity, Leukopenia OMIM:243500
Greenberg Dysplasia
Hepatomegaly, Hepatic calcification, Bone marrow hypocellularity, Hepatosplenomegaly, Extramedull... OMIM:215140
Familial Adenomatous Polyposis 1
Adrenocortical carcinoma, Osteoma, Astrocytoma, Adrenocortical adenoma, Adenomatous colonic polyp... OMIM:175100
Diamond-Blackfan Anemia 11
Anemia, Neutropenia, Bone marrow hypocellularity, Anemia of inadequate production OMIM:614900
Colorectal Cancer, Susceptibility To, 10
Endometrial carcinoma, Colorectal polyposis, Carcinoma OMIM:612591
Dyskeratosis Congenita, Autosomal Dominant 1
Myelodysplasia, Bone marrow hypocellularity, Squamous cell carcinoma of the skin, Anemia, Cirrhos... OMIM:127550
Griscelli Syndrome
Hepatomegaly, Leukopenia, Lymphadenopathy, Hepatitis, Bone marrow hypocellularity, Splenomegaly, ... ORPHA:381
Autoimmune Lymphoproliferative Syndrome
Neoplasm of the skin, Thyroid carcinoma, Elevated proportion of CD4-negative, CD8-negative, alpha... ORPHA:3261
Felty Syndrome
Hepatomegaly, Neutropenia, Lymphadenopathy, Abnormal lymphocyte morphology, Bone marrow hypocellu... ORPHA:47612
Fanconi Anemia, Complementation Group J
Bone marrow hypocellularity OMIM:609054
Aregenerative Anemia
Neutropenia, Abnormal proportion of CD8-positive T cells, Lymphadenopathy, Bone marrow hypocellul... ORPHA:101096
Fanconi Anemia, Complementation Group Q
Biliary atresia, Bone marrow hypocellularity OMIM:615272
Familial Adenomatous Polyposis
Neoplasm of the gallbladder, Astrocytoma, Neoplasm of the adrenal gland, Cholangiocarcinoma, Aden... ORPHA:733
Adult-Onset Still Disease
Hepatomegaly, Leukocytosis, Hepatitis, Bone marrow hypocellularity, Splenomegaly, Neutrophilia, G... ORPHA:829
Tarp Syndrome
Extramedullary hematopoiesis ORPHA:2886
X-Linked Lymphoproliferative Disease
Lymphadenopathy, Splenomegaly, Absent natural killer cells, Hepatosplenomegaly, Lymphocytosis, Pa... ORPHA:2442
Hoyeraal-Hreidarsson Syndrome
Anemia, Bone marrow hypocellularity, Neoplasm, Thrombocytopenia, Abnormal leukocyte morphology ORPHA:3322
Turcot Syndrome With Polyposis
Astrocytoma, Thyroid carcinoma, Adenomatous colonic polyposis, Leukemia, Brain neoplasm, Basal ce... ORPHA:99818
Dyskeratosis Congenita, Autosomal Dominant 6
Pancytopenia, Aplastic anemia, Bone marrow hypocellularity OMIM:616553
Dyskeratosis Congenita, Autosomal Recessive 5
Bone marrow hypocellularity, Leukopenia OMIM:615190
Dyskeratosis Congenita, Autosomal Dominant 2
Leukopenia, Bone marrow hypocellularity, Pancytopenia, Thrombocytopenia, Aplastic anemia OMIM:613989
Encephalomyopathy, Mitochondrial, Due To Voltage-Dependent Anion Channel Deficiency
Anemia, Thrombocytopenia, Neutropenia, Bone marrow hypocellularity OMIM:614520
Congenital Progressive Bone Marrow Failure-B-Cell Immunodeficiency-Skeletal Dysplasia Syndrome
B lymphocytopenia, Myelodysplasia, Neutropenia, Leukopenia, Bone marrow hypocellularity, Anemia, ... ORPHA:508542
Abnormal CD4:CD8 ratio, Neutropenia, Abnormal proportion of CD8-positive T cells, Leukopenia, Neu... ORPHA:443811
Shwachman-Diamond Syndrome
Chronic neutropenia, Hepatomegaly, Macrocytic anemia, Myelodysplasia, Neutropenia, Pancytopenia, ... ORPHA:811
Schimke Immuno-Osseous Dysplasia
Decreased proportion of naive CD8 T cells, Neutropenia, Lymphoproliferative disorder, Bone marrow... ORPHA:1830
Osteopetrosis, Autosomal Dominant 2
Bone marrow hypocellularity OMIM:166600
Fanconi Anemia, Complementation Group C
Neutropenia, Leukemia, Bone marrow hypocellularity, Anemia, Reticulocytopenia, Pancytopenia, Thro... OMIM:227645
Mucopolysaccharidosis-Plus Syndrome
Hepatomegaly, Neutropenia, Leukopenia, Bone marrow hypocellularity, Anemia, Splenomegaly, Macrove... OMIM:617303
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Hepatomegaly, Leukocytosis, Thrombocytosis, Pancytopenia, Leukopenia, Lymphoproliferative disorde... OMIM:615688
Legionnaires Disease
Lymphadenopathy, Hepatitis, Bone marrow hypocellularity, Splenomegaly, Lymphopenia, Jaundice ORPHA:549
3-Methylglutaconic Aciduria Type 7
Neutropenia, Bone marrow hypocellularity, Hepatic steatosis, Elevated hepatic transaminase, Infec... ORPHA:445038
Bone Marrow Failure Syndrome 3
Pancytopenia, Acute myeloid leukemia, Aplastic anemia, Bone marrow hypocellularity OMIM:617052
Fanconi Anemia, Complementation Group L
Anemia, Bone marrow hypocellularity OMIM:614083
Dyskeratosis Congenita, Autosomal Dominant 3
Leukopenia, Bone marrow hypocellularity, Pancytopenia, Thrombocytopenia, Aplastic anemia OMIM:613990
Cranioectodermal Dysplasia 4
Bone marrow hypocellularity OMIM:614378
Dyskeratosis Congenita, X-Linked
Myelodysplasia, Hodgkin lymphoma, Leukopenia, Carcinoma, Bone marrow hypocellularity, Anemia, Cir... OMIM:305000
Dyskeratosis Congenita, Autosomal Recessive 1
Thrombocytopenia, Aplastic anemia, Bone marrow hypocellularity, Hepatic fibrosis OMIM:224230
Fanconi Anemia, Complementation Group I
Neutropenia, Bone marrow hypocellularity OMIM:609053
Mccune-Albright Syndrome
Benign gastrointestinal tract tumors, Hepatitis, Hepatocellular adenoma, Bone marrow hypocellular... ORPHA:562
Fanconi Anemia, Complementation Group D2
Neutropenia, Leukemia, Bone marrow hypocellularity, Anemia, Reticulocytopenia, Pancytopenia, Thro... OMIM:227646
Fanconi Anemia, Complementation Group F
Anemia, Thrombocytopenia, Bone marrow hypocellularity, Leukopenia OMIM:603467
Dyskeratosis Congenita
Hepatomegaly, Neoplasm of the pancreas, Neoplasm, Lymphoma, Splenomegaly, Cirrhosis, Bone marrow ... ORPHA:1775
Pearson Syndrome
Hepatomegaly, Neutropenia, Pancytopenia, Macronodular cirrhosis, Bone marrow hypocellularity, Ane... ORPHA:699
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Leukopenia, Anemia, Bone marrow hypocellularity, Hepatosplenomegaly, Thrombocytopenia ORPHA:505248
Revesz Syndrome
Aplastic anemia, Bone marrow hypocellularity OMIM:268130
Osteopetrosis With Renal Tubular Acidosis
Hepatomegaly, Leukopenia, Bone marrow hypocellularity, Anemia, Pancytopenia, Thrombocytopenia, El... ORPHA:2785
Cerebroretinal Microangiopathy With Calcifications And Cysts 1
Anemia, Thrombocytopenia, Bone marrow hypocellularity OMIM:612199
Camurati-Engelmann Disease
Anemia, Bone marrow hypocellularity OMIM:131300
Leukocyte Adhesion Deficiency
Leukocytosis, Thrombocytosis, Polycythemia, Bone marrow hypocellularity, Acute myeloid leukemia, ... ORPHA:2968
Jacobsen Syndrome
Thrombocytopenia, Bone marrow hypocellularity ORPHA:2308


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mzf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mzf1.

No publications found that use IMPC mice or data for Mzf1.

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