Pitx1 - paired-like homeodomain transcription factor 1 | International Mouse Phenotyping Consortium

Genes Phenotypes

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Gene: Pitx1

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Name

paired-like homeodomain transcription factor 1

MGI ID

MGI:107374

Synonyms

Bft Ptx1 P-OTX Potx

Viability

Homozygous - Lethal

Embryo viewer

N/A

Other links

MGI Ensembl

Significant phenotypes (7) Measurements chart (266) All data table (829)

Expression & images (0) Disease models (0) Order (2)

Significant

Not Significant

Not tested

View body weight measurements

Phenotype	System	Allele	Zyg	Sex	Life Stage	P Value
fused phalanges		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	9.74×10^-07
abnormal autopod morphology		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	9.74×10^-07
increased bone mineral content		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	3.19×10^-21
abnormal nail morphology		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	1.06×10^-05
abnormal digit morphology		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	2.43×10^-11
decreased circulating insulin level		Pitx1^{em1(IMPC)Wtsi}	HET		Early adult	3.87×10^-08
preweaning lethality, complete penetrance		Pitx1^{em1(IMPC)Wtsi}	HOM		Early adult	0.00

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Select physiological systems to view:

Viewing: all phenotypes

Select physiological systems to view:

Viewing: all phenotypes

Expression

Expression data not available

Associated Images

Ear epidermis immunophenotyping
12 Images

DSS Histology
8 Images

Anti-nuclear antibody assay
4 Images

Legacy Phenotype Associated Images

Pitx1^{em1(IMPC)Wtsi}
HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
WT, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
WT, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
HET, Female, WTSI

View all 65 images

Pitx1^{em1(IMPC)Wtsi}
foot digit 1, polydactyly, polysyndactyly, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
hindlimb, polydactyly, polysyndactyly, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
polydactyly, polysyndactyly, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
polysyndactyly, polydactyly, HET, Male, WTSI

Pitx1^{em1(IMPC)Wtsi}
head, abnormal snout morphology, asymmetric snout, WT, Male, WTSI

View all 18 images

Pitx1^{em1(IMPC)Wtsi}
abnormal cornea morphology, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
abnormal cornea morphology, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
abnormal placement of pupils, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
abnormal cornea morphology, HET, Female, WTSI

Pitx1^{em1(IMPC)Wtsi}
abnormal cornea morphology, HET, Male, WTSI

Pitx1^{em1(IMPC)Wtsi}
HOM, Male, WTSI

Pitx1^{em1(IMPC)Wtsi}
HOM, Male, WTSI

Disease Models

By Annotation and Orthology (0)
By phenotypic Similarity (0)

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MGI Allele	Allele Type	Produced
Pitx1^{tm208889(L1L2_Bact_P)}		Targeting vectors
Pitx1^{em1(IMPC)Wtsi}	Exdel	Mice

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