Rbfox3 | RNA binding protein, fox-1 homolog (C. elegans) 3

GeneMGI:106368Synonyms: Hrnbp3, NeuN, +2 more

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased grip strength2 supporting datasetsRbfox3tm1a(EUCOMM)HmguhomozygoteEarly adult5.11x10-6 
increased startle reflex4 supporting datasetsRbfox3tm1a(EUCOMM)HmguhomozygoteEarly adult2.49x10-5 
decreased circulating alkaline phosphatase level1 supporting datasetRbfox3tm1a(EUCOMM)HmguhomozygoteEarly adult2.23x10-7 
abnormal tail movements1 supporting datasetRbfox3tm1a(EUCOMM)HmguhomozygoteEarly adult1.01x10-5 
abnormal response to new environment1 supporting datasetRbfox3tm1a(EUCOMM)HmguhomozygoteEarly adult2.06x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rbfox3tm1(EGFP_CreERT2)WtsiReporter-tagged deletion allele (with selection cassette)ES Cell
mouse
Rbfox3tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Rbfox3tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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