Gene: Slx4

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Name
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI ID
MGI:106299
Synonyms
D16Bwg1016e Btbd12
Embryo Screen
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
corneal opacity Slx4tm1a(EUCOMM)Wtsi HOM postnatal 7.16×10-06
abnormal eyelid aperture Slx4tm1a(EUCOMM)Wtsi HOM postnatal 9.84×10-05
abnormal eye size Slx4tm1a(EUCOMM)Wtsi HOM postnatal 3.27×10-07
preweaning lethality, incomplete penetrance Slx4tm1a(EUCOMM)Wtsi HOM n/a 0.00
abnormal cranium morphology Slx4tm1a(EUCOMM)Wtsi HOM postnatal 8.53×10-06
increased bone mineral density Slx4tm1a(EUCOMM)Wtsi HET postnatal 4.11×10-05
abnormal cornea morphology Slx4tm1a(EUCOMM)Wtsi HOM postnatal 3.26×10-07
vertebral fusion Slx4tm1a(EUCOMM)Wtsi HOM postnatal 1.00×10-05
abnormal placement of pupils Slx4tm1a(EUCOMM)Wtsi HOM postnatal 1.02×10-05
abnormal eye morphology Slx4tm1a(EUCOMM)Wtsi HOM postnatal 4.88×10-05
abnormal iris morphology Slx4tm1a(EUCOMM)Wtsi HOM postnatal 6.12×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (2/584) N/A
Aorta 3 No N/A
Blood vessel 3 No N/A
Bone 3 No N/A
Brain 3 No  (3/3) N/A
Brainstem 3 No N/A
Brown adipose tissue 3 No N/A
Cartilage tissue 3 No  (2/3) N/A
Cerebellum 3 No N/A
Cerebral cortex 3 No N/A
Eye 3 No N/A
Gall bladder 3 No N/A
Heart 3 No N/A
Hippocampus 3 No N/A
Hypothalamus 3 No N/A
Kidney 3 No  (18/584)  (1/3) N/A
Large intestine 3 No  (10/584) N/A
Liver 3 No N/A
Lower urinary tract 3 No N/A
Lung 3 No N/A
Lymph node 3 No N/A
Mammary gland 3 No N/A
Esophagus 3 No N/A
Olfactory lobe 3 No N/A
Ovary 3 No  (1/584) N/A
Oviduct 3 No N/A
Pancreas 3 No  (5/584) N/A
Parathyroid gland 3 No N/A
Peripheral nervous system 3 No  (3/3) N/A
Peyer's patch 3 No N/A
Pituitary gland 3 No N/A
Prostate gland 3 No  (12/584) N/A
Skeletal muscle tissue 3 No N/A
Skin 3 No N/A
Small intestine 3 No  (9/584) N/A
Spinal cord 3 No  (3/3) N/A
Spleen 3 No  (2/584) N/A
Stomach 3 No  (12/584) N/A
Striatum 3 No N/A
Testis 3 No  (2/584)  (1/3) N/A
Thymus 3 No N/A
Thyroid gland 3 No  (15/584) N/A
Trachea 3 No  (2/3) N/A
Uterus 3 No N/A
White adipose tissue 3 No N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Slx4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells