Genes Phenotypes

Gene: Slx4

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Name
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
MGI ID
MGI:106299
Synonyms
Btbd12 D16Bwg1016e
Viability
N/A
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (11) Measurements chart (156) All data table (448)
Expression & images (45) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral density Slx4tm1a(EUCOMM)Wtsi HET Early adult 7.16×10-08
corneal opacity Slx4tm1a(EUCOMM)Wtsi HOM Early adult 9.54×10-06
anophthalmia Slx4tm1a(EUCOMM)Wtsi HOM Early adult 9.05×10-05
abnormal eyelid aperture Slx4tm1a(EUCOMM)Wtsi HOM Early adult 1.55×10-06
abnormal cornea morphology Slx4tm1a(EUCOMM)Wtsi HOM Early adult 2.91×10-08
abnormal placement of pupils Slx4tm1a(EUCOMM)Wtsi HOM Early adult 7.16×10-05
abnormal iris morphology Slx4tm1a(EUCOMM)Wtsi HOM Early adult 1.49×10-05
abnormal eye morphology Slx4tm1a(EUCOMM)Wtsi HOM Early adult 2.78×10-05
abnormal eye size Slx4tm1a(EUCOMM)Wtsi HOM Early adult 6.57×10-08
impaired pupillary reflex Slx4tm1a(EUCOMM)Wtsi HOM Early adult 4.68×10-05
decreased body weight Slx4tm1a(EUCOMM)Wtsi HET Early adult 1.37×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No  (2/584) N/A
Aorta 3 No N/A
Blood vessel 3 No N/A
Bone 3 No N/A
Brain 3 No  (3/3) N/A
Brainstem 3 No N/A
Brown adipose tissue 3 No N/A
Cartilage tissue 3 No  (2/3) N/A
Cerebellum 3 No N/A
Cerebral cortex 3 No N/A
Eye 3 No N/A
Gall bladder 3 No N/A
Heart 3 No N/A
Hippocampus 3 No N/A
Hypothalamus 3 No N/A
Kidney 3 No  (18/584)  (1/3) N/A
Large intestine 3 No  (10/584) N/A
Liver 3 No N/A
Lower urinary tract 3 No N/A
Lung 3 No N/A
Lymph node 3 No N/A
Mammary gland 3 No N/A
Esophagus 3 No N/A
Olfactory lobe 3 No N/A
Ovary 3 No  (1/584) N/A
Oviduct 3 No N/A
Pancreas 3 No  (5/584) N/A
Parathyroid gland 3 No N/A
Peripheral nervous system 3 No  (3/3) N/A
Peyer's patch 3 No N/A
Pituitary gland 3 No N/A
Prostate gland 3 No  (12/584) N/A
Skeletal muscle tissue 3 No N/A
Skin 3 No N/A
Small intestine 3 No  (9/584) N/A
Spinal cord 3 No  (3/3) N/A
Spleen 3 No  (2/584) N/A
Stomach 3 No  (12/584) N/A
Striatum 3 No N/A
Testis 3 No  (2/584)  (1/3) N/A
Thymus 3 No N/A
Thyroid gland 3 No  (15/584) N/A
Trachea 3 No  (2/3) N/A
Uterus 3 No N/A
White adipose tissue 3 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Slx4tm1a(EUCOMM)Wtsi
brain, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
brain, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
trachea, HET, Male, WTSI

View all 23 images

Slx4tm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
trachea, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
thymus, WT, Female, WTSI

View all 12 images

Slx4tm1a(EUCOMM)Wtsi
brain, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
brain, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
peripheral nervous system, HET, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
trachea, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
nasal cavity epithelium, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
trachea, thyroid gland, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
nasal cavity, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
kidney, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
skull, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
skull, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
bone, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
stomach, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
stomach body, stomach, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
trachea, thyroid gland, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
thyroid gland, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
testis, HET, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
ovary, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
nasal cavity epithelium, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
nasal cavity, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
cartilage tissue, HET, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
cartilage tissue, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
thymus, WT, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Slx4tm1a(EUCOMM)Wtsi
body, HOM, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
head, HOM, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
forearm, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
head, HOM, Male, WTSI

View all 204 images

Slx4tm1a(EUCOMM)Wtsi
eye, cornea/lens fusion, impaired pupillary reflex, abnormal placement of pupils, corneal opacity, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
eye, eyelids fail to open, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
eye, eyelids fail to open, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
eye, corneal opacity, cornea/lens fusion, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
eye, abnormal retinal pigmentation, abnormal retinal blood vessel pattern, HOM, Female, WTSI

View all 9 images

Slx4tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
back skin, WT, Female, WTSI
Slx4tm1a(EUCOMM)Wtsi
back skin, WT, Female, WTSI

View all 7 images

Slx4tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
decreased retrosplenial granular cortex size, HOM, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
decreased retrosplenial granular cortex size, HOM, Male, WTSI

View all 6 images

Slx4tm1a(EUCOMM)Wtsi
WT, Male, WTSI
Slx4tm1a(EUCOMM)Wtsi
WT, Male, WTSI

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Slx4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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