Gene: Cdc42

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cranium morphology Cdc42tm1b(EUCOMM)Hmgu HET Early adult 1.08×10-05
decreased circulating serum albumin level Cdc42tm1b(EUCOMM)Hmgu HET Early adult 3.11×10-05
preweaning lethality, complete penetrance Cdc42tm1b(EUCOMM)Hmgu HOM   Early adult 0.00
embryonic lethality prior to tooth bud stage Cdc42tm1b(EUCOMM)Hmgu HOM   E12.5 0.00
abnormal retina morphology Cdc42tm1b(EUCOMM)Hmgu HET Early adult 1.80×10-09
increased circulating aspartate transaminase level Cdc42tm1b(EUCOMM)Hmgu HET Early adult 3.89×10-05
increased lean body mass Cdc42tm1b(EUCOMM)Hmgu HET Early adult 6.55×10-05
enlarged kidney Cdc42tm1b(EUCOMM)Hmgu HET Early adult 0.00
increased circulating alkaline phosphatase level Cdc42tm1b(EUCOMM)Hmgu HET Early adult 1.76×10-05
embryonic lethality prior to organogenesis Cdc42tm1b(EUCOMM)Hmgu HOM   E9.5 0.00
short tibia Cdc42tm1b(EUCOMM)Hmgu HET   Early adult 3.59×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2)  Wholemount images
Aorta 2 No  (1/583)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Wholemount images
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583)  (2/2)  Wholemount images
Esophagus 2 No  (7/407)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583)  (2/2)  Wholemount images
Lymph node 2 No  (1/583)  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/583)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/583)  (2/2)  Wholemount images
Parathyroid gland 2 No  (1/563)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/583)  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/583)  (2/2)  Wholemount images
Prostate gland 2 No  (12/583)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/583)  (2/2)  Wholemount images
Small intestine 2 No  (9/583)  (2/2)  Wholemount images
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583)  (1/2)  Wholemount images
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583)  (2/2)  Wholemount images
Thyroid gland 2 No  (17/583)  (2/2)  Wholemount images
Trachea 2 No  (3/583)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
3  (6/505)  (3/3) N/A
3  (1/505)  (1/3) N/A
3  (1/506)  (3/3) N/A
3  (1/505)  (3/3) N/A
3  (1/505)  (1/3) N/A
3  (1/505)  (3/3) N/A
3  (1/505)  (3/3) N/A
3  (1/505)  (1/3) N/A
3  (5/505)  (3/3) N/A
3  (1/505)  (1/3) N/A
3  (6/505)  (3/3) N/A
3  (1/505)  (3/3) N/A
3  (1/503)  (1/3) N/A
3  (1/503)  (1/3) N/A
3  (1/505)  (1/3) N/A
3  (1/505)  (1/3) N/A
3  (1/505)  (3/3) N/A
3  (1/503)  (1/3) N/A
3  (1/505) N/A
3  (1/505)  (3/3) N/A
3  (1/505)  (3/3) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
25 Images
Echo: M-Mode Images
32 Images
Embryo LacZ: LacZ images wholemount
5 Images

 Disease Models

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MGI Allele Allele Type Produced
Cdc42tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Cdc42tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdc42tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdc42tm536(L1L2_gt0) Targeting vectors

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