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Gene: Atf6b MGI:105121

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Gene Summary

Name:
activating transcription factor 6 beta
Synonyms:
Creb-rp,  ATF6beta,  Crebl1

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Atf6btm1.1(KOMP)Vlcg HOM   Early adult 0.00
abnormal skin morphology Atf6btm1.1(KOMP)Vlcg HET Early adult 0.00
scaly skin Atf6btm1.1(KOMP)Vlcg HET Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 50% (1 of 2)
Aorta N/A heterozygote 100% (2 of 2)
Blood N/A heterozygote Not available
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 50% (1 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 50% (1 of 2)
Cerebellum N/A heterozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 100% (2 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 100% (2 of 2)
Epididymis N/A heterozygote 50% (1 of 2)
Esophagus N/A heterozygote 100% (2 of 2)
Eye N/A heterozygote 100% (2 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 100% (2 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Ileum N/A heterozygote 100% (2 of 2)
Jejunum N/A heterozygote 100% (2 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 100% (2 of 2)
Liver N/A heterozygote 50% (1 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 100% (2 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 50% (1 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 100% (2 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Ovary N/A heterozygote 50% (1 of 2)
Oviduct N/A heterozygote 50% (1 of 2)
Pancreas N/A heterozygote 100% (2 of 2)
Parathyroid gland N/A heterozygote 50% (1 of 2)
Parotid gland N/A heterozygote 100% (2 of 2)
Penis N/A heterozygote 50% (1 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 100% (2 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Quadriceps N/A heterozygote 50% (1 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 100% (2 of 2)
Small intestine N/A heterozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (2 of 2)
Spleen N/A heterozygote 50% (1 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 100% (2 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 100% (2 of 2)
Submandibular gland N/A heterozygote 50% (1 of 2)
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 50% (1 of 2)
Thyroid gland N/A heterozygote 50% (1 of 2)
Tongue N/A heterozygote 100% (2 of 2)
Trachea N/A heterozygote 100% (2 of 2)
Trigeminal V nerve N/A heterozygote 100% (2 of 2)
Urinary bladder N/A heterozygote 100% (2 of 2)
Uterus N/A heterozygote 50% (1 of 2)
Vagina N/A heterozygote 50% (1 of 2)
Vas deferens N/A heterozygote 50% (1 of 2)
Vascular system N/A heterozygote Not available
Vesicular gland N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
jejunum
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

32 Images

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Adult LacZ

LacZ Images Section

137 Images

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X-ray

XRay Images Whole Body Lateral Orientation

16 Images

View images

Human diseases caused by Atf6b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Atf6b by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Peeling Skin Syndrome 5
Epidermal acanthosis, Scaling skin OMIM:617115
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Peeling Skin Syndrome 3
Erythema, White scaling skin OMIM:616265
Amyloidosis, Primary Localized Cutaneous, 1
Dry skin, Scaling skin OMIM:105250
Epidermolytic Hyperkeratosis 1
Epidermal acanthosis, Scaling skin OMIM:113800
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Epidermal acanthosis OMIM:615028
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Ichthyosis Hystrix, Curth-Macklin Type
Scaling skin OMIM:146590
Keratosis Palmoplantaris Striata Ii
Epidermal acanthosis OMIM:612908
Ichthyosis, Congenital, Autosomal Recessive 14
Erythema, Scaling skin OMIM:617571
Acral Self-Healing Collodion Baby
Erythema, Palmoplantar scaling skin, Lack of skin elasticity ORPHA:281127
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Erythema, Scaling skin, Palmoplantar scaling skin, Dry skin ORPHA:530838
Psoriasis 2
Epidermal acanthosis, Scaling skin OMIM:602723
Palmoplantar Keratoderma, Nagashima Type
Epidermal acanthosis OMIM:615598
Acral Peeling Skin Syndrome
Erythema, Excessive wrinkling of palmar skin, Scaling skin ORPHA:263534
Verrucous Hemangioma
Epidermal acanthosis ORPHA:464318
Ichthyosis Vulgaris
Dry skin, Absent keratohyalin granules OMIM:146700
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Dry skin, Epidermal acanthosis, Cutis laxa, Scaling skin ORPHA:2269
Erythrokeratodermia Variabilis Et Progressiva 4
Erythema, Epidermal acanthosis OMIM:617526
Peeling Skin Syndrome 6
Dry skin, Scaling skin OMIM:618084
Peeling Skin Syndrome 4
Epidermal acanthosis, Scaling skin OMIM:607936
Idiopathic Localized Lipodystrophy
Erythema, Scaling skin ORPHA:90158
Ichthyosis, Annular Epidermolytic, 2
Erythema, Scaling skin OMIM:620148
White Sponge Nevus 2
Epidermal acanthosis OMIM:615785
Aicardi-Goutieres Syndrome 5
Dry skin, Scaling skin OMIM:612952
Ichthyosis With Erythrokeratoderma
Erythema, Epidermal acanthosis, Scaling skin OMIM:620507
Hypotrichosis Simplex Of The Scalp
Epidermal acanthosis, Scaling skin ORPHA:90368
Familial Reactive Perforating Collagenosis
Abnormal epidermal morphology ORPHA:79147
Ichthyosis, Congenital, Autosomal Recessive 6
Dry skin, Epidermal acanthosis, Scaling skin OMIM:612281
Centrifugal Lipodystrophy
Erythema, Scaling skin ORPHA:90156
Ichthyosis, Annular Epidermolytic, 1
Erythema, Scaling skin OMIM:607602
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Dry skin, Acantholysis, Epidermal acanthosis, Scaling skin OMIM:616295
Ichthyosis, Spastic Quadriplegia, And Impaired Intellectual Development
Erythema, Scaling skin, Dry skin OMIM:614457
Ichthyosis, Congenital, Autosomal Recessive 5
Epidermal acanthosis, White scaling skin OMIM:604777
Peeling Skin Syndrome 1
Scaling skin OMIM:270300
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
Elastosis Perforans Serpiginosa
Epidermal acanthosis, Cutis laxa ORPHA:79148
Bathing Suit Ichthyosis
Epidermal acanthosis, Scaling skin ORPHA:100976
Cutaneous Mastocytoma
Erythema, Scaling skin ORPHA:79455
Pemphigus Foliaceus
Erythema, Acantholysis, Skin vesicle, Scaling skin ORPHA:79481
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Psoriasiform lesion, Scaling skin ORPHA:284426
Atrophoderma Vermiculata
Erythema, Abnormal epidermal morphology ORPHA:79100
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin OMIM:604536
Infantile Digital Fibromatosis
Epidermal acanthosis ORPHA:199267
Bazex Syndrome
Scaling skin ORPHA:166113
Ichthyosis With Confetti
Scaling skin OMIM:609165
Mal De Meleda
Erythema, Epidermal acanthosis ORPHA:87503
Seborrhea-Like Dermatitis With Psoriasiform Elements
Epidermal acanthosis OMIM:610227
Acrokeratosis Verruciformis
Acantholysis, Epidermal acanthosis OMIM:101900
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Dry skin, Scaling skin OMIM:618373
Palmoplantar Keratoderma, Punctate Type Ia
Epidermal acanthosis OMIM:148600
Ichthyosis, Congenital, Autosomal Recessive 7
Epidermal acanthosis OMIM:615022
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Epidermal acanthosis OMIM:615735
Familial Benign Chronic Pemphigus
Erythema, Acantholysis, Skin vesicle ORPHA:2841
Congenital Disorder Of Glycosylation, Type If
Dry skin, Scaling skin OMIM:609180
Keratoderma Hereditarium Mutilans With Ichthyosis
Epidermal acanthosis, Scaling skin on fingertip ORPHA:79395
Acute Generalized Exanthematous Pustulosis
Skin vesicle, Acantholysis, Purpura, Scaling skin ORPHA:293173
Erythrokeratodermia Variabilis Et Progressiva 1
Epidermal acanthosis OMIM:133200
Ichthyosis, Congenital, Autosomal Recessive 8
Erythema, Epidermal acanthosis OMIM:613943
Acute Radiation Syndrome
Skin ulcer, Scaling skin ORPHA:454831
Mpdu1-Cdg
Scaling skin ORPHA:79323
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
Recon Progeroid Syndrome
Dry skin, Scaling skin OMIM:620370
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
Acantholysis, Palmoplantar scaling skin, Palmoplantar erythema OMIM:605676
Erythrokeratodermia Variabilis Et Progressiva 3
Erythema, Epidermal acanthosis OMIM:617525
Epidermolytic Palmoplantar Keratoderma
Epidermal acanthosis ORPHA:2199
Basan Syndrome
Epidermal acanthosis OMIM:129200
Singleton-Merten Syndrome 2
Psoriasiform lesion OMIM:616298
Vulvovaginal Gingival Syndrome
Erythema, Epidermal acanthosis ORPHA:83453
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Woolly Hair-Skin Fragility Syndrome
Acantholysis OMIM:620415
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Scaling skin OMIM:606367
Lipoid Proteinosis Of Urbach And Wiethe
Reduced epidermal extracellular matrix protein 1 protein expression OMIM:247100
Subacute Cutaneous Lupus Erythematosus
Psoriasiform lesion ORPHA:163525
Immunodeficiency 58
Psoriasiform lesion, Scaling skin OMIM:618131
Graft Versus Host Disease
Scaling skin ORPHA:39812
Proteus Syndrome
Epidermal acanthosis OMIM:176920
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Bacterial Toxic-Shock Syndrome
Scaling skin, Ecchymosis ORPHA:36234
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Dry skin, Facial erythema, Scaling skin ORPHA:1010
Superficial Epidermolytic Ichthyosis
Erythema, Acantholysis ORPHA:455
Porphyria Cutanea Tarda
Scaling skin ORPHA:101330
Huriez Syndrome
Epidermal acanthosis OMIM:181600
Acrokeratosis Verruciformis Of Hopf
Epidermal acanthosis ORPHA:79151
Kid Syndrome
Epidermal acanthosis, Scaling skin ORPHA:477
Olmsted Syndrome, X-Linked
Epidermal acanthosis OMIM:300918
Myoectodermal Gonadal Dysgenesis Syndrome
Dry skin, Scaling skin OMIM:618419
Neonatal Inflammatory Skin And Bowel Disease
Erythema, Scaling skin ORPHA:294023
Immunodeficiency, Common Variable, 8, With Autoimmunity
Psoriasiform lesion OMIM:614700
Riddle Syndrome
Erythema, Scaling skin ORPHA:420741
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Epidermal acanthosis OMIM:148700
Congenital Syphilis
Palmoplantar scaling skin, Purpura, Petechiae ORPHA:499009
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Skin ulcer, Scaling skin ORPHA:2526
Hypotrichosis And Recurrent Skin Vesicles
Skin vesicle, Epidermal acanthosis OMIM:613102
Parkes Weber Syndrome
Skin ulcer, Scaling skin ORPHA:90307
Acrokeratoelastoidosis Of Costa
Epidermal acanthosis ORPHA:38
Ichthyosis Prematurity Syndrome
Epidermal acanthosis OMIM:608649
Rat-Bite Fever
Scaling skin ORPHA:31205
Ectodermal Dysplasia/Short Stature Syndrome
Epidermal acanthosis OMIM:616029
Ichthyosis, Congenital, Autosomal Recessive 9
Epidermal acanthosis OMIM:615023
Psoriasis 14, Pustular
Erythema, Epidermal acanthosis OMIM:614204
Ichthyosis, Congenital, Autosomal Recessive 1
Epidermal acanthosis OMIM:242300
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Erythema, Dry skin, Facial erythema, Cutis laxa, Scaling skin OMIM:619503
Cole Disease
Epidermal acanthosis OMIM:615522
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Dry skin, Epidermal acanthosis OMIM:618527
Ectodermal Dysplasia-Skin Fragility Syndrome
Scaling skin ORPHA:158668
Autoinflammation With Arthritis And Dyskeratosis
Dry skin, Epidermal acanthosis OMIM:617388
Ichthyosis, Congenital, Autosomal Recessive 2
Erythema, Epidermal acanthosis OMIM:242100
Olmsted Syndrome 2
Epidermal acanthosis OMIM:619208
Restrictive Dermopathy
Dermal translucency, Scaling skin ORPHA:1662
Palmoplantar Carcinoma, Multiple Self-Healing
Epidermal acanthosis OMIM:615225
Woodhouse-Sakati Syndrome
Scaling skin ORPHA:3464
Restrictive Dermopathy 1
Scaling skin OMIM:275210
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform lesion ORPHA:85436
Kawasaki Disease
Palmoplantar erythema, Scaling skin on fingertip ORPHA:2331
Punctate Palmoplantar Keratoderma Type 1
Abnormal epidermal morphology, Epidermal acanthosis ORPHA:79501
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Dry skin, Epidermal acanthosis OMIM:607626
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Dry skin, Perianal erythema, Scaling skin OMIM:308205
Odontoonychodermal Dysplasia
Erythema, Epidermal acanthosis, Palmoplantar erythema, Dry skin OMIM:257980
Pseudoxanthoma Elasticum
Cutis laxa, Civatte bodies OMIM:264800
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Epidermal acanthosis OMIM:612852
Naxos Disease
Acantholysis, Epidermal acanthosis OMIM:601214
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Erythema, Epidermal acanthosis OMIM:308050
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Epidermal acanthosis ORPHA:83617

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atf6b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atf6b.

No publications found that use IMPC mice or data for Atf6b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atf6btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Atf6btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Atf6btm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Atf6btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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