Gene Summary

activating transcription factor 6 beta
Creb-rp,  ATF6beta,  Crebl1

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Atf6btm1.1(KOMP)Vlcg HET Early adult 0.00
preweaning lethality, incomplete penetrance Atf6btm1.1(KOMP)Vlcg HOM   Early adult 0.00
scaly skin Atf6btm1.1(KOMP)Vlcg HET Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images heterozygote 50% (1 of 2)
Aorta  Section images heterozygote 100% (2 of 2)
Brown adipose tissue  Section images heterozygote 50% (1 of 2)
Cecum  Section images heterozygote 50% (1 of 2)
Cerebellum  Section images heterozygote 100% (2 of 2)
Colon  Section images heterozygote 100% (2 of 2)
Duodenum  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Esophagus  Section images heterozygote 100% (2 of 2)
Eye  Section images heterozygote 100% (2 of 2)
Harderian gland  Section images heterozygote 100% (2 of 2)
Ileum  Section images heterozygote 100% (2 of 2)
Jejunum  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Liver  Section images heterozygote 50% (1 of 2)
Lung  Section images heterozygote 100% (2 of 2)
Mesenteric adipose tissue  Section images heterozygote 50% (1 of 2)
Midbrain  Section images heterozygote 100% (2 of 2)
Olfactory lobe  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Oviduct  Section images heterozygote 50% (1 of 2)
Pancreas  Section images heterozygote 100% (2 of 2)
Parathyroid gland  Section images heterozygote 50% (1 of 2)
Parotid gland  Section images heterozygote 100% (2 of 2)
Penis  Section images heterozygote 50% (1 of 2)
Pituitary gland  Section images heterozygote 100% (2 of 2)
Prostate gland  Section images heterozygote 50% (1 of 2)
Quadriceps  Section images heterozygote 50% (1 of 2)
Skin  Section images heterozygote 100% (2 of 2)
Spinal cord  Section images heterozygote 100% (2 of 2)
Spleen  Section images heterozygote 50% (1 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Sublingual gland  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Thymus  Section images heterozygote 50% (1 of 2)
Thyroid gland  Section images heterozygote 50% (1 of 2)
Tongue  Section images heterozygote 100% (2 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Trigeminal V nerve  Section images heterozygote 100% (2 of 2)
Urinary bladder  Section images heterozygote 100% (2 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Vagina  Section images heterozygote 50% (1 of 2)
Vas deferens  Section images heterozygote 50% (1 of 2)
Vesicular gland  Section images heterozygote 50% (1 of 2)
Blood N/A heterozygote Not available
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote Not available
Cartilage tissue N/A heterozygote Not available
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Diaphragm N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Large intestine N/A heterozygote 100% (2 of 2)
Lower urinary tract N/A heterozygote Not available
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Small intestine N/A heterozygote 100% (2 of 2)
Stomach pyloric region N/A heterozygote Not available
Striatum N/A heterozygote Not available
Vascular system N/A heterozygote Not available
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

137 Images


XRay Images Whole Body Lateral Orientation

16 Images


XRay Images Whole Body Dorso Ventral

32 Images

Human diseases caused by Atf6b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Atf6b by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Peeling Skin Syndrome 5
Epidermal acanthosis, Scaling skin OMIM:617115
Keratosis Palmoplantaris Striata Ii
Epidermal acanthosis OMIM:612908
Peeling Skin Syndrome 3
Erythema, White scaling skin OMIM:616265
Amyloidosis, Primary Localized Cutaneous, 1
Dry skin, Scaling skin OMIM:105250
Epidermolytic Hyperkeratosis 1
Epidermal acanthosis, Scaling skin OMIM:113800
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Epidermal acanthosis OMIM:615028
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Ichthyosis Hystrix, Curth-Macklin Type
Scaling skin OMIM:146590
Ichthyosis, Congenital, Autosomal Recessive 14
Erythema, Scaling skin OMIM:617571
Acral Self-Healing Collodion Baby
Palmoplantar scaling skin, Erythema, Lack of skin elasticity ORPHA:281127
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Palmoplantar scaling skin, Erythema, Scaling skin, Dry skin ORPHA:530838
Psoriasis 2
Epidermal acanthosis, Scaling skin OMIM:602723
Palmoplantar Keratoderma, Nagashima Type
Epidermal acanthosis OMIM:615598
Acral Peeling Skin Syndrome
Erythema, Scaling skin, Excessive wrinkling of palmar skin ORPHA:263534
Verrucous Hemangioma
Epidermal acanthosis ORPHA:464318
Acrokeratosis Verruciformis
Epidermal acanthosis OMIM:101900
Erythrokeratodermia Variabilis Et Progressiva 4
Erythema, Epidermal acanthosis OMIM:617526
Peeling Skin Syndrome 6
Dry skin, Scaling skin OMIM:618084
Peeling Skin Syndrome 4
Epidermal acanthosis, Scaling skin OMIM:607936
Idiopathic Localized Lipodystrophy
Erythema, Scaling skin ORPHA:90158
Ichthyosis Vulgaris
Absent keratohyalin granules, Dry skin OMIM:146700
Ichthyosis, Annular Epidermolytic, 2
Erythema, Scaling skin OMIM:620148
Lupus Erythematosus Tumidus
Scaling skin ORPHA:90283
Aicardi-Goutieres Syndrome 5
Dry skin, Scaling skin OMIM:612952
White Sponge Nevus 2
Epidermal acanthosis OMIM:615785
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Dry skin, Epidermal acanthosis, Scaling skin, Cutis laxa ORPHA:2269
Ichthyosis, Congenital, Autosomal Recessive 6
Dry skin, Epidermal acanthosis, Scaling skin OMIM:612281
Bathing Suit Ichthyosis
Palmoplantar scaling skin, Epidermal acanthosis, Scaling skin ORPHA:100976
Centrifugal Lipodystrophy
Erythema, Scaling skin ORPHA:90156
Ichthyosis, Annular Epidermolytic, 1
Erythema, Scaling skin OMIM:607602
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Dry skin, Epidermal acanthosis, Scaling skin, Acantholysis OMIM:616295
Ichthyosis, Congenital, Autosomal Recessive 5
Epidermal acanthosis, White scaling skin OMIM:604777
Ichthyosis, Spastic Quadriplegia, And Impaired Intellectual Development
Erythema, Dry skin, Scaling skin OMIM:614457
Familial Reactive Perforating Collagenosis
Abnormal epidermal morphology ORPHA:79147
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
Elastosis Perforans Serpiginosa
Epidermal acanthosis, Cutis laxa ORPHA:79148
Peeling Skin Syndrome 1
Scaling skin OMIM:270300
Cutaneous Mastocytoma
Erythema, Scaling skin ORPHA:79455
Hypotrichosis Simplex Of The Scalp
Epidermal acanthosis, Scaling skin ORPHA:90368
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Psoriasiform lesion, Scaling skin ORPHA:284426
Pemphigus Foliaceus
Skin vesicle, Erythema, Scaling skin, Acantholysis ORPHA:79481
Atrophoderma Vermiculata
Abnormal epidermal morphology, Erythema ORPHA:79100
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin OMIM:604536
Infantile Digital Fibromatosis
Epidermal acanthosis ORPHA:199267
Ichthyosis With Confetti
Scaling skin OMIM:609165
Bazex Syndrome
Scaling skin ORPHA:166113
Seborrhea-Like Dermatitis With Psoriasiform Elements
Epidermal acanthosis OMIM:610227
Mal De Meleda
Erythema, Epidermal acanthosis ORPHA:87503
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Dry skin, Scaling skin OMIM:618373
Palmoplantar Keratoderma, Punctate Type Ia
Epidermal acanthosis OMIM:148600
Ichthyosis, Congenital, Autosomal Recessive 7
Epidermal acanthosis OMIM:615022
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Epidermal acanthosis OMIM:615735
Congenital Disorder Of Glycosylation, Type If
Dry skin, Scaling skin OMIM:609180
Familial Benign Chronic Pemphigus
Skin vesicle, Erythema, Acantholysis ORPHA:2841
Erythrokeratodermia Variabilis Et Progressiva 1
Epidermal acanthosis OMIM:133200
Acute Generalized Exanthematous Pustulosis
Skin vesicle, Purpura, Scaling skin, Acantholysis ORPHA:293173
Ichthyosis, Congenital, Autosomal Recessive 8
Erythema, Epidermal acanthosis OMIM:613943
Keratoderma Hereditarium Mutilans With Ichthyosis
Scaling skin on fingertip, Epidermal acanthosis ORPHA:79395
Acute Radiation Syndrome
Scaling skin, Skin ulcer ORPHA:454831
Scaling skin ORPHA:79323
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
Recon Progeroid Syndrome
Dry skin, Scaling skin OMIM:620370
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
Palmoplantar erythema, Palmoplantar scaling skin, Acantholysis OMIM:605676
Erythrokeratodermia Variabilis Et Progressiva 3
Erythema, Epidermal acanthosis OMIM:617525
Singleton-Merten Syndrome 2
Psoriasiform lesion OMIM:616298
Epidermolytic Palmoplantar Keratoderma
Epidermal acanthosis ORPHA:2199
Basan Syndrome
Epidermal acanthosis OMIM:129200
Vulvovaginal Gingival Syndrome
Erythema, Epidermal acanthosis ORPHA:83453
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Scaling skin OMIM:606367
Subacute Cutaneous Lupus Erythematosus
Psoriasiform lesion ORPHA:163525
Lipoid Proteinosis Of Urbach And Wiethe
Reduced epidermal extracellular matrix protein 1 protein expression OMIM:247100
Immunodeficiency 58
Psoriasiform lesion, Scaling skin OMIM:618131
Graft Versus Host Disease
Scaling skin ORPHA:39812
Proteus Syndrome
Epidermal acanthosis OMIM:176920
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Bacterial Toxic-Shock Syndrome
Ecchymosis, Scaling skin ORPHA:36234
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Dry skin, Scaling skin, Facial erythema ORPHA:1010
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Superficial Epidermolytic Ichthyosis
Erythema, Acantholysis ORPHA:455
Porphyria Cutanea Tarda
Scaling skin ORPHA:101330
Huriez Syndrome
Epidermal acanthosis OMIM:181600
Kid Syndrome
Epidermal acanthosis, Scaling skin ORPHA:477
Hypotrichosis And Recurrent Skin Vesicles
Skin vesicle, Epidermal acanthosis OMIM:613102
Myoectodermal Gonadal Dysgenesis Syndrome
Dry skin, Scaling skin OMIM:618419
Neonatal Inflammatory Skin And Bowel Disease
Erythema, Scaling skin ORPHA:294023
Olmsted Syndrome, X-Linked
Epidermal acanthosis OMIM:300918
Riddle Syndrome
Erythema, Scaling skin ORPHA:420741
Immunodeficiency, Common Variable, 8, With Autoimmunity
Psoriasiform lesion OMIM:614700
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Epidermal acanthosis OMIM:148700
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Scaling skin, Skin ulcer ORPHA:2526
Acrokeratosis Verruciformis Of Hopf
Epidermal acanthosis, Acantholysis ORPHA:79151
Acrokeratoelastoidosis Of Costa
Epidermal acanthosis ORPHA:38
Parkes Weber Syndrome
Scaling skin, Skin ulcer ORPHA:90307
Rat-Bite Fever
Scaling skin ORPHA:31205
Ichthyosis Prematurity Syndrome
Epidermal acanthosis OMIM:608649
Cole Disease
Epidermal acanthosis OMIM:615522
Ichthyosis, Congenital, Autosomal Recessive 9
Epidermal acanthosis OMIM:615023
Ectodermal Dysplasia/Short Stature Syndrome
Epidermal acanthosis OMIM:616029
Psoriasis 14, Pustular
Erythema, Epidermal acanthosis OMIM:614204
Ichthyosis, Congenital, Autosomal Recessive 1
Epidermal acanthosis OMIM:242300
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Erythema, Cutis laxa, Facial erythema, Scaling skin, Dry skin OMIM:619503
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Dry skin, Epidermal acanthosis OMIM:618527
Ectodermal Dysplasia-Skin Fragility Syndrome
Scaling skin ORPHA:158668
Autoinflammation With Arthritis And Dyskeratosis
Dry skin, Epidermal acanthosis OMIM:617388
Ichthyosis, Congenital, Autosomal Recessive 2
Erythema, Epidermal acanthosis OMIM:242100
Olmsted Syndrome 2
Epidermal acanthosis OMIM:619208
Restrictive Dermopathy
Scaling skin, Dermal translucency ORPHA:1662
Palmoplantar Carcinoma, Multiple Self-Healing
Epidermal acanthosis OMIM:615225
Woodhouse-Sakati Syndrome
Scaling skin ORPHA:3464
Restrictive Dermopathy 1
Scaling skin OMIM:275210
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform lesion ORPHA:85436
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Dry skin, Perianal erythema, Scaling skin OMIM:308205
Punctate Palmoplantar Keratoderma Type 1
Abnormal epidermal morphology, Epidermal acanthosis ORPHA:79501
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Dry skin, Epidermal acanthosis OMIM:607626
Odontoonychodermal Dysplasia
Palmoplantar erythema, Erythema, Dry skin, Epidermal acanthosis OMIM:257980
Pseudoxanthoma Elasticum
Civatte bodies, Cutis laxa OMIM:264800
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Epidermal acanthosis OMIM:612852
Naxos Disease
Epidermal acanthosis, Acantholysis OMIM:601214
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Erythema, Epidermal acanthosis OMIM:308050
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Epidermal acanthosis ORPHA:83617


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atf6b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atf6b.

No publications found that use IMPC mice or data for Atf6b.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atf6btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Atf6btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Atf6btm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Atf6btm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter