Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Serpina3n by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Pudendal Neuralgia | Scrotal pain, Paroxysmal rectal pain, Neuralgia, Allodynia, Vulvodynia, Anal pain, Pelvic pain | ORPHA:60039 | |
Trigeminal Neuralgia | Trigeminal neuralgia, Ocular pain, Mandibular pain, Allodynia | ORPHA:221091 | |
Complex Regional Pain Syndrome | Limb pain, Allodynia | ORPHA:83452 | |
Anterior Cutaneous Nerve Entrapment Syndrome | Abdominal pain, Back pain, Allodynia | ORPHA:51890 | |
Neurotrophic Keratopathy | Allodynia | ORPHA:137596 | |
Spinal Cord Injury | Allodynia | ORPHA:90058 | |
Benign Schwannoma | Pain, Allodynia | ORPHA:252164 | |
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type) | Abdominal pain, Abdominal cramps, Allodynia | OMIM:603041 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Serpina3ntm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Serpina3ntm41268(L1L2_st1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Serpina3ntm41268(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Serpina3ntm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Serpina3nem1(IMPC)J | Exon Deletion | Mice |
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