The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Serpina3n by phenotypic similarity.
||Ocular pain, Mandibular pain, Trigeminal neuralgia, Allodynia||ORPHA:221091|
|Complex Regional Pain Syndrome||
||Limb pain, Allodynia||ORPHA:83452|
|Anterior Cutaneous Nerve Entrapment Syndrome||
||Back pain, Allodynia, Abdominal pain||ORPHA:51890|
|Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)||
||Abdominal cramps, Allodynia, Abdominal pain||OMIM:603041|
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|MGI Allele||Allele Type||Produced|
|Serpina3ntm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Serpina3ntm41268(L1L2_st1)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Serpina3ntm41268(L1L2_Bact_P)||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors|
|Serpina3ntm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|