Gene Summary

Name:
zinc finger protein 91
Synonyms:
A530054C17Rik,  Pzf,  9130014I08Rik

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin coloration Zfp91em1(IMPC)Tcp HOM E15.5 0.00
decreased body length Zfp91em1(IMPC)Tcp HET Early adult 4.51×10-06
enlarged lymph nodes Zfp91em1(IMPC)Tcp HET Early adult 0.00
edema Zfp91em1(IMPC)Tcp HOM E15.5 0.00
increased startle reflex Zfp91em1(IMPC)Tcp HET Early adult 2.14×10-06
pallor Zfp91em1(IMPC)Tcp HOM E15.5 0.00
abnormal embryo size Zfp91em1(IMPC)Tcp HOM E15.5 0.00
abnormal embryo size Zfp91em1(IMPC)Tcp HOM E9.5 0.00
preweaning lethality, complete penetrance Zfp91em1(IMPC)Tcp HOM   Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Ophthalmoscopy

100 Images

Gross Morphology Embryo E14.5-E15.5

Images

44 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

MicroCT E14.5-E15.5

Embryo reconstruction

7 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Eye Morphology

Images Slit Lamp

12 Images

Gross Morphology Embryo E9.5

Images

2 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Zfp91 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Zfp91 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Kaposi Sarcoma, Susceptibility To
Edema, Hypermelanotic macule OMIM:148000
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor, Albinism, Hypopigmentation of the skin ORPHA:2786
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Mastocytosis, Cutaneous
Edema, Hypermelanotic macule, Erythema OMIM:154800
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Acral Self-Healing Collodion Baby
Palmoplantar scaling skin, Edema of the dorsum of hands, Lack of skin elasticity, Edema of the do... ORPHA:281127
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Cone-Rod Dystrophy 11
Pallor OMIM:610381
X-Linked Sideroblastic Anemia
Pallor, Hyperpigmentation of the skin ORPHA:75563
Peripheral Cone Dystrophy
Pallor OMIM:609021
Breath-Holding Spells
Pallor OMIM:607578
Hb Bart'S Hydrops Fetalis
Hydrops fetalis, Pallor, Polyhydramnios, Oligohydramnios ORPHA:163596
Dermatitis, Atopic
Pallor, Facial erythema, Dry skin OMIM:603165
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Congenital Heart Block
Peripheral edema, Hydrops fetalis, Pleural effusion, Pericardial effusion, Intrauterine growth re... ORPHA:60041
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Lymphatic Malformation 11
Lymphedema, Pedal edema OMIM:619401
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Optic Atrophy 1
Pallor OMIM:165500
Intellectual Developmental Disorder, Autosomal Recessive 54
Exaggerated startle response OMIM:617028
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Hemoglobin D Disease
Pallor ORPHA:90039
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema, Cerebral edema ORPHA:439218
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Pallor OMIM:613561
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor, Nonimmune hydrops fetalis OMIM:266200
Lymphatic Malformation 8
Polyhydramnios, Pleural effusion, Generalized edema, Pericardial effusion, Nonimmune hydrops fetalis OMIM:618773
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Pulmonary Edema Of Mountaineers, Susceptibility To
Edema, Pulmonary edema OMIM:178400
American Trypanosomiasis
Edema, Pallor, Periorbital edema ORPHA:3386
Evans Syndrome
Petechiae, Pallor ORPHA:1959
Irida Syndrome
Pallor ORPHA:209981
Retinitis Pigmentosa 51
Pallor OMIM:613464
Anemia, Hypochromic Microcytic, With Iron Overload 2
Cafe-au-lait spot, Pallor OMIM:615234
Cyclic Vomiting Syndrome
Pallor OMIM:500007
Lymphatic Malformation 7
Pulmonary edema, Chylothorax, Lymphedema, Pleural effusion, Ascites, Increased nuchal translucenc... OMIM:617300
Thiamine-Responsive Megaloblastic Anemia Syndrome
Pallor ORPHA:49827
Deafness-Lymphedema-Leukemia Syndrome
Pallor, Lymphedema ORPHA:3226
Anemia, Congenital Dyserythropoietic, Type Ib
Pallor OMIM:615631
Hyperinsulinism Due To Ucp2 Deficiency
Pallor ORPHA:276556
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Pallor ORPHA:276575
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor ORPHA:276580
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Myelofibrosis
Purpura, Pallor OMIM:254450
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Primary Myelofibrosis
Petechiae, Purpura, Ecchymosis, Pallor ORPHA:824
Retinitis Pigmentosa 75
Pallor OMIM:617023
Fanconi Anemia, Complementation Group I
Cafe-au-lait spot, Pallor, Intrauterine growth retardation OMIM:609053
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Elliptocytosis 1
Pallor OMIM:611804
Myopathic Ehlers-Danlos Syndrome
Pallor ORPHA:536516
Dravet Syndrome
Pallor ORPHA:33069
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Edema, Anemic pallor ORPHA:329971
Lymphangiectasia, Pulmonary, Congenital
Palpebral edema, Polyhydramnios, Chylothorax, Lymphedema, Pleural effusion, Ascites, Chylous asci... OMIM:265300
Cold Agglutinin Disease
Pallor ORPHA:56425
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor OMIM:611590
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Beta-Ketothiolase Deficiency
Edema, Pallor, Dehydration ORPHA:134
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Lymph node hypoplasia, Splenomegaly, Aplasia of the thymus, Absent tonsils, Generalized lymphaden... OMIM:602450
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Waldenström Macroglobulinemia
Purpura, Pleural effusion, Periorbital edema, Pallor, Pedal edema ORPHA:33226
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Pallor OMIM:600462
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Cafe-au-lait spot, Pallor ORPHA:300298
Tay-Sachs Disease
Pallor OMIM:272800
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Idiopathic Pulmonary Hemosiderosis
Pallor ORPHA:99931
Sepsis In Premature Infants
Edema, Petechiae, Pallor, Purpura ORPHA:90051
Refractory Anemia With Excess Blasts
Anemic pallor, Pedal edema ORPHA:86839
Rheumatic Fever
Pallor, Erythema ORPHA:3099
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Pallor ORPHA:263455
Senior-Loken Syndrome 8
Pallor OMIM:616307
Plummer-Vinson Syndrome
Pallor ORPHA:54028
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor, Dehydration OMIM:246450
3-Hydroxy-3-Methylglutaric Aciduria
Edema, Pallor, Dehydration ORPHA:20
Dominant Beta-Thalassemia
Pallor, Skin ulcer, Hyperpigmentation of the skin ORPHA:231226
Childhood Absence Epilepsy
Pallor ORPHA:64280
Congenital Dyserythropoietic Anemia Type Iii
Pallor ORPHA:98870
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Oculogyric crisis, Athetosis, Blepharospasm, Limb dystonia, Exaggerated startle resp... OMIM:608643
Letterer-Siwe Disease
Pallor OMIM:246400
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response OMIM:618201
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Fumarase Deficiency
Pallor, Polyhydramnios, Ascites OMIM:606812
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Anemia, Sideroblastic, And Spinocerebellar Ataxia
Intrauterine growth retardation, Pallor OMIM:301310
Sandhoff Disease, Infantile Form
Hepatosplenomegaly, Exaggerated startle response ORPHA:309155
Beta-Thalassemia Major
Pallor, Skin ulcer, Hyperpigmentation of the skin ORPHA:231214
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Purine Nucleoside Phosphorylase Deficiency
Tremor, Lymph node hypoplasia, Splenomegaly OMIM:613179
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Gm2 Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response ORPHA:309246
Pearson Marrow-Pancreas Syndrome
Pallor, Hydrops fetalis, Dehydration, Erythema OMIM:557000
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Incontinentia Pigmenti
Abnormality of skin pigmentation, Pallor, Erythema OMIM:308300
Fanconi Anemia, Complementation Group C
Cafe-au-lait spot, Anemic pallor, Intrauterine growth retardation, Hyperpigmentation of the skin OMIM:227645
Fanconi Anemia, Complementation Group E
Cafe-au-lait spot, Anemic pallor, Hyperpigmentation of the skin OMIM:600901
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia ORPHA:276
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Fanconi Anemia, Complementation Group A
Cafe-au-lait spot, Abnormality of skin pigmentation, Anemic pallor OMIM:227650
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Aregenerative Anemia
Pallor ORPHA:101096
Alternating Hemiplegia Of Childhood
Pallor, Dehydration ORPHA:2131
Adenohypophysitis
Pallor ORPHA:95512
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response OMIM:184850
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Panhypophysitis
Pallor ORPHA:95513
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
Truncal titubation, Tremor, Exaggerated startle response OMIM:618056
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
Infection-Related Hemolytic Uremic Syndrome
Edema, Pallor, Pleural empyema, Generalized edema ORPHA:544482
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Sheehan Syndrome
Pallor, Dry skin ORPHA:91355
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Pituitary Apoplexy
Pallor ORPHA:95613
Neurodevelopmental Disorder With Speech Impairment And With Or Without Seizures
Exaggerated startle response OMIM:620114
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor ORPHA:98849
Idiopathic Hypereosinophilic Syndrome
Angioedema, Pallor, Pleural effusion, Joint swelling ORPHA:3260
Prolactinoma
Pallor ORPHA:2965
Neurodegeneration With Developmental Delay, Early Respiratory Failure, Myoclonic Seizures, And Brain Abnormalities
Tremor, Exaggerated startle response OMIM:620327
Gm2-Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response OMIM:272750
Histiocytoid Cardiomyopathy
Pulmonary edema, Pallor ORPHA:137675
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Exaggerated startle response OMIM:608800
Degcags Syndrome
Polyhydramnios, Hypopigmentation of the skin, Abnormality of skin pigmentation, Intrauterine grow... OMIM:619488
Leukodystrophy, Hypomyelinating, 13
Exaggerated startle response OMIM:616881
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Pallor OMIM:277400
Esophageal Atresia
Pallor, Polyhydramnios ORPHA:1199
Sandhoff Disease
Hepatosplenomegaly, Exaggerated startle response OMIM:268800
Fanconi Anemia, Complementation Group D2
Cafe-au-lait spot, Abnormality of skin pigmentation, Anemic pallor OMIM:227646
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Dystonia, Exaggerated startle response ORPHA:438216
Neuroblastoma
Anemic pallor ORPHA:635
Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
Exaggerated startle response OMIM:617864
Von Hippel-Lindau Disease
Pallor, Macular edema ORPHA:892
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Pallor ORPHA:91347
Diamond-Blackfan Anemia
Pallor, Nonimmune hydrops fetalis ORPHA:124
Tay-Sachs Disease
Tremor, Laryngeal dystonia, Dystonia, Exaggerated startle response ORPHA:845
Diamond-Blackfan Anemia 1
Intrauterine growth retardation, Pallor, Spina bifida occulta OMIM:105650
Gm1 Gangliosidosis Type 1
Hepatosplenomegaly, Exaggerated startle response ORPHA:79255
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Developmental And Epileptic Encephalopathy 49
Exaggerated startle response OMIM:617281
Plaa-Associated Neurodevelopmental Disorder
Dystonia, Exaggerated startle response ORPHA:521426
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Asparagine Synthetase Deficiency
Tremor, Exaggerated startle response OMIM:615574
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755
Combined Oxidative Phosphorylation Deficiency 58
Exaggerated startle response OMIM:620451
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Autosomal Recessive Malignant Osteopetrosis
Pallor ORPHA:667
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Exaggerated startle response OMIM:617527
Multiple Mitochondrial Dysfunctions Syndrome 7
Dystonia, Exaggerated startle response OMIM:620423
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Dystonia, Exaggerated startle response ORPHA:438213
Congenital Total Pulmonary Venous Return Anomaly
Pallor ORPHA:99125
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zfp91

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zfp91.

No publications found that use IMPC mice or data for Zfp91.

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MGI Allele Allele Type Produced
Zfp91em1(IMPC)Tcp Exon Deletion Mice
Zfp91tm194308(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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