Nrcam | neuronal cell adhesion molecule

GeneMGI:104750Synonyms: C030017F07Rik, Bravo, +1 more

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Behavior/neurological

14 No significant impact

7 Not tested

Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
26Embryo tissues

Phenotypes

limb grasping1 supporting datasetNrcamtm2e.1(KOMP)WtsiheterozygoteEarly adult5.45x10-5 
convulsive seizures1 supporting datasetNrcamtm2e.1(KOMP)WtsihomozygoteEarly adult7.49x10-5 
increased fasting circulating glucose level1 supporting datasetNrcamtm2e.1(KOMP)WtsiheterozygoteEarly adult3.38x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
brainheterozygoten/a0% (0/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
epididymisheterozygoten/a0% (0/1)87.5% (21/24)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Nrcamtm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Nrcamtm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Nrcamtm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Nrcamtm2e(KOMP)WtsiTargeted, non-conditional alleleES Cell
mouse
Nrcamtm2e.1(KOMP)WtsiPromoter excision from Targeted, non-conditional allelemouse

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