Col4a3 | collagen, type IV, alpha 3

GeneMGI:104688Synonyms: alpha3(IV), tumstatin

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Renal/urinary system

14 No significant impact

4 Not tested

Gene metrics:8Significant phenotypes
7Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

decreased basophil cell number1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult4.98x10-5 
decreased hemoglobin content1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult4.24x10-8 
increased neutrophil cell number2 supporting datasetsCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult3.09x10-8 
decreased lymphocyte cell number1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult4.88x10-8 
increased kidney weight1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult1.46x10-18 
increased large unstained cell number1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult9.12x10-5 
decreased circulating amylase level1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult4.33x10-5 
irregularly shaped pupil1 supporting datasetCol4a3tm1b(EUCOMM)WtsihomozygoteEarly adult9.4x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Col4a3tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Col4a3tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Col4a3tm1c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Col4a3tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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