Ap2a2 | adaptor-related protein complex 2, alpha 2 subunit
Physiological systems
18 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging
14 No significant impact
6 Not tested
Data collections
Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
increased circulating cholesterol level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
increased circulating LDL cholesterol level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
decreased circulating serum albumin level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 | ||
increased circulating LDL cholesterol level | 1 supporting dataset | Ap2a2em1(IMPC)Wtsi | heterozygote | Early adult | 2.8x10-8 | ||
absent pinna reflex | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.26x10-9 | ||
preweaning lethality, incomplete penetrance | 1 supporting dataset | Ap2a2em1(IMPC)Wtsi | homozygote | Early adult | N/A * | ||
increased circulating HDL cholesterol level | 1 supporting dataset | Ap2a2em1(IMPC)Wtsi | heterozygote | Early adult | 6.4x10-5 | ||
increased circulating iron level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.06x10-6 | ||
increased circulating free fatty acids level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.14x10-7 | ||
decreased circulating fructosamine level | 1 supporting dataset | Ap2a2tm1b(EUCOMM)Wtsi | homozygote | Early adult | 0 |
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adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
External links
No external links available for Ap2a2.
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Ap2a2em1(IMPC)Wtsi | Deletion | | mouse |
Ap2a2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
Ap2a2tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Ap2a2tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |