Genes Phenotypes

Gene: Ap2a2

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Name
adaptor-related protein complex 2, alpha 2 subunit
MGI ID
MGI:101920
Synonyms
alpha-C adaptin Adtab alpha-adaptin C L25 2410074K14Rik
Viability
Homozygous - Viable Homozygous - Subviable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (411) All data table (1612)
Expression & images (45) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating cholesterol level Ap2a2em1(IMPC)Wtsi HET Early adult 3.35×10-05
absent pinna reflex Ap2a2tm1b(EUCOMM)Wtsi HOM Early adult 1.25×10-09
increased circulating LDL cholesterol level Ap2a2em1(IMPC)Wtsi HET Early adult 1.73×10-08
preweaning lethality, incomplete penetrance Ap2a2em1(IMPC)Wtsi HOM Early adult 0.00
increased circulating HDL cholesterol level Ap2a2em1(IMPC)Wtsi HET Early adult 4.88×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Blood vessel 2 No N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No  (1/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No N/A
Esophagus 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No  (1/2) N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Ap2a2tm1b(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
lymph node, mesenteric lymph node, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
adrenal gland, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
pancreas, HET, Female, WTSI

View all 22 images

Ap2a2tm1b(EUCOMM)Wtsi
adrenal gland, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
pancreas, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
testis, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
oesophagus, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
urinary bladder, lower urinary tract, HET, Female, WTSI

View all 15 images

Ap2a2tm1b(EUCOMM)Wtsi
oesophagus, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
large intestine, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
small intestine, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
gall bladder, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
trigeminal V nerve, peripheral nervous system, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
spinal cord, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
brain, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
urinary bladder, lower urinary tract, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
kidney, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
urinary bladder, lower urinary tract, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
adrenal gland, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
parathyroid gland, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
testis, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
uterus, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
cartilage tissue, rib, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
brown adipose tissue, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
heart, aorta, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
lymph node, mesenteric lymph node, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
skin, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
cartilage tissue, rib, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
lung, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
eye, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
65 Images
X-ray: XRay Images Whole Body Dorso Ventral
85 Images
X-ray: XRay Images Forepaw
33 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
32 Images
X-ray: XRay Images Skull Lateral Orientation
32 Images
DSS Histology
12 Images
Eye Morphology: Images Slit Lamp
1 Images
Anti-nuclear antibody assay
6 Images
Legacy Phenotype Associated Images
Ap2a2tm1b(EUCOMM)Wtsi
HOM, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
HOM, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
HOM, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
HET, Female, WTSI

View all 165 images

Ap2a2tm1b(EUCOMM)Wtsi
TS20 chorioallantoic placenta, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
TS20 forebrain, TS20 oral cavity, TS20 mandibular process, TS20 ear, TS20 skin, TS20 brain, TS20 hindbrain, TS20 maxillary process, TS20 tongue, HET, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
TS20 liver, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
TS20 stomach, HET, Female, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
TS20 head, HET, Male, WTSI
Ap2a2em1(IMPC)Wtsi
abnormal ventral coat pigmentation, abnormal coat/hair pigmentation, WT, Male, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
HOM, Unsexed, WTSI
Ap2a2tm1b(EUCOMM)Wtsi
corneal opacity, HET, Female, WTSI

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Ap2a2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ap2a2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Ap2a2em1(IMPC)Wtsi Exdel Mice
Ap2a2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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