Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
LIM homeobox protein 4
Synonyms:
Gsh-4,  Gsh4,  A330062J17Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lhx4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lhx4 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Combined Pituitary Hormone Deficiencies, Genetic Forms
Abnormal prolactin level, Agenesis of corpus callosum, Septo-optic dysplasia, Hypogonadotropic hy... ORPHA:95494
Pituitary Stalk Interruption Syndrome
Death in infancy, Diabetes insipidus, Septo-optic dysplasia, Abnormality of the hypothalamus-pitu... ORPHA:95496
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Inappropriate antidiuretic hormone secretion, Thyroid hypoplasia, Hypogonadotropic hypogonadism, ... ORPHA:226307
Pituitary Hormone Deficiency, Combined, 4
Adrenal insufficiency, Hypothyroidism, Impaired growth-hormone response to insulin stimulation test OMIM:262700

The table below shows human diseases predicted to be associated to Lhx4 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Wheezing, Neonatal respiratory distress, Crackles, Elevated bronchoalveolar lavage fluid lymphocy... OMIM:610978
Bronchiolitis Obliterans With Obstructive Pulmonary Disease
Bronchiolitis obliterans, Hypoxemia, Pneumonia, Bronchiectasis, Reduced forced expiratory volume ... ORPHA:1303
Bronchopulmonary Dysplasia
Wheezing, Central apnea, Hyperoxemia, Abnormal respiratory system physiology, Tracheobronchomalac... ORPHA:70589
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome
Wheezing, Honeycomb lung, Hypoxemia, Chronic bronchitis, Chronic pulmonary obstruction, Bronchiec... ORPHA:79127
Ciliary Dyskinesia, Primary, 47, And Lissencephaly
Bronchiectasis, Lissencephaly, Respiratory distress, Abnormal mucociliary clearance, Recurrent re... OMIM:619466
Asbestos Intoxication
Wheezing, Lung adenocarcinoma, Pleural thickening, Exertional dyspnea, Restrictive ventilatory de... ORPHA:2302
Thyroid Hormone Metabolism, Abnormal
Elevated circulating thyroid-stimulating hormone concentration OMIM:609698
Surfactant Metabolism Dysfunction, Pulmonary, 3
Desquamative interstitial pneumonitis, Neonatal respiratory distress, Death in infancy, Nonspecif... OMIM:610921
Adult Acute Respiratory Distress Syndrome
Hypoxemia, Pneumonia, Diabetic ketoacidosis, Abnormal blood gas level, Pulmonary edema, Pulmonary... ORPHA:70578
Mucus Inspissation Of Respiratory Tract
Chronic pulmonary obstruction, Bronchiectasis, Chronic sinusitis, Recurrent respiratory infection... OMIM:253240
Ciliary Dyskinesia, Primary, 21
Neonatal respiratory distress, Ciliary dyskinesia, Bronchiectasis, Chronic sinusitis, Recurrent p... OMIM:615294
Surfactant Metabolism Dysfunction, Pulmonary, 2
Desquamative interstitial pneumonitis, Nonspecific interstitial pneumonia, Spontaneous pneumothor... OMIM:610913
Acute Interstitial Pneumonia
Reticulonodular pattern on pulmonary HRCT, Hypoxemia, Crackles, Bronchiectasis, Tachypnea, Interl... ORPHA:79126
Meconium Aspiration Syndrome
Wheezing, Hypoxemia, Maternal diabetes, Atelectasis, Transient pulmonary infiltrates, Pneumothora... ORPHA:70588
Ciliary Dyskinesia, Primary, 29
Ciliary dyskinesia, Bronchiectasis, Recurrent respiratory infections, Decreased nasal nitric oxid... OMIM:615872
Staphylococcal Necrotizing Pneumonia
Hypoxemia, Pneumonia, Increased circulating procalcitonin concentration, Tachypnea, Pneumothorax,... ORPHA:36238
Severe Acute Respiratory Syndrome
Hypoxemia, Cough, Respiratory distress, Diabetes mellitus, Acute infectious pneumonia, Chronic lu... ORPHA:140896
Ciliary Dyskinesia, Primary, 20
Ciliary dyskinesia, Bronchiectasis, Respiratory insufficiency due to defective ciliary clearance,... OMIM:615067
Pulmonary Blastoma
Cough, Pulmonary infiltrates, Recurrent pneumonia, Dyspnea, Pleuropulmonary blastoma ORPHA:64741
Ciliary Dyskinesia, Primary, 33
Ciliary dyskinesia, Recurrent bronchitis, Bronchiectasis, Chronic rhinitis, Cough, Recurrent lowe... OMIM:616726
Sarcoidosis, Susceptibility To, 2
Hypoxemia, Bronchiectasis, Pneumothorax, Pulmonary arterial hypertension, Elevated bronchoalveola... OMIM:612387
Idiopathic Chronic Eosinophilic Pneumonia
Wheezing, Hypoxemia, Crackles, Abnormal pulmonary thoracic imaging finding, Hypersensitivity pneu... ORPHA:2902
Pneumocystosis
Hypoxemia, Respiratory insufficiency, Interstitial pneumonitis, Exertional dyspnea, Combined cyst... ORPHA:723
Cryptogenic Organizing Pneumonia
Wheezing, Hypoxemia, Bronchial breath sound, Crackles, Pneumothorax, Ground-glass opacification, ... ORPHA:1302
Recurrent Respiratory Papillomatosis
Wheezing, Stridor, Respiratory insufficiency, Tachypnea, Upper airway obstruction, Respiratory di... ORPHA:60032
Infant Acute Respiratory Distress Syndrome
Hypoxemia, Pneumonia, Tachypnea, Respiratory tract infection, Pulmonary edema, Cyanosis, Respirat... ORPHA:70587
Hereditary Pulmonary Alveolar Proteinosis
Crazy paving pattern, Hypoxemia, Crackles, Tachypnea, Cough, Respiratory distress, Acute infectio... ORPHA:264675
Pulmonary Alveolar Proteinosis, Acquired
Hypoxemia, Lung abscess, Pneumonia, Cough, Cyanosis, Decreased DLCO, Restrictive ventilatory defe... OMIM:610910
Respiratory Distress Syndrome In Premature Infants
Neonatal respiratory distress, Tachypnea, Respiratory distress, Pulmonary edema, Dyspnea, Atelect... OMIM:267450
Pituicytoma
Increased circulating prolactin concentration, Hypogonadotropic hypogonadism, Pituitary hypothyro... ORPHA:251623
Familial Nasal Acilia
Abnormal respiratory motile cilium morphology, Bronchiectasis, Chronic rhinitis, Chronic sinusiti... ORPHA:922
Retinitis Pigmentosa, X-Linked, And Sinorespiratory Infections, With Or Without Deafness
Chronic sinusitis, Atelectasis, Recurrent bronchitis OMIM:300455
Panbronchiolitis, Diffuse
Wheezing, Hypoxemia, Crackles, Bronchiectasis, Rhonchi, Cough OMIM:604809
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency
Elevated circulating thyroid-stimulating hormone concentration, Increased circulating T4 level, D... ORPHA:171706
Diffuse Alveolar Hemorrhage
Hypoxemia, Irregular septal thickening on pulmonary HRCT, Ground-glass opacification, Cough, Pulm... ORPHA:90060
Chronic Pneumonitis Of Infancy
Hypoxemia, Tachypnea, Ground-glass opacification, Cough, Respiratory distress, Cyanosis, Intercos... ORPHA:91359
Pulmonary Capillary Hemangiomatosis
Hypoxemia, Pulmonary capillary hemangiomatosis, Centrilobular ground-glass opacification on pulmo... ORPHA:199241
Acute Lung Injury
Hypoxemia, Pneumonia, Tachypnea, Respiratory distress, Abnormal pulmonary interstitial morphology... ORPHA:178320
Lymphoid Interstitial Pneumonia
Wheezing, Subpleural interstitial thickening, Hypoxemia, Crackles, Bronchiectasis, Centrilobular ... ORPHA:79128
Primary Pulmonary Hypoplasia
Abnormal breath sound, Hypoxemia, Neonatal respiratory distress, Tachypnea, Pneumothorax, Apnea, ... ORPHA:2257
Tracheobronchopathia Osteochondroplastica
Wheezing, Productive cough, Stridor, Respiratory insufficiency, Pneumonia, Upper airway obstructi... ORPHA:3348
Pulmonary Alveolar Microlithiasis
Testicular microlithiasis, Pleural thickening, Exertional dyspnea, Restrictive ventilatory defect... ORPHA:60025
Hypothyroidism, Congenital, Nongoitrous, 8
Decreased circulating free T4 level, Central hypothyroidism, Inappropriately normal thyroid-stimu... OMIM:301033
Rowley-Rosenberg Syndrome
Pulmonary arterial hypertension, Recurrent pneumonia, Atelectasis OMIM:268500
Idiopathic Acute Eosinophilic Pneumonia
Respiratory insufficiency, Abnormal pattern of respiration, Cough, Pulmonary infiltrates, Abnorma... ORPHA:724
Autoimmune Pulmonary Alveolar Proteinosis
Crazy paving pattern, Hypoxemia, Crackles, Cough, Cyanosis, Decreased DLCO, Restrictive ventilato... ORPHA:747
Congenital Diaphragmatic Hernia
Hypoxemia, Pulmonary hypoplasia, Respiratory distress ORPHA:2140
Hypothyroidism, Central, With Testicular Enlargement
Inappropriately normal thyroid-stimulating hormone level, Reduced TSH response to thyrotrophin-re... OMIM:300888
Bronchogenic Cyst
Pneumonia, Bronchogenic cyst, Cough, Abnormal pleura morphology, Pulmonary cyst, Dyspnea, Abnorma... ORPHA:2357
Pituitary Carcinoma
Increased circulating prolactin concentration, Enlarged pituitary gland, Diabetes insipidus, Pitu... ORPHA:300385
Idiopathic Pulmonary Fibrosis
Honeycomb lung, Crackles, Bronchiectasis, Ground-glass opacification, Cough, Exertional dyspnea, ... ORPHA:2032
Growth Hormone Deficiency, Isolated Partial
Small pituitary gland, Decreased response to growth hormone stimulation test OMIM:615925
Avian Influenza
Productive cough, Hypoxemia, Pneumonia, Tachypnea, Pneumothorax, Ground-glass opacification, Coug... ORPHA:454836
Ventilator-Induced Diaphragmatic Dysfunction
Hypercapnia, Respiratory insufficiency due to muscle weakness, Reduced maximal inspiratory pressu... ORPHA:505395
Slc35A1-Cdg
Respiratory distress, Hypoxemia, Pulmonary hemorrhage, Pneumonia ORPHA:238459
Plectin-Related Limb-Girdle Muscular Dystrophy R17
Exertional dyspnea, Atelectasis, Pulmonary fibrosis, Bronchiolitis ORPHA:254361
Surfactant Metabolism Dysfunction, Pulmonary, 1
Desquamative interstitial pneumonitis, Neonatal respiratory distress, Death in infancy, Tachypnea... OMIM:265120
Hyperthyroidism, Familial Gestational
Hyperthyroidism, Increased circulating T4 level, Decreased thyroid-stimulating hormone level OMIM:603373
Primary Ciliary Dyskinesia
Wheezing, Productive cough, Pulmonary situs ambiguus, Neonatal respiratory distress, Bronchiectas... ORPHA:244
Non-Acquired Panhypopituitarism
Abnormal prolactin level, Hypogonadotropic hypogonadism, Pituitary hypothyroidism, Decreased circ... ORPHA:90695
Myotubular Myopathy With Abnormal Genital Development
Death in infancy, Unilateral cryptorchidism, Neonatal death, Respiratory distress, Bilateral cryp... OMIM:300219
X-Linked Acrogigantism
Enlarged pituitary gland, Adrenocorticotropic hormone deficiency, Diabetes insipidus, Increased s... ORPHA:300373
Hypothyroidism, Congenital, Nongoitrous, 9
Thyroid hypoplasia, Central hypothyroidism, Decreased circulating free T4 level, Inappropriately ... OMIM:301035
Waardenburg Syndrome Type 3
Acrocyanosis, Tracheomalacia, Atelectasis, Microcephaly ORPHA:896
Ciliary Dyskinesia, Primary, 1
Pneumonia, Recurrent bronchitis, Bronchiectasis, Chronic rhinitis, Ciliary dyskinesia, Chronic si... OMIM:244400
Interstitial Lung And Liver Disease
Hypoxemia, Respiratory insufficiency, Cough, Abnormal pulmonary interstitial morphology, Pulmonar... OMIM:615486
Placental Insufficiency
Hypoxemia, Abnormal lung morphology ORPHA:439167
Combined Pituitary Hormone Deficiencies, Genetic Forms
Abnormal prolactin level, Agenesis of corpus callosum, Septo-optic dysplasia, Hypogonadotropic hy... ORPHA:95494
Tempi Syndrome
Abnormality of the pulmonary vasculature, Hypoxemia, Transudative pleural effusion ORPHA:284227
Congenital Disorder Of Glycosylation, Type Iiq
Small pituitary gland, Secondary microcephaly, Hypoplasia of the corpus callosum, Diffuse cerebra... OMIM:617395
Neonatal Acute Respiratory Distress Due To Sp-B Deficiency
Neonatal respiratory distress, Interstitial pneumonitis, Tachypnea, Spontaneous neonatal pneumoth... ORPHA:217563
Acquired Methemoglobinemia
Respiratory distress, Hypoxemia, Cyanosis, Dyspnea ORPHA:464453
Surfactant Metabolism Dysfunction, Pulmonary, 5
Respiratory insufficiency, Interlobular septal thickening, Ground-glass opacification, Exertional... OMIM:614370
Surfactant Metabolism Dysfunction, Pulmonary, 4
Reduced forced expiratory volume in one second, Tachypnea, Ground-glass opacification, Decreased ... OMIM:300770
Pulmonary Arteriovenous Malformation
Hypoxemia, Epistaxis, Pulmonary arterial hypertension, Pulmonary hemorrhage, Cough, Pleural empye... ORPHA:2038
Sarcoidosis, Susceptibility To, 1
Abnormal salivary gland morphology, Hypoxemia, Bronchiectasis, Pulmonary arterial hypertension, C... OMIM:181000
Bdv Syndrome
Central hypothyroidism, Type II diabetes mellitus, Decreased circulating free T4 level, Hypogonad... OMIM:619326
Respiratory Underresponsiveness To Hypoxia And Hypercapnia
Respiratory failure, Hypercapnia, Respiratory insufficiency OMIM:267480
Car T Cell Therapy-Associated Cytokine Release Syndrome
Hypoxemia, Tachypnea, Pulmonary edema, Respiratory failure, Pleural effusion ORPHA:542323
Pericardial And Diaphragmatic Defect
Neonatal respiratory distress, Hypoxemia, Pulmonary sequestration, Pulmonary hypoplasia ORPHA:2847
Thyroid Hormone Resistance, Selective Pituitary
Impaired sensitivity to thyroid hormone, Hyperthyroidism, Elevated circulating thyroid-stimulatin... OMIM:145650
Congenitally Uncorrected Transposition Of The Great Arteries
Hypoxemia, Maternal diabetes, Tachypnea, Cyanosis, Anomalous pulmonary venous return ORPHA:860
Panhypophysitis
Increased circulating prolactin concentration, Abnormal size of pituitary gland, Decreased circul... ORPHA:95513
Non-Functioning Pituitary Adenoma
Adrenal insufficiency, Increased serum testosterone level, Abnormality of the pituitary gland, Ad... ORPHA:91349
Pulmonary Non-Tuberculous Mycobacterial Infection
Chronic pulmonary obstruction, Crackles, Bronchiectasis, Pneumothorax, Cough, Respiratory distres... ORPHA:411703
Chronic Visceral Acid Sphingomyelinase Deficiency
Decreased serum insulin-like growth factor 1, Cholelithiasis, Abnormal blood gas level, Abnormal ... ORPHA:77293
Bickerstaff Brainstem Encephalitis
Pneumonia, Hypercapnia, Abnormal thalamic MRI signal intensity, Respiratory tract infection, Resp... ORPHA:79138
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Intercostal muscle weakness, Respiratory insufficiency, Pulmonary arterial hypertension, Recurren... ORPHA:258
Adenohypophysitis
Adrenocorticotropic hormone deficiency, Abnormal size of pituitary gland, Decreased circulating c... ORPHA:95512
Scedosporiosis
Sinusitis, Bronchial breath sound, Abnormal respiratory system physiology, Pneumonia, Pleuritis, ... ORPHA:449280
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Small pituitary gland, Cryptorchidism, Decreased testicular size OMIM:614880
Absence Of The Pulmonary Artery
Hypocapnia, Bronchiectasis, Pulmonary arterial hypertension, Cyanosis, Pulmonary edema, Recurrent... ORPHA:980
Idiopathic Pulmonary Hemosiderosis
Restrictive ventilatory defect, Crackles, Ground-glass opacification, Cough, Respiratory failure,... ORPHA:99931
Sickle Cell Anemia
Hypoxemia, Pigment gallstones ORPHA:232
Hypothyroidism, Congenital, Nongoitrous, 1
Thyroid hypoplasia, Elevated circulating thyroid-stimulating hormone concentration, Congenital hy... OMIM:275200
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Decreased serum insulin-like growth factor 1, Abnormal size of pituitary gland, Bronchiectasis, R... ORPHA:293978
Lymphangioleiomyomatosis
Pneumothorax, Cough, Pulmonary lymphangiomyomatosis, Pulmonary infiltrates, Restrictive ventilato... ORPHA:538
Congenital Tricuspid Valve Dysplasia
Hypoxemia, Tachypnea, Cyanosis, Anomalous pulmonary venous return, Respiratory failure, Respirato... ORPHA:555874
Gangliocytoma
Abnormal prolactin level, Abnormality of the pituitary gland, Pituitary prolactin cell adenoma, E... ORPHA:251937
Whim Syndrome
Sinusitis, Pneumonia, Bronchiectasis, Parotitis, Respiratory tract infection, Recurrent upper res... ORPHA:51636
Achondroplasia
Restrictive ventilatory defect, Hypoxemia, Obstructive sleep apnea, Central sleep apnea ORPHA:15
Infantile Multisystem Neurologic-Endocrine-Pancreatic Disease
Hypoxemia, Aplasia/Hypoplasia of the pancreas, Hyperechogenic pancreas, Diabetes mellitus, Hypoth... ORPHA:456312
Autosomal Dominant Hyper-Ige Syndrome
Recurrent respiratory infections, Cough, Atelectasis ORPHA:2314
Farber Disease
Respiratory insufficiency, Respiratory distress, Recurrent upper respiratory tract infections, Di... ORPHA:333
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Tachypnea, Hypoplasia of the corpus callosum, Respiratory insufficiency, Atelectasis OMIM:618278
Oculopharyngodistal Myopathy 1
Hypercapnia, Respiratory insufficiency due to muscle weakness, Respiratory distress, Aspiration, ... OMIM:164310
Central Hypoventilation Syndrome, Congenital, 1
Hypoxemia, Hypercapnia, Apnea, Central hypoventilation, Hypoventilation, Nocturnal hypoventilation OMIM:209880
Dysmorphism-Short Stature-Deafness-Disorder Of Sex Development Syndrome
Hypoxemia, Pulmonary arterial hypertension, Recurrent respiratory infections, Cryptorchidism, Mic... ORPHA:2282
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Increased circulating progesterone, Decreased circulating aldosterone level, Increased serum test... ORPHA:90794
Short-Rib Thoracic Dysplasia 12
Hypoplastic nipples, Anencephaly, Respiratory insufficiency, Neonatal death, Pulmonary hypoplasia... OMIM:269860
Blue Diaper Syndrome
Elevated circulating thyroid-stimulating hormone concentration, Decreased circulating T4 level ORPHA:94086
Malignant Hyperthermia, Susceptibility To, 5
Hypercapnia OMIM:601887
Brain-Lung-Thyroid Syndrome
Hypoparathyroidism, Neonatal respiratory distress, Congenital hypothyroidism, Pulmonary arterial ... ORPHA:209905
Isolated Right Ventricular Hypoplasia
Hypoxemia, Cyanosis, Dyspnea ORPHA:439
Zygomycosis
Sinusitis, Pneumothorax, Epistaxis, Rhinorrhea, Cough, Pulmonary infiltrates, Diabetes mellitus, ... ORPHA:73263
Tularemia
Pneumonia, Abnormal pulmonary thoracic imaging finding, Cough, Respiratory distress, Pulmonary in... ORPHA:3392
Pituitary Deficiency Due To Rathke Cleft Cysts
Enlarged pituitary gland, Diabetes insipidus, Hypogonadotropic hypogonadism, Pituitary hypothyroi... ORPHA:91350
Lujo Hemorrhagic Fever
Crackles, Rhinitis, Respiratory distress, Cerebral edema, Nonproductive cough, Atelectasis ORPHA:319213
Sickle Cell Anemia
Hypoxemia, Cholelithiasis OMIM:603903
Prolactinoma
Central adrenal insufficiency, Adrenocorticotropic hormone deficiency, Hypogonadotropic hypogonad... ORPHA:2965
Giant Axonal Neuropathy
Abnormality of the pituitary gland ORPHA:643
Congenital Fiber-Type Disproportion Myopathy
Hypoxemia, Intercostal muscle weakness, Hypercapnia, Respiratory insufficiency due to muscle weak... ORPHA:2020
Brain Malformation-Congenital Heart Disease-Postaxial Polydactyly Syndrome
Pulmonary artery stenosis, Posterior pituitary hypoplasia, Abnormality of the anterior pituitary ORPHA:75389
Neonatal Marfan Syndrome
Neonatal respiratory distress, Hypoxemia, Emphysema, Decreased testicular size ORPHA:284979
Pituitary Dermoid And Epidermoid Cysts
Increased circulating prolactin concentration, Enlarged pituitary gland, Hypogonadism, Panhypopit... ORPHA:91351
Pancreatic Agenesis-Holoprosencephaly Syndrome
Hypoxemia, Absent gallbladder, Pancreatic aplasia, Neonatal insulin-dependent diabetes mellitus, ... ORPHA:556955
Pituitary Stalk Interruption Syndrome
Death in infancy, Diabetes insipidus, Septo-optic dysplasia, Abnormality of the hypothalamus-pitu... ORPHA:95496
Glycogen Storage Disease Due To Acid Maltase Deficiency
Respiratory insufficiency, Respiratory insufficiency due to muscle weakness, Exertional dyspnea, ... ORPHA:365
Cardiogenic Shock
Hypoxemia, Dyspnea, Crackles, Increased pulmonary capillary wedge pressure ORPHA:97292
Sheehan Syndrome
Central adrenal insufficiency, Abnormal size of pituitary gland, Decreased circulating cortisol l... ORPHA:91355
B3Galt6-Related Spondylodysplastic Ehlers-Danlos Syndrome
Pulmonary hypoplasia, Respiratory insufficiency, Repeated pneumothoraces, Respiratory distress, R... ORPHA:536467
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Inappropriate antidiuretic hormone secretion, Thyroid hypoplasia, Hypogonadotropic hypogonadism, ... ORPHA:226307
Oculocerebrorenal Syndrome Of Lowe
Death in infancy, Diabetes insipidus, Respiratory insufficiency, Recurrent respiratory infections... ORPHA:534
Igg4-Related Thyroid Disease
Goiter, Nodular goiter, Abnormality of the pituitary gland, Euthyroid goiter, Thyrotoxicosis with... ORPHA:64744
Chronic Thromboembolic Pulmonary Hypertension
Reduced FEV1/FVC ratio, Pulmonary arterial hypertension, Central sleep apnea, Exertional dyspnea,... ORPHA:70591
Rh Deficiency Syndrome
Tachypnea, Hypoxemia ORPHA:71275
Cystic Echinococcosis
Abnormal pulmonary thoracic imaging finding, Ovarian cyst, Multiple pulmonary cysts, Asthma, Pulm... ORPHA:400
Joubert Syndrome 38
Small pituitary gland, Decreased response to growth hormone stimulation test, Decreased serum ins... OMIM:619476
22Q11.2 Deletion Syndrome
Hypoparathyroidism, Arrhinencephaly, Chronic pulmonary obstruction, Atelectasis, Abnormal lung lo... ORPHA:567
Tsh-Secreting Pituitary Adenoma
Central adrenal insufficiency, Enlarged pituitary gland, Goiter, Hypogonadotropic hypogonadism, D... ORPHA:91347
Malignant Hyperthermia Of Anesthesia
Tachypnea, Hypercapnia ORPHA:423
Acute Liver Failure
Adrenal insufficiency, Abnormal respiratory system physiology, Abnormal pattern of respiration, C... ORPHA:90062
Goodpasture Syndrome
Hemosiderin-laden macrophages in bronchoalveolar fluid, Restrictive ventilatory defect, Bloody br... OMIM:233450
Telangiectasia, Hereditary Hemorrhagic, Type 1
Hypoxemia, Reduced FEV1/FVC ratio, Spontaneous, recurrent epistaxis, Pulmonary hemorrhage, Pulmon... OMIM:187300
Relapsing Polychondritis
Dyspnea, Atelectasis, Cough, Abnormal pattern of respiration ORPHA:728
Eisenmenger Syndrome
Wheezing, Hypoxemia, Aortopulmonary window, Pulmonary arterial hypertension, Exertional dyspnea, ... ORPHA:97214
Duplication Of The Pituitary Gland
Abnormal hypothalamus morphology, Agenesis of corpus callosum, Microcephaly, Abnormality of the p... ORPHA:314621
Exercise-Induced Malignant Hyperthermia
Tachypnea, Hypocapnia, Crackles ORPHA:466650
Chand Syndrome
Atelectasis ORPHA:1401
Igg4-Related Ophthalmic Disease
Sinusitis, Neoplasm of the lung, Abnormality of the anterior pituitary, Thyroiditis, Abnormal lun... ORPHA:449563
Primary Sjögren Syndrome
Lymphocytic interstitial pneumonia, Parotitis, Abnormal pulmonary interstitial morphology, Thyroi... ORPHA:289390
Pituitary Hormone Deficiency, Combined, 4
Adrenal insufficiency, Hypothyroidism, Impaired growth-hormone response to insulin stimulation test OMIM:262700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lhx4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lhx4.

No publications found that use IMPC mice or data for Lhx4.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Lhx4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lhx4tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter