International Mouse Phenotyping Consortium: Insights from the Past, Shaping the Future
The conference will take place on 22 January 2026.
Join us for this online event to discuss the rationale for continuing the IMPC initiative, propose modifications to its structure and strategy, and provide guidance on enhancing the scientific value and utility of the project’s next phase.
Please see the agenda and registration details below.
About the Conference
The key aim of this online conference is to:
- Highlight the IMPC’s major research achievements.
- Demonstrate how IMPC data has transformed our understanding of human gene function.
- Discuss the vision, priorities, and structure of the IMPC’s next phase.
The conference will bring together experts in mouse genetics and genomic medicine to examine future challenges and unmet needs at the interface of these fields, and to explore how future work and collaboration can address them. As the IMPC plans its next phase, we invite the research community to help shape future priorities in mouse model production and phenotyping.
Format
The conference will feature: presentations, panel discussions, interactive breakout sessions. Attendees will be able to engage via live chat, ask questions, and share feedback.
Registration
Registration is mandatory through this page.
Agenda
Current schedule, speaker lineup and session topics.
Times shown in multiple time zones
EDT: Eastern (UTC−4)
PDT: Pacific (UTC−7)
CET: Central Europe (UTC+1)
Each slot lists times in EDT / PDT / CET order.
11.00–11.20 EDT
08.00–08.20 PDT
17.00–17.20 CET
08.00–08.20 PDT
17.00–17.20 CET
Welcome and Introduction
5 min each
(introductory talks) –
20 min
(introductory talks) –
20 min
Jason Heaney (IMPC Chair)
Martin Hrabe de Angelis (Infrafrontier ERIC, Germany)
Je Kyung Seong (KMPC, South Korea)
11.20–12.20 EDT
08.20–09.20 PDT
17.20–18.20 CET
08.20–09.20 PDT
17.20–18.20 CET
Session 1. Update on IMPC production and phenotyping efforts to date
Chairs:
Colin Fletcher (NHGRI/NIH, Washington, USA);
Oleg Mirochnitchenko (ORIP/OD/NIH, Washington, USA)
Colin Fletcher (NHGRI/NIH, Washington, USA);
Oleg Mirochnitchenko (ORIP/OD/NIH, Washington, USA)
11.20–11.35 EDT
08.20–08.35 PDT
17.20–17.35 CET
08.20–08.35 PDT
17.20–17.35 CET
Jason Heaney (BCM, USA)
Presentation of the IMPC Programme – Key discoveries / Big picture
10 min presentation + 5 min questions
11.35–11.50 EDT
08.35–08.50 PDT
17.35–17.50 CET
08.35–08.50 PDT
17.35–17.50 CET
Lauryl Nutter (TCP, Canada)
Production and distribution effort
10 min presentation + 5 min questions
11.50–12.05 EDT
08.50–09.05 PDT
17.50–18.05 CET
08.50–09.05 PDT
17.50–18.05 CET
Jacqui White (The Jackson Laboratory, USA)
Phenotyping effort
10 min presentation + 5 min questions
12.05–12.20 EDT
09.05–09.20 PDT
18.05–18.20 CET
09.05–09.20 PDT
18.05–18.20 CET
MPI2 — TBD
IMPC Data collection, analysis, and interpretation
10 min presentation + 5 min questions
12.20–12.40 EDT
09.20–09.40 PDT
18.20–18.40 CET
09.20–09.40 PDT
18.20–18.40 CET
Coffee / Lunch break (20 min)
12.40–14.25 EDT
09.40–11.25 PDT
18.40–20.25 CET
09.40–11.25 PDT
18.40–20.25 CET
Session 2. Informing human gene function using knockout mice: IMPC achievements and empowering community research
Chair: Jesse Mager (UMass, USA)
12.40–12.55 EDT
09.40–09.55 PDT
18.40–18.55 CET
09.40–09.55 PDT
18.40–18.55 CET
Yann Hérault (ICS, France)
Overview of IMPC data contributions to research
10 min presentation + 5 min questions
12.55–13.10 EDT
09.55–10.10 PDT
18.55–19.10 CET
09.55–10.10 PDT
18.55–19.10 CET
Steve Murray (The Jackson Laboratory, USA)
Lessons from more than 2,700 Essential Genes
10 min presentation + 5 min questions
13.10–13.25 EDT
10.10–10.25 PDT
19.10–19.25 CET
10.10–10.25 PDT
19.10–19.25 CET
Nadine Spielmann (GMC, Germany)
Late Adult Phenotyping
10 min presentation + 5 min questions
13.25–13.40 EDT
10.25–10.40 PDT
19.25–19.40 CET
10.25–10.40 PDT
19.25–19.40 CET
Speaker — TBD
Title TBC
10 min presentation + 5 min questions
13.40–13.55 EDT
10.40–10.55 PDT
19.40–19.55 CET
10.40–10.55 PDT
19.40–19.55 CET
Sabine Hoelter-Koch (GMC, Germany)
Uptake of IMPC work/publications for development of pre-clinical models / pre-clinical studies
10 min presentation + 5 min questions
13.55–14.25 EDT
10.55–11.25 PDT
19.55–20.25 CET
10.55–11.25 PDT
19.55–20.25 CET
Kent Lloyd (University of California at Davis, USA)
Summary of the RFI & Survey assessing IMPC to date and rationale for completing in vivo functional annotation
20 min presentation + 10 min questions
14.25–14.45 EDT
11.25–11.45 PDT
20.25–20.45 CET
11.25–11.45 PDT
20.25–20.45 CET
Coffee break (20 min)
14.45–15.25 EDT
11.45–12.25 PDT
20.45–21.25 CET
11.45–12.25 PDT
20.45–21.25 CET
Session 3. Scope and structure of a next phase of IMPC
Chairs: Steve Brown (ICS, France)
14.45–14.55 EDT
11.45–11.55 PDT
20.45–20.55 CET
11.45–11.55 PDT
20.45–20.55 CET
Kevin Peterson (The Jackson Laboratory, USA)
Value for completing the remaining genes
8 min presentation + 2 min questions
14.55–15.05 EDT
11.55–12.05 PDT
20.55–21.05 CET
11.55–12.05 PDT
20.55–21.05 CET
Naoki Kubo (RIKEN, Japan)
Functional annotation of non-coding sequences
8 min presentation + 2 min questions
15.05–15.15 EDT
12.05–12.15 PDT
21.05–21.15 CET
12.05–12.15 PDT
21.05–21.15 CET
Infrafrontier, TBD
Future Plans
8 min presentation + 2 min questions
15.15–15.25 EDT
12.15–12.25 PDT
21.15–21.25 CET
12.15–12.25 PDT
21.15–21.25 CET
Brendan Lee (BCM, USA)
Rare diseases
8 min presentation + 2 min questions
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout sessions: future focus of the IMPC (45 min)
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session I
Completing the null resource
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session II
Modeling rare disease variants
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session III
Probing other features of the genome
16.10–16.30 EDT
13.10–13.30 PDT
22.10–22.30 CET
13.10–13.30 PDT
22.10–22.30 CET
Coffee break (20 min)
16.30–17.00 EDT
13.30–14.00 PDT
22.30–23.00 CET
13.30–14.00 PDT
22.30–23.00 CET
Summary of Break-out sessions
30 min
17.00-17.05 EDT
14.00–14.05 PDT
23.00–23.05 CET
14.00–14.05 PDT
23.00–23.05 CET
IMPC prioritization poll
5 min
17.05–17.45 EDT
14.05–14.45 PDT
23.05–23.45 CET
14.05–14.45 PDT
23.05–23.45 CET
Final Discussion — Future Priorities, Thoughts on Break-out Summaries, Funding
40 min
17.45–18.00 EDT
14.45–15.00 PDT
23.45–00.00 CET (+1)
14.45–15.00 PDT
23.45–00.00 CET (+1)
Closing remarks
15 min
18.00 EDT
15.00 PDT
00.00 CET (+1)
15.00 PDT
00.00 CET (+1)