International Mouse Phenotyping Consortium: Insights from the Past, Shaping the Future
The conference will take place on 22 January 2026.
Join us for this online event to discuss the rationale for continuing the IMPC initiative, propose modifications to its structure and strategy, and provide guidance on enhancing the scientific value and utility of the project’s next phase.
Please see the agenda and registration details below.
About the Conference
The key aim of this online conference is to:
- Highlight the IMPC’s major research achievements.
- Demonstrate how IMPC data has transformed our understanding of human gene function.
- Discuss the vision, priorities, and structure of the IMPC’s next phase.
The conference will bring together experts in mouse genetics and genomic medicine to examine future challenges and unmet needs at the interface of these fields, and to explore how future work and collaboration can address them. As the IMPC plans its next phase, we invite the research community to help shape future priorities in mouse model production and phenotyping.
Format
The conference will feature: presentations, panel discussions, interactive breakout sessions. Attendees will be able to engage via live chat, ask questions, and share feedback.
Registration
Registration is mandatory through this page.
Agenda
Current schedule, speaker lineup and session topics.
Times shown in multiple time zones
EDT: Eastern (UTC−4)
PDT: Pacific (UTC−7)
CET: Central Europe (UTC+1)
Each slot lists times in EDT / PDT / CET order.
11.00–11.20 EDT
08.00–08.20 PDT
17.00–17.20 CET
08.00–08.20 PDT
17.00–17.20 CET
Welcome and Introduction
5 min each
(introductory talks) –
20 min
(introductory talks) –
20 min
Jason Heaney (IMPC Chair)
Welcome address – Short Introduction
Welcome address – Short Introduction
Martin Hrabe de Angelis (Infrafrontier ERIC, Germany)
Je Kyung Seong (KMPC, South Korea)
Understanding Human Health with Animal Models in the AI Era
Understanding Human Health with Animal Models in the AI Era
11.20–12.20 EDT
08.20–09.20 PDT
17.20–18.20 CET
08.20–09.20 PDT
17.20–18.20 CET
Session 1. Update on IMPC production and phenotyping efforts to date
Chairs:
Colin Fletcher (NHGRI/NIH, Washington, USA);
Oleg Mirochnitchenko (ORIP/OD/NIH, Washington, USA)
Colin Fletcher (NHGRI/NIH, Washington, USA);
Oleg Mirochnitchenko (ORIP/OD/NIH, Washington, USA)
11.20–11.35 EDT
08.20–08.35 PDT
17.20–17.35 CET
08.20–08.35 PDT
17.20–17.35 CET
Jason Heaney (Baylor College of Medicine, USA)
The Past and Future of the IMPC – Setting the Stage
10 min presentation + 5 min questions
11.35–11.50 EDT
08.35–08.50 PDT
17.35–17.50 CET
08.35–08.50 PDT
17.35–17.50 CET
Lauryl Nutter (The Center for Phenogenomics, Canada)
IMPC Production – Resource & Technology Development
10 min presentation + 5 min questions
11.50–12.05 EDT
08.50–09.05 PDT
17.50–18.05 CET
08.50–09.05 PDT
17.50–18.05 CET
Jacqui White (The Jackson Laboratory, USA)
Building a comprehensive catalogue of mammalian gene function
10 min presentation + 5 min questions
12.05–12.20 EDT
09.05–09.20 PDT
18.05–18.20 CET
09.05–09.20 PDT
18.05–18.20 CET
Piia Keskivali-Bond (MRC Harwell, UK)/ Robert Wilson (EBI, UK)/ Pilar Cacheiro (QMUL,UK)
Data analysis, interpretation, and presentation at mousephenotype.org
10 min presentation + 5 min questions
12.20–12.40 EDT
09.20–09.40 PDT
18.20–18.40 CET
09.20–09.40 PDT
18.20–18.40 CET
Coffee / Lunch break (20 min)
12.40–14.25 EDT
09.40–11.25 PDT
18.40–20.25 CET
09.40–11.25 PDT
18.40–20.25 CET
Session 2. Informing human gene function using knockout mice: IMPC achievements and empowering community research
Chairs:
Jesse Mager (University of Massachusetts-Amherst, USA)
John Mudgett (Chair, IMPC Panel of Scientific Consultants/PSC)
Jesse Mager (University of Massachusetts-Amherst, USA)
John Mudgett (Chair, IMPC Panel of Scientific Consultants/PSC)
12.40–12.55 EDT
09.40–09.55 PDT
18.40–18.55 CET
09.40–09.55 PDT
18.40–18.55 CET
Yann Hérault (ICS, France)
Overview of IMPC data contributions including major past papers
10 min presentation + 5 min questions
12.55–13.10 EDT
09.55–10.10 PDT
18.55–19.10 CET
09.55–10.10 PDT
18.55–19.10 CET
Steve Murray (The Jackson Laboratory, USA)
Lessons from more than 2,700 Essential Genes
10 min presentation + 5 min questions
13.10–13.25 EDT
10.10–10.25 PDT
19.10–19.25 CET
10.10–10.25 PDT
19.10–19.25 CET
Nadine Spielmann (GMC, Germany)
Aging under genetic manipulation will alter the heart in significant and diverse ways
10 min presentation + 5 min questions
13.25–13.40 EDT
10.25–10.40 PDT
19.25–19.40 CET
10.25–10.40 PDT
19.25–19.40 CET
Bob Braun (The Jackson Laboratory, USA)
Infertility
10 min presentation + 5 min questions
13.40–13.55 EDT
10.40–10.55 PDT
19.40–19.55 CET
10.40–10.55 PDT
19.40–19.55 CET
Sabine Hoelter-Koch (GMC, Germany)
Uptake of IMPC resources for preclinical research
10 min presentation + 5 min questions
13.55–14.25 EDT
10.55–11.25 PDT
19.55–20.25 CET
10.55–11.25 PDT
19.55–20.25 CET
Kent Lloyd (University of California at Davis, USA)
Summary of results of the Survey sent to the research community soliciting their assessment of IMPC to date and the scientific rationale and value for continuing to complete the in vivo functional annotation of the human orthologous genes in the mouse genome.
20 min presentation + 10 min questions
14.25–14.45 EDT
11.25–11.45 PDT
20.25–20.45 CET
11.25–11.45 PDT
20.25–20.45 CET
Coffee break (20 min)
14.45–15.25 EDT
11.45–12.25 PDT
20.45–21.25 CET
11.45–12.25 PDT
20.45–21.25 CET
Session 3. Scope and structure of a next phase of IMPC
Chairs:
Steve Brown (Former Chair IMPC Steering Committee)
Steve Brown (Former Chair IMPC Steering Committee)
14.45–14.55 EDT
11.45–11.55 PDT
20.45–20.55 CET
11.45–11.55 PDT
20.45–20.55 CET
Kevin Peterson (The Jackson Laboratory, USA)
Completing the Mouse Null Resource: Opportunities, Obstacles, and Next Steps
8 min presentation + 2 min questions
14.55–15.05 EDT
11.55–12.05 PDT
20.55–21.05 CET
11.55–12.05 PDT
20.55–21.05 CET
Naoki Kubo (RIKEN, Japan)
Functional annotation of non-coding sequences
8 min presentation + 2 min questions
15.05–15.15 EDT
12.05–12.15 PDT
21.05–21.15 CET
12.05–12.15 PDT
21.05–21.15 CET
Johannes Beckers (Infrafrontier, Germany)
INFRAFRONTIER: Advancing Europe’s Infrastructure for Human Disease Modelling
8 min presentation + 2 min questions
15.15–15.25 EDT
12.15–12.25 PDT
21.15–21.25 CET
12.15–12.25 PDT
21.15–21.25 CET
Brendan Lee (Baylor College of Medicine, USA)
Impact and future for modeling rare human diseases in mice
8 min presentation + 2 min questions
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Break-out sessions (45 min)
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session I
Completing the protein coding gene null resource
Chair
Kevin Peterson
Kevin Peterson
Panelists
Kent Lloyd
Jesse Mager
Damian Smedley
Kent Lloyd
Jesse Mager
Damian Smedley
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session II
Rare disease variants
Chair
Jason Heaney
Jason Heaney
Panelists
Brendan Lee
Cat Lutz
Radislav Sedláček
Brendan Lee
Cat Lutz
Radislav Sedláček
15.25–16.10 EDT
12.25–13.10 PDT
21.25–22.10 CET
12.25–13.10 PDT
21.25–22.10 CET
Breakout Session III
Other parts of the genome
Chair
Steve Brown
Steve Brown
Panelists
Toshihiko Shiroishi
Yann Hérault
Naoki Kubo
Ivan Marazzi
Toshihiko Shiroishi
Yann Hérault
Naoki Kubo
Ivan Marazzi
16.10–16.30 EDT
13.10–13.30 PDT
22.10–22.30 CET
13.10–13.30 PDT
22.10–22.30 CET
Coffee break (20 min)
16.30–17.00 EDT
13.30–14.00 PDT
22.30–23.00 CET
13.30–14.00 PDT
22.30–23.00 CET
Summary of Break-out sessions
30 min
17.00-17.05 EDT
14.00–14.05 PDT
23.00–23.05 CET
14.00–14.05 PDT
23.00–23.05 CET
IMPC prioritization poll
5 min
17.05–17.45 EDT
14.05–14.45 PDT
23.05–23.45 CET
14.05–14.45 PDT
23.05–23.45 CET
Final Discussion — Future Priorities, Thoughts on Break-out Summaries, Funding
40 min
17.45–18.00 EDT
14.45–15.00 PDT
23.45–00.00 CET (+1)
14.45–15.00 PDT
23.45–00.00 CET (+1)
Closing remarks
15 min
18.00 EDT
15.00 PDT
00.00 CET (+1)
15.00 PDT
00.00 CET (+1)