MP:0020179 (abnormal IgG3 level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: abnormal IgG3 level

Definition

deviation from the normal levels of immunoglobulin class G3 level

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 5

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Myl4 Myl4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased IgG3 level	IgG3 Immunoglobulin	HMGU EuroPhenome	5.67×10^-08
Usp12 Usp12^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	increased IgG3 level	IgG3 Immunoglobulin	HMGU EuroPhenome	2.85×10^-07
Aco2 Aco2^{Gt(EUC0050e03)Hmgu}	HET	Early adult	decreased IgG3 level	IgG3 Immunoglobulin	HMGU EuroPhenome	9.34×10^-06
Mysm1 Mysm1^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased IgG3 level	IgG3 Immunoglobulin	HMGU EuroPhenome	1.09×10^-05
Plcg2 Plcg2^Ali14	HET	Early adult	decreased IgG3 level	IgG3 Immunoglobulin	HMGU EuroPhenome	3.13×10^-05

Download data as: TSV XLS

Procedure
Immunoglobulin
Immunoglobulin concentration

4.50% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal IgG3 level (5/111)

2.83% females (3/106) 0.97% males (1/103)

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