Phenotype: abnormal basophil cell number

Definition
deviation of the count of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal basophil cell number

Total number of significant genotype-phenotype associations: 165

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Cdc42ep5
Cdc42ep5tm1(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
0.00
Ces2e
Ces2eem1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
0.00
Hectd4
Hectd4em1(IMPC)Marc
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
0.00
Ppp1r14a
Ppp1r14aem1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
0.00
Usp31
Usp31em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
0.00
Zswim1
Zswim1tm1b(KOMP)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
0.00
Brix1
Brix1tm1b(KOMP)Mbp
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
8.41×10-45
Erich2
Erich2em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.08×10-44
Hectd1
Hectd1tm1b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.21×10-40
Etaa1
Etaa1em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
5.12×10-40
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.45×10-38
Cyld
Cyldem2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.96×10-35
Suv39h2
Suv39h2em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
9.90×10-32
Spata16
Spata16em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.51×10-30
Otud6a
Otud6atm1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
3.37×10-28
Usp15
Usp15em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.10×10-26
Kdm1a
Kdm1atm1(NCOM)Mfgc
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.11×10-26
Usp46
Usp46em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
5.54×10-25
Hnrnpd
Hnrnpdtm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
8.46×10-25
Stra6l
Stra6ltm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
2.94×10-23
Emc4
Emc4tm1(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
4.31×10-23
Atg4a
Atg4aem2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.11×10-22
Itprid1
Itprid1em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.23×10-21
Usp26
Usp26em1(IMPC)Marc
HEM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
7.84×10-21
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.34×10-20
Usp45
Usp45em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
4.18×10-20
Hnrnpdl
Hnrnpdlem1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
7.98×10-20
Otud6b
Otud6btm1b(EUCOMM)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
1.71×10-19
Fbxw8
Fbxw8tm1b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
2.92×10-19
Hnrnpr
Hnrnprem1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
5.98×10-19
Bap1
Bap1em2(IMPC)Marc
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
8.85×10-19
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.09×10-18
Atg4c
Atg4cem2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
5.29×10-18
Prdm2
Prdm2em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
2.95×10-16
Fbxo28
Fbxo28em1(IMPC)Mhzh
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.78×10-16
Rbm11
Rbm11em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
2.91×10-15
Brcc3
Brcc3em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.42×10-14
Prmt6
Prmt6em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.77×10-14
Ufc1
Ufc1em1(IMPC)Marc
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.07×10-13
Psmd14
Psmd14tm1b(NCOM)Cmhd
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.63×10-13
Cimip2b
Cimip2btm1(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
3.66×10-13
Eddm3b
Eddm3btm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
4.01×10-12
Sirt1
Sirt1tm1b(EUCOMM)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
6.63×10-12
Vav2
Vav2em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
5.66×10-11
Klk4
Klk4tm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.50×10-10
Fancl
Fancltm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.58×10-10
Apbb3
Apbb3em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
2.26×10-10
Atp13a5
Atp13a5em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
5.78×10-10
Fkbp5
Fkbp5tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.34×10-09
Has1
Has1tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
3.85×10-09
Phldb2
Phldb2em1(IMPC)H
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
9.16×10-09
Fbxo27
Fbxo27em2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.06×10-08
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi
HOM Late adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
1.47×10-08
Fbxl18
Fbxl18tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
3.65×10-08
Kcnj9
Kcnj9tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
4.39×10-08
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult decreased basophil cell number Basophil differential count
Hematology
TCP
IMPC
4.54×10-08
Usp16
Usp16tm1b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
4.98×10-08
Bok
Boktm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
1.77×10-07
Herc6
Herc6tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.89×10-07
Parp12
Parp12tm1.1(KOMP)Vlcg
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.99×10-07
Kcnk13
Kcnk13em1(IMPC)H
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
2.04×10-07
Aars2
Aars2tm1(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
2.05×10-07
Bod1
Bod1tm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
2.87×10-07
Nexmif
Nexmifem1(IMPC)Tcp
HEM Early adult increased basophil cell number Basophil differential count
Hematology
TCP
IMPC
3.14×10-07
Fbxo15
Fbxo15em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
4.34×10-07
Limd1
Limd1em1(IMPC)H
HOM Late adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
5.80×10-07
Tnip1
Tnip1tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
6.14×10-07
Cxcl13
Cxcl13em2(IMPC)H
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
6.31×10-07
Fbxl19
Fbxl19tm1b(EUCOMM)Wtsi
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
7.58×10-07
Art1
Art1tm1b(EUCOMM)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
8.03×10-07
Pcdhb13
Pcdhb13em1(IMPC)Tcp
HOM Early adult decreased basophil cell number Basophil cell count
Hematology
TCP
IMPC
8.67×10-07
Smoc1
Smoc1tm1b(EUCOMM)Wtsi
HET   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
1.14×10-06
Ube2z
Ube2zem1(IMPC)Marc
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.35×10-06
Cilk1
Cilk1tm1b(KOMP)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.43×10-06
Epg5
Epg5em1(IMPC)H
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
1.52×10-06
Lsm14a
Lsm14atm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
2.04×10-06
Fbxw2
Fbxw2tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
2.09×10-06
Hirip3
Hirip3tm1.1(KOMP)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
2.17×10-06
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
2.73×10-06
Stat1
Stat1tm2b(EUCOMM)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
ICS
IMPC
2.83×10-06
Acsm1
Acsm1em1(IMPC)Mhzh
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.13×10-06
Herc4
Herc4tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.16×10-06
Gp9
Gp9tm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
3.74×10-06
Ace
Acetm1.1(KOMP)Vlcg
HET Early adult increased basophil cell number Basophil differential count
Hematology
UC Davis
IMPC
4.32×10-06
Cd1d1
Cd1d1em1(IMPC)H
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
4.34×10-06
Nherf1
Nherf1em1(IMPC)H
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
4.66×10-06
Ctu2
Ctu2tm1(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
4.67×10-06
Trim37
Trim37em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
4.99×10-06
Alg1
Alg1tm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
5.44×10-06
Pard3
Pard3tm1b(KOMP)Wtsi
HET Early adult decreased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
5.64×10-06
Ric8b
Ric8btm1b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
6.58×10-06
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
7.56×10-06
Fbxo38
Fbxo38em2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
9.67×10-06
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
9.68×10-06
Bcar3
Bcar3em1(IMPC)Mbp
HOM Early adult increased basophil cell number Basophil differential count
Hematology
UC Davis
IMPC
1.07×10-05
Nsg1
Nsg1tm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.22×10-05
Fbxl2
Fbxl2em2(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.25×10-05
Atg4b
Atg4bem1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
1.48×10-05
Hook3
Hook3tm1b(NCOM)Mfgc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
1.49×10-05
Phf21b
Phf21bem1(IMPC)Marc
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.60×10-05
Chrna10
Chrna10em1(IMPC)Mbp
HOM Early adult increased basophil cell number Basophil differential count
Hematology
UC Davis
IMPC
1.60×10-05
Tmem8b
Tmem8bem1(IMPC)Tcp
HET Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
1.63×10-05
Nos3
Nos3em1(IMPC)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
1.64×10-05
Blnk
Blnkem1(IMPC)H
HOM Early adult decreased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
1.72×10-05
Bbof1
Bbof1em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
1.76×10-05
Chmp4c
Chmp4ctm1b(EUCOMM)Wtsi
HOM Early adult decreased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
1.82×10-05
Rft1
Rft1tm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
2.00×10-05
Zfp503
Zfp503em1(IMPC)Mbp
HET Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
2.02×10-05
Btg1
Btg1em1(IMPC)Mbp
HOM   Early adult increased basophil cell number Basophil differential count
Hematology
UC Davis
IMPC
2.09×10-05
Ramp1
Ramp1tm1b(EUCOMM)Wtsi
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
2.21×10-05
Ldb3
Ldb3tm2b(EUCOMM)Hmgu
HET   Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
2.42×10-05
Hddc2
Hddc2em1(IMPC)H
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
2.74×10-05
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
2.89×10-05
Tra2a
Tra2atm2b(EUCOMM)Hmgu
HET   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
2.99×10-05
Got1
Got1tm1b(EUCOMM)Hmgu
HET Early adult decreased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
3.21×10-05
Lpin3
Lpin3tm1b(KOMP)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
3.43×10-05
Opn3
Opn3em1(IMPC)Mbp
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
3.88×10-05
Apof
Apoftm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil cell count
Hematology
UC Davis
IMPC
3.89×10-05
Usp26
Usp26em1(IMPC)Marc
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.98×10-05
Phf11a
Phf11atm1b(NCOM)Mfgc
HET Early adult increased basophil cell number Basophil cell count
Hematology
MARC
IMPC
3.98×10-05
Mmgt2
Mmgt2tm1b(EUCOMM)Wtsi
HOM Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
4.46×10-05
Spink2
Spink2tm1.1(KOMP)Vlcg
HOM Early adult increased basophil cell number Basophil differential count
Hematology
UC Davis
IMPC
4.68×10-05
Fbxo9
Fbxo9tm1b(EUCOMM)Hmgu
HOM Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
4.68×10-05
Speg
Spegtm1b(KOMP)Wtsi
HET Early adult increased basophil cell number Basophil differential count
Hematology
MARC
IMPC
4.71×10-05
Slc7a5
Slc7a5em1(IMPC)H
HET Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
4.74×10-05
Col4a3
Col4a3tm1b(EUCOMM)Wtsi
HOM Early adult decreased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
4.98×10-05
Ube2b
Ube2btm1b(EUCOMM)Wtsi
HET Early adult decreased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
5.38×10-05
Abcb4
Abcb4em1(IMPC)H
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
5.72×10-05
Arhgef18
Arhgef18tm1b(KOMP)Mbp
HET Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
6.11×10-05
Kcnj10
Kcnj10tm1b(KOMP)Wtsi
HET Early adult decreased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
6.14×10-05
Clstn1
Clstn1tm1b(EUCOMM)Hmgu
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
6.64×10-05
Ahcy
Ahcytm1b(EUCOMM)Hmgu
HET Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
6.74×10-05
Boc
Boctm1b(KOMP)Wtsi
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
6.79×10-05
Cldn9
Cldn9em1(IMPC)H
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
7.26×10-05
Ntrk1
Ntrk1tm1b(EUCOMM)Wtsi
HET   Early adult increased basophil cell number Basophil differential count
Hematology
MRC Harwell
IMPC
7.83×10-05
Cib2
Cib2tm1b(EUCOMM)Wtsi
HOM Early adult increased basophil cell number Basophil cell count
Hematology
MRC Harwell
IMPC
8.59×10-05
Ifi44
Ifi44tm1b(KOMP)Wtsi
HOM   Early adult increased basophil cell number Basophil cell count
Hematology
TCP
IMPC
9.85×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Hematology

 Phenotype associations stats

4.64% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal basophil cell number (135/2911)

2.13% females (63/2960) 2.92% males (86/2946)

Select a parameter    



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