Phenotype: decreased large unstained cell number

Definition
decreased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts
Synonyms
decreased LUC number
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased large unstained cell number

Total number of significant genotype-phenotype associations: 23

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
ICS
IMPC
1.43×10-08
Pdpr
Pdprtm1b(EUCOMM)Wtsi
HOM   Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
ICS
IMPC
1.69×10-07
Pkn1
Pkn1tm1b(KOMP)Wtsi
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
2.52×10-07
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET   Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
ICS
IMPC
7.55×10-07
Dyrk2
Dyrk2em1(IMPC)Ics
HET Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
ICS
IMPC
1.31×10-06
Fabp1
Fabp1tm1b(EUCOMM)Hmgu
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
MRC Harwell
IMPC
2.43×10-06
Itgae
Itgaetm1b(EUCOMM)Wtsi
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
3.30×10-06
Avp
Avptm1b(EUCOMM)Wtsi
HET Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
7.96×10-06
Xbp1
Xbp1tm1b(EUCOMM)Wtsi
HET Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
1.27×10-05
Ikzf3
Ikzf3tm1(KOMP)Vlcg
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
RBRC
IMPC
3.32×10-05
Stx7
Stx7em1(IMPC)Rbrc
HOM   Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
RBRC
IMPC
3.99×10-05
Ppm1m
Ppm1mtm2b(EUCOMM)Hmgu
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
MRC Harwell
IMPC
5.06×10-05
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM   Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
5.93×10-05
Cd46
Cd46em1(IMPC)H
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
5.94×10-05
Ptdss1
Ptdss1tm1b(EUCOMM)Hmgu
HOM   Early adult decreased large unstained cell number Large Unstained Cell (LUC) differential count
Hematology
ICS
IMPC
7.25×10-05
Blnk
Blnkem1(IMPC)H
HOM Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
MRC Harwell
IMPC
8.32×10-05
Ecrg4
Ecrg4tm1b(EUCOMM)Hmgu
HOM   Early adult decreased large unstained cell number Large Unstained Cell (LUC) count
Hematology
ICS
IMPC
9.63×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Hematology

 Phenotype associations stats

1.74% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased large unstained cell number (17/978)

0.63% females (6/959) 1.14% males (11/961)

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