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Phenotype: increased physiological sensitivity to xenobiotic

Definition
decrease in the dose or concentration of a compound foreign to living organisms required to induce a specific level of physiological response or increase in the severity of physiological response to a given dose or concentration of a compound foreign to living organisms
Synonyms
increased susceptibility to xenobiotics,  decreased resistance to xenobiotics,  increased physiological sensitivity to xenobiotics
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased physiological sensitivity to xenobiotic

Total number of significant genotype-phenotype associations: 1

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Lta
Ltatm1.1(KOMP)Vlcg 		HOM Early adult increased bronchoconstrictive response 12.5 Mch Enhanced pause
Challenge Whole Body Plethysmography		 TCP
IMPC		 8.65×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Challenge Whole Body Plethysmography

 Phenotype associations stats

1.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased physiological sensitivity to xenobiotic (1/56)

0.00% females (0/55) 1.75% males (1/57)

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