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Phenotype: abnormal NK T cell number

Definition
deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
Synonyms
abnormal natural killer T cell number,  abnormal NK T lymphocyte number,  abnormal NK T-cell number,  abnormal natural killer T-lymphocyte number,  abnormal NK T-lymphocyte number,  abnormal natural killer T-cell number,  abnormal NKT cell number,  abnormal natural killer T lymphocyte number,  abnormal natural T cell number
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal NK T cell number

Total number of significant genotype-phenotype associations: 107

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult increased Ly6C-positive NK T cell number Ly6C+ NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker CD4-positive NK T cell number Resting CD4+ NKT cells - % of CD4+ NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Effector CD4- NKT cells - % of CD4- NKT cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Effector CD4- NKT cells - % of CD4- NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased KLRG1-positive CD4-negative NK T cell number KLRG1+ CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Effector CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult decreased CD4-positive NK T cell number Total CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Clpp
Clpptm1a(EUCOMM)Wtsi 		HOM   Early adult decreased NK T cell number Total NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased NK T cell number Total NKT cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker CD4-positive NK T cell number Resting CD4+ NKT cells - % of CD4+ NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD4- NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased CD4-positive NK T cell number Total CD4+ NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi 		HOM   Early adult increased CD4-negative NK T cell number Total CD4- NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Cxcr2
Cxcr2tm1a(EUCOMM)Wtsi 		HOM   Early adult increased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult decreased NK T cell number Total NKT cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Dph6
Dph6tm1a(KOMP)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gimap6
Gimap6tm1a(KOMP)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Effector CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gimap6
Gimap6tm1a(KOMP)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gimap6
Gimap6tm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-negative NK T cell number Total CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased Ly6C-positive NK T cell number Ly6C+ NKT cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult decreased CD4-positive NK T cell number Total CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM   Early adult increased CD4-negative NK T cell number Total CD4- NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Gmds
Gmdstm1a(KOMP)Wtsi 		HOM Early adult increased NK T cell number NKT cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Hbs1l
Hbs1ltm1a(KOMP)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD4- NKT cells
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Ncf2
Ncf2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased NK T cell number NKT cell number
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Pepd
Pepdtm1a(KOMP)Wtsi 		HOM   Early adult decreased Ly6C-positive NK T cell number Ly6C+ NKT cells - % of lymphocytes
Spleen Immunophenotyping		 WTSI
3i		 0.00
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult increased memory-marker CD4-negative NK T cell number Effector CD4- NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased KLRG1-positive CD4-negative NK T cell number KLRG1+ CD4- NKT cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased Ly6C-positive NK T cell number Ly6C+ NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number Resting CD4- NKT cells - % of CD4- NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased CD4-positive NK T cell number Total CD4+ NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult increased CD4-negative NK T cell number Total CD4- NKT cells - % of NKT cells
Spleen Immunophenotyping		 WTSI
3i		 0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM   Early adult decreased NK T cell number Total NKT cells - % of CD45+
Spleen Immunophenotyping		 WTSI
3i		 0.00
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.46×10-12
Tmem150b
Tmem150bem1(IMPC)Ccpcz 		HOM Early adult decreased memory-marker CD4-positive NK T cell number CD4 CD44+CD62L+ NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 1.75×10-12
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult increased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.85×10-12
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased Ly6C-positive NK T cell number NKT Subsets (Q1)
Immunophenotyping		 CCP-IMG
IMPC		 2.09×10-11
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult increased memory-marker CD4-negative NK T cell number DN CD44+CD62L+ NKT cells
Immunophenotyping		 HMGU
IMPC		 7.36×10-11
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased NK T cell number NKT Cells (panel B)
Immunophenotyping		 CCP-IMG
IMPC		 1.33×10-10
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.57×10-10
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.87×10-10
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult increased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 5.95×10-10
Cd38
Cd38em1(IMPC)Ccpcz 		HOM Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.00×10-09
Ubd
Ubdtm1b(EUCOMM)Wtsi 		HOM Early adult decreased memory-marker CD4-positive NK T cell number CD4 CD44+CD62L+ NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 1.59×10-09
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased CD4-negative NK T cell number DN NKT cells
Immunophenotyping		 HMGU
IMPC		 2.44×10-09
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult increased NK T cell number NKT Cells (panel B)
Immunophenotyping		 HMGU
IMPC		 1.79×10-08
Arb2a
Arb2aem2(IMPC)Ccpcz 		HOM Early adult decreased Ly6C-positive NK T cell number NKT Subsets (Q3)
Immunophenotyping		 CCP-IMG
IMPC		 3.09×10-07
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased NK T cell number NKT cells (panel A)
Immunophenotyping		 HMGU
IMPC		 5.91×10-07
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult increased Ly6C-positive NK T cell number NKT Subsets (Q3)
Immunophenotyping		 CCP-IMG
IMPC		 7.09×10-07
Rhobtb1
Rhobtb1em2(IMPC)Ccpcz 		HOM Early adult increased Ly6C-positive NK T cell number NKT Subsets (Q3)
Immunophenotyping		 CCP-IMG
IMPC		 1.09×10-06
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.14×10-06
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 1.16×10-06
Ubd
Ubdtm1b(EUCOMM)Wtsi 		HOM Early adult increased CD4-positive, CD25-positive NK T cell number CD4 CD25+ NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 1.37×10-06
Bahd1
Bahd1tm2b(KOMP)Wtsi 		HET Early adult increased CD4-negative NK T cell number DN NKT cells
Immunophenotyping		 ICS
IMPC		 1.63×10-06
Psmb11
Psmb11em1(IMPC)Ccpcz 		HOM Early adult increased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.65×10-06
Stk26
Stk26tm1b(EUCOMM)Hmgu 		HEM Early adult increased NK T cell number NKT Cells (panel B)
Immunophenotyping		 CCP-IMG
IMPC		 2.75×10-06
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM   Early adult decreased memory-marker CD4-negative NK T cell number DN CD44+CD62L- NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 3.94×10-06
Pax5
Pax5tm1b(EUCOMM)Wtsi 		HET Early adult increased memory-marker CD4-positive NK T cell number CD4 CD44+CD62L- NKT cells
Immunophenotyping		 HMGU
IMPC		 4.63×10-06
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM Early adult decreased CD4-negative NK T cell number DN NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 6.14×10-06
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased CD4-negative NK T cell number DN NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 6.17×10-06
Bahd1
Bahd1tm2b(KOMP)Wtsi 		HET Early adult increased memory-marker CD4-negative NK T cell number DN CD44+CD62L- NKT cells
Immunophenotyping		 ICS
IMPC		 6.66×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM Early adult decreased Ly6C-positive NK T cell number NKT Subsets (Q1)
Immunophenotyping		 HMGU
IMPC		 7.45×10-06
Nub1
Nub1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased memory-marker CD4-negative NK T cell number DN CD44+CD62L- NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 1.22×10-05
Pax5
Pax5tm1b(EUCOMM)Wtsi 		HET Early adult increased CD4-positive NK T cell number CD4 NKT cells
Immunophenotyping		 HMGU
IMPC		 1.30×10-05
Bahd1
Bahd1tm2b(KOMP)Wtsi 		HET Early adult increased NK T cell number NKT Cells (panel B)
Immunophenotyping		 ICS
IMPC		 1.38×10-05
Atad2b
Atad2btm1b(EUCOMM)Hmgu 		HOM Early adult decreased NK T cell number NKT Cells (panel B)
Immunophenotyping		 ICS
IMPC		 1.44×10-05
Bach2
Bach2tm1b(EUCOMM)Wtsi 		HOM Early adult decreased memory-marker CD4-negative NK T cell number DN CD44+CD62L- NKT cells
Immunophenotyping		 HMGU
IMPC		 2.16×10-05
Gpr83
Gpr83em1(IMPC)Ccpcz 		HOM Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 2.27×10-05
Tppp3
Tppp3em1(IMPC)Ccpcz 		HET Early adult increased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.05×10-05
Amelx
Amelxem1(IMPC)Ccpcz 		HEM Early adult decreased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.43×10-05
Amelx
Amelxem1(IMPC)Ccpcz 		HEM Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.53×10-05
Amelx
Amelxem1(IMPC)Ccpcz 		HEM Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 3.86×10-05
Tppp3
Tppp3em1(IMPC)Ccpcz 		HET Early adult increased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.27×10-05
Mfng
Mfngem1(IMPC)Ccpcz 		HOM   Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 4.47×10-05
Lgr5
Lgr5em1(IMPC)Kmpc 		HET   Early adult increased CD4-negative, CD25-positive NK T cell number DN CD25+ NKT cells
Immunophenotyping		 KMPC
IMPC		 5.38×10-05
Gpr83
Gpr83em1(IMPC)Ccpcz 		HOM Early adult decreased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 5.99×10-05
Asb2
Asb2tm2b(KOMP)Wtsi 		HET   Early adult increased Ly6C-positive NK T cell number NKT Subsets (Q1)
Immunophenotyping		 KMPC
IMPC		 6.41×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM   Early adult decreased NK T cell number NKT cells (panel A)
Immunophenotyping		 CCP-IMG
IMPC		 6.45×10-05
Pip4p1
Pip4p1em1(IMPC)Ccpcz 		HOM   Early adult increased CD4-negative, CD25-positive NK T cell number DN CD25+ NKT cells
Immunophenotyping		 CCP-IMG
IMPC		 8.23×10-05
Gpr83
Gpr83em1(IMPC)Ccpcz 		HOM Early adult decreased memory-marker CD4-positive NK T cell number Effector CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 8.28×10-05
Cimap1b
Cimap1bem1(IMPC)Ccpcz 		HOM   Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 8.36×10-05
Babam1
Babam1em1(IMPC)Ccpcz 		HOM Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.10×10-05
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM Early adult decreased CD4-negative NK T cell number DN NKT cells
Immunophenotyping		 HMGU
IMPC		 9.11×10-05
Prss57
Prss57em1(IMPC)Ccpcz 		HOM   Early adult decreased NK T cell number NKT cells (panel A) - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.20×10-05
Babam1
Babam1em1(IMPC)Ccpcz 		HOM   Early adult decreased CD4-positive NK T cell number CD4+ NKT cells - % of live leukocytes (Panel A)
Immunophenotyping		 CCP-IMG
IMPC		 9.48×10-05
Pdia6
Pdia6tm1b(EUCOMM)Hmgu 		HET Late adult decreased CD4-positive NK T cell number CD4 NKT cells
Immunophenotyping		 HMGU
IMPC		 0.000100

Download data as:   TSV   XLS

 The way we measure

Procedure
Immunophenotyping
Buffy coat peripheral blood leukocyte immunophenotyping
FACS
Mesenteric Lymph Node Immunophenotyping
Spleen Immunophenotyping
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

4.86% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal NK T cell number (39/802)

4.96% females (18/363) 3.59% males (13/362)

Select a parameter    



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