Phenotype: abnormal brainstem morphology

Definition
any structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord
Synonyms
abnormal brain stem morphology,  abnormal truncus encephali morphology,  brainstem dysplasia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal brainstem morphology

Total number of significant genotype-phenotype associations: 17

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Ambra1
Ambra1em1(IMPC)Bay
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
BCM
IMPC
0.00
Anapc15
Anapc15tm1.1(KOMP)Vlcg
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
JAX
IMPC
0.00
Bbox1
Bbox1tm1b(KOMP)Wtsi
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
BCM
IMPC
0.00
Calu
Caluem1(IMPC)Tcp
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Cecr2
Cecr2tm2b(EUCOMM)Hmgu
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Cecr2
Cecr2tm2b(EUCOMM)Hmgu
HET E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Inpp5e
Inpp5etm1.1(KOMP)Vlcg
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Laptm4b
Laptm4btm1e.1(KOMP)Wtsi
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Pygo2
Pygo2tm1b(EUCOMM)Wtsi
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Ranbp1
Ranbp1tm1b(KOMP)Wtsi
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Scrib
Scribtm1b(NCOM)Mfgc
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
TCP
IMPC
0.00
Snx3
Snx3tm1.1(KOMP)Vlcg
HOM E12.5 abnormal midbrain morphology Midbrain morphology
Gross Morphology Embryo E12.5
JAX
IMPC
0.00

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 The way we measure

 Phenotype associations stats

1.65% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal brainstem morphology (11/668)

1.20% females (7/581) 1.60% males (9/562)

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