banner
Genes Phenotypes Help, News, Blog

Phenotype: decreased circulating cholesterol level

Definition
less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
Synonyms
hypocholesterolaemia,  decreased total circulating cholesterol level,  hypocholesterolemia,  reduced circulating cholesterol level,  low total circulating cholesterol level
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased circulating cholesterol level

Total number of significant genotype-phenotype associations: 375

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Slc29a3
Slc29a3em1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.22×10-43
Slc29a3
Slc29a3em1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.26×10-41
Atp13a3
Atp13a3em1(IMPC)J 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 2.42×10-33
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 5.86×10-25
Apoc4
Apoc4tm1.1(KOMP)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 8.78×10-24
Tnip1
Tnip1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 5.22×10-23
Pcsk9
Pcsk9tm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 3.71×10-21
Tnip1
Tnip1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 9.32×10-20
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 1.38×10-19
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 2.48×10-16
Cpgi5563
Cpgi5563tm1.1(NCC)WCS 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.57×10-15
Cpgi5563
Cpgi5563tm1.1(NCC)WCS 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.44×10-15
Slc29a3
Slc29a3em1(IMPC)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.45×10-14
Atp13a3
Atp13a3em1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 1.87×10-14
Sec16b
Sec16btm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.04×10-14
Angptl3
Angptl3tm2b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 2.29×10-13
Sec16b
Sec16btm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 2.62×10-13
Sox21
Sox21em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 2.87×10-13
Tex261
Tex261tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.04×10-13
Akap9
Akap9tm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 2.52×10-12
Nrxn1
Nrxn1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 6.36×10-12
Brd7
Brd7tm3a(EUCOMM)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 WTSI
MGP		 6.98×10-12
Zfand6
Zfand6em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 8.70×10-12
Angptl3
Angptl3tm2b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 8.88×10-12
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 9.34×10-12
Acsl5
Acsl5tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.02×10-11
Akap9
Akap9tm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 1.86×10-11
Plcg2
Plcg2Ali14 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
EuroPhenome		 2.82×10-11
Ttc28
Ttc28tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 4.98×10-11
Tex261
Tex261tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.45×10-11
Vangl2
Vangl2Lp 		HET Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 5.94×10-11
Far2
Far2tm2b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 9.38×10-11
Dym
Dymem1(IMPC)Tcp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 9.46×10-11
Hr
Hrem1(IMPC)H 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 1.19×10-10
Akap9
Akap9tm1a(KOMP)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.44×10-10
Larp1
Larp1em1(IMPC)Mbp 		HET Late adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.56×10-10
Sik3
Sik3tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.90×10-10
Sec24a
Sec24atm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 3.62×10-10
Acsl5
Acsl5tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 4.72×10-10
Dcun1d3
Dcun1d3em1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.78×10-10
Peak1
Peak1em1(IMPC)J 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 5.81×10-10
Sec24a
Sec24atm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.08×10-09
Apoc4
Apoc4tm1.1(KOMP)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.17×10-09
Nrxn1
Nrxn1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 1.78×10-09
Baz1b
Baz1btm2a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 2.03×10-09
Dcun1d3
Dcun1d3em1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.15×10-09
Cenpo
Cenpotm1b(KOMP)Mbp 		HET Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 2.31×10-09
Dbn1
Dbn1tm1b(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 BCM
IMPC		 3.53×10-09
Baat
Baatem1(IMPC)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.81×10-09
Tmem203
Tmem203em1(IMPC)H 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 5.05×10-09
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 5.18×10-09
Larp1
Larp1em1(IMPC)Mbp 		HET Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 5.63×10-09
Dusp7
Dusp7tm1(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MARC
IMPC		 7.14×10-09
Tial1
Tial1tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.44×10-09
Sox21
Sox21em1(IMPC)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 9.29×10-09
Atad2b
Atad2btm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 1.05×10-08
Baat
Baatem1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.12×10-08
Dll1
Dll1tm1Gos 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical chemistry (GMC)		 HMGU
EuroPhenome		 1.38×10-08
Ttc28
Ttc28tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 1.93×10-08
Kics2
Kics2tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MARC
IMPC		 2.10×10-08
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 2.27×10-08
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.56×10-08
Peak1
Peak1em1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 2.65×10-08
Zfp84
Zfp84tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.19×10-08
Setd1a
Setd1atm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 3.22×10-08
Setd1a
Setd1atm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 3.39×10-08
Sar1b
Sar1btm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 3.40×10-08
Nsf
Nsftm1b(KOMP)Mbp 		HET Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 4.01×10-08
Sar1b
Sar1btm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.32×10-08
Hr
Hrem1(IMPC)H 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 4.34×10-08
Rc3h2
Rc3h2tm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
EuroPhenome		 5.20×10-08
Etv6
Etv6em1(IMPC)Rbrc 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 RBRC
IMPC		 5.76×10-08
Zfand6
Zfand6em1(IMPC)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 7.52×10-08
Arhgap22
Arhgap22tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.66×10-08
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.75×10-08
Lactb
Lactbtm1.1(KOMP)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 8.37×10-08
Tial1
Tial1tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 9.18×10-08
Arhgef4
Arhgef4tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 1.30×10-07
Camsap3
Camsap3tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.30×10-07
Ywhab
Ywhabtm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.34×10-07
Fads1
Fads1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.52×10-07
Trim8
Trim8em1(IMPC)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.52×10-07
Smc5
Smc5tm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 1.67×10-07
Mta1
Mta1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 1.74×10-07
Dym
Dymem1(IMPC)Tcp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 1.85×10-07
Pex3
Pex3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.97×10-07
Far2
Far2tm2b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 2.16×10-07
Elmod1
Elmod1tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.63×10-07
Nab2
Nab2tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 2.64×10-07
Tmem203
Tmem203em1(IMPC)H 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 2.64×10-07
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.81×10-07
Cpgi5563
Cpgi5563tm1.1(NCC)WCS 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.86×10-07
Sar1b
Sar1btm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 2.93×10-07
C1qtnf1
C1qtnf1em1(IMPC)Mbp 		HOM Late adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 2.94×10-07
Nab2
Nab2tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 3.10×10-07
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 3.10×10-07
Ahrr
Ahrrtm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 3.23×10-07
Ywhab
Ywhabtm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 3.45×10-07
Ctsa
Ctsatm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 3.54×10-07
Pcdhb13
Pcdhb13em1(IMPC)Tcp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 3.78×10-07
Myzap
Myzapem1(IMPC)J 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 3.95×10-07
Atp8b1
Atp8b1em1(IMPC)Tcp 		HOM Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 4.01×10-07
Spns2
Spns2tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 4.12×10-07
Xbp1
Xbp1tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
EuroPhenome		 4.17×10-07
Gc
Gctm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 4.30×10-07
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.38×10-07
Gda
Gdatm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.41×10-07
Sec16b
Sec16btm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.71×10-07
Sqstm1
Sqstm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.94×10-07
Atad3a
Atad3atm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.11×10-07
4933434E20Rik
4933434E20Riktm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.29×10-07
Baz1b
Baz1btm2a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 5.45×10-07
Fbf1
Fbf1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.90×10-07
Slc16a2
Slc16a2tm1a(KOMP)Wtsi 		HEM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 6.03×10-07
Vil1
Vil1em1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.61×10-07
Sqstm1
Sqstm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 7.20×10-07
Dbn1
Dbn1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 7.29×10-07
Spns2
Spns2tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 7.41×10-07
Cpgi15344
Cpgi15344tm1.1(NCC)WCS 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.41×10-07
Txndc5
Txndc5tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 7.90×10-07
Setd1a
Setd1atm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 8.49×10-07
Fam117b
Fam117btm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 8.86×10-07
Cracdl
Cracdltm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.92×10-07
Hspb6
Hspb6em1(IMPC)J 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 9.70×10-07
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 9.90×10-07
Rbpj
Rbpjtm1b(EUCOMM)Hmgu 		HET   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 9.99×10-07
Gc
Gctm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.00×10-06
Smc5
Smc5tm1b(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 1.09×10-06
Vil1
Vil1em1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.14×10-06
Dnajc10
Dnajc10tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 1.23×10-06
Kics2
Kics2tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MARC
IMPC		 1.32×10-06
Pcsk5
Pcsk5tm1b(KOMP)Mbp 		HET Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 1.34×10-06
Pex3
Pex3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 1.36×10-06
Csnk2a2
Csnk2a2em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.43×10-06
Sik1
Sik1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.43×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 1.46×10-06
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 1.53×10-06
Tmc6
Tmc6tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.72×10-06
Tnks
Tnksem1(IMPC)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.73×10-06
Fa2h
Fa2hem1(IMPC)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.82×10-06
Cenpo
Cenpotm1b(KOMP)Mbp 		HET Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 1.85×10-06
Tnks
Tnksem1(IMPC)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.88×10-06
Ube3b
Ube3bGt(RRJ142)Byg 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 2.06×10-06
Camsap3
Camsap3tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.12×10-06
Fgd5
Fgd5em1(IMPC)Mbp 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 2.14×10-06
Dusp7
Dusp7tm1(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MARC
IMPC		 2.27×10-06
Tagap1
Tagap1em1(IMPC)Tcp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 2.56×10-06
Wrap53
Wrap53tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.58×10-06
Zfp84
Zfp84tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.58×10-06
Dbnl
Dbnltm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 2.76×10-06
Dync1i2
Dync1i2tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 2.81×10-06
C1qtnf1
C1qtnf1em1(IMPC)Mbp 		HOM Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 2.90×10-06
Trim8
Trim8em1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.09×10-06
Bcorl1
Bcorl1em1(IMPC)Tcp 		HEM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 3.29×10-06
Sgo1
Sgo1tm1a(EUCOMM)Wtsi 		HET   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 3.30×10-06
Enc1
Enc1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.63×10-06
Ptcd3
Ptcd3tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 4.17×10-06
Hspb6
Hspb6em1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 4.33×10-06
Dusp26
Dusp26tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.37×10-06
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.51×10-06
Plekhf2
Plekhf2em1(IMPC)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 4.61×10-06
Trim56
Trim56tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.83×10-06
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 4.93×10-06
4933434E20Rik
4933434E20Riktm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.07×10-06
Cbx6
Cbx6tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.10×10-06
Tex261
Tex261tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.33×10-06
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 5.40×10-06
Dscc1
Dscc1tm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 5.56×10-06
Slc38a2
Slc38a2tm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.81×10-06
Col18a1
Col18a1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 5.97×10-06
Cracdl
Cracdltm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.01×10-06
Rhd
Rhdtm1e(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 6.09×10-06
Atad3a
Atad3atm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.13×10-06
Amfr
Amfrtm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 6.23×10-06
Dusp26
Dusp26tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 6.23×10-06
Trim56
Trim56tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.28×10-06
Myzap
Myzapem1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 6.33×10-06
Lactb
Lactbtm1.1(KOMP)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 6.76×10-06
Micos13
Micos13tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 7.19×10-06
Bcorl1
Bcorl1em1(IMPC)Tcp 		HEM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 7.58×10-06
Pcsk5
Pcsk5tm1b(KOMP)Mbp 		HET Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 7.64×10-06
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 8.63×10-06
Spns2
Spns2tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 8.86×10-06
Trmt1
Trmt1tm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 9.00×10-06
Sidt2
Sidt2em1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 9.06×10-06
Elmod1
Elmod1tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 9.48×10-06
Krtap17-1
Krtap17-1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 9.92×10-06
Csmd3
Csmd3em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 9.99×10-06
Slc16a2
Slc16a2tm1a(KOMP)Wtsi 		HEM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.03×10-05
Ngdn
Ngdntm1b(EUCOMM)Wtsi 		HET   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.07×10-05
Sqstm1
Sqstm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.11×10-05
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 HMGU
EuroPhenome		 1.13×10-05
Ccdc92
Ccdc92tm1b(KOMP)Mbp 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.14×10-05
Sesn3
Sesn3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.16×10-05
Setd1b
Setd1btm1.2(IMPC)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.17×10-05
Rgp1
Rgp1tm1.1(KOMP)Vlcg 		HET   Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 1.17×10-05
Cdk12
Cdk12em1(IMPC)Tcp 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 1.20×10-05
Atp11a
Atp11atm1e(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.21×10-05
Plekhf2
Plekhf2em1(IMPC)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.22×10-05
Gpr146
Gpr146em1(IMPC)H 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 1.22×10-05
Dlg2
Dlg2tm1Dsb 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 1.24×10-05
Prkd3
Prkd3tm1b(EUCOMM)Wtsi 		HET   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.27×10-05
Fhl1
Fhl1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 1.37×10-05
Fbf1
Fbf1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.40×10-05
Tox
Toxtm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.40×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 1.43×10-05
Cenph
Cenphtm1b(EUCOMM)Hmgu 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.46×10-05
Enc1
Enc1tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.51×10-05
Ankrd12
Ankrd12tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
EuroPhenome		 1.53×10-05
Krt7
Krt7tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.57×10-05
Bzw2
Bzw2tm1b(KOMP)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 1.57×10-05
Hells
Hellstm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 HMGU
EuroPhenome		 1.59×10-05
Pkn2
Pkn2tm1b(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.59×10-05
Dbnl
Dbnltm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 1.61×10-05
Ube3b
Ube3bGt(RRJ142)Byg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 1.62×10-05
Ddx51
Ddx51tm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.67×10-05
Prkd3
Prkd3tm1b(EUCOMM)Wtsi 		HET   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 1.68×10-05
Setd1b
Setd1btm1.2(IMPC)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.69×10-05
Elk4
Elk4tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 HMGU
EuroPhenome		 1.71×10-05
Pnpt1
Pnpt1tm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 1.72×10-05
Kat2b
Kat2bem1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.73×10-05
Cyfip1
Cyfip1tm2a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.74×10-05
Tmod1
Tmod1tm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 1.74×10-05
Rhd
Rhdtm1e(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 WTSI
EuroPhenome		 1.74×10-05
Parvb
Parvbtm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
EuroPhenome		 1.81×10-05
Atp11a
Atp11atm1e(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.81×10-05
Micos13
Micos13tm1.1(KOMP)Vlcg 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 1.94×10-05
Wrap53
Wrap53tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 1.95×10-05
Arhgef4
Arhgef4tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 1.97×10-05
Atad2b
Atad2btm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 2.08×10-05
Emcn
Emcnem1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.15×10-05
Sidt2
Sidt2em1(IMPC)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.19×10-05
Atg4b
Atg4btm1b(EUCOMM)Hmgu 		HOM Late adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 2.29×10-05
Atg4b
Atg4btm1b(EUCOMM)Hmgu 		HOM Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 2.46×10-05
Abcb4
Abcb4em1(IMPC)H 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 2.50×10-05
Etv6
Etv6em1(IMPC)Rbrc 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 RBRC
IMPC		 2.53×10-05
Gpld1
Gpld1tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 2.57×10-05
C2cd4b
C2cd4bem1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.61×10-05
Wdtc1
Wdtc1tm1a(KOMP)Wtsi 		HOM   Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.62×10-05
Kat2b
Kat2bem1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.73×10-05
Gpr146
Gpr146em1(IMPC)H 		HOM   Late adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 2.74×10-05
Pcdhb13
Pcdhb13em1(IMPC)Tcp 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 2.77×10-05
Slain2
Slain2em1(IMPC)J 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 2.83×10-05
Vangl2
Vangl2Lp 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 2.88×10-05
Bhlhe40
Bhlhe40tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 2.89×10-05
Dnmt3a
Dnmt3atm1b(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 3.10×10-05
Setbp1
Setbp1tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 3.11×10-05
Lmod3
Lmod3em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.22×10-05
Sec24a
Sec24atm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 3.23×10-05
Sgo1
Sgo1tm1a(EUCOMM)Wtsi 		HET   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 3.24×10-05
Kif21b
Kif21btm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 3.28×10-05
Morc2a
Morc2aem1(IMPC)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.29×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.31×10-05
Cygb
Cygbtm1b(EUCOMM)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.36×10-05
Abhd8
Abhd8tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 BCM
IMPC		 3.38×10-05
Camsap3
Camsap3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.40×10-05
Myh7b
Myh7btm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.52×10-05
Tmem248
Tmem248tm1.1(KOMP)Vlcg 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.53×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
EuroPhenome		 3.57×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 3.59×10-05
Anxa6
Anxa6tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 3.62×10-05
Susd6
Susd6tm1b(KOMP)Wtsi 		HOM   Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 3.70×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 3.76×10-05
Abhd14a
Abhd14atm2a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.79×10-05
Pkn2
Pkn2tm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 3.80×10-05
Padi4
Padi4em1(IMPC)Mbp 		HOM Late adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 3.83×10-05
Fbf1
Fbf1tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.87×10-05
Tmem42
Tmem42tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 3.89×10-05
Vkorc1l1
Vkorc1l1em1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 3.94×10-05
Becn1
Becn1tm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 4.03×10-05
Rab36
Rab36tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL cholesterol
Plasma Chemistry		 JAX
IMPC		 4.08×10-05
Wdr47
Wdr47tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 4.31×10-05
Dnajc10
Dnajc10tm1a(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 4.39×10-05
Dscc1
Dscc1tm1a(KOMP)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.44×10-05
Ube2d1
Ube2d1tm3e(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.46×10-05
Ube3b
Ube3bGt(RRJ142)Byg 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 4.52×10-05
Dmxl2
Dmxl2tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.53×10-05
Tmc6
Tmc6tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 4.80×10-05
Rundc1
Rundc1tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 4.81×10-05
Llgl2
Llgl2tm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 4.94×10-05
Esco1
Esco1tm1(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 5.06×10-05
Sidt2
Sidt2em1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.22×10-05
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 5.25×10-05
Rhbdf2
Rhbdf2Rhbdf2 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 5.31×10-05
Tuft1
Tuft1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.35×10-05
Dlg2
Dlg2tm1Dsb 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 5.36×10-05
Eps8l2
Eps8l2tm1b(EUCOMM)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 5.38×10-05
Emcn
Emcnem1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.45×10-05
Celsr1
Celsr1Scy 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
EuroPhenome		 5.62×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 5.63×10-05
Psg20
Psg20em1(IMPC)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.74×10-05
Ppp2r5c
Ppp2r5cem1(IMPC)Mbp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 5.76×10-05
Gda
Gdatm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 5.87×10-05
Ctsa
Ctsatm2b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 6.11×10-05
Pgam5
Pgam5tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 ICS
IMPC		 6.15×10-05
Rab36
Rab36tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 6.27×10-05
Wdtc1
Wdtc1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.48×10-05
Dscc1
Dscc1tm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 6.51×10-05
Marchf9
Marchf9tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Fasted Clinical Chemistry		 MRC Harwell
EuroPhenome		 6.52×10-05
Ngdn
Ngdntm1b(EUCOMM)Wtsi 		HET   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 6.72×10-05
Dusp16
Dusp16em1(IMPC)Tcp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 TCP
IMPC		 6.76×10-05
Wrap53
Wrap53tm1b(EUCOMM)Wtsi 		HET Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 6.77×10-05
Zfp787
Zfp787em1(IMPC)J 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 6.82×10-05
Anxa6
Anxa6tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 6.90×10-05
Nucks1
Nucks1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 6.92×10-05
Nucks1
Nucks1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 HMGU
IMPC		 7.07×10-05
Celf4
Celf4tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.15×10-05
Cpgi15344
Cpgi15344tm1.1(NCC)WCS 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.16×10-05
Palm
Palmem1(IMPC)Wtsi 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.18×10-05
Tcf7l1
Tcf7l1tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 7.30×10-05
Pgam5
Pgam5tm1b(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 ICS
IMPC		 7.37×10-05
Larp1
Larp1em1(IMPC)Mbp 		HET   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 7.40×10-05
Hells
Hellstm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Fasted Clinical Chemistry		 HMGU
EuroPhenome		 7.52×10-05
Sag
Sagtm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.66×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating LDL cholesterol level LDL-cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 7.67×10-05
C2cd4b
C2cd4bem1(IMPC)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 7.86×10-05
Camsap3
Camsap3tm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.07×10-05
Cbx6
Cbx6tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.11×10-05
Rapgefl1
Rapgefl1tm1a(KOMP)Wtsi 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 8.29×10-05
Zfp558
Zfp558em1(IMPC)Mbp 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 8.33×10-05
Dync1i2
Dync1i2tm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
MGP		 8.40×10-05
Zfp182
Zfp182tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.44×10-05
Rpia
Rpiatm1a(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.53×10-05
Pex3
Pex3tm1a(EUCOMM)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 WTSI
MGP		 8.67×10-05
Rrbp1
Rrbp1em1(IMPC)J 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 JAX
IMPC		 8.72×10-05
Slc38a2
Slc38a2tm1a(KOMP)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 8.82×10-05
Adgrf5
Adgrf5tm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 8.91×10-05
Fbxo41
Fbxo41tm1.1(KOMP)Vlcg 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 UC Davis
IMPC		 9.01×10-05
Rab5c
Rab5ctm1a(EUCOMM)Wtsi 		HET Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 9.02×10-05
Fto
Ftotm1a(EUCOMM)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
EuroPhenome		 9.09×10-05
Fa2h
Fa2hem1(IMPC)Mbp 		HOM   Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 UC Davis
IMPC		 9.09×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 9.23×10-05
Pabpc4
Pabpc4tm1a(KOMP)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 WTSI
IMPC		 9.24×10-05
Bcorl1
Bcorl1em1(IMPC)Tcp 		HOM Early adult decreased circulating cholesterol level Total cholesterol
Clinical Chemistry		 TCP
IMPC		 9.37×10-05
Gpr146
Gpr146em1(IMPC)H 		HOM Late adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 MRC Harwell
IMPC		 9.42×10-05
Rad1
Rad1tm1b(KOMP)Wtsi 		HET Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 JAX
IMPC		 9.45×10-05
Nes
Nestm1b(KOMP)Wtsi 		HOM   Early adult decreased circulating cholesterol level Total cholesterol
Plasma Chemistry		 JAX
IMPC		 9.72×10-05
Pepd
Pepdtm1b(KOMP)Wtsi 		HOM Early adult decreased circulating HDL cholesterol level HDL-cholesterol
Clinical Chemistry		 HMGU
IMPC		 9.75×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Fasted Clinical Chemistry
Plasma Chemistry
Terminal Bleed

 Phenotype associations stats

2.76% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating cholesterol level (202/7313)

0.54% females (40/7445) 2.25% males (167/7429)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter