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Phenotype: vertebral fusion

Definition
the union of one or more vertebrae into a single structure
Synonyms
fused vertebrae,  vertebral ankylosis
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with vertebral fusion

Total number of significant genotype-phenotype associations: 68

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Xbp1
Xbp1tm1a(EUCOMM)Wtsi 		HET Early adult vertebral fusion Fusion of vertebrae
X-Ray		 ICS
EuroPhenome		 3.68×10-21
Ttc28
Ttc28tm1b(EUCOMM)Hmgu 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 TCP
IMPC		 2.24×10-12
Slc29a1
Slc29a1tm2b(NCOM)Mfgc 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 TCP
IMPC		 3.43×10-10
Cbx5
Cbx5tm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 2.57×10-09
Cbx5
Cbx5tm1a(EUCOMM)Wtsi 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 4.88×10-08
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 1.67×10-07
Wdr37
Wdr37tm1a(KOMP)Wtsi 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 1.67×10-07
Ube2g1
Ube2g1tm1b(EUCOMM)Hmgu 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 RBRC
IMPC		 2.60×10-07
Il12a
Il12atm1b(EUCOMM)Hmgu 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 MRC Harwell
IMPC		 5.25×10-07
Setd3
Setd3tm1.1(NCOM)Mfgc 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 TCP
IMPC		 6.83×10-07
Fgf20
Fgf20em1(IMPC)Ccpcz 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 CCP-IMG
IMPC		 7.24×10-07
Sirt3
Sirt3tm1b(EUCOMM)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 MRC Harwell
IMPC		 7.84×10-07
Gna11
Gna11tm1b(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 MRC Harwell
IMPC		 8.18×10-07
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 MRC Harwell
IMPC		 1.31×10-06
Ankrd13a
Ankrd13aGt(RRH308)Byg 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-Ray		 WTSI
MGP		 1.94×10-06
Pdss2
Pdss2tm1b(EUCOMM)Hmgu 		HET Early adult vertebral fusion Fusion of vertebrae
X-ray		 MRC Harwell
IMPC		 2.03×10-06
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 CCP-IMG
IMPC		 3.15×10-06
Rnf168
Rnf168tm2b(EUCOMM)Hmgu 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 CCP-IMG
IMPC		 4.07×10-06
Fbn2
Fbn2em1(IMPC)Rbrc 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 RBRC
IMPC		 5.23×10-06
Fgf20
Fgf20em1(IMPC)Ccpcz 		HOM   Early adult fusion of vertebral arches Fusion of processes
X-ray		 CCP-IMG
IMPC		 5.60×10-06
Ube2g1
Ube2g1tm1b(EUCOMM)Hmgu 		HOM   Early adult fusion of vertebral arches Fusion of processes
X-ray		 RBRC
IMPC		 5.70×10-06
Asxl1
Asxl1tm1a(EUCOMM)Wtsi 		HET Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 6.98×10-06
Ppp5c
Ppp5ctm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
EuroPhenome		 6.98×10-06
Cenpj
Cenpjtm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 7.23×10-06
Aff3
Aff3tm1a(EUCOMM)Wtsi 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 7.64×10-06
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi 		HOM   Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 9.17×10-06
Xndc1
Xndc1tm1a(EUCOMM)Wtsi 		HOM   Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 9.17×10-06
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.10×10-05
Fggy
Fggytm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.15×10-05
Gm13547
Gm13547tm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.15×10-05
Zscan2
Zscan2tm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.15×10-05
Gyg1
Gyg1tm1b(KOMP)Wtsi 		HET Early adult vertebral fusion Fusion of vertebrae
X-ray		 BCM
IMPC		 1.25×10-05
Abca4
Abca4tm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.31×10-05
Ushbp1
Ushbp1tm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 1.31×10-05
Kat14
Kat14tm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
EuroPhenome		 1.54×10-05
Gbx1
Gbx1Gbx1 		HOM Early adult vertebral fusion Fusion of vertebrae
X-Ray		 ICS
EuroPhenome		 1.80×10-05
Arpc2
Arpc2tm1a(EUCOMM)Wtsi 		HET   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 2.22×10-05
Rhou
Rhoutm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 2.29×10-05
Dscc1
Dscc1tm1a(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 3.12×10-05
Selenon
Selenontm1a(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 3.12×10-05
Rlim
Rlimem1(IMPC)Rbrc 		HEM Early adult fusion of vertebral arches Fusion of processes
X-ray		 RBRC
IMPC		 3.45×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-Ray		 WTSI
EuroPhenome		 3.65×10-05
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi 		HOM Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 3.70×10-05
Lyplal1
Lyplal1tm1a(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 3.92×10-05
Os9
Os9tm1a(EUCOMM)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 3.92×10-05
Sel1l
Sel1ltm1e(KOMP)Wtsi 		HET Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 3.92×10-05
Setd5
Setd5tm1a(EUCOMM)Wtsi 		HET Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 3.92×10-05
Wdr37
Wdr37tm1a(KOMP)Wtsi 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 3.92×10-05
Pals2
Pals2em1(IMPC)Rbrc 		HOM   Early adult fusion of vertebral arches Fusion of processes
X-ray		 RBRC
IMPC		 4.49×10-05
Tmem248
Tmem248tm1.1(KOMP)Vlcg 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 UC Davis
IMPC		 4.79×10-05
Tmc6
Tmc6tm1a(EUCOMM)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 5.02×10-05
Spred1
Spred1em1(IMPC)Ccpcz 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 CCP-IMG
IMPC		 5.27×10-05
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 5.49×10-05
Slc25a21
Slc25a21tm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
MGP		 5.49×10-05
Gramd2a
Gramd2aem1(IMPC)Tcp 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 TCP
IMPC		 7.67×10-05
Fbrsl1
Fbrsl1em1(IMPC)Tcp 		HOM Early adult vertebral fusion Fusion of vertebrae
X-ray		 TCP
IMPC		 8.56×10-05
Ppp1r42
Ppp1r42tm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 8.79×10-05
Scn3b
Scn3btm1a(KOMP)Wtsi 		HOM   Early adult vertebral fusion Fusion of vertebrae
X-ray		 WTSI
IMPC		 8.79×10-05
Bptf
Bptfem1(IMPC)Bay 		HET   Early adult vertebral fusion Fusion of vertebrae
X-ray		 BCM
IMPC		 8.94×10-05
Wac
Wactm2b(EUCOMM)Wtsi 		HET Early adult fusion of vertebral arches Fusion of processes
X-ray		 WTSI
IMPC		 9.73×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
X-ray
X-Ray
X-Ray (GMC)

 Phenotype associations stats

1.70% of tested genes with null mutations on a B6N genetic background have a phenotype association to vertebral fusion (53/3121)

0.51% females (16/3132) 0.77% males (24/3136)

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