Phenotype: abnormal QRS complex

Definition
anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal QRS complex

Total number of significant genotype-phenotype associations: 49

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Hddc3
Hddc3tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 9.77×10-09
Ecrg4
Ecrg4tm1b(EUCOMM)Hmgu
HOM Early adult shortened QRS complex duration Electrocardiogram (ECG) | QRS ICS | IMPC 1.49×10-08
Tssk5
Tssk5tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS JAX | IMPC 1.59×10-08
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.87×10-08
Rnd2
Rnd2em1(IMPC)Mbp
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 2.93×10-08
Vrk1
Vrk1em1(IMPC)Mbp
HET Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 3.03×10-07
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS HMGU | IMPC 3.04×10-07
Trpc5
Trpc5tm1b(KOMP)Wtsi
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS RBRC | IMPC 2.00×10-06
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS TCP | IMPC 3.01×10-06
Fastkd5
Fastkd5em1(IMPC)J
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS JAX | IMPC 3.74×10-06
Kcnd1
Kcnd1tm1.1(KOMP)Vlcg
HEM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 5.04×10-06
Zbtb48
Zbtb48em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 6.76×10-06
Plscr1
Plscr1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS ICS | IMPC 9.60×10-06
4933428G20Rik
4933428G20Riktm1.1(KOMP)Vlcg
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.17×10-05
4933428G20Rik
4933428G20Riktm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.27×10-05
Bbs1
Bbs1em1(IMPC)Mbp
HET Early adult shortened QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.38×10-05
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.41×10-05
Mgrn1
Mgrn1em1(IMPC)Tcp
HET Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS TCP | IMPC 1.43×10-05
Stbd1
Stbd1tm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS TCP | IMPC 2.82×10-05
Gsg1l
Gsg1lem1(IMPC)Mbp
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 3.30×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS BCM | IMPC 3.44×10-05
Ecrg4
Ecrg4tm1b(EUCOMM)Hmgu
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS ICS | IMPC 4.50×10-05
Foxo4
Foxo4tm1.1(KOMP)Vlcg
HEM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 4.71×10-05
Amigo1
Amigo1tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS JAX | IMPC 5.37×10-05
Olfr376
Olfr376em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 5.49×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS TCP | IMPC 6.13×10-05
E130311K13Rik
E130311K13Rikem1(IMPC)J
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS JAX | IMPC 6.47×10-05
Acoxl
Acoxlem1(IMPC)Mbp
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS UC Davis | IMPC 6.51×10-05
Brd4
Brd4tm1b(EUCOMM)Wtsi
HET Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS BCM | IMPC 7.82×10-05
Ythdf3
Ythdf3em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 8.45×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi
HOM Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS CCP-IMG | IMPC 9.59×10-05
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET Early adult abnormal QRS complex Electrocardiogram (ECG) | QRS BCM | IMPC 9.74×10-05

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 The way we measure

 Phenotype associations stats

0.70% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QRS complex (29/4139)

0.22% females (9/4050) 0.27% males (11/4040)



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