Phenotype: abnormal bone mineralization

Definition
defect in the process by which minerals are deposited into bone
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal bone mineralization

Total number of significant genotype-phenotype associations: 99

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Ostes
Ostes
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 6.53×10-25
Akt2
Akt2tm1Wcs
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight WTSI | EuroPhenome 4.90×10-17
Acp2
Acp2tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 2.08×10-14
Kcnj16
Kcnj16tm1Sjtu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 1.38×10-13
Ctnnb1
Ctnnb1Bfc
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 1.24×10-12
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 9.18×10-11
Sfrp2
Sfrp2C50F
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 2.17×10-10
Phex
Phexnot yet available
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight HMGU | EuroPhenome 2.83×10-10
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 2.97×10-10
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 4.21×10-10
Ankrd11
Ankrd11Yod
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 5.76×10-10
Mir96
Mir96Dmdo
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content WTSI | EuroPhenome 1.13×10-09
Parvb
Parvbtm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 1.07×10-08
Myo7a
Myo7aHdb
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight WTSI | EuroPhenome 1.27×10-08
Rnf169
Rnf169tm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | MGP 1.47×10-08
Sfrp2
Sfrp2I153N
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 1.62×10-08
BC055324
BC055324tm1a(EUCOMM)Hmgu
HET postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | MGP 1.63×10-08
Mta1
Mta1tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight WTSI | EuroPhenome 1.75×10-08
Sfrp2
Sfrp2tm1Aksh
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 3.38×10-08
Xbp1
Xbp1tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content HMGU | EuroPhenome 8.14×10-08
Ablim1
Ablim1tm1H
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 1.02×10-07
Pgd
Pgdtm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content ICS | EuroPhenome 1.63×10-07
Rxrg
Rxrg
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight ICS | EuroPhenome 6.28×10-07
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 7.28×10-07
Nmnat1
Nmnat1tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 9.81×10-07
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content HMGU | MGP 1.14×10-06
Epc1
Epc1tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | BMC/Body weight WTSI | EuroPhenome 1.60×10-06
Fbxo11
Fbxo11Jf
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 3.71×10-06
Mrps35
Mrps35tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content ICS | EuroPhenome 4.21×10-06
Cisd2
Cisd2tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 4.36×10-06
Rhbdd1
Rhbdd1tm1.1Mfm
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 4.82×10-06
Babam2
Babam2tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 5.14×10-06
Fgl1
Fgl1tm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content ICS | EuroPhenome 6.37×10-06
Ttll4
Ttll4tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 6.92×10-06
Sfrp1
Sfrp1tm1Aksh
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 6.96×10-06
Cyb561
Cyb561tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | EuroPhenome 7.41×10-06
Dhx40
Dhx40tm1(NCOM)Cmhd
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight CMHD | EuroPhenome 7.80×10-06
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 8.48×10-06
D430041D05Rik
D430041D05Riktm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 1.12×10-05
Prss50
Prss50tm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 1.18×10-05
Plcg2
Plcg2Ali14
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content HMGU | EuroPhenome 1.60×10-05
Fam117b
Fam117btm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | EuroPhenome 1.86×10-05
Rhbdf2
Rhbdf2not yet available
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | EuroPhenome 2.14×10-05
Mpi
Mpitm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | MGP 2.16×10-05
Gnas
Gnastm1Jop
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 3.04×10-05
March9
March9tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 3.07×10-05
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 3.23×10-05
Per2
Per2tm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | MGP 3.55×10-05
Ddx52
Ddx52tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content ICS | EuroPhenome 4.48×10-05
Cul7
Cul7tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 4.68×10-05
Gse1
Gse1tm1a(EUCOMM)Wtsi
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 5.95×10-05
Gna11
Gna11tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 7.11×10-05
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 8.18×10-05
Vangl2
Vangl2Lp
HET postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | EuroPhenome 8.24×10-05
Tbc1d2b
Tbc1d2btm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | BMC/Body weight MRC Harwell | EuroPhenome 8.30×10-05
Clk1
Clk1tm1a(EUCOMM)Wtsi
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 9.31×10-05
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM postnatal abnormal bone mineralization DEXA | Bone Mineral Content MRC Harwell | MGP 9.47×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.15% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal bone mineralization (55/4776)

0.97% females (46/4740) 1.03% males (49/4756)

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