Definition
any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
Synonyms
abnormal splenic white pulp morphology
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with abnormal spleen white pulp morphology
Total number of significant genotype-phenotype associations: 7
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Arhgef1 Arhgef1tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Cog6 Cog6tm1a(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Dph6 Dph6tm1a(KOMP)Wtsi |
HOM | Early adult | increased marginal zone B cell number | Marginal zone B cells - % of CD45+ Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Gm5544 Gm5544tm1a(KOMP)Wtsi |
HET | Early adult | decreased marginal zone B cell number | Marginal zone B cells - % of B2 cells Spleen Immunophenotyping |
WTSI 3i |
0.00 | |
| Bach2 Bach2tm1b(EUCOMM)Wtsi |
HOM | Early adult | decreased marginal zone B cell number | MZB (CD21/35 high) Immunophenotyping |
HMGU IMPC |
9.79×10-08 | |
| Myoz1 Myoz1tm1b(EUCOMM)Hmgu |
HOM | Late adult | increased marginal zone B cell number | MZB (CD21/35 high) Immunophenotyping |
HMGU IMPC |
8.45×10-05 |