Definition
anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)
Synonyms
contextual conditioning anomalies,
abnormal contextual conditioning behaviour,
contextual fear conditioning abnormalities,
abnormal contextual fear conditioning
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with abnormal contextual conditioning behavior
Total number of significant genotype-phenotype associations: 40
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Plaat5 Plaat5em1(IMPC)Tcp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
3.00×10-12 | |
| Gria1 Gria1em1(IMPC)H |
HOM | Late adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
MRC Harwell IMPC |
6.61×10-10 | |
| Ms4a4a Ms4a4aem1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
2.50×10-08 | |
| Sox2 Sox2em1(IMPC)Mbp |
HET | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
3.00×10-08 | |
| Gmppa Gmppaem1(IMPC)Tcp |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
3.61×10-08 | |
| Dele1 Dele1em2(IMPC)Ccpcz |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
7.43×10-07 | |
| Thra Thratm1b(EUCOMM)Wtsi |
HET | Late adult | abnormal contextual conditioning behavior | % Freezing duration context-1 Fear Conditioning |
ICS IMPC |
3.41×10-06 | |
| Tmprss2 Tmprss2tm2b(EUCOMM)Hmgu |
HOM | Early adult | abnormal contextual conditioning behavior | % Freezing duration context-1 Fear Conditioning |
ICS IMPC |
4.02×10-06 | |
| Mir124a-2 Mir124a-2tm1b(mirKO)Wtsi |
HET | Early adult | abnormal contextual conditioning behavior | % Context freezing total Fear Conditioning |
ICS IMPC |
5.88×10-06 | |
| Atad2b Atad2btm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal contextual conditioning behavior | % Freezing duration context-2 Fear Conditioning |
ICS IMPC |
6.00×10-06 | |
| Cartpt Cartptem1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
6.06×10-06 | |
| Hmbox1 Hmbox1em1(IMPC)Tcp |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
9.33×10-06 | |
| Thra Thratm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal contextual conditioning behavior | % Freezing duration context-2 Fear Conditioning |
ICS IMPC |
2.01×10-05 | |
| Babam1 Babam1em1(IMPC)Ccpcz |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
2.46×10-05 | |
| Ubqln4 Ubqln4em1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
2.64×10-05 | |
| Nab2 Nab2tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal contextual conditioning behavior | Context freezing total Fear Conditioning |
ICS IMPC |
2.65×10-05 | |
| Ap4e1 Ap4e1tm1b(KOMP)Wtsi |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
3.12×10-05 | |
| Nexmif Nexmifem1(IMPC)Tcp |
HEM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
3.20×10-05 | |
| Aak1 Aak1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal contextual conditioning behavior | Context freezing total Fear Conditioning |
ICS IMPC |
3.39×10-05 | |
| Kcnt2 Kcnt2em1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
3.51×10-05 | |
| Il2ra Il2ratm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal contextual conditioning behavior | % Freezing duration context-1 Fear Conditioning |
ICS IMPC |
3.52×10-05 | |
| Tmtc2 Tmtc2em2(IMPC)Kmpc |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
KMPC IMPC |
3.85×10-05 | |
| Ptchd1 Ptchd1tm1b(KOMP)IcsOrl |
HOM | Early adult | abnormal contextual conditioning behavior | Context freezing total Fear Conditioning |
ICS IMPC |
4.08×10-05 | |
| Pgbd5 Pgbd5em1(IMPC)Tcp |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
4.84×10-05 | |
| Irag1 Irag1em1(IMPC)Ccpcz |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
5.00×10-05 | |
| Rab19 Rab19tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal contextual conditioning behavior | Context freezing total Fear Conditioning |
ICS IMPC |
5.41×10-05 | |
| Ubl7 Ubl7em1(IMPC)Tcp |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
5.73×10-05 | |
| Serac1 Serac1em1(IMPC)Tcp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
6.56×10-05 | |
| Slc25a18 Slc25a18tm1b(KOMP)Wtsi |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
KMPC IMPC |
6.57×10-05 | |
| Wdr27 Wdr27em1(IMPC)Ccpcz |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
8.45×10-05 | |
| Ppp4c Ppp4cem1(IMPC)Ics |
HET | Early adult | abnormal contextual conditioning behavior | % Freezing duration context-3 Fear Conditioning |
ICS IMPC |
9.12×10-05 | |
| Cacna2d1 Cacna2d1em1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
9.33×10-05 | |
| Marchf3 Marchf3tm1b(EUCOMM)Hmgu |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
9.50×10-05 | |
| Ubd Ubdtm1b(EUCOMM)Wtsi |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
CCP-IMG IMPC |
9.90×10-05 | |
| Prkab1 Prkab1tm1b(KOMP)Wtsi |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
9.91×10-05 | |
| Tmem225 Tmem225em1(IMPC)Mbp |
HOM | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
9.93×10-05 | |
| Asic1 Asic1em1(IMPC)Mbp |
HOM | Early adult | impaired contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
UC Davis IMPC |
9.95×10-05 | |
| Cyp21a1 Cyp21a1em1(IMPC)Tcp |
HET | Early adult | enhanced contextual conditioning behavior | Difference in Context and Conditioning Baseline % Freezing Fear Conditioning |
TCP IMPC |
9.96×10-05 |