Gross Pathology and Tissue Collection: Images

WT Images

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

15 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; Inguinal lymph nodes were enlarged (1.5x3mm); lymph nodes - enlarged lymph nodes, area=1.5x3, inguinal,
Comments (in English): Lateral view,
Comments (in English): Internal view

15 weeks old

16 weeks old

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.; brain - normal, There is homorrahage damage on the area of under the brain stem. due to cervical dislocation slightly.,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

16 weeks old

Mutant Images

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, area=10x7, small stomach,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There were hair loss and scabs on right and left side of low back skin. Sizes were 25x11mm for left side and 20x15mm for right side Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No other significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=5x9, subcutenious red lesion on right thigh; lymph nodes - enlarged lymph nodes, area=3x2; skin - thick skin, back skin; testes - small testis, area=6x4,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There was a patch of hairless skin on ventral side of neck between forelimbs Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of hairless skin on neck between forelimbs; hairless patch; area=23x10,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There was a patch of hairless skin on ventral side of neck between forelimbs Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of hairless skin on neck between forelimbs; hairless patch; area=23x10,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There were hair loss and scabs on right and left side of low back skin. Sizes were 25x11mm for left side and 20x15mm for right side Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No other significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - abnormal skin morphology, area=5x9, subcutenious red lesion on right thigh; lymph nodes - enlarged lymph nodes, area=3x2; skin - thick skin, back skin; testes - small testis, area=6x4,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Skin: PATO:0000627,
Skin: MP:0002060,
Skin: PATO:0001323,
Comments (in English): There was a patch of hairless skin on ventral side of neck between forelimbs Animal was bright, alert and responsive with normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin.,
Comments (in English): Lateral view,
Comments (in English): skin; Lateral view of hairless skin on neck between forelimbs; hairless patch; area=23x10,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There were scabs and hair loss on left side of low back skin. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - thick skin, area=14x10, low back,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): There were scabs and hair loss on left side of low back skin. Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; skin - thick skin, area=14x10, low back,
Comments (in English): Lateral view,
Comments (in English): Internal view

16 weeks old

Ptp4a2em1(IMPC)Tcp homozygote

Comments (in English): Animal was bright, alert and responsive with healthy furcoat and normal posture. There were no discharges or secretions from the nares, conjunctiva, aural, urogenital or anal openings. No significant external lesions found on the body.; The following tissues were examined: calvarium, cerebrum, cerebellum, eyes, ears, tongue, Harderian gland, Zymbal gland, salivary glands, nasal sinuses, teeth, trachea, lungs, heart, thymus, thyroid gland, spleen, liver, gall bladder, pancreas, esophagus, stomach, large and small intestines, kidneys, urinary tract, adrenal gland, reproductive organs, lymph nodes, spinal cord, bone, skeletal muscle, brown fat, and skin. ; stomach - abnormal stomach morphology, area=10x7, small stomach,
Comments (in English): Lateral view,
Comments (in English): Internal view

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