Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data; LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data; LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; RIGHT EYE: Slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, crystallized debris, slight hemorrhage, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data; LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data; LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Crystallized debris, slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage; RIGHT EYE: Very slight lens opacity, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data; LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: LEFT EYE: Crystallized debris, multiple tiny hyaloid, slight lens opacity, some rd8, very slight hemorrhage,
Ophthalmoscope Observation: RIGHT EYE: Severe corneal opacity, retina no data

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia, ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, very slight hremorrhage; RIGHT EYE: Some lens opacity, slight dysplasia,

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, very slight hemorrhage; RIGHT EYE: Hyaloid present, slight blood vessel crossing

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Tiny hyaloid present, slightly early blood vessel branching,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Slight dysplasia

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris ; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; LEFT EYE: Slightly lens opacity,
Ophthalmoscope Observation: Both eyes slight early blood vessel branching, some rd8, slight dysplasia; RIGHT EYE: Very slight lens opacity, crystallized debris

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes slight lens opacity, slight hemorrhage, some rd8 ; RIGHT EYE:

15 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; LEFT EYE: Tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight hemorrhage, slightly early blood vessel branching; RIGHT EYE: Some dysplasia clusters

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia ; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; LEFT EYE: Very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8; RIGHT EYE: Crystallized debris, slight dysplasia

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; RIGHT EYE: Slight blood vessel crossing and early branching, very slight molten patches,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8 ; LEFT EYE:

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Slight lens opacity, crystallized debris,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Some lens opacity, difficult to focus and image

14 weeks old

Rnase6em1(IMPC)Tcp homozygote

Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; LEFT EYE: Slight lens opacity,
Ophthalmoscope Observation: Both eyes crystallized debris, some rd8 ; RIGHT EYE: Multiple small hyaloid present, very slight lens opacity, blood vessel slightly early branching

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