Eye Morphology: Images Ophthalmoscopy

WT Images

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right eye, retina not clearly visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Left retina has abnormal texture, structure, colour

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: Mild opacity in right eye, retina appears normal

15 weeks old

Ophthalmoscope Observation: Patch of dysplasia in lower left retina

14 weeks old

Ophthalmoscope Observation: White mass in anterior of eye

14 weeks old

Ophthalmoscope Observation: Yellow body adjacent to optic disc

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opaque cornea in right and left eye, retina not well observed

14 weeks old

Ophthalmoscope Observation: White patch in left retina

15 weeks old

Ophthalmoscope Observation: Holes in left retina

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

14 weeks old

14 weeks old

Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8, hyaloid present; L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: some Rd8; R eye: some hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large white deposit in right retina

14 weeks old

Ophthalmoscope Observation: Bluish tint in right retina, yellow body near optic disc

15 weeks old

Ophthalmoscope Observation: LEFT EYE:,
Ophthalmoscope Observation: RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: Sept 29/17 both eyes: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some Rd8,
Ophthalmoscope Observation: R eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: R eye: some hemorrhage; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

14 weeks old

Ophthalmoscope Observation: Cataract obstruction in right eye

14 weeks old

Ophthalmoscope Observation: Yellow body in left retina

15 weeks old

Ophthalmoscope Observation: Slight corneal opacity in left eye; Yellow body on left cornea

14 weeks old

15 weeks old

Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8,
Ophthalmoscope Observation: R eye: opacity on lens, branches vessels, hyaloid present; L eye: some Rd8; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: LEFT EYE:

15 weeks old

Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes,
Ophthalmoscope Observation: R eye: hyaloid present; A lot of rd8 both eyes; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Opacity in right and left eyes, retinas not very visible

15 weeks old

Ophthalmoscope Observation: Right retina bluish in colour; Yellow body in anterior of eye

14 weeks old

Ophthalmoscope Observation: Both eyes: little bit of hemorrhage,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; LEFT EYE:,
Ophthalmoscope Observation: Both eyes: little bit of hemorrhage ; RIGHT EYE:

15 weeks old

Ophthalmoscope Observation: L eye: some Rd8,
Ophthalmoscope Observation: L eye: some Rd8; LEFT EYE:,
Ophthalmoscope Observation: L eye: some Rd8; RIGHT EYE:

14 weeks old

Ophthalmoscope Observation: Large yellow body obstructing right eye

Mutant Images

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; LEFT EYE: Some dysplasia, slight hemorrhaging. Blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8 and lens opacity (difficult to focus).; RIGHT EYE: Slight dysplasia, some hemorrhaging

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; LEFT EYE: Corneal opacity, some lens opacity, massive hyaloid and bright crystallized debris present, retina difficult to focus,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; LEFT EYE: Multiple tiny hyaloid present,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; LEFT EYE: Some lens opacity, blood vessel slightly early branching,
Ophthalmoscope Observation: Both eyes some rd8, slight hemorrhage ; RIGHT EYE: Slight lens opacity

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; LEFT EYE: Some lens opacity (difficult to focus).,
Ophthalmoscope Observation: Both eyes some rd8, dysplasia and hemorrhaging.; RIGHT EYE: Slight lens opacity.

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; LEFT EYE: Some lens opacity,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, slight hemorrhage, very slight molten patches; RIGHT EYE: Slight lens opacity, hyaloid and crystallized debris present, dark ring / abnormal pigmentation around optic disc, blood vessel early branching and crossing

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; LEFT EYE: Hyaloid present,
Ophthalmoscope Observation: Restless mouse. Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage; RIGHT EYE: Blood vessel early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); RIGHT EYE: Small lesion present,
Ophthalmoscope Observation: Both eyes some rd8, some dysplasia, slight lens opacity (difficult to focus); LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Bright crystallized debris

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; LEFT EYE: Crystallized debris, blood vessel early branching, slight dysplasia,
Ophthalmoscope Observation: Both eyes slight lens opacity, hyaloid present, some rd8, slight hemorrhage; RIGHT EYE: Some dysplasia

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; LEFT EYE: Some lens opacity, slight dysplasia,
Ophthalmoscope Observation: Both eyes some rd8; RIGHT EYE: Slight lens opacity, blood vessel early branching and crossing, some dysplasia, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; LEFT EYE: Some lens opacity (difficult to focus),
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia ; RIGHT EYE: Slight lens opacity, crystallized debris, slight hemorrhage

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; LEFT EYE: Some lens opacity, crystallized debris, lesion present,
Ophthalmoscope Observation: Both eyes some rd8, slight dysplasia, very slight hemorrhage; RIGHT EYE: Slight lens opacity, hyaloid present, blood vessel slightly early branching

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; RIGHT EYE: Small hyaloid and crystallized debris present, slight dysplasia,
Ophthalmoscope Observation: Both eyes some lens opacity (difficult to focus), blood vessel early branching, some rd8, slight hemorrhage; LEFT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; LEFT EYE: Crystallized debris,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia, slight hemorrhage ; RIGHT EYE:

14 weeks old

Uap1em1(IMPC)Tcp heterozygote

Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus); LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; LEFT EYE: Slight hemorrhage,
Ophthalmoscope Observation: Both eyes slight lens opacity, some rd8, slight dysplasia ; RIGHT EYE: Hyaloid and crystallized debris present (dificcult to focus)

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