Spleen Immunophenotyping: Images associated with FACS analysis
WT Images
15 weeks old
Mature NK cells - % of NK cellls: 79.014
15 weeks old
Resting Treg cells - % of Treg: 58.223
15 weeks old
Conventional DC (cDC) - % of CD45+: 1.509
15 weeks old
Resting CD4- NKT cells - % of CD4- NKT cells: 65.42
15 weeks old
CD11b-low cDC - % of cDC: 44.004
15 weeks old
KLRG1+ CD4+ T helper cells - % of CD45+: 0.16
15 weeks old
Effector gd cells - % of CD45+: 0.504
15 weeks old
Immature NK cells - % of lymphocytes: 0.621
15 weeks old
Total CD4- NKT cells - % of CD45+: 0.33
15 weeks old
CD4+ T helper cells - % of CD4+: 88.702
15 weeks old
B1a cells - % of B cells: 1.383
15 weeks old
Germinal centre B cells - % of CD45+: 0.24
15 weeks old
Marginal zone B cells - % of B2 cells: 6.071
15 weeks old
CD11b-low cDC - % of CD45+: 0.664
15 weeks old
Macrophages - % of CD45+: 0.616
15 weeks old
Effector Treg cells - % of CD45+: 0.617
15 weeks old
Effector CD8+ T cells - % of CD8+: 6.136
15 weeks old
Ly6C+ NKT cells - % of lymphocytes: 0.53
15 weeks old
Mature NK cells - % of lymphocytes: 2.337
15 weeks old
Naive CD8+ T cells - % of CD45+: 5.623
15 weeks old
Plasma cells - % of CD45+: 0.106
15 weeks old
Effector NK cells - % of CD45+: 0.361
15 weeks old
B2 t1 + t2 cells - % of B2 cells: 9.78
15 weeks old
Resting CD4+ T helper cells - % of CD4+ T helper cells: 70.523
15 weeks old
KLRG1+ Treg cells - % of CD45+: 0.131
15 weeks old
CD5+ gd T cells - % of CD45+: 0.499
15 weeks old
Effector CD4- NKT cells - % of CD4- NKT cells: 34.58
15 weeks old
CD11b-high cDC - % of CD45+: 0.84
15 weeks old
KLRG1+ CD4+ T helper cells - % of CD4+ T helper cells: 1.394
15 weeks old
Total ab T cells - % of CD45+: 22.716
15 weeks old
Effector CD8+ T cells - % of CD45+: 0.591
15 weeks old
Effector CD4+ T helper cells - % of CD45+: 3.361
15 weeks old
Total gd T cells - % of CD45+: 1.223
15 weeks old
Plasma cells - % of B2 cells: 0.169
15 weeks old
Resting CD4+ NKT cells - % of CD4+ NKT cells: 16.46
15 weeks old
Plasmacytoid DC - % of DC: 19.041
15 weeks old
Total CD4+ T cells - % of CD45+: 12.97
15 weeks old
Effector gd T cells - % of gd T cells: 41.226
15 weeks old
Resting CD8+ T cells - % of CD45+: 3.147
15 weeks old
Total CD8+ T cells - % of ab T cells: 42.423
15 weeks old
Effector CD4+ NKT cells - % of CD45+: 0.268
15 weeks old
Marginal zone precursor B cells - % of CD45+: 2.948
15 weeks old
CD103+ CD11b-low cDC - % of CD45+: 0.064
15 weeks old
Resting CD8+ T cells - % of CD8+: 32.653
15 weeks old
Total B2 cells - % of B cells: 98.617
15 weeks old
Resting NK cells - % of CD45+: 2.079
15 weeks old
Total CD4+ T cells - % of ab T cells: 57.099
15 weeks old
Total Treg cells - % of CD45+: 1.486
15 weeks old
Immature NK cells - % of NK cells: 20.986
15 weeks old
Ly6C+ immature NK cells - % of lymphocytes: 0.09
Mutant Images
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 79.413
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.422
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 16.264
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.228
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 35.847
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.431
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 45.96
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 18.506
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 47.24
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 37.162
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 63.582
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 17.268
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 22.055
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 18.135
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 61.032
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 37.264
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 12.252
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 29.362
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 9.711
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 27.598
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 34.066
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD11b-high cDC - % of CD45+: 0.724
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 22.354
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 9.99
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 33.446
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 3.389
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 78.557
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.592
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 19.814
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 2.244
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 15.717
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 37.639
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 2.498
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 17.218
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 9.535
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 62.171
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 34.054
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 32.515
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 2.377
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 41.673
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 43.773
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD11b-high cDC - % of CD45+: 0.578
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 42.854
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 1.287
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 23.13
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 61.981
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 31.66
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 20.238
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 39.532
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 45.35
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 9.554
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 21.651
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.414
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 1.217
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 74.314
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 2.23
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 33.817
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 47.152
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 35.381
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 9.581
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 15.872
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 46.33
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 84.463
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 43.996
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 64.017
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B2 cells - % of CD45+: 45.267
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 35.68
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 35.472
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 38.538
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 22.496
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 20.401
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.593
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 7.183
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 36.643
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 79.301
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 47.878
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 23.886
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 21.336
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Follicular B cells - % of CD45+: 34.412
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 38.413
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 35.42
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.404
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.175
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 2.197
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 34.452
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD4+ T helper cells - % of CD45+: 20.068
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total ab T cells - % of CD45+: 32.815
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 46.867
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 10.876
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.382
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of CD45+: 19.323
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 1.981
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 2.247
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 14.263
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of NK cells: 17.182
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting Treg cells - % of CD45+: 1.468
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total T cells - % of CD45+: 37.184
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 23.588
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD8+: 78.139
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total Treg cells - % of CD45+: 2.193
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Effector gd T cells - % of gd T cells: 23.722
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 16.602
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Naive CD8+ T cells - % of CD45+: 10.058
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.22
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
CD11b-high cDC - % of CD45+: 0.842
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD4+ T cells - % of ab T cells: 63.018
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Transitional 1 B cells - % of CD45+: 1.334
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Resting CD4+ T helper cells - % of CD45+: 14.774
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
KLRG1+ NK cells - % of CD45+: 0.136
16 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total CD8+ T cells - % of ab T cells: 36.345
15 weeks old
Duoxa2tm1b(KOMP)Wtsi homozygote
Total B cells - % of CD45+: 50.106
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